Q12524
Gene name |
PCD1 (YLR151C, L9634.8) |
Protein name |
Peroxisomal coenzyme A diphosphatase 1, peroxisomal |
Names |
|
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YLR151C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q12524
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q12524-F1 | Predicted | AlphaFoldDB |
2 variants for Q12524
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s12-442035 | 235 | T>I | No | SGRP | |
| s12-441926 | 271 | I>M | No | SGRP |
No associated diseases with Q12524
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| peroxisome | A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity | Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate (8-oxo-dGTP) + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate (8-oxo-dGMP) + diphosphate. 8-oxo-dGTP is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA. |
| 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity | Catalysis of the reaction: 8-oxo-7,8-dihydroguanosine triphosphate (8-oxo-GTP) + H2O = 8-oxo-7,8-dihydroguanosine diphosphate (8-oxo-GDP) + phosphate. 8-oxo-7,8-dihydroguanosine triphosphate (8-oxo-GTP) is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for transcription. |
| acetyl-CoA hydrolase activity | Catalysis of the reaction: acetyl-CoA + H(2)O = acetate + CoA + H(+). |
| CoA pyrophosphatase activity | Catalysis of the reaction: coenzyme A or its derivatives + H2O = 3',5'-ADP + 4'-phosphopantetheine. |
| magnesium ion binding | Binding to a magnesium (Mg) ion. |
| manganese ion binding | Binding to a manganese ion (Mn). |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| coenzyme A catabolic process | The chemical reactions and pathways resulting in the breakdown of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. |
| DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. |
| nucleoside diphosphate metabolic process | The chemical reactions and pathways involving a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q99P30 | Nudt7 | Peroxisomal coenzyme A diphosphatase NUDT7 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MILSQRRMLS | SKQLIENLIR | YKFHKTPYTR | SSIWPFKRNS | AVIILLFIGM | KGELRVLLTK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RSRTLRSFSG | DVSFPGGKAD | YFQETFESVA | RREAEEEIGL | PHDPEVLHKE | FGMKLDNLVM |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DMPCYLSRTF | LSVKPMVCFL | YKDKLEKHED | KYKVPLDIRK | FFGKLNPGET | SSLFSVPLND |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LVIHLLPEAD | EDVKSYQAEY | FERKEYKLNW | GGIKWLIMHY | HFHVANNNEM | PWLQTIEDLS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SSDEDGVDGG | IFRFRDLWGL | TCKILFDVSC | IANGLMDEKL | KGELGHEDLI | VGLHDYGNQM |
| 310 | 320 | 330 | |||
| QPNGRSEWEI | GMINGDRNLK | YSDVIPEYYM | KHLLECRSLW |