Q8CGQ8
PR
Gene name |
Slc24a4 |
Protein name |
Sodium/potassium/calcium exchanger 4 |
Names |
Na(+)/K(+)/Ca(2+)-exchange protein 4, Solute carrier family 24 member 4 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:238384 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8CGQ8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8CGQ8-F1 | Predicted | AlphaFoldDB |
27 variants for Q8CGQ8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs257079051 | 8 | R>P | No | EVA | |
| rs3389228521 | 24 | G>S | No | EVA | |
| rs229937378 | 31 | A>T | No | EVA | |
| rs3389258494 | 93 | K>* | No | EVA | |
| rs3389266272 | 121 | F>L | No | EVA | |
| rs3389248994 | 174 | V>G | No | EVA | |
| rs3389254093 | 187 | V>M | No | EVA | |
| rs3410870204 | 199 | T>M | No | EVA | |
| rs3389229690 | 207 | S>Y | No | EVA | |
| rs3389254384 | 211 | T>M | No | EVA | |
| rs3389264801 | 230 | E>K | No | EVA | |
| rs3389229697 | 245 | M>T | No | EVA | |
| rs3389257231 | 254 | F>Y | No | EVA | |
| rs3389271306 | 267 | P>Q | No | EVA | |
| rs3389187273 | 359 | N>T | No | EVA | |
| rs3389249015 | 374 | M>V | No | EVA | |
| rs3389215664 | 407 | V>E | No | EVA | |
| rs3389229682 | 421 | K>N | No | EVA | |
| rs3403654964 | 423 | D>GVG* | No | EVA | |
| rs36368773 | 430 | T>M | No | EVA | |
| rs3389257218 | 488 | I>M | No | EVA | |
| rs3389252008 | 488 | I>V | No | EVA | |
| rs3389258516 | 550 | T>R | No | EVA | |
| rs3389266206 | 577 | H>Y | No | EVA | |
| rs3389258493 | 591 | V>M | No | EVA | |
| rs3389215649 | 594 | L>F | No | EVA | |
| rs3389255454 | 617 | M>I | No | EVA |
No associated diseases with Q8CGQ8
2 regional properties for Q8CGQ8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Sodium/calcium exchanger membrane region | 104 - 244 | IPR004837-1 |
| domain | Sodium/calcium exchanger membrane region | 453 - 604 | IPR004837-2 |
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| apical plasma membrane | The region of the plasma membrane located at the apical end of the cell. |
| cone photoreceptor outer segment | The outer segment of a vertebrate cone photoreceptor that contains membrane discs that are contiguous with the ciliary membrane and containing opsin photoreceptor proteins. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| vesicle | Any small, fluid-filled, spherical organelle enclosed by membrane. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium channel activity | Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
| calcium, potassium:sodium antiporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + K+(in) + Na+(out) = Ca2+(out) + K+(out) + Na+(in). |
| calcium-dependent protein binding | Binding to a protein or protein complex in the presence of calcium. |
| calcium:sodium antiporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in). |
| calmodulin binding | Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. |
| symporter activity | Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. |
23 GO annotations of biological process
| Name | Definition |
|---|---|
| amelogenesis | The process whose specific outcome is the formation of tooth enamel, occurring in two stages: secretory stage and maturation stage. |
| calcium ion export across plasma membrane | The directed movement of calcium ions from inside of a cell, across the plasma membrane and into the extracellular region. |
| calcium ion homeostasis | Any process involved in the maintenance of an internal steady state of calcium ions within an organism or cell. |
| calcium ion import across plasma membrane | The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol. |
| calcium ion transmembrane transport | A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. |
| cellular calcium ion homeostasis | Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell. |
| cellular response to high light intensity | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high light intensity stimulus. |
| cone photoresponse recovery | The processes required for a cone photoreceptor to recover, following light activation, so that it can respond to a subsequent light stimulus. Cone recovery requires the shutoff of active participants in the phototransduction cascade, including the visual pigment and downstream signal transducers. |
| detection of chemical stimulus involved in sensory perception of smell | The series of events involved in the perception of smell in which an olfactory chemical stimulus is received and converted into a molecular signal. |
| drinking behavior | The specific behavior of an organism relating to the intake of liquids, especially water. |
| membrane repolarization | The process in which ions are transported across a membrane such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential. |
| negative regulation of calcium-mediated signaling | Any process that stops, prevents, or reduces the frequency, rate or extent of calcium-mediated signaling. |
| olfactory nerve maturation | A developmental process, independent of morphogenetic (shape) change, that is required for the olfactory nerve to attain its fully functional state. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem. |
| phototransduction | The sequence of reactions within a cell required to convert absorbed photons into a molecular signal. |
| positive regulation of gene expression | Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
| potassium ion transmembrane transport | A process in which a potassium ion is transported from one side of a membrane to the other. |
| regulation of eating behavior | Any process that modulates the frequency, rate or extent of eating behavior. |
| regulation of G protein-coupled receptor signaling pathway | Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway. |
| regulation of signaling receptor activity | Any process that modulates the frequency, rate or extent of a signaling receptor activity. Receptor activity is when a molecule combines with an extracellular or intracellular messenger to initiate a change in cell activity. |
| response to melanocyte-stimulating hormone | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a melanocyte-stimulating hormone stimulus. The binding of any one of three melanocyte-stimulating hormones causes dispersal of melanosomes in melanophores of poikilothermic vertebrates. |
| response to odorant | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an odorant stimulus. An odorant is any substance capable of stimulating the sense of smell. |
| sensory perception of smell | The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process. |
| sodium ion transmembrane transport | A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. |
3 homologous proteins in AiPD
| 10 | 20 | 30 | 40 | 50 | 60 |
| MALRGLIRQS | KVRRRREMLP | QQVGFVCAVL | ALVCCASGLF | GSLGHKTASA | GKHVLLDTWR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NRKLMAPING | TPLAKNCTDP | AIHEFPTDLF | SNKERQHGAV | LLHILGALYM | FYALAIVCDD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FFVPSLEKIC | EKLHLSEDVA | GATFMAAGSS | TPELFASVIG | VFITHGDVGV | GTIVGSAVFN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ILCIIGVCGL | FAGQVVRLTW | WAVCRDSVYY | TLSVIVLIAF | IYDEEIVWWE | GLVLIILYVF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| YILIMKYNMK | MQTFFTTKQK | SIANGNPVSN | ELEDGNDLYD | GSYDDPSVPL | LGQVKEKPPY |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GKTPVVMVDE | ILSSSPPKFT | FPEAGLRIMI | TNKFGPRTRL | RMASRIIINE | RQRLINSANG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VNSKPLQNGR | HENMENGNVP | VENPEDPQQG | QEQQPPPQPP | PPEPESVETV | FLSPFSMPEA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KGDKAKWVFT | WPLIFLLCVT | IPNCSKPRWE | KFFMVTFITA | TLWIAVFSYL | MVWLVTIIGY |
| 490 | 500 | 510 | 520 | 530 | 540 |
| TLGIPDVIMG | ITFLAAGTSV | PDCMASLIVA | RQGLGDMAVS | NTIGSNVFDI | LVGLGIPWGL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| QTMVINYGST | VKINSRGLVY | SVVLLLGSVA | LTVLGIHLNK | WRLDRKLGIY | VLVLYAVFLC |
| 610 | 620 | ||||
| FSIMIEFNVF | TFVNLPMCRE | DD |