Q99N96
Gene name |
Mrpl1 |
Protein name |
39S ribosomal protein L1, mitochondrial |
Names |
L1mt, MRP-L1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:94061 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q99N96
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q99N96-F1 | Predicted | AlphaFoldDB |
16 variants for Q99N96
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs216906141 | 5 | V>I | No | EVA | |
| rs108387726 | 9 | R>C | No | EVA | |
| rs37922898 | 19 | C>S | No | EVA | |
| rs221790151 | 34 | V>M | No | EVA | |
| rs3412161842 | 42 | H>Q | No | EVA | |
| rs3388767231 | 42 | H>R | No | EVA | |
| rs3388768799 | 119 | F>S | No | EVA | |
| rs3388771488 | 141 | T>I | No | EVA | |
| rs3388772508 | 147 | S>I | No | EVA | |
| rs3388743489 | 155 | F>L | No | EVA | |
| rs3388769805 | 159 | V>D | No | EVA | |
| rs3388767246 | 161 | K>N | No | EVA | |
| rs3388772527 | 230 | S>F | No | EVA | |
| rs243788003 | 255 | Q>P | No | EVA | |
| rs33633475 | 294 | F>L | No | EVA | |
| rs235196282 | 299 | F>L | No | EVA |
No associated diseases with Q99N96
No regional properties for Q99N96
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q99N96 | |||
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosolic large ribosomal subunit | The large subunit of a ribosome located in the cytosol. |
| mitochondrial inner membrane | The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. |
| mitochondrial large ribosomal subunit | The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site). |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| structural constituent of ribosome | The action of a molecule that contributes to the structural integrity of the ribosome. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| maturation of LSU-rRNA | Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule. |
| mitochondrial translation | The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code. |
| translation | The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAAAVRCLRR | VLIHHQRHCL | CKMASQASLY | PCSVNSLLHN | RHFAAAAAAA | TKPARKIKKG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AKEKTSDEKP | VDDIEKIKSY | TYMESDPEDD | VYLKRLYPRR | IYEVEKAIHL | LKKFQVLDFT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NPKQGVYLDL | TLDMALGKKK | TVEPFASVIA | LPHLFSSEVN | KVAVFTANAS | EIKIAEENGA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AFAGGTDLVK | KIMDDEVVVD | FYVAVPEIMG | ELNPLRKKLK | KRFPKATRNS | IGRDIPKMLE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LFKTAHEIMV | DEERQNFLST | KIATLDMPSD | QIAANLQAVI | NEVCKHRPLN | LGPFVVRAFL |
| 310 | 320 | 330 | |||
| RSSTSEGLLL | KTDSLLPKEA | KTTEAETEET | QTAEAA |