A6QPQ5

PR
Gene name
MRPL1
Protein name
39S ribosomal protein L1, mitochondrial
Names
L1mt, MRP-L1
Species
Bos taurus (Bovine)
KEGG Pathway
bta:504835
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

12-103 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for A6QPQ5

Entry ID Method Resolution Chain Position Source
2FTC EM - A 123-311 PDB
AF-A6QPQ5-F1 Predicted AlphaFoldDB

35 variants for A6QPQ5

Variant ID(s) Position Change Description Diseaes Association Provenance
rs476348548 14 H>R No EVA
rs382121571 51 K>T No EVA
rs480763095 54 K>I No EVA
rs447697074 72 I>K No EVA
rs466140919 74 S>* No EVA
rs722261815 76 P>L No EVA
rs433122307 79 E>A No EVA
rs470033021 107 K>N No EVA
rs455441247 116 N>T No EVA
rs473974651 128 D>G No EVA
rs440873321 129 M>I No EVA
rs458278162 134 K>N No EVA
rs481558493 193 Q>K No EVA
rs479018078 214 L>Q No EVA
rs441670813 250 E>D No EVA
rs460122484 254 E>* No EVA
rs478571934 258 A>E No EVA
rs462598918 260 L>R No EVA
rs481022434 261 D>Y No EVA
rs441628268 262 M>L No EVA
rs461702723 263 P>Q No EVA
rs480145940 265 D>A No EVA
rs442456050 272 Q>K No EVA
rs465870621 289 F>S No EVA
rs432826279 290 V>L No EVA
rs471143973 294 F>V No EVA
rs444720706 297 S>N No EVA
rs475215730 299 T>K No EVA
rs442196446 300 S>I No EVA
rs460644402 303 L>* No EVA
rs479132890 304 L>I No EVA
rs439663250 307 I>M No EVA
rs717186099 308 E>Q No EVA
rs458145090 315 G>R No EVA
rs482991154 325 V>G No EVA

No associated diseases with A6QPQ5

No regional properties for A6QPQ5

Type Name Position InterPro Accession
No domain, repeats, and functional sites for A6QPQ5

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosolic large ribosomal subunit The large subunit of a ribosome located in the cytosol.
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.

2 GO annotations of molecular function

Name Definition
RNA binding Binding to an RNA molecule or a portion thereof.
structural constituent of ribosome The action of a molecule that contributes to the structural integrity of the ribosome.

2 GO annotations of biological process

Name Definition
maturation of LSU-rRNA Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule.
translation The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9BYD6 MRPL1 39S ribosomal protein L1, mitochondrial Homo sapiens (Human) PR
Q99N96 Mrpl1 39S ribosomal protein L1, mitochondrial Mus musculus (Mouse) PR
10 20 30 40 50 60
MAATVRCFGR VLIHHQRCSL ATVTSQTSLY PCCIYVPVPN RHFAAAAKPA KKTKKGTKEK
70 80 90 100 110 120
ASNEKKDDIE KIKSYPFMEG EPEDDVYLKR LYPRQIYEVE KAVNLLKKFQ VLDFTNPKQG
130 140 150 160 170 180
VYLDLTLDMT LGKKKKVEPF ASVLSLPYPF ISEMSKVAVF TGNASEIKIA EENGAAFAGG
190 200 210 220 230 240
TNLIQKILDD EIQADFYIAV PEIMPELNPL RKKLKTRFPK FNRNSVGRDI PKMLELFKTG
250 260 270 280 290 300
LEIKVDEERE NFLETKIATL DMPSDQIAAN LQAVINEVCR QRPLNLGPFV VRAFLRSSTS
310 320
EGLLLKIEPL LPKEGETKES DKKAV