Q99P30
Gene name |
Nudt7 |
Protein name |
Peroxisomal coenzyme A diphosphatase NUDT7 |
Names |
Nucleoside diphosphate-linked moiety X motif 7, Nudix motif 7 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:67528 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q99P30
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q99P30-F1 | Predicted | AlphaFoldDB |
19 variants for Q99P30
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs37317033 | 8 | P>R | No | EVA | |
| rs248116858 | 15 | L>P | No | EVA | |
| rs46278253 | 49 | R>K | No | EVA | |
| rs46278253 | 49 | R>T | No | EVA | |
| rs3389010270 | 66 | R>M | No | EVA | |
| rs3388995335 | 68 | P>H | No | EVA | |
| rs251176023 | 70 | E>Q | No | EVA | |
| rs3389014301 | 82 | D>A | No | EVA | |
| rs3389011999 | 86 | T>R | No | EVA | |
| rs3388964328 | 113 | Y>N | No | EVA | |
| rs3399625581 | 123 | P>H | No | EVA | |
| rs3399625589 | 125 | V>G | No | EVA | |
| rs265158723 | 168 | R>C | No | EVA | |
| rs253464934 | 192 | T>P | No | EVA | |
| rs219582869 | 209 | A>T | No | EVA | |
| rs247371693 | 211 | K>E | No | EVA | |
| rs3388964339 | 212 | I>M | No | EVA | |
| rs1132667931 | 216 | L>F | No | EVA | |
| rs232868378 | 229 | W>R | No | EVA |
No associated diseases with Q99P30
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| peroxisomal matrix | The volume contained within the membranes of a peroxisome; in many cells the matrix contains a crystalloid core largely composed of urate oxidase. |
| peroxisome | A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| acetyl-CoA hydrolase activity | Catalysis of the reaction: acetyl-CoA + H(2)O = acetate + CoA + H(+). |
| CoA pyrophosphatase activity | Catalysis of the reaction: coenzyme A or its derivatives + H2O = 3',5'-ADP + 4'-phosphopantetheine. |
| magnesium ion binding | Binding to a magnesium (Mg) ion. |
| manganese ion binding | Binding to a manganese ion (Mn). |
| snoRNA binding | Binding to a small nucleolar RNA. |
10 GO annotations of biological process
| Name | Definition |
|---|---|
| acetyl-CoA catabolic process | The chemical reactions and pathways resulting in the breakdown of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated. |
| brown fat cell differentiation | The process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria. |
| butyryl-CoA catabolic process | The chemical reactions a resulting in the resulting in the breakdown of butyryl-CoA. |
| coenzyme A catabolic process | The chemical reactions and pathways resulting in the breakdown of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. |
| malonyl-CoA catabolic process | The chemical reactions and pathways resulting in the breakdown of malonyl-CoA, the S-malonyl derivative of coenzyme A. |
| medium-chain fatty-acyl-CoA catabolic process | The chemical reactions and pathways resulting in the breakdown of medium-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a medium-chain fatty-acyl group. A medium-chain fatty acid is a fatty acid with a chain length of between C6 and C12. |
| nucleoside diphosphate metabolic process | The chemical reactions and pathways involving a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar. |
| propionyl-CoA catabolic process | The chemical reactions and pathways resulting in the breakdown of propionyl-CoA. |
| propionyl-CoA metabolic process | The chemical reactions and pathways involving propionyl-CoA. |
| succinyl-CoA catabolic process | The chemical reactions and pathways resulting in the breakdown of succinyl-CoA. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q12524 | PCD1 | Peroxisomal coenzyme A diphosphatase 1, peroxisomal | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSRPCGLPEP | VRNNLIDDAK | ARLRKSDVGT | RYSHLSSNKF | SVLVPLLARG | GKLYLMFTVR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SDKLKREPGE | VCFPGGKRDP | VDTDDTATAL | REAQEEVGLH | PHQVEVVSHL | VPYVFDNDAL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VTPVVGFLDH | NFQAQPNADE | VKEVFFVPLD | YFLHPQVYYQ | KQITQSGRDF | IMHCFEYKDP |
| 190 | 200 | 210 | 220 | 230 | |
| ETGVNYLIQG | MTSKLAVLVA | LIILEQSPAF | KIDFDLHDLI | PSCERTFLWR | YSLSKL |