AiPD: Autoinhibited Protein Database

Q99598

Gene name	TSNAX (TRAX)
Protein name	Translin-associated protein X
Names	Translin-associated factor X
Species	Homo sapiens (Human)
KEGG Pathway	hsa:7257
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-70 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-70 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

3 structures for Q99598

Entry ID	Method	Resolution	Chain	Position	Source
3PJA	X-ray	300 A	J/K/L	1-290	PDB
3QB5	X-ray	295 A	K	1-290	PDB
AF-Q99598-F1	Predicted				AlphaFoldDB

182 variants for Q99598

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
TCGA novel	2	S>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA345341725 rs1227388030	7	S>L		No	ClinGen gnomAD
rs1319462174 CA345341744	10	F>L		No	ClinGen TOPMed
CA1453270 rs201535941	11	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs1462181060 CA345341762	13	R>K		No	ClinGen gnomAD
rs953094494 CA39313233	14	K>N		No	ClinGen Ensembl
rs1056232468 CA39313234	15	H>R		No	ClinGen TOPMed
rs1000997476 CA39313235	16	D>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
RCV000891355 CA1453272 rs144584692	17	N>S		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs781694916 CA1453274	19	P>L		No	ClinGen ExAC TOPMed gnomAD
rs748769707 CA1453275	20	H>R		No	ClinGen ExAC TOPMed gnomAD
CA39313237 rs11559026	22	Q>*		No	ClinGen Ensembl
rs1380485002 CA345341828	22	Q>H		No	ClinGen gnomAD
rs756734169 CA1453276	22	Q>R		No	ClinGen ExAC gnomAD
rs1558115664 CA345341829	23	R>G		No	ClinGen Ensembl
CA345341857 rs1212399424	27	K>E		No	ClinGen gnomAD
rs1283831955 CA345341867	28	D>Y		No	ClinGen TOPMed
CA39313238 rs747020107	29	V>I		No	ClinGen Ensembl
rs746984160 CA1453282	32	S>F		No	ClinGen ExAC gnomAD
rs746984160 CA345341895	32	S>Y		No	ClinGen ExAC gnomAD
CA1453284 rs199769657	34	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA345341905 rs1215872911	34	P>S		No	ClinGen TOPMed
rs1293399840 CA345341918	36	M>T		No	ClinGen TOPMed
CA39313239 rs143038752	38	A>T		No	ClinGen ESP TOPMed
rs893818608	41	S>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs768442482 CA1453301	42	F>S		No	ClinGen ExAC gnomAD
CA39314186 rs1012297675	43	Q>R		No	ClinGen TOPMed gnomAD
CA1453302 rs183434354	48	A>E		No	ClinGen 1000Genomes ExAC gnomAD
CA39314187 rs183434354	48	A>G		No	ClinGen 1000Genomes ExAC gnomAD
rs371162355 CA39314188	50	H>R		No	ClinGen Ensembl
rs773241491 CA1453305	51	D>G		No	ClinGen ExAC gnomAD
rs762977792 CA1453306	55	R>G		No	ClinGen ExAC TOPMed gnomAD
CA345342065 rs1301719579	55	R>I		No	ClinGen gnomAD
CA345342063 rs1301719579	55	R>K		No	ClinGen gnomAD
rs766607406 CA1453307	56	L>F		No	ClinGen ExAC TOPMed gnomAD
rs1240407829 CA345342078	57	V>G		No	ClinGen gnomAD
TCGA novel	58	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs774496340 CA1453308	61	R>G		No	ClinGen ExAC gnomAD
rs774496340 CA1453309	61	R>W		No	ClinGen ExAC gnomAD
CA1453310 rs767919069	63	I>M		No	ClinGen ExAC gnomAD
TCGA novel	64	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	66	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA345342135 rs1239568408	66	E>V		No	ClinGen gnomAD
rs753202892 CA1453311	67	S>N		No	ClinGen ExAC TOPMed gnomAD
CA345342138 rs1292560195	67	S>R		No	ClinGen gnomAD
CA1453312 rs753202892	67	S>T		No	ClinGen ExAC TOPMed gnomAD
rs764881773 CA1453313	69	R>K		No	ClinGen ExAC TOPMed gnomAD
CA1453315 rs757936141	71	I>M		No	ClinGen ExAC gnomAD
rs749986409 CA1453314	71	I>V		No	ClinGen ExAC gnomAD
TCGA novel	74	L>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA345342193 rs1437711581	75	H>R		No	ClinGen gnomAD
rs779867950 CA1453316	77	I>V		No	ClinGen ExAC TOPMed gnomAD
CA345342212 rs1385273685	78	T>S		No	ClinGen TOPMed gnomAD
CA345342219 rs1227246082	79	S>N		No	ClinGen TOPMed
rs761382545 CA1453341	82	D>N		No	ClinGen ExAC gnomAD
CA1453342 rs375022282	83	M>T		No	ClinGen ESP ExAC gnomAD
rs747164945 CA1453343	86	I>T		No	ClinGen ExAC TOPMed gnomAD
rs1316664309 CA345340236	86	I>V		No	ClinGen TOPMed
rs1572115636 CA345340251	88	T>I		No	ClinGen Ensembl
rs369133346 CA345340277	92	I>F		No	ClinGen ESP TOPMed gnomAD
CA1453345 rs771056384	92	I>T		No	ClinGen ExAC gnomAD
CA39314742 rs369133346	92	I>V		No	ClinGen ESP TOPMed gnomAD
rs1263756207 CA345340291	94	L>*		No	ClinGen gnomAD
rs1383353473 CA345340299	95	D>G		No	ClinGen TOPMed
CA345340296 rs1403022385	95	D>N		No	ClinGen TOPMed
CA1453346 rs372784677	96	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA1453347 rs746117139	97	V>A		No	ClinGen ExAC gnomAD
rs1425326818 CA345340309	97	V>I		No	ClinGen TOPMed
rs772372056 CA1453348	99	Q>E		No	ClinGen ExAC gnomAD
rs1428779847 CA345340324	99	Q>R		No	ClinGen gnomAD
rs1558125382 CA345340332	100	K>R		No	ClinGen Ensembl
rs892421074 CA39314743	101	I>L		No	ClinGen Ensembl
rs761137587 CA1453350	102	F>L		No	ClinGen ExAC gnomAD
rs976727040 CA39314744	103	Q>R		No	ClinGen TOPMed
rs769077257 CA1453351	105	A>V		No	ClinGen ExAC gnomAD
rs758918758 CA1453356	110	G>E		No	ClinGen ExAC TOPMed gnomAD
rs1384152627 CA345340410	112	D>G		No	ClinGen gnomAD
rs150826166 CA39314745	112	D>Y		No	ClinGen ESP
rs752223523 CA1453358	113	M>I		No	ClinGen ExAC gnomAD
rs767211115 CA1453357	113	M>T		No	ClinGen ExAC gnomAD
rs763862746 CA1453360	114	H>Q		No	ClinGen ExAC gnomAD
CA1453359 rs755968071	114	H>Y		No	ClinGen ExAC gnomAD
CA1453361 rs753821248	115	Q>E		No	ClinGen ExAC TOPMed gnomAD
rs1572115834 CA345340433	115	Q>H		No	ClinGen Ensembl
COSM210320 rs757155042 CA345340450	118	R>*	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs757155042 CA1453362	118	R>G		No	ClinGen ExAC gnomAD
rs1327306485 CA345340453	118	R>Q		No	ClinGen gnomAD
rs757662645 CA39314746	120	I>F		No	ClinGen Ensembl
rs778677444 CA1453363	122	T>A		No	ClinGen ExAC TOPMed gnomAD
rs745984318 CA1453364	122	T>I		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	123	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA39316972 rs954489279	128	V>G		No	ClinGen TOPMed
CA39316973 rs929212910	132	S>C		No	ClinGen Ensembl
CA345340567 rs1335712167	134	Q>R		No	ClinGen gnomAD
CA345340579 rs1165640475	136	F>I		No	ClinGen gnomAD
CA1453383 rs756999364	137	I>F		No	ClinGen ExAC TOPMed gnomAD
rs765236626 CA1453384	139	T>A		No	ClinGen ExAC gnomAD
rs750263571 CA39316974	140	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs750263571 CA1453385	140	R>G		No	ClinGen ExAC TOPMed gnomAD
CA345340607 rs758573869	140	R>L		No	ClinGen ExAC TOPMed gnomAD
COSM3804325 COSM3804324 rs758573869 CA1453386	140	R>Q	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	143	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs779987602 CA1453387	144	S>N		No	ClinGen ExAC gnomAD
CA1453389 rs755278086	145	M>R		No	ClinGen ExAC gnomAD
CA345340676 rs1252203573	150	K>E		No	ClinGen gnomAD
CA345340702 rs1445778412	153	I>M		No	ClinGen TOPMed gnomAD
CA1453394 rs773834413	153	I>V		No	ClinGen ExAC TOPMed gnomAD
CA39316975 rs367646519	154	F>S		No	ClinGen ESP
COSM3724001 CA1453395 COSM3724002 rs760939212	155	T>M	upper_aerodigestive_tract Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA345340714 rs760939212	155	T>R		No	ClinGen ExAC TOPMed gnomAD
CA345340712 rs1445375967	155	T>S		No	ClinGen gnomAD
CA39316976 rs947882979	157	E>K		No	ClinGen TOPMed
CA1453398 rs145493559	159	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1163829764 CA345340743	160	G>R		No	ClinGen gnomAD
rs1558138779 CA345340765	163	N>H		No	ClinGen Ensembl
rs768705359	164	K>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs372798782 CA39316977	165	T>N		No	ClinGen ESP
CA345340781 rs1467136209	165	T>P		No	ClinGen TOPMed gnomAD
CA345340803 rs1276589577	166	P>T		No	ClinGen gnomAD
CA1453440 rs776335200	168	S>A		No	ClinGen ExAC gnomAD
CA39317313 rs980900170	168	S>C		No	ClinGen gnomAD
CA345340830 rs1445795951	170	A>V		No	ClinGen TOPMed
rs769683037 CA1453442	176	G>D		No	ClinGen ExAC gnomAD
CA1453443 rs772856706	177	T>S		No	ClinGen ExAC TOPMed gnomAD
rs1191266088 CA345340879	177	T>S		No	ClinGen gnomAD
rs1422606447 CA345340892	179	R>K		No	ClinGen gnomAD
CA345340907 rs1353064555	181	R>S		No	ClinGen Ensembl
rs189489803 CA1453444	182	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs766429793 CA1453445	184	P>L		No	ClinGen ExAC gnomAD
CA345340931 rs1289941262	186	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA345340939 rs1422953437	187	Y>N		No	ClinGen gnomAD
CA39317314 rs949404482	190	G>E		No	ClinGen TOPMed
rs767689300 CA1453448	192	A>S		No	ClinGen ExAC TOPMed gnomAD
CA1453449 rs753011195	193	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs756257776 CA1453450	197	E>A		No	ClinGen ExAC gnomAD
CA345341024 rs1346467821	200	R>Q		No	ClinGen gnomAD
rs778015919 CA1453451	200	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	201	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	202	C>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1453452 rs754176844	203	I>F		No	ClinGen ExAC gnomAD
CA1453453 rs757585498	206	V>L		No	ClinGen ExAC gnomAD
CA39317316 rs181169848	208	N>D		No	ClinGen 1000Genomes
CA345341081 rs1344891056	208	N>I		No	ClinGen gnomAD
CA1453454 rs779399170	211	I>T		No	ClinGen ExAC gnomAD
rs1558141216 CA345341113	213	T>A		No	ClinGen Ensembl
rs1351825073 CA345341119	214	P>A		No	ClinGen gnomAD
CA1453457 rs768216336	219	Q>K		No	ClinGen ExAC TOPMed gnomAD
CA345341158 COSM3977194 rs1452025202	219	Q>L	lung [Cosmic]	No	ClinGen cosmic curated gnomAD
CA1453458 rs780661031	221	L>S		No	ClinGen ExAC gnomAD
rs769366885 CA1453461	222	R>C		No	ClinGen ExAC TOPMed gnomAD
rs762657262 CA1453462	222	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs769366885 CA1453460	222	R>S		No	ClinGen ExAC TOPMed gnomAD
CA1453463 rs770843314	223	Q>H		No	ClinGen ExAC gnomAD
CA345341182 rs1365088199	223	Q>R		No	ClinGen gnomAD
CA345341190 rs1572155878	224	V>G		No	ClinGen Ensembl
rs1451497711 CA345341196	225	Y>F		No	ClinGen gnomAD
CA1453464 rs774485592	226	D>V		No	ClinGen ExAC gnomAD
TCGA novel	227	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1572155897 CA345341214	228	F>V		No	ClinGen Ensembl
CA345341225 rs1157612542	229	S>L		No	ClinGen gnomAD
rs1407481145 CA345341238	231	I>T		No	ClinGen gnomAD
CA39317319 rs1048476383	235	G>R		No	ClinGen TOPMed gnomAD
CA345341280 rs1311562437	238	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	239	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA39317320 rs781186877	247	K>T		No	ClinGen Ensembl
TCGA novel	249	S>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs568025672 CA1453469	251	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1199114030 CA345341432	259	A>D		No	ClinGen gnomAD
TCGA novel	260	L>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs750966099 CA1453473	261	K>E		No	ClinGen ExAC gnomAD
CA1453475 rs780557987	269	K>Q		No	ClinGen ExAC gnomAD
rs770241132 CA1453476	270	H>R		No	ClinGen ExAC TOPMed gnomAD
rs777351433 CA1453478	271	M>T		No	ClinGen ExAC gnomAD
CA345341521 rs1466614815	272	L>S		No	ClinGen gnomAD
rs1337184662 CA345341534	274	D>G		No	ClinGen TOPMed
CA345341589 rs1398733775	282	M>K		No	ClinGen gnomAD
rs1398733775 CA345341590	282	M>T		No	ClinGen gnomAD
CA39317321 rs1039923749	284	D>A		No	ClinGen TOPMed gnomAD
CA345341605 rs1039923749	284	D>G		No	ClinGen TOPMed gnomAD
CA345341610 rs1355055944 COSM533214	285	Q>E	lung [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1315792010 CA345341621	286	E>G		No	ClinGen gnomAD
rs1231949062 CA345341641	289	I>F		No	ClinGen Ensembl

No associated diseases with Q99598

No regional properties for Q99598

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q99598

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm, perinuclear region Golgi apparatus Nucleus	Accumulate in the Golgi complex of mid-late pachytene spermatocytes (By similarity) Expressed in the cytoplasm in the presence of TSN
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

7 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endoribonuclease complex	A protein complex which is capable of endoribonuclease activity.
Golgi apparatus	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
perinuclear region of cytoplasm	Cytoplasm situated near, or occurring around, the nucleus.

8 GO annotations of molecular function

Name	Definition
A2A adenosine receptor binding	Binding to an A2A adenosine receptor.
DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
endoribonuclease activity	Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks.
metal ion binding	Binding to a metal ion.
protein-containing complex binding	Binding to a macromolecular complex.
RNA binding	Binding to an RNA molecule or a portion thereof.
sequence-specific DNA binding	Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
single-stranded DNA binding	Binding to single-stranded DNA.

3 GO annotations of biological process

Name	Definition
cell differentiation	The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
siRNA processing	A process leading to the generation of a functional small interfering RNA (siRNA). Includes the cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides. May also include amplification of the siRNA by RNA-directed RNA polymerase.
spermatogenesis	The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9QZE7	Tsnax	Translin-associated protein X	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MSNKEGSGGF	RKRKHDNFPH	NQRREGKDVN	SSSPVMLAFK	SFQQELDARH	DKYERLVKLS
70	80	90	100	110	120
RDITVESKRT	IFLLHRITSA	PDMEDILTES	EIKLDGVRQK	IFQVAQELSG	EDMHQFHRAI
130	140	150	160	170	180
TTGLQEYVEA	VSFQHFIKTR	SLISMDEINK	QLIFTTEDNG	KENKTPSSDA	QDKQFGTWRL
190	200	210	220	230	240
RVTPVDYLLG	VADLTGELMR	MCINSVGNGD	IDTPFEVSQF	LRQVYDGFSF	IGNTGPYEVS
250	260	270	280
KKLYTLKQSL	AKVENACYAL	KVRGSEIPKH	MLADVFSVKT	EMIDQEEGIS