AiPD: Autoinhibited Protein Database

Q99627

Gene name	COPS8 (CSN8)
Protein name	COP9 signalosome complex subunit 8
Names	SGN8, Signalosome subunit 8, COP9 homolog, hCOP9, JAB1-containing signalosome subunit 8
Species	Homo sapiens (Human)
KEGG Pathway	hsa:10920
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

151-209 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

151-209 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

12 structures for Q99627

Entry ID	Method	Resolution	Chain	Position	Source
4D10	X-ray	380 A	H/P	2-209	PDB
4D18	X-ray	408 A	H/P	1-209	PDB
4WSN	X-ray	550 A	H/P/X/f/n/v	1-209	PDB
6R6H	EM	840 A	H	1-209	PDB
6R7F	EM	820 A	H	1-209	PDB
6R7H	EM	880 A	H	11-209	PDB
6R7I	EM	590 A	H	1-209	PDB
6R7N	EM	650 A	H	11-209	PDB
8H38	EM	425 A	H	1-209	PDB
8H3A	EM	751 A	H	1-209	PDB
8H3F	EM	673 A	H	1-209	PDB
AF-Q99627-F1	Predicted				AlphaFoldDB

143 variants for Q99627

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
TCGA novel	1	M>?	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs756826172 CA2186951	2	P>L		No	ClinGen ExAC TOPMed gnomAD
CA67763681 rs1050649170	4	A>E		No	ClinGen gnomAD
CA351458727 rs1050649170	4	A>V		No	ClinGen gnomAD
CA2186953 rs745586469	5	V>G		No	ClinGen ExAC gnomAD
CA351458739 rs1200856087	6	M>I		No	ClinGen gnomAD
rs1490286521 CA351458738	6	M>R		No	ClinGen gnomAD
CA351458734 rs1265753960	6	M>V		No	ClinGen gnomAD
CA2186956 rs201162093	7	A>G		No	ClinGen 1000Genomes ExAC gnomAD
rs1432012693 CA351458743	7	A>S		No	ClinGen TOPMed gnomAD
CA351458744 rs1432012693	7	A>T		No	ClinGen TOPMed gnomAD
CA2186955 rs201162093	7	A>V		No	ClinGen 1000Genomes ExAC gnomAD
rs566472436 CA2186957	8	E>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1286979398 CA351458746	8	E>K		No	ClinGen TOPMed
rs1372169103 CA351458754	9	S>G		No	ClinGen gnomAD
rs747018225 CA2186960	11	F>C		No	ClinGen ExAC gnomAD
rs1404042230 CA351458773	11	F>L		No	ClinGen gnomAD
CA351458767 rs1483077031	11	F>L		No	ClinGen gnomAD
rs771082299 CA2186961	12	S>T		No	ClinGen ExAC gnomAD
CA351458793 rs1175330926	14	K>R		No	ClinGen TOPMed
CA2186962 rs374765254	15	K>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1380623240 CA351458809	16	L>F		No	ClinGen gnomAD
TCGA novel	19	Q>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs765450341 CA2186964	23	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs945712898 CA67763771	26	E>K		No	ClinGen TOPMed
rs761872610 CA2186993	27	A>G		No	ClinGen ExAC gnomAD
CA2186995 rs749888932	29	G>R		No	ClinGen ExAC gnomAD
rs1472168901 CA351458921	31	I>T		No	ClinGen TOPMed
rs1158311732 CA351458919	31	I>V		No	ClinGen gnomAD
rs760280890 CA2186996	33	T>A		No	ClinGen ExAC gnomAD
rs1455443582 CA351458936	34	P>A		No	ClinGen TOPMed gnomAD
CA67764784 rs538156644	35	P>A		No	ClinGen Ensembl
rs1307961618 CA351458943	35	P>L		No	ClinGen gnomAD
rs753583849 CA2186998	38	G>C		No	ClinGen ExAC gnomAD
rs758812813 CA2186999	39	Q>E		No	ClinGen ExAC gnomAD
rs375734947 CA2187002	47	H>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA2187004 rs745910235	48	N>S		No	ClinGen ExAC TOPMed gnomAD
CA351459056 rs1324233860	50	M>I		No	ClinGen gnomAD
CA351459042 rs1244534508	50	M>T		No	ClinGen gnomAD
rs769905651 CA2187005	50	M>V		No	ClinGen ExAC gnomAD
CA2187039 rs758990973	51	N>D		No	ClinGen ExAC gnomAD
rs144623210 CA67765722	51	N>S		No	ClinGen ESP TOPMed
rs764905331 CA2187040	53	A>V		No	ClinGen ExAC gnomAD
CA2187041 rs775047015	54	R>I		No	ClinGen ExAC gnomAD
rs1290812773 CA351459117	59	R>K		No	ClinGen gnomAD
rs1316977411 CA351459122	60	I>L		No	ClinGen Ensembl
CA67765747 rs373635523	62	P>L		No	ClinGen ESP TOPMed gnomAD
rs1473100894 CA351459151	64	I>M		No	ClinGen TOPMed
rs115111928 CA2187042	64	I>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA67766467 rs368486540	68	N>H		No	ClinGen gnomAD
TCGA novel	71	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2187053 rs746814284	72	G>E		No	ClinGen ExAC gnomAD
CA2187055 rs776741758	73	G>E		No	ClinGen ExAC gnomAD
CA351459220 rs776741758	73	G>V		No	ClinGen ExAC gnomAD
rs769239916 CA2187057	80	R>S		No	ClinGen ExAC gnomAD
CA2187058 rs775197908	81	I>M		No	ClinGen ExAC gnomAD
rs762583635 CA2187059	83	Q>*		No	ClinGen ExAC gnomAD
CA351459287 rs1439692218	83	Q>R		No	ClinGen TOPMed
CA2187060 rs763744436	84	R>K		No	ClinGen ExAC TOPMed gnomAD
CA351459298 rs1253260742	85	D>H		No	ClinGen TOPMed gnomAD
CA2187061 rs542558520	87	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2187063 rs766828214	90	Y>C		No	ClinGen ExAC gnomAD
CA2187064 rs754340188	91	T>A		No	ClinGen ExAC gnomAD
CA351459348 rs1397583681	92	T>I		No	ClinGen gnomAD
TCGA novel	92	T>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs139644507 CA2187065	93	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA2187066 rs765289634	94	N>S		No	ClinGen ExAC TOPMed gnomAD
CA351459362 COSM3051211 rs1239765594	95	A>T	ovary Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs373956441 CA2187067	101	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA351459417 rs1193021671	102	V>A		No	ClinGen TOPMed
CA2187068 rs758482926	108	A>S		No	ClinGen ExAC gnomAD
rs919142701 CA67766572	108	A>V		No	ClinGen TOPMed
TCGA novel	110	R>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs777181775 CA2187083	111	D>G		No	ClinGen ExAC gnomAD
TCGA novel	111	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA67769068 rs1031626586	112	A>G		No	ClinGen TOPMed
CA2187084 rs760027685	116	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs752671265 CA2187086	117	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1434384413 CA351459539	119	A>G		No	ClinGen gnomAD
rs151029276 CA351459559	123	Q>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs151029276 CA2187087	123	Q>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA67769091 rs202129594 COSM239426	124	A>V	prostate [Cosmic]	No	ClinGen cosmic curated 1000Genomes gnomAD
CA2187089 rs751881755	126	T>A		No	ClinGen ExAC gnomAD
rs780919409 CA2187091	128	I>L		No	ClinGen ExAC gnomAD
CA351459589 rs780919409	128	I>V		No	ClinGen ExAC gnomAD
rs780058598 CA2187094	131	D>N		No	ClinGen ExAC gnomAD
rs780058598 CA2187095	131	D>Y		No	ClinGen ExAC gnomAD
TCGA novel	134	A>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs778513456 CA2187097	135	A>D		No	ClinGen ExAC TOPMed gnomAD
CA2187100 rs771279491	138	G>A		No	ClinGen ExAC TOPMed gnomAD
rs1222585991 CA351459669	140	P>H		No	ClinGen TOPMed
rs1284049446 CA351459672	141	V>I		No	ClinGen TOPMed
rs759959050 CA2187102	143	E>D		No	ClinGen ExAC gnomAD
CA2187103 rs188786181	146	K>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2187104 rs776105885	146	K>R		No	ClinGen ExAC gnomAD
rs915395164 CA67770320	148	I>T		No	ClinGen Ensembl
rs769293749 CA2187123	148	I>V		No	ClinGen ExAC gnomAD
rs774518250 CA2187124	153	W>G		No	ClinGen ExAC TOPMed gnomAD
rs199507598 CA2187125	155	A>G		No	ClinGen 1000Genomes ExAC gnomAD
rs1171053320 CA351459797	157	S>C		No	ClinGen TOPMed
rs1289460533 CA351459804	158	T>I		No	ClinGen gnomAD
CA2187126 rs375150277	159	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA67770335 rs375150277	159	T>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs773519722 CA2187127	161	M>I		No	ClinGen ExAC gnomAD
CA351459817 rs1229654159	161	M>V		No	ClinGen gnomAD
rs926332839 CA67770341	162	V>I		No	ClinGen TOPMed
rs1239053824 CA351459845	165	R>S		No	ClinGen gnomAD
rs114346618 CA2187129	167	P>L		No	ClinGen 1000Genomes ExAC gnomAD
CA351459861 rs1246101629	168	V>L		No	ClinGen TOPMed
rs1245619754 CA351459882	169	A>V		No	ClinGen TOPMed
CA351459896 rs34344319	172	L>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs756873308 CA351459902	173	D>A		No	ClinGen ExAC TOPMed gnomAD
rs756873308 CA2187156	173	D>G		No	ClinGen ExAC TOPMed gnomAD
rs749047467 CA67771007	173	D>N		No	ClinGen TOPMed gnomAD
rs781010844 CA2187157	177	N>H		No	ClinGen ExAC gnomAD
CA351459934 rs896653342	178	K>E		No	ClinGen TOPMed gnomAD
CA67771033 rs896653342	178	K>Q		No	ClinGen TOPMed gnomAD
CA351459936 rs1359370324	178	K>R		No	ClinGen gnomAD
CA351459946 rs1228244316	179	F>L		No	ClinGen TOPMed
CA67771038 rs200178841	179	F>S		No	ClinGen 1000Genomes
TCGA novel	179	F>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1013953350 CA67771042	180	I>T		No	ClinGen TOPMed
CA67771043 rs1013667723	181	P>L		No	ClinGen TOPMed
CA351459954 rs111953822	181	P>S		No	ClinGen ExAC TOPMed gnomAD
CA2187158 rs111953822	181	P>T		No	ClinGen ExAC TOPMed gnomAD
CA67771046 rs886439960	182	L>S		No	ClinGen TOPMed gnomAD
CA351459995 rs1172969723	185	P>H		No	ClinGen TOPMed
rs761257535 CA2187174	186	A>G		No	ClinGen ExAC TOPMed gnomAD
CA2187175 rs767243543	187	P>A		No	ClinGen ExAC gnomAD
CA2187176 rs750154058	188	V>F		No	ClinGen ExAC gnomAD
TCGA novel	188	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA67771830 rs779489336	191	I>L		No	ClinGen ExAC gnomAD
CA2187178 rs779489336	191	I>V		No	ClinGen ExAC gnomAD
TCGA novel	192	P>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA351460038 rs1259244150	193	N>S		No	ClinGen TOPMed
TCGA novel	194	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs377323601 CA2187179	194	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA2187180 rs758884554	196	Q>P		No	ClinGen ExAC gnomAD
rs778166607 CA2187181	198	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1333303626 CA351460083	200	L>M		No	ClinGen gnomAD
rs747071033 CA2187182	201	T>A		No	ClinGen ExAC gnomAD
CA67771880 rs1009873765	202	D>Y		No	ClinGen Ensembl
CA2187183 rs557901190	203	Y>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD

No associated diseases with Q99627

2 regional properties for Q99627

Type	Name	Position	InterPro Accession
domain	Proteasome component (PCI) domain	8 - 179	IPR000717
domain	CSN8/PSMD8/EIF3K	34 - 164	IPR033464

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

7 GO annotations of cellular component

Name	Definition
COP9 signalosome	A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
perinuclear region of cytoplasm	Cytoplasm situated near, or occurring around, the nucleus.

No GO annotations of molecular function

Name	Definition
No GO annotations for molecular function

7 GO annotations of biological process

Name	Definition
activation of NF-kappaB-inducing kinase activity	The stimulation of the activity of NF-kappaB-inducing kinase through phosphorylation at specific residues.
COP9 signalosome assembly	The aggregation, arrangement and bonding together of a set of components to form a COP9 signalosome.
negative regulation of cell population proliferation	Any process that stops, prevents or reduces the rate or extent of cell proliferation.
protein deneddylation	The removal of a ubiquitin-like protein of the NEDD8 type from a protein.
protein neddylation	Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein.
protein phosphorylation	The process of introducing a phosphate group on to a protein.
regulation of protein neddylation	Any process that modulates the frequency, rate or extent of protein neddylation.

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q7ZUZ0	cops8	COP9 signalosome complex subunit 8	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MPVAVMAESA	FSFKKLLDQC	ENQELEAPGG	IATPPVYGQL	LALYLLHNDM	NNARYLWKRI
70	80	90	100	110	120
PPAIKSANSE	LGGIWSVGQR	IWQRDFPGIY	TTINAHQWSE	TVQPIMEALR	DATRRRAFAL
130	140	150	160	170	180
VSQAYTSIIA	DDFAAFVGLP	VEEAVKGILE	QGWQADSTTR	MVLPRKPVAG	ALDVSFNKFI
190	200
PLSEPAPVPP	IPNEQQLARL	TDYVAFLEN