AiPD: Autoinhibited Protein Database

Q99618

Gene name	CDCA3 (C8, GRCC8, TOME1)
Protein name	Cell division cycle-associated protein 3
Names	Gene-rich cluster protein C8, Trigger of mitotic entry protein 1, TOME-1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:83461
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

131-205 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

131-205 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q99618

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q99618-F1	Predicted				AlphaFoldDB

208 variants for Q99618

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs782452444 CA383682435	2	G>D		No	ClinGen ExAC gnomAD
rs782452444 CA6417940	2	G>V		No	ClinGen ExAC gnomAD
CA232404515 rs923260950	5	K>E		No	ClinGen Ensembl
CA383682402 rs1555126363	7	V>I		No	ClinGen gnomAD
CA6417939 rs782210466	8	P>S		No	ClinGen ExAC gnomAD
CA383682391 rs1161135579	9	V>I		No	ClinGen TOPMed
CA6417937 rs782645027	12	A>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1424017122 CA383682372	12	A>P		No	ClinGen TOPMed
CA6417936 rs781866897	13	R>G		No	ClinGen ExAC gnomAD
CA6417935 rs782778605	14	P>R		No	ClinGen ExAC gnomAD
CA6417933 rs781815396	15	P>L		No	ClinGen ExAC gnomAD
CA6417932 rs782737903	16	P>S		No	ClinGen ExAC TOPMed gnomAD
CA232404481 rs1015007220	18	N>S		No	ClinGen TOPMed gnomAD
CA383682321 rs1372637150	20	H>P		No	ClinGen TOPMed
CA383682318 rs1555126338	21	L>M		No	ClinGen gnomAD
CA383682317 rs1555126338	21	L>V		No	ClinGen gnomAD
rs1555126335 CA383682308	22	A>V		No	ClinGen gnomAD
CA383682291 rs1392017699	25	A>V		No	ClinGen TOPMed
rs782795902 CA6417928	26	D>E		No	ClinGen ExAC gnomAD
rs1555126331 CA383682287	26	D>G		No	ClinGen gnomAD
rs1555126329 CA383682275	28	R>C		No	ClinGen gnomAD
CA383682274 rs1555126327	28	R>H		No	ClinGen gnomAD
CA383682261 rs1555126318	30	P>L		No	ClinGen gnomAD
CA6417927 rs782148255	30	P>S		No	ClinGen ExAC TOPMed gnomAD
rs782034838 CA6417926	31	S>T		No	ClinGen ExAC TOPMed gnomAD
CA383682250 rs1362044198	32	A>G		No	ClinGen TOPMed
CA6417925 rs782308916	36	R>L		No	ClinGen ExAC TOPMed gnomAD
rs371648676 CA6417924	37	T>I		No	ClinGen ESP ExAC gnomAD
rs371648676 CA6417923	37	T>S		No	ClinGen ESP ExAC gnomAD
rs367977966 CA6417922	39	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA6417902 rs376349479	41	V>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs782699295 CA232404289	41	V>L		No	ClinGen gnomAD
rs782699295 CA383681461	41	V>M		No	ClinGen gnomAD
CA383681419 rs1269920247	43	S>T		No	ClinGen TOPMed gnomAD
rs150858074 CA6417901	44	S>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6417900 rs782618257	44	S>Y		No	ClinGen ExAC gnomAD
CA383681384 rs1555126214	46	Q>*		No	ClinGen gnomAD
rs1591598972 CA383681363	47	P>L		No	ClinGen Ensembl
CA232404272 rs781871819	47	P>S		No	ClinGen 1000Genomes
rs782668155 CA6417897	51	A>T		No	ClinGen ExAC gnomAD
rs1555126205 CA383681309	51	A>V		No	ClinGen gnomAD
rs1555126198 CA383681290	52	G>E		No	ClinGen gnomAD
rs143204334 CA6417896	52	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA6417895 rs781791457	54	Q>E		No	ClinGen ExAC gnomAD
rs782463014 CA6417893	57	G>C		No	ClinGen ExAC gnomAD
CA383681208 rs1555126192	57	G>D		No	ClinGen gnomAD
CA383681192 rs1555126190	58	L>P		No	ClinGen gnomAD
CA383681169 rs1281005923	59	K>N		No	ClinGen TOPMed
rs1322457268 CA383681118	62	Q>R		No	ClinGen TOPMed gnomAD
CA383681110 rs1203718070	63	D>N		No	ClinGen TOPMed gnomAD
TCGA novel	65	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	66	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA383681057 rs1555126172	66	P>T		No	ClinGen gnomAD
rs565223479 CA6417892	67	R>C		No	ClinGen ExAC TOPMed gnomAD
CA6417891 rs565223479	67	R>G		No	ClinGen ExAC TOPMed gnomAD
CA232404257 rs200589400	67	R>H		No	ClinGen 1000Genomes gnomAD
CA383681020 rs1445195137	68	S>C		No	ClinGen TOPMed
rs1214996993 CA383680944	71	L>R		No	ClinGen TOPMed
CA6417889 rs781886575	72	G>D		No	ClinGen ExAC TOPMed gnomAD
rs371123912 CA6417890	72	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs782043036 CA6417887	73	I>M		No	ClinGen ExAC gnomAD
CA232404233 rs781953121	73	I>T		No	ClinGen Ensembl
CA383680861 rs1591598782	75	R>Q		No	ClinGen Ensembl
CA6417886 rs781928783	75	R>W		No	ClinGen ExAC gnomAD
rs367726225 CA6417884	78	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA383680765 rs1177234591	80	T>A		No	ClinGen TOPMed
rs782009387 CA6417882	81	S>G		No	ClinGen ExAC gnomAD
CA383680738 rs782009387	81	S>R		No	ClinGen ExAC gnomAD
CA383680705 rs1404463390	81	S>R		No	ClinGen TOPMed
rs1591598730 CA383680703	82	S>G		No	ClinGen Ensembl
CA232404213 rs907981293	83	G>R		No	ClinGen TOPMed gnomAD
CA383680499 rs1555125913	85	P>L		No	ClinGen gnomAD
rs781862723 CA6417867	86	P>A		No	ClinGen ExAC gnomAD
rs782448572	86	P>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6417866 rs199570707	86	P>Q		No	ClinGen ExAC TOPMed gnomAD
rs200642081 CA6417862	90	V>M		No	ClinGen ExAC TOPMed gnomAD
CA6417861 rs370001043	92	Q>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA6417860 rs370001043	92	Q>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs782354922 CA6417859	93	L>M		No	ClinGen ExAC TOPMed gnomAD
rs782238115 CA6417858	93	L>P		No	ClinGen ExAC gnomAD
rs782400815 CA6417856	94	S>I		No	ClinGen ExAC gnomAD
CA383680384 rs1383107905	95	E>*		No	ClinGen TOPMed
CA6417854 rs782560815	95	E>D		No	ClinGen ExAC gnomAD
rs782289099 CA6417855	95	E>V		No	ClinGen ExAC gnomAD
rs782448737 CA6417853	96	V>I		No	ClinGen ExAC gnomAD
rs1423743530 CA383680363	97	F>L		No	ClinGen TOPMed
TCGA novel	98	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs375991472 CA6417851	100	E>Q		No	ClinGen ESP ExAC gnomAD
rs1555125873 CA383680308	101	D>A		No	ClinGen gnomAD
TCGA novel	101	D>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs782534214 CA6417850	102	S>C		No	ClinGen ExAC gnomAD
TCGA novel	102	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA383680273 rs1555125868	104	S>T		No	ClinGen gnomAD
rs190568415 CA6417848	107	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA383680231 rs1459693024	108	P>R		No	ClinGen TOPMed gnomAD
rs139284506 CA6417847	109	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1555125860 CA383680217	110	P>S		No	ClinGen gnomAD
CA6417846 rs782433124	111	V>F		No	ClinGen ExAC TOPMed gnomAD
rs1555125854 CA383680198	113	P>S		No	ClinGen gnomAD
rs781809709 CA6417845	114	P>Q		No	ClinGen ExAC gnomAD
rs916693207 CA232403828	114	P>S		No	ClinGen Ensembl
TCGA novel	115	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA383680181 rs1312131146	116	A>T		No	ClinGen TOPMed gnomAD
rs782732105 CA6417843	117	P>L		No	ClinGen ExAC gnomAD
CA383680172 rs1555125846	117	P>T		No	ClinGen gnomAD
CA6417842 rs782102936	120	S>A		No	ClinGen ExAC gnomAD
CA383680128 rs1381281802	121	E>K		No	ClinGen TOPMed
CA6417841 rs781851667	122	L>M		No	ClinGen ExAC gnomAD
CA6417840 rs782766296	122	L>S		No	ClinGen ExAC gnomAD
rs1555125838 CA383680064	125	P>L		No	ClinGen gnomAD
CA232403789 rs78438445	126	L>M		No	ClinGen Ensembl
rs78438445 CA232403785	126	L>V		No	ClinGen Ensembl
CA6417838 rs782205021	127	G>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs782299216 CA383680034	128	T>I		No	ClinGen ExAC TOPMed gnomAD
rs782299216 CA6417837	128	T>N		No	ClinGen ExAC TOPMed gnomAD
rs782063251 CA6417836	131	S>C		No	ClinGen ExAC gnomAD
rs782605381 CA232403771	131	S>P		No	ClinGen Ensembl
CA6417834 rs376208679	132	V>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA6417835 rs781943723	132	V>F		No	ClinGen ExAC TOPMed gnomAD
rs1555125807 CA383679947	135	Q>R		No	ClinGen gnomAD
CA6417832 rs782682791	136	M>T		No	ClinGen ExAC gnomAD
rs1555125802 CA383679919	137	P>S		No	ClinGen gnomAD
CA383679897 rs1555125797	139	W>G		No	ClinGen gnomAD
CA383679856 rs1200403454	141	Q>H		No	ClinGen TOPMed gnomAD
CA383679869 rs1457846278	141	Q>K		No	ClinGen TOPMed
rs373439221 CA6417831	142	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA383679847 rs373439221	142	T>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs146777519 CA6417830	144	F>S		No	ClinGen ESP ExAC gnomAD
rs782576813 CA6417829	149	V>L		No	ClinGen ExAC gnomAD
rs1591597383 CA383679681	154	E>D		No	ClinGen Ensembl
TCGA novel	155	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1444006988 CA383679654	156	R>S		No	ClinGen TOPMed
CA6417826 rs181204084 COSM147404	158	P>S	stomach [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA6417825 rs782631792	159	T>I		No	ClinGen ExAC gnomAD
CA232403730 rs989131108	161	T>I		No	ClinGen Ensembl
rs1591597349 CA383679618	161	T>P		No	ClinGen Ensembl
CA383679613 rs1415711890	162	P>S		No	ClinGen TOPMed
rs953702214 CA232403729	164	A>S		No	ClinGen TOPMed gnomAD
rs1555125764 CA383679542	167	S>I		No	ClinGen gnomAD
rs201851783 CA383679522	169	D>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6417823 rs201851783	169	D>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA383679471 rs1333488035	173	R>G		No	ClinGen TOPMed gnomAD
CA6417822 rs113507914	174	D>N		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	182	G>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1555125746 CA383679356	182	G>S		No	ClinGen Ensembl
TCGA novel	183	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1555125703 CA383679299	184	M>V		No	ClinGen gnomAD
CA6417807 rs199554560	185	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
rs782553512 CA6417806 COSM942961	185	R>H	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs199554560 CA383679283	185	R>S		No	ClinGen 1000Genomes ExAC gnomAD
CA383679270 rs1555125700	186	N>D		No	ClinGen gnomAD
rs1555125696 CA383679237	188	W>*		No	ClinGen gnomAD
rs1427299737 CA383679218	189	K>R		No	ClinGen TOPMed gnomAD
CA383679187 rs1555125685	193	S>N		No	ClinGen gnomAD
rs1414334126 CA383679164	194	K>R		No	ClinGen TOPMed
CA383679151 rs1591597112	195	V>L		No	ClinGen Ensembl
CA383679135 rs1555125679	196	L>V		No	ClinGen gnomAD
rs1555125672 CA383679072	200	P>S		No	ClinGen gnomAD
rs142590132 CA6417800	201	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA383679041 rs1591597042	202	T>P		No	ClinGen Ensembl
TCGA novel	203	I>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6417799 rs782798012	203	I>V		No	ClinGen ExAC gnomAD
rs1555125652 CA383678924	208	N>S		No	ClinGen gnomAD
CA232403525 rs895108356	209	S>F		No	ClinGen gnomAD
CA6417797 rs782558357	209	S>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6417795 rs201465861	210	P>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs1220104412 CA383678869	211	G>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA383678846 rs1555125640	212	T>I		No	ClinGen gnomAD
CA383678858 rs1591596982	212	T>P		No	ClinGen Ensembl
rs1565523716 CA383678822	214	T>I		No	ClinGen Ensembl
rs1280734352 CA383678811	215	L>P		No	ClinGen TOPMed
rs781955213 CA6417794 COSM942960	216	R>*	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA383678796 rs1322261982	216	R>Q		No	ClinGen TOPMed
CA6417773 rs782030784	218	G>V		No	ClinGen ExAC gnomAD
rs782699279 CA6417772	219	K>R		No	ClinGen ExAC TOPMed gnomAD
CA6417769 rs369606193	220	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6417770 rs148172476 COSM179596	220	R>W	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs1591596715 CA383678613	221	P>S		No	ClinGen Ensembl
CA6417768 rs782713955	223	P>S		No	ClinGen 1000Genomes ExAC gnomAD
CA383678477 rs782439674	227	N>D		No	ClinGen ExAC TOPMed gnomAD
CA6417765 rs782439674	227	N>H		No	ClinGen ExAC TOPMed gnomAD
rs782182693 CA6417764	228	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1555125556 CA383678392	231	L>I		No	ClinGen gnomAD
CA6417763 rs782594919	234	G>A		No	ClinGen ExAC gnomAD
rs782233142 CA6417761	236	I>V		No	ClinGen ExAC TOPMed gnomAD
CA6417760 rs782638944	237	L>P		No	ClinGen ExAC gnomAD
CA383678286 rs1178603986	238	G>R		No	ClinGen TOPMed
rs782515898 CA6417759	239	T>S		No	ClinGen ExAC gnomAD
rs200884660 CA6417756	241	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs200884660 CA6417757	241	R>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6417755 rs200884660	241	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1162110476 CA383678242	242	L>F		No	ClinGen TOPMed
CA6417753 rs376989216	245	T>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs149921153 CA6417752	246	G>E		No	ClinGen 1000Genomes ExAC gnomAD
rs1565523413 CA383678153	248	R>*		No	ClinGen Ensembl
CA383678151 rs1555125529	248	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA383678125 rs1333476903	250	W>G		No	ClinGen TOPMed gnomAD
rs149041953 CA232403313	253	G>D		No	ClinGen ESP gnomAD
rs61733172 CA6417749	253	G>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs149041953 CA383678060	253	G>V		No	ClinGen ESP gnomAD
rs782328318 CA6417748	254	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA383677978 rs1555125514	258	K>N		No	ClinGen gnomAD
TCGA novel	262	H>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs782089102 CA6417747	262	H>Y		No	ClinGen ExAC TOPMed gnomAD
CA383677912 rs781965657	263	F>L		No	ClinGen ExAC TOPMed gnomAD
rs1555125507 CA383677897	265	L>F		No	ClinGen gnomAD
CA383677891 rs1210666852	266	V>L		No	ClinGen TOPMed
CA383677884 rs1456523153	267	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD

No associated diseases with Q99618

No regional properties for Q99618

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q99618

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm, cytosol
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

2 GO annotations of cellular component

Name	Definition
adherens junction	A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

No GO annotations of molecular function

Name	Definition
No GO annotations for molecular function

3 GO annotations of biological process

Name	Definition
cell cycle	The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
cell division	The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
protein ubiquitination	The process in which one or more ubiquitin groups are added to a protein.

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q68FW2	Cdca3	Cell division cycle-associated protein 3	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MGSAKSVPVT	PARPPPHNKH	LARVADPRSP	SAGILRTPIQ	VESSPQPGLP	AGEQLEGLKH
70	80	90	100	110	120
AQDSDPRSPT	LGIARTPMKT	SSGDPPSPLV	KQLSEVFETE	DSKSNLPPEP	VLPPEAPLSS
130	140	150	160	170	180
ELDLPLGTQL	SVEEQMPPWN	QTEFPSKQVF	SKEEARQPTE	TPVASQSSDK	PSRDPETPRS
190	200	210	220	230	240
SGSMRNRWKP	NSSKVLGRSP	LTILQDDNSP	GTLTLRQGKR	PSPLSENVSE	LKEGAILGTG
250	260
RLLKTGGRAW	EQGQDHDKEN	QHFPLVES