Q7ZUZ0
Gene name |
cops8 (zgc:56319) |
Protein name |
COP9 signalosome complex subunit 8 |
Names |
Signalosome subunit 8 |
Species |
Danio rerio (Zebrafish) (Brachydanio rerio) |
KEGG Pathway |
dre:393198 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q7ZUZ0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q7ZUZ0-F1 | Predicted | AlphaFoldDB |
No variants for Q7ZUZ0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q7ZUZ0 | |||||
No associated diseases with Q7ZUZ0
5 regional properties for Q7ZUZ0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | C2 domain | 1 - 115 | IPR000008-1 |
| domain | C2 domain | 124 - 247 | IPR000008-2 |
| domain | von Willebrand factor, type A | 289 - 495 | IPR002035 |
| domain | Copine, C-terminal | 263 - 524 | IPR010734 |
| domain | Copine, C2B domain | 139 - 251 | IPR037768 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| COP9 signalosome | A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| COP9 signalosome assembly | The aggregation, arrangement and bonding together of a set of components to form a COP9 signalosome. |
| protein deneddylation | The removal of a ubiquitin-like protein of the NEDD8 type from a protein. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q99627 | COPS8 | COP9 signalosome complex subunit 8 | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPVCVMMAEL | DEKLLLQFET | QELEAPGGIA | TPQVYSQLLV | LYLLHNDMNN | ARYLWKRIPQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AIKTANPEMA | AIWAVGQRIW | QRDFPGIYSA | IAAYQWSESI | LPVMEALRES | TRRRAYGLVA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QAYTSISAED | FAAFVGYSVE | EAVKGVVSHG | WQADPNTRMI | MPQKPDPPPV | SLVPNEQQLA |
| 190 | |||||
| RLTDYVAFLE | N |