AiPD: Autoinhibited Protein Database

Q96TA1

Gene name	NIBAN2
Protein name	Protein Niban 2
Names	Meg-3, Melanoma invasion by ERK, MINERVA, Niban-like protein 1, Protein FAM129B
Species	Homo sapiens (Human)
KEGG Pathway	hsa:64855
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

529-746 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

529-746 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

2 structures for Q96TA1

Entry ID	Method	Resolution	Chain	Position	Source
7CTP	X-ray	180 A	A	2-560	PDB
AF-Q96TA1-F1	Predicted				AlphaFoldDB

682 variants for Q96TA1

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1237821465 CA375176650	3	D>G		No	ClinGen TOPMed
rs751782877 CA5248142	3	D>Y		No	ClinGen ExAC TOPMed gnomAD
rs893290433 CA201165520	5	L>V		No	ClinGen TOPMed gnomAD
rs1303164823 CA375176619	8	H>P		No	ClinGen TOPMed gnomAD
rs1468736657 CA375176617	8	H>Q		No	ClinGen gnomAD
rs1232511245 CA375176615	9	L>V		No	ClinGen TOPMed gnomAD
CA375176593 rs1406756070	12	A>S		No	ClinGen TOPMed gnomAD
CA201165512 rs1025119122	14	R>C		No	ClinGen gnomAD
rs990992552 CA201165499	16	H>L		No	ClinGen TOPMed
CA375176565 rs1410051782	16	H>Q		No	ClinGen TOPMed
rs1311548936 CA375176569	16	H>Y		No	ClinGen TOPMed gnomAD
CA5248124 rs139344456	20	K>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA5248123 rs777969730	22	G>R		No	ClinGen ExAC TOPMed gnomAD
rs1163243069 CA375175229 COSM1460095	25	L>M	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA5248122 rs146201580	26	T>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA5248121 COSM3395576 rs146201580 COSM1242255	26	T>M	pancreas oesophagus [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs755039023 CA5248119	27	E>Q		No	ClinGen ExAC gnomAD
CA375175193 rs1390551203	30	Q>H		No	ClinGen TOPMed
rs1222586896 CA375175187	31	F>S		No	ClinGen gnomAD
rs756095017 CA5248116	35	Q>L		No	ClinGen ExAC TOPMed gnomAD
rs375235621 CA200258472	37	G>D		No	ClinGen ESP TOPMed gnomAD
CA5248115 rs750268900	38	V>M		No	ClinGen ExAC TOPMed gnomAD
CA375175134 rs1213272894	39	A>T		No	ClinGen TOPMed gnomAD
CA5248113 rs761543447	41	F>L		No	ClinGen ExAC gnomAD
CA375175119 rs1357205731	41	F>S		No	ClinGen TOPMed
CA375175114 rs1205029958	42	N>D		No	ClinGen TOPMed
CA5248112 rs773811404	42	N>S		No	ClinGen ExAC gnomAD
rs763627681 CA5248111	43	S>G		No	ClinGen ExAC gnomAD
CA5248109 rs143275059 CA5248110	43	S>R		No	ClinGen ESP ExAC TOPMed gnomAD
COSM752678 rs1227581070 CA375175096	44	M>I	lung [Cosmic]	No	ClinGen cosmic curated Ensembl
rs771469290 CA5248108	44	M>T		No	ClinGen ExAC gnomAD
rs371920682 CA5248107	45	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs773683224 COSM292749 CA5248106	45	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs748405028 CA5248104	47	E>K		No	ClinGen ExAC gnomAD
CA5248103 rs778959952	48	I>F		No	ClinGen ExAC gnomAD
CA5248102 rs201665892	49	E>A		No	ClinGen 1000Genomes ExAC gnomAD
rs201665892 CA200258471	49	E>G		No	ClinGen 1000Genomes ExAC gnomAD
rs368077273 CA5248101	50	G>D		No	ClinGen ESP ExAC gnomAD
rs1208828145 CA375175062	50	G>S		No	ClinGen gnomAD
rs1588166711 CA375175058	51	T>A		No	ClinGen Ensembl
CA5248100 rs780246456	51	T>M		No	ClinGen ExAC gnomAD
CA375175055 rs780246456	51	T>R		No	ClinGen ExAC gnomAD
CA5248097 rs767352381	54	P>L		No	ClinGen ExAC gnomAD
CA375175034 rs1343680020	55	Q>R		No	ClinGen gnomAD
rs1300709103 CA375175022	56	A>S		No	ClinGen gnomAD
CA375175026 rs1300709103	56	A>T		No	ClinGen gnomAD
rs751249160 CA5248095	59	L>P		No	ClinGen ExAC gnomAD
TCGA novel	60	W>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5248094 rs371821621	61	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
rs762563150 CA5248093	61	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA375174938 rs762563150	61	R>L		No	ClinGen ExAC gnomAD
CA375174945 rs371821621	61	R>S		No	ClinGen ESP ExAC gnomAD
CA374973255 rs1259071014	63	V>M		No	ClinGen TOPMed gnomAD
CA374973217 rs1173273237	65	L>V		No	ClinGen gnomAD
CA5248065 rs769087468	66	D>G		No	ClinGen ExAC gnomAD
rs143489395 CA5248066	66	D>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs182478049 CA5248063	67	E>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA374973197 rs1338536194	67	E>K		No	ClinGen TOPMed gnomAD
COSM455366 rs769941762 CA5248062	68	R>C	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs138792807 CA5248061	68	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA374973181 rs769941762	68	R>S		No	ClinGen ExAC TOPMed gnomAD
rs374845565 CA5248060	69	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
COSM3413344 CA5248058 rs541599134 COSM3413345	70	V>I	Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA374973147 rs541599134	70	V>L		No	ClinGen ExAC TOPMed gnomAD
CA5248056 rs368490986	72	S>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs200797290 CA5248054	74	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs754633835 CA374973046	75	L>F		No	ClinGen ExAC gnomAD
rs754633835 CA5248053	75	L>I		No	ClinGen ExAC gnomAD
rs765905648 CA5248051	76	F>L		No	ClinGen ExAC gnomAD
rs1215989744 CA374973020	76	F>S		No	ClinGen gnomAD
rs757758810 CA5248050	77	Q>*		No	ClinGen ExAC gnomAD
CA374973002 rs757758810	77	Q>E		No	ClinGen ExAC gnomAD
CA374972983 rs1294194236	77	Q>H		No	ClinGen TOPMed gnomAD
CA374972943 rs1220589133	79	Q>R		No	ClinGen gnomAD
CA5248049 rs752049706	80	E>K		No	ClinGen ExAC TOPMed gnomAD
CA199858966 rs1018370537	81	D>E		No	ClinGen Ensembl
CA5248048 rs764587574	81	D>V		No	ClinGen ExAC TOPMed
CA5248046 rs375771095	82	S>N		No	ClinGen ESP ExAC gnomAD
rs775976278 CA5248045	84	K>R		No	ClinGen ExAC TOPMed gnomAD
CA374972735 rs1276306450	88	R>C		No	ClinGen TOPMed gnomAD
CA5248043 COSM280942 rs549746967	88	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs549746967 CA374972729	88	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1276306450 CA374972740	88	R>S		No	ClinGen TOPMed gnomAD
TCGA novel	91	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA374972683 rs1266164191	91	L>P		No	ClinGen TOPMed
COSM1105342 rs776632695 CA5248041	92	V>M	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA374972651 rs1265982133	93	P>S		No	ClinGen TOPMed
rs1263650284 CA374972613	94	H>L		No	ClinGen gnomAD
CA374972570 rs746952339	96	Y>*		No	ClinGen ExAC TOPMed gnomAD
CA5248040 rs770984314	96	Y>S		No	ClinGen ExAC TOPMed gnomAD
rs370720142 CA5248037	97	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA5248038 rs370720142	97	G>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA374972550 rs1422100447	98	L>P		No	ClinGen gnomAD
rs999816109 CA199858955	100	L>F		No	ClinGen Ensembl
CA199858953 rs75835777	101	Y>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs201758465 CA5248035	101	Y>C		No	ClinGen 1000Genomes ExAC gnomAD
CA5248033 rs547821680	102	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5248032 rs779439041	103	N>S		No	ClinGen ExAC TOPMed gnomAD
CA5248030 rs752137422	104	K>E		No	ClinGen ExAC TOPMed gnomAD
CA374972449 rs527792182	105	A>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1454432753 CA374972452	105	A>T		No	ClinGen Ensembl
rs527792182 CA5248029	105	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA5247999 rs762857729	107	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs375126632 CA5247997	109	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs375126632 CA5247996	109	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5247998 rs775120448	109	R>W		No	ClinGen ExAC TOPMed gnomAD
CA374971532 rs1207987286	110	Q>H		No	ClinGen gnomAD
rs201445763 CA374971474	111	V>A		No	ClinGen ExAC gnomAD
CA5247994 COSM3847686 rs201445763	111	V>G	breast [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs755416285 CA5247991	112	P>L		No	ClinGen ExAC
CA5247987 rs750582287	114	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA5247986 rs767584590	115	A>G		No	ClinGen ExAC TOPMed
CA5247984 rs143200470	116	V>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5247985 rs147548410	116	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs139246176 CA5247983	118	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs544648831 CA5247982	119	S>G		No	ClinGen 1000Genomes ExAC gnomAD
CA5247981 rs575722854	119	S>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA
rs962144039 CA199858456	122	Y>C		No	ClinGen Ensembl
CA374971116 rs1320381466	122	Y>H		No	ClinGen gnomAD
CA199858454 rs1019088353	123	K>Q		No	ClinGen TOPMed gnomAD
CA374971058 rs1367034836	123	K>R		No	ClinGen TOPMed
CA5247980 rs769655791	126	T>M		No	ClinGen ExAC TOPMed gnomAD
rs769655791 CA374970941	126	T>R		No	ClinGen ExAC TOPMed gnomAD
rs889351224 CA199858452	127	S>Y		No	ClinGen Ensembl
CA5247977 rs146496636	128	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs146496636 CA5247976	128	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA5247975 rs777115465	130	Q>K		No	ClinGen ExAC TOPMed gnomAD
rs1243485514 CA374970687	134	L>P		No	ClinGen TOPMed
rs1490454798 CA374970650	135	I>T		No	ClinGen TOPMed
rs749743591 CA5247973	137	N>I		No	ClinGen ExAC gnomAD
rs749743591 CA5247974	137	N>T		No	ClinGen ExAC gnomAD
CA374970517 rs113635787	140	P>S		No	ClinGen ExAC TOPMed gnomAD
CA5247972 rs113635787	140	P>T		No	ClinGen ExAC TOPMed gnomAD
CA5247948 rs747143090	142	T>I		No	ClinGen ExAC TOPMed gnomAD
CA374969922 rs747143090	142	T>N		No	ClinGen ExAC TOPMed gnomAD
CA5247947 rs550046797	143	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs148122479 CA5247943	146	S>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1564301870 CA374969811	146	S>P		No	ClinGen Ensembl
rs766071759 CA5247941	147	G>S		No	ClinGen ExAC TOPMed gnomAD
CA199858164 rs944462596	148	S>G		No	ClinGen TOPMed gnomAD
COSM1489678 CA374969727 rs1197237555	149	A>T	breast [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
TCGA novel	150	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5247940 rs760386366	150	P>S		No	ClinGen ExAC gnomAD
rs1235501532 CA374969626	151	I>V		No	ClinGen TOPMed gnomAD
rs772668983 CA5247939	152	L>I		No	ClinGen ExAC TOPMed gnomAD
rs1300814996 CA374969564	153	K>R		No	ClinGen gnomAD
rs1300814996 CA374969569	153	K>T		No	ClinGen gnomAD
CA374969458 rs1359636928	156	T>A		No	ClinGen TOPMed gnomAD
CA374969445 rs1588161081	156	T>I		No	ClinGen Ensembl
CA5247936 rs761365112	157	Q>R		No	ClinGen ExAC gnomAD
CA374969401 rs1444393736	158	F>L		No	ClinGen gnomAD
rs773824609 CA5247935	158	F>L		No	ClinGen ExAC gnomAD
rs547390879 CA5247934	159	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5247930 rs747289335	162	L>F		No	ClinGen ExAC gnomAD
CA5247929 rs777810202	165	P>A		No	ClinGen ExAC gnomAD
rs932165843 CA199858154	165	P>L		No	ClinGen TOPMed gnomAD
CA5247928 rs368076473	166	Y>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA5247926 rs559492611 COSM150721	167	A>V	stomach [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA5247924 rs148940802	168	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs147101023 CA5247923	168	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA374969084 rs1564301770	169	H>P		No	ClinGen Ensembl
TCGA novel	170	Y>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5247921 rs750109688	172	F>L		No	ClinGen ExAC gnomAD
rs1237668902 CA374969019	172	F>Y		No	ClinGen TOPMed gnomAD
rs767118080 CA5247920	173	C>Y		No	ClinGen ExAC gnomAD
CA5247919 rs761452503	174	M>I		No	ClinGen ExAC gnomAD
CA374968961 rs1397747476	174	M>V		No	ClinGen TOPMed gnomAD
rs144153796 CA5247917	178	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
COSM1251739 rs1053267708 CA199858141	178	A>V	oesophagus [Cosmic]	No	ClinGen cosmic curated Ensembl
CA374968831 COSM271246 rs1439442732	179	E>K	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA374968805 rs1369443647	180	Q>R		No	ClinGen gnomAD
rs201972811 CA5247915	181	D>N		No	ClinGen 1000Genomes ExAC TOPMed
rs1588160938 CA374968605	189	D>G		No	ClinGen Ensembl
CA374968610 rs1422592360	189	D>H		No	ClinGen gnomAD
rs1205784096 CA374968551	191	I>L		No	ClinGen gnomAD
CA374968520 rs772489458	192	R>P		No	ClinGen ExAC TOPMed gnomAD
CA5247911 rs772489458	192	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs773593282 CA5247912	192	R>W	Variant assessed as Somatic; 4.641e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1588160907 CA374968503	193	H>Y		No	ClinGen Ensembl
rs1169433371 CA374968472	194	C>G		No	ClinGen TOPMed
CA5247910 rs574705265	195	N>S		No	ClinGen 1000Genomes ExAC gnomAD
rs928898969 CA199858129	196	N>S		No	ClinGen Ensembl
TCGA novel	199	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA199856904 rs374309098	199	P>R		No	ClinGen ESP TOPMed gnomAD
CA5247884 rs780973652	199	P>S		No	ClinGen ExAC gnomAD
rs546026967 CA5247883	200	E>G		No	ClinGen 1000Genomes ExAC gnomAD
rs1012564890 CA199856902	203	K>E		No	ClinGen TOPMed
rs746686598 CA5247882	203	K>R		No	ClinGen ExAC TOPMed gnomAD
CA199856898 rs758013461	208	A>G		No	ClinGen ExAC TOPMed gnomAD
CA5247880 rs758013461	208	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1289523954 CA374964987	211	D>E		No	ClinGen gnomAD
rs764790646 CA5247878	211	D>G		No	ClinGen ExAC gnomAD
rs756590981 CA5247877 COSM1460094	214	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs1398722495 CA374964939	214	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA199856895 rs557183200	215	M>L		No	ClinGen 1000Genomes TOPMed gnomAD
CA374964898 rs1221660805	217	R>*		No	ClinGen TOPMed
rs1415080533 CA374964897	217	R>Q		No	ClinGen gnomAD
rs1427396009 CA374964882	218	Q>E		No	ClinGen gnomAD
CA199856894 rs776987381	219	S>F		No	ClinGen Ensembl
rs202060817 CA5247876	221	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs112085953 CA199856890	223	Y>C		No	ClinGen gnomAD
COSM1674844 COSM1674843 CA374964793 rs1490814073	223	Y>H	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed
rs112085953 CA374964784	223	Y>S		No	ClinGen gnomAD
rs892032640 CA199856887	224	G>S		No	ClinGen TOPMed gnomAD
rs774831020 CA5247873	225	T>S		No	ClinGen ExAC TOPMed gnomAD
CA374964730 rs1442452958	226	W>L		No	ClinGen gnomAD
rs764480989 CA5247872	227	E>K		No	ClinGen ExAC gnomAD
CA5247870 rs775450090	230	C>Y		No	ClinGen ExAC gnomAD
CA5247868 rs200408710	233	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1588156269 CA374964525	234	V>L		No	ClinGen Ensembl
CA374964076 rs1263298439	242	M>I		No	ClinGen TOPMed gnomAD
rs1474571112 CA374964080	242	M>T		No	ClinGen gnomAD
rs1195318917 CA374963928	246	G>A		No	ClinGen gnomAD
rs1554765657 CA374963948	246	G>S		No	ClinGen Ensembl
CA374963092 rs1288318217	253	L>F		No	ClinGen TOPMed gnomAD
rs757854593 CA374963080	254	G>R		No	ClinGen ExAC gnomAD
rs757854593 CA5247839	254	G>S		No	ClinGen ExAC gnomAD
rs567489926 CA5247838	255	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA199856731 rs949854154	255	P>S		No	ClinGen TOPMed
rs942990871 CA199856726	256	R>Q		No	ClinGen Ensembl
CA5247836 rs528422288	256	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5247835 rs752982270	257	L>V		No	ClinGen ExAC
CA374962984 rs1294399421	258	K>Q		No	ClinGen gnomAD
CA199856723 rs958664647	259	G>E		No	ClinGen TOPMed gnomAD
CA374962913 rs1588155787	260	K>N		No	ClinGen Ensembl
CA5247833 rs368493830	261	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs368493830 CA374962901	261	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs765537378 CA5247834	261	P>T		No	ClinGen ExAC TOPMed gnomAD
CA374962747 rs760610518	264	R>L		No	ClinGen ExAC TOPMed gnomAD
rs760610518 CA5247830	264	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs139508754 CA5247831	264	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs150543761 CA5247827	266	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5247828 rs374266414	266	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs755295232 CA5247797	271	I>F		No	ClinGen ExAC gnomAD
CA374962311 rs1377421221	272	S>L		No	ClinGen TOPMed gnomAD
rs1360397846 CA374962253	273	D>V		No	ClinGen gnomAD
rs901693409 CA199856688	274	A>S		No	ClinGen gnomAD
CA5247793 rs750580619	275	V>M		No	ClinGen ExAC TOPMed gnomAD
CA374962122 rs147526033	277	H>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA5247790 rs147526033	277	H>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs775395342 CA5247788	277	H>Q		No	ClinGen ExAC gnomAD
CA5247789 rs61742100	277	H>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA374962033 rs1177250674	278	M>L		No	ClinGen gnomAD
CA374961954 rs1419008015	279	V>A		No	ClinGen gnomAD
CA199856680 rs1055620927	279	V>M		No	ClinGen TOPMed
CA5247786 rs765051115	280	Y>H		No	ClinGen ExAC gnomAD
CA5247785 rs139210254	281	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs776220337 CA5247784	282	Q>*		No	ClinGen ExAC gnomAD
CA374961751 rs1276762151	284	K>M		No	ClinGen TOPMed
CA374961687 rs140486340	285	A>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs147294840 CA5247783	285	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5247782 rs140486340	285	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5247780 rs202219424	286	R>C		No	ClinGen ExAC TOPMed gnomAD
CA5247779 COSM1651495 rs749689723 COSM1105338	286	R>H	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA374961585 CA5247778 rs756382989	287	F>L		No	ClinGen ExAC TOPMed gnomAD
CA5247776 rs746012686	288	E>K		No	ClinGen ExAC TOPMed gnomAD
CA5247775 CA374961451 rs757238376	290	V>L		No	ClinGen ExAC TOPMed gnomAD
CA5247774 rs757238376	290	V>M		No	ClinGen ExAC TOPMed gnomAD
rs751640282 CA5247773	291	L>P		No	ClinGen ExAC
TCGA novel	292	S>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs758406762 CA5247771	293	K>E		No	ClinGen ExAC TOPMed gnomAD
CA5247770 rs752599208	295	Q>E		No	ClinGen ExAC TOPMed gnomAD
CA5247769 rs765067952	295	Q>R		No	ClinGen ExAC gnomAD
CA199856662 rs954429436	297	V>L		No	ClinGen TOPMed
rs759229840 CA5247768	298	Q>E		No	ClinGen ExAC gnomAD
rs753390875 CA5247767	298	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs138211609 CA5247766	299	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA199856657 rs950198104	300	A>V		No	ClinGen TOPMed gnomAD
rs150439612 CA5247763	301	M>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA5247764 rs772674360	301	M>V		No	ClinGen ExAC gnomAD
CA374960913 rs1263470572	303	A>P		No	ClinGen TOPMed
rs1261386723 CA374960855	304	V>I		No	ClinGen TOPMed gnomAD
rs770106268 CA374960821	305	I>F		No	ClinGen ExAC TOPMed gnomAD
CA5247759 rs770106268	305	I>L		No	ClinGen ExAC TOPMed gnomAD
rs746127851 CA374960765	306	R>*		No	ClinGen ExAC gnomAD
CA199856650 rs748154341	306	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs371085080 CA5247756	309	M>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs1464587213 CA374960655	309	M>V		No	ClinGen TOPMed
rs963915552 CA199856647	310	D>E		No	ClinGen TOPMed gnomAD
rs368195302 CA5247755	312	I>V		No	ClinGen ESP ExAC gnomAD
CA374960305 rs1341971403	314	T>A		No	ClinGen gnomAD
CA374960276 rs141392004	314	T>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5247754 rs141392004	314	T>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1341971403 CA374960314	314	T>P		No	ClinGen gnomAD
CA374960063 rs1391938484	320	A>D		No	ClinGen gnomAD
rs758425249 CA5247753	320	A>S		No	ClinGen ExAC gnomAD
CA5247752 rs752617608	324	R>*		No	ClinGen ExAC gnomAD
CA5247751 rs778880991	324	R>Q	Variant assessed as Somatic; 4.626e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA5247711 rs776876414	326	F>S		No	ClinGen ExAC gnomAD
rs761011053 CA5247709	327	I>L		No	ClinGen ExAC gnomAD
rs761011053 CA5247710	327	I>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs772398032 CA5247706	329	P>A		No	ClinGen ExAC TOPMed gnomAD
CA5247707 rs772398032	329	P>S		No	ClinGen ExAC TOPMed gnomAD
CA5247703 rs774480906	330	K>M		No	ClinGen ExAC TOPMed gnomAD
CA5247704 rs748275528	330	K>Q		No	ClinGen ExAC gnomAD
CA199853995 rs774480906	330	K>R		No	ClinGen ExAC TOPMed gnomAD
rs1432585831 CA374956508	331	A>T		No	ClinGen gnomAD
CA199853994 rs377686230	334	C>W		No	ClinGen ESP gnomAD
rs1179119334 CA374956415	334	C>Y		No	ClinGen gnomAD
CA5247701 rs574506801	335	V>M		No	ClinGen ExAC TOPMed gnomAD
rs374128661 CA5247699	336	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs779715730 CA5247700	336	R>W		No	ClinGen ExAC gnomAD
CA374956318 rs1323478175	337	N>H		No	ClinGen gnomAD
rs370582135 CA5247698	338	H>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA374956123 rs1347550190	341	P>L		No	ClinGen gnomAD
rs780863400 CA5247697	343	I>N		No	ClinGen ExAC gnomAD
rs553619776 CA5247696	344	P>L		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	345	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA199853991 rs1021547146	346	I>V		No	ClinGen TOPMed
rs755447369 CA5247693	350	L>R		No	ClinGen ExAC gnomAD
CA374955835 rs1414408132	351	M>I		No	ClinGen gnomAD
rs766673423 CA5247691	352	V>L		No	ClinGen ExAC gnomAD
CA374955775 rs1174213962	354	T>A		No	ClinGen TOPMed
rs761168162 CA5247690	354	T>N		No	ClinGen ExAC
rs967723354 CA199853990	358	F>I		No	ClinGen Ensembl
CA5247688 rs767914409	361	V>M		No	ClinGen ExAC TOPMed gnomAD
rs1010285462 CA199853989	362	R>Q		No	ClinGen TOPMed gnomAD
TCGA novel	362	R>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA374955413 rs1259035907	367	K>R		No	ClinGen gnomAD
rs1185274770 CA374955369	369	V>I		No	ClinGen gnomAD
CA5247685 rs768713976	370	T>A		No	ClinGen ExAC gnomAD
CA5247684 rs749213184	370	T>M		No	ClinGen ExAC TOPMed gnomAD
CA199853988 rs145531660	371	D>Y		No	ClinGen ESP TOPMed
CA5247682 rs769689758	372	M>I		No	ClinGen ExAC gnomAD
TCGA novel	374	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs745730530 CA5247681	376	V>I		No	ClinGen ExAC TOPMed gnomAD
rs780953007 CA5247680	377	I>V		No	ClinGen ExAC
CA374955122 COSM1206083 rs1232824519	379	E>K	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
CA374955057 rs140423692	381	G>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA374955054 rs1588151343	381	G>D		No	ClinGen Ensembl
rs140423692 CA5247677 COSM160897	381	G>S	breast [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA5247676 rs540149997	382	I>M		No	ClinGen 1000Genomes ExAC gnomAD
CA374954968 rs1205418344	384	K>Q		No	ClinGen TOPMed
rs752123683 CA5247675	386	G>S		No	ClinGen ExAC
CA5247672 rs750871615	387	E>Q		No	ClinGen ExAC gnomAD
rs1299377727 CA374954071	389	M>I		No	ClinGen gnomAD
rs376859514 CA5247647	389	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA5247646 rs765238042	390	E>Q		No	ClinGen ExAC gnomAD
rs1353539934 CA374953958	392	L>M		No	ClinGen gnomAD
CA374953906 rs1176392630	393	S>P		No	ClinGen gnomAD
rs770835912 CA5247644	394	R>P		No	ClinGen ExAC TOPMed gnomAD
rs770835912 CA5247643	394	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs375242377 CA5247645	394	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA374953818 rs772875373	396	A>E		No	ClinGen ExAC TOPMed gnomAD
CA5247641 rs772875373	396	A>G		No	ClinGen ExAC TOPMed gnomAD
CA5247642 rs772875373	396	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1253368694 CA374953793	397	Y>D		No	ClinGen gnomAD
CA374953753 rs1588150420	398	H>P		No	ClinGen Ensembl
CA374953739 rs1238227388	398	H>Q		No	ClinGen gnomAD
rs1002407596 CA199853831	398	H>Y		No	ClinGen TOPMed gnomAD
TCGA novel	400	L>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1588150409 CA374953685	400	L>P		No	ClinGen Ensembl
rs1277926473 CA374953605	403	Q>H		No	ClinGen gnomAD
CA199853829 rs1022973680	404	S>T		No	ClinGen TOPMed
CA5247636 rs371866914	406	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs781775048 CA5247634	411	S>L		No	ClinGen ExAC TOPMed gnomAD
rs757701903 CA5247633	413	R>*		No	ClinGen ExAC gnomAD
rs747464870 CA5247632	413	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA374953278 rs532985458	415	D>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5247631 rs532985458	415	D>Y		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA374953227 rs1173402184	416	G>R		No	ClinGen gnomAD
rs1007895082 CA199853828	418	Q>*		No	ClinGen Ensembl
CA374953123 rs1454676347	420	R>Q		No	ClinGen gnomAD
CA374953028 rs1588150358	422	D>E		No	ClinGen Ensembl
rs1366023746 CA374952953	424	S>F		No	ClinGen gnomAD
CA5247628 rs765325817	425	S>G		No	ClinGen ExAC gnomAD
rs755103095 CA5247627	426	T>M		No	ClinGen ExAC TOPMed gnomAD
CA199853827 rs112626528	428	V>L		No	ClinGen ExAC gnomAD
rs112626528 CA5247625	428	V>M		No	ClinGen ExAC gnomAD
rs1209866487 CA374952686	432	R>*		No	ClinGen gnomAD
CA5247624 rs760512238	432	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1262383084 CA374952634	433	A>T		No	ClinGen gnomAD
rs773069484 CA5247623	435	I>M		No	ClinGen ExAC gnomAD
CA5247621 rs761557803	438	R>G		No	ClinGen ExAC TOPMed gnomAD
CA5247619 rs768399125	438	R>P		No	ClinGen ExAC TOPMed gnomAD
rs768399125 CA5247620	438	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA5247622 rs761557803	438	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1453484364 CA374952376	439	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1190742477 CA374950638	442	D>N		No	ClinGen TOPMed gnomAD
CA5247593 rs779233626	444	A>T		No	ClinGen ExAC gnomAD
CA374950546 rs1253502362	444	A>V		No	ClinGen gnomAD
CA374950511 rs1203889019	445	V>G		No	ClinGen TOPMed
rs749442375 CA5247591	445	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA199853776 rs957168977	446	Y>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA5247590 rs780212910	447	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA374950318 rs1227108228	449	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA374950283 rs1372223884	450	T>N		No	ClinGen gnomAD
rs1306212988 CA374950263	451	L>V		No	ClinGen gnomAD
CA5247587 rs781029894	453	H>Y		No	ClinGen ExAC gnomAD
rs757249342 CA5247586	454	Q>H		No	ClinGen ExAC gnomAD
rs1394577849 CA374950079	455	E>K		No	ClinGen gnomAD
rs1588149898 CA374950025	456	L>R		No	ClinGen Ensembl
rs763915075 CA5247584	457	G>V		No	ClinGen ExAC TOPMed gnomAD
CA199853774 rs987078182	459	G>E		No	ClinGen Ensembl
rs376530400 CA5247583	462	K>*		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	463	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5247582 rs752246319	464	E>D		No	ClinGen ExAC gnomAD
CA374949672 rs1246109495	467	K>Q		No	ClinGen gnomAD
TCGA novel	467	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs955254047 CA374949630	468	S>C		No	ClinGen gnomAD
CA199853773 rs955254047	468	S>F		No	ClinGen gnomAD
CA5247579 rs776203950	469	I>T		No	ClinGen ExAC gnomAD
CA5247580 rs759011266	469	I>V		No	ClinGen ExAC gnomAD
CA5247578 rs772509598	471	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA374949528 rs1282922087	471	R>W		No	ClinGen TOPMed gnomAD
CA374949503 rs1280695837	472	V>I		No	ClinGen gnomAD
rs768965151 CA374949377	475	R>L		No	ClinGen ExAC TOPMed gnomAD
CA5247575 rs768965151	475	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs779130348 CA199853772	475	R>W		No	ClinGen TOPMed
CA374948993 rs1188630808	481	D>E		No	ClinGen gnomAD
rs1253131819 CA374948996	481	D>G		No	ClinGen TOPMed
rs1419855882 COSM1105333 CA374949012	481	D>N	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1197734178 CA374948979	482	Y>C		No	ClinGen TOPMed
CA374948988 rs1175220571	482	Y>N		No	ClinGen TOPMed gnomAD
COSM1292794 rs372270814 CA5247530	483	D>N	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA374948908 rs1194824413	484	S>C		No	ClinGen TOPMed gnomAD
CA374948839 rs1299771498	487	V>M		No	ClinGen TOPMed
rs772145640 CA5247528	488	R>G		No	ClinGen ExAC
CA5247527 rs201233827	488	R>Q		No	ClinGen ExAC gnomAD
rs772145640 CA5247529	488	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA
CA199853741 rs1003409103	490	R>K		No	ClinGen TOPMed
rs1221013569 CA374948733	490	R>S		No	ClinGen gnomAD
rs778602006 CA374948628	493	R>P		No	ClinGen ExAC TOPMed gnomAD
CA5247526 rs778602006	493	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA374948537 COSM141278 rs1216080262	495	A>V	upper_aerodigestive_tract Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1564292908 CA374948449	499	I>F		No	ClinGen Ensembl
rs1441547016 CA374948425	499	I>M		No	ClinGen gnomAD
CA374948411 rs1373182512	500	S>N		No	ClinGen gnomAD
TCGA novel	500	S>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs369275279 CA5247523	501	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA5247522 rs762335780	502	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA5247520 rs766948602	503	F>V		No	ClinGen ExAC gnomAD
CA374948201 rs1564292860	509	A>D		No	ClinGen Ensembl
CA5247517 rs765640749	509	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1564292860 CA374948182	509	A>V		No	ClinGen Ensembl
CA5247516 rs759988005	510	P>S		No	ClinGen ExAC gnomAD
CA374948165 rs759988005	510	P>T		No	ClinGen ExAC gnomAD
rs1222392858 CA374948122	512	C>F		No	ClinGen TOPMed gnomAD
CA5247515 rs754252948	513	K>T		No	ClinGen ExAC gnomAD
rs200796169 CA5247514	514	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA5247487 rs769529372	515	E>K		No	ClinGen ExAC
rs745642516 CA5247486	517	P>L		No	ClinGen ExAC TOPMed gnomAD
rs201427745 CA5247484	518	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs780940200 CA5247485	518	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA5247483 rs746590065	520	Q>*		No	ClinGen ExAC gnomAD
rs1262473946 CA374947916	521	E>K		No	ClinGen gnomAD
CA374947901 rs1588149295	522	L>M		No	ClinGen Ensembl
CA374947890 rs1206250254	523	I>L		No	ClinGen gnomAD
CA5247481 rs755550771	526	D>N		No	ClinGen ExAC TOPMed gnomAD
rs749769768 CA5247480	528	A>S		No	ClinGen ExAC gnomAD
rs780583830 CA5247479	529	R>G		No	ClinGen ExAC gnomAD
rs1312435928 CA374947747	529	R>M		No	ClinGen TOPMed gnomAD
CA374947749 rs1312435928	529	R>T		No	ClinGen TOPMed gnomAD
rs1588149264 CA374947721	531	I>F		No	ClinGen Ensembl
rs1023527621 CA199853729	531	I>T		No	ClinGen TOPMed
rs1319164490 CA374947641	536	T>A		No	ClinGen gnomAD
CA5247477 rs750783560	536	T>M		No	ClinGen ExAC TOPMed gnomAD
rs751672920 CA5247474	538	E>D		No	ClinGen ExAC gnomAD
CA374947589 rs1416553114	538	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA5247472 rs762901875	541	V>M		No	ClinGen ExAC gnomAD
TCGA novel	544	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5247470 rs139005563	545	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs759396491 CA5247469	546	M>T		No	ClinGen ExAC gnomAD
CA199853688 rs964730229	552	A>G		No	ClinGen TOPMed
CA374947343 rs1291900719	552	A>S		No	ClinGen TOPMed
rs1476721745 CA374947168	555	E>D		No	ClinGen gnomAD
CA199853686 rs893611586	555	E>G		No	ClinGen Ensembl
CA199853687 rs1010714502	555	E>K		No	ClinGen gnomAD
CA374947157 rs1376579729	556	A>G		No	ClinGen gnomAD
CA5247441 rs771249314	557	A>T		No	ClinGen ExAC TOPMed gnomAD
CA5247440 rs530994276	557	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA199853685 rs999847409	558	V>L		No	ClinGen TOPMed gnomAD
CA374947124 rs999847409	558	V>M		No	ClinGen TOPMed gnomAD
rs561975739 CA5247438	559	Q>R		No	ClinGen 1000Genomes ExAC gnomAD
rs1199260355 CA374947093	560	R>G		No	ClinGen TOPMed gnomAD
rs115851622 CA5247437	563	N>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1280206442 CA374947000	563	N>S		No	ClinGen gnomAD
rs1280206442 CA374946998	563	N>T		No	ClinGen gnomAD
rs1348822015 CA374946968	564	L>V		No	ClinGen gnomAD
CA199853684 rs1046063862	566	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs754978264 CA5247435	566	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA374946912 rs1375847353	567	D>H		No	ClinGen gnomAD
rs1336017958 CA374946841	569	M>T		No	ClinGen gnomAD
CA374946771 rs1401479162	571	M>I		No	ClinGen gnomAD
rs1158616246 CA374946762	572	H>Y		No	ClinGen gnomAD
TCGA novel	573	N>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5247433 rs766314238	575	D>A		No	ClinGen ExAC gnomAD
CA199853683 rs947716661	575	D>N		No	ClinGen TOPMed gnomAD
rs1239589624 CA374946611	576	P>S		No	ClinGen gnomAD
rs374596457 CA5247431	577	N>D		No	ClinGen ESP ExAC TOPMed
TCGA novel	577	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA374946588 rs1588148818	577	N>T		No	ClinGen Ensembl
rs1588148813 CA374946546	578	L>R		No	ClinGen Ensembl
CA374946540 rs1588148802	579	H>P		No	ClinGen Ensembl
CA5247430 rs750226176	579	H>Y		No	ClinGen ExAC gnomAD
CA5247428 rs761497532	583	E>K		No	ClinGen ExAC TOPMed gnomAD
CA374946445 rs1277939529	584	G>D		No	ClinGen TOPMed
CA374946460 rs1327190124	584	G>S		No	ClinGen gnomAD
CA5247426 rs768241453	585	A>T		No	ClinGen ExAC gnomAD
rs1241045536 CA374946412	585	A>V		No	ClinGen TOPMed
rs1357674150 CA374946397	586	P>S		No	ClinGen gnomAD
rs1357674150 CA374946404	586	P>T		No	ClinGen gnomAD
CA374946342 rs560007259	588	D>H		No	ClinGen 1000Genomes ExAC TOPMed
rs560007259 CA5247424	588	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed
CA199853680 rs560007259	588	D>Y		No	ClinGen 1000Genomes ExAC TOPMed
rs148561996 CA5247422	589	W>C		No	ClinGen ESP ExAC gnomAD
CA5247423 rs141939389	589	W>L		No	ClinGen ESP ExAC gnomAD
rs772289133 CA5247420	590	G>A		No	ClinGen ExAC gnomAD
CA5247421 rs778056027	590	G>S		No	ClinGen ExAC gnomAD
CA5247418 rs778990077	591	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs778990077 CA199853679	591	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA374946198 rs1415591703	593	Y>H		No	ClinGen gnomAD
rs545428563 CA199853678	594	S>N		No	ClinGen 1000Genomes TOPMed gnomAD
rs201626107 CA5247414	597	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1214458262 CA374946053	597	G>V		No	ClinGen gnomAD
CA5247412 rs202172377	598	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA374946049 rs202172377	598	G>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5247410 rs751207485	599	G>D		No	ClinGen ExAC TOPMed gnomAD
CA5247411 rs751207485	599	G>V		No	ClinGen ExAC TOPMed gnomAD
CA5247408 rs762438907	600	G>A		No	ClinGen ExAC gnomAD
CA5247409 rs763807793	600	G>S		No	ClinGen ExAC TOPMed gnomAD
CA374945935 rs1441073820	602	P>L		No	ClinGen gnomAD
CA374945896 rs1351231490	604	P>S		No	ClinGen gnomAD
rs377673278 CA5247404	605	S>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA5247403 rs761179641	605	S>N		No	ClinGen ExAC gnomAD
rs772381828 CA5247400	606	T>P		No	ClinGen ExAC
CA5247399 rs144706217	607	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs144706217 CA5247398	607	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs369677680 CA374945794	608	E>D		No	ClinGen ESP TOPMed gnomAD
CA374945784 COSM1314469 rs1273088198	609	S>L	Variant assessed as Somatic; impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs1221130428 CA374945779	610	A>P		No	ClinGen gnomAD
CA199853675 rs953815241	611	T>A		No	ClinGen TOPMed
rs368668074 CA5247396	613	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1230414074 CA374945660	615	K>Q		No	ClinGen gnomAD
rs956182494 CA199853674	616	R>*		No	ClinGen TOPMed gnomAD
CA374945618 rs1296840465	616	R>L		No	ClinGen TOPMed gnomAD
CA374945625 rs1296840465	616	R>Q		No	ClinGen TOPMed gnomAD
CA374945606 rs745760357	617	R>L		No	ClinGen ExAC TOPMed gnomAD
rs745760357 CA5247393	617	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA5247394 rs756007878	617	R>W		No	ClinGen ExAC TOPMed gnomAD
COSM1206084 CA5247392 rs574662860	618	R>C	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs757157689 CA5247391	618	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA5247389 rs763712715	619	A>T		No	ClinGen ExAC gnomAD
CA374945513 rs1388655929	621	Q>E		No	ClinGen TOPMed
rs138795717 CA199853672	622	V>L		No	ClinGen ESP
rs138795717 CA199853673	622	V>M		No	ClinGen ESP
CA199853671 rs1004449875	624	S>C		No	ClinGen TOPMed
CA5247387 rs372906105	625	V>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs1564291808 CA374945322	628	D>E		No	ClinGen Ensembl
rs1423162727 CA374945327	628	D>G		No	ClinGen gnomAD
CA374945316 rs1190754375	629	E>G		No	ClinGen gnomAD
CA5247385 rs193108069	631	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA374945253 rs1207001494	632	G>W		No	ClinGen gnomAD
CA5247384 rs565794127	634	P>H		No	ClinGen 1000Genomes ExAC gnomAD
CA199853670 rs565794127	634	P>L		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	634	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1564291771 CA374945138	637	A>T		No	ClinGen Ensembl
rs1045761065 CA199853669	638	S>R		No	ClinGen TOPMed
rs767977239 CA5247383	642	P>S		No	ClinGen ExAC gnomAD
rs762228282 CA5247382	644	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1467060235 CA374944890	644	P>S		No	ClinGen TOPMed gnomAD
rs1298540817 CA374944864	645	A>V		No	ClinGen TOPMed gnomAD
rs552467244 CA5247379	647	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA374944800 rs769862019	648	D>E		No	ClinGen ExAC TOPMed gnomAD
CA374944825 rs1370350299	648	D>N		No	ClinGen gnomAD
rs1175425003 CA374944752	651	T>I		No	ClinGen gnomAD
rs757247618 CA5247374	652	E>G		No	ClinGen ExAC gnomAD
CA374944751 rs1401404117	652	E>K		No	ClinGen gnomAD
CA199853668 rs539417380	653	I>F		No	ClinGen 1000Genomes ExAC gnomAD
rs777559244 CA5247372	653	I>S		No	ClinGen ExAC TOPMed gnomAD
CA5247373 rs539417380	653	I>V		No	ClinGen 1000Genomes ExAC gnomAD
CA5247371 rs149367067	654	R>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5247370 rs752348939	654	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs754519412 CA5247368	655	G>A		No	ClinGen ExAC TOPMed gnomAD
rs1254216466 CA374944703	655	G>R		No	ClinGen gnomAD
rs1054963926 CA199853667	656	L>Q		No	ClinGen TOPMed gnomAD
CA5247365 rs762246656	658	A>S		No	ClinGen ExAC gnomAD
CA199853666 rs1037408206	660	G>C		No	ClinGen gnomAD
rs764477616 CA5247363	660	G>D		No	ClinGen ExAC TOPMed gnomAD
rs764477616 CA374944612	660	G>V		No	ClinGen ExAC TOPMed gnomAD
rs374739971 CA199853665	662	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs374739971 CA5247361	662	R>Q	Variant assessed as Somatic; 5.835e-05 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA5247362 rs763105834	662	R>W		No	ClinGen ExAC TOPMed gnomAD
rs770136344 CA5247360	663	P>L		No	ClinGen ExAC
rs1157115339 CA374944585	664	E>K		No	ClinGen TOPMed gnomAD
CA5247359 rs759747875	665	S>G		No	ClinGen ExAC gnomAD
CA5247358 rs776796459	665	S>R		No	ClinGen ExAC gnomAD
CA374944557 rs1218723902	666	P>T		No	ClinGen TOPMed
TCGA novel	667	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5247357 rs746906163	667	P>Q		No	ClinGen ExAC gnomAD
CA5247356 rs746906163	667	P>R		No	ClinGen ExAC gnomAD
rs1165176326 CA374944545	667	P>S		No	ClinGen gnomAD
CA374944523 rs1249721709	669	A>T		No	ClinGen gnomAD
rs1181223185 CA374944511	669	A>V		No	ClinGen gnomAD
rs1313050195 CA374944493	670	G>D		No	ClinGen TOPMed gnomAD
rs61751870 CA5247354 COSM455364	670	G>S	breast [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs561939837 CA5247353	671	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA374944475 rs1328026703	672	L>V		No	ClinGen gnomAD
rs1564291596 CA374944458	673	L>F		No	ClinGen Ensembl
CA374944441 rs1247394971	674	N>D		No	ClinGen gnomAD
rs1320320548 CA374944434	674	N>S		No	ClinGen gnomAD
CA374944402 rs1368040545	675	G>E		No	ClinGen gnomAD
rs753357409 CA5247350	675	G>R		No	ClinGen ExAC gnomAD
TCGA novel	676	A>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	676	A>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1318594516 CA374944394	676	A>S		No	ClinGen TOPMed gnomAD
rs1318594516 CA374944398	676	A>T		No	ClinGen TOPMed gnomAD
rs1434513278 CA374944380	677	P>S		No	ClinGen TOPMed gnomAD
rs1434513278 CA374944384	677	P>T		No	ClinGen TOPMed gnomAD
CA374944367 rs779474504	678	A>S		No	ClinGen ExAC TOPMed gnomAD
rs779474504 CA5247349	678	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1459197750 CA374944348	679	G>E		No	ClinGen gnomAD
rs986388865 CA199853663	680	E>D		No	ClinGen TOPMed gnomAD
rs1162769547 CA374944332	680	E>G		No	ClinGen gnomAD
CA374944340 rs1366501155	680	E>K		No	ClinGen gnomAD
CA199853662 rs754137868	681	S>I		No	ClinGen Ensembl
rs11545938 CA199853661	681	S>R		No	ClinGen Ensembl
CA199853660 rs914550442	682	P>S		No	ClinGen Ensembl
CA199853659 rs34456155	684	P>L		No	ClinGen Ensembl
CA5247348 rs757794622	684	P>S		No	ClinGen ExAC TOPMed gnomAD
rs752056887 CA5247347	685	K>N		No	ClinGen ExAC gnomAD
CA374944220 rs1314752944	686	A>T		No	ClinGen TOPMed
CA5247345 rs548335804	687	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA374944188 rs1211283657	687	A>V		No	ClinGen gnomAD
CA374944183 rs1487337466	688	P>A		No	ClinGen gnomAD
CA5247343 rs765569017	689	E>K		No	ClinGen ExAC TOPMed
rs1229664414 CA374944155	689	E>V		No	ClinGen gnomAD
CA5247342 rs759764034	690	A>S		No	ClinGen ExAC TOPMed gnomAD
CA374944143 rs759764034	690	A>T		No	ClinGen ExAC TOPMed gnomAD
CA374944119 rs1227696252	691	S>F		No	ClinGen gnomAD
rs1331767928 CA374944102	692	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs368592407 CA5247337	693	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs773237268 CA5247339	693	P>S		No	ClinGen ExAC TOPMed gnomAD
CA5247338 rs773237268	693	P>T		No	ClinGen ExAC TOPMed gnomAD
CA5247334 rs144973598	696	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA199853658 rs757748473	697	P>L		No	ClinGen TOPMed gnomAD
rs142795970 CA5247333	698	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1474763898 CA374943957	701	L>P		No	ClinGen TOPMed gnomAD
TCGA novel	702	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1004425358 CA199853657	703	P>S		No	ClinGen TOPMed gnomAD
CA374943918 rs1431071100	704	G>R		No	ClinGen gnomAD
CA5247329 rs138757858	706	A>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs138757858 CA5247328	706	A>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA374943867 rs138757858	706	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA374943854 rs1564291375	706	A>V		No	ClinGen Ensembl
CA5247327 rs753109201	708	D>N		No	ClinGen ExAC gnomAD
CA5247326 rs765655789	710	G>E		No	ClinGen ExAC TOPMed gnomAD
rs1248890502 CA374943725	711	P>S		No	ClinGen gnomAD
rs759857601 CA5247325	712	P>R		No	ClinGen ExAC gnomAD
CA5247321 rs202140368	713	K>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs773156678 CA5247320	715	S>T		No	ClinGen ExAC gnomAD
rs761592691 CA5247318	716	D>N		No	ClinGen ExAC gnomAD
CA374943569 rs1410154652	717	Q>R		No	ClinGen gnomAD
rs1352117009 CA374943430	720	G>R		No	ClinGen TOPMed gnomAD
rs1306041877 CA374941907	722	Q>*		No	ClinGen gnomAD
CA374941889 rs1409284439	722	Q>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1483703974 CA374941901	722	Q>R		No	ClinGen gnomAD
CA5247317 rs774165481	723	V>A		No	ClinGen ExAC gnomAD
TCGA novel	723	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1173786135 CA374941868	724	S>A		No	ClinGen gnomAD
CA5247316 rs768392476	724	S>C		No	ClinGen ExAC gnomAD
rs1453810853 CA374941845	725	S>G		No	ClinGen TOPMed
CA5247315 rs749061678	727	S>R		No	ClinGen ExAC TOPMed gnomAD
CA374941780 rs1182466211	728	S>R		No	ClinGen gnomAD
CA199853653 rs886157167	729	H>Y		No	ClinGen TOPMed gnomAD
rs769327730 CA5247313	730	P>L		No	ClinGen ExAC gnomAD
CA5247311 rs187699931	731	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1344430685 CA374941701	732	L>R		No	ClinGen gnomAD
rs1268942506 CA374941651	734	T>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1042198755 CA374941631	734	T>I		No	ClinGen TOPMed gnomAD
rs1042198755 CA199853652	734	T>S		No	ClinGen TOPMed gnomAD
CA374941560 rs1276071380	737	E>G		No	ClinGen TOPMed
rs748553061 CA5247309	737	E>K		No	ClinGen ExAC gnomAD
TCGA novel	738	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA374941534 rs1441254634	738	D>Y		No	ClinGen gnomAD
rs1588148044 CA374941366	742	V>G		No	ClinGen Ensembl
CA5247308 rs779538130	742	V>L		No	ClinGen ExAC TOPMed gnomAD
rs779538130 CA374941381	742	V>M		No	ClinGen ExAC TOPMed gnomAD
rs755431231 CA5247307	743	Q>R		No	ClinGen ExAC gnomAD
CA374941286 rs1393731348	745	E>A		No	ClinGen TOPMed gnomAD
rs1293211239 CA374941280	745	E>D		No	ClinGen TOPMed
CA374941301 rs1393731348	745	E>V		No	ClinGen TOPMed gnomAD

No associated diseases with Q96TA1

1 regional properties for Q96TA1

Type	Name	Position	InterPro Accession
domain	Pleckstrin homology domain	68 - 192	IPR001849

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm, cytosol Cell junction, adherens junction Membrane ; Lipid-anchor	In exponentially growing cells, exclusively cytoplasmic Cell membrane localization is observed when cells reach confluency and during telophase In melanoma cells, targeting to the plasma membrane may be impaired by C-terminal phosphorylation
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

7 GO annotations of cellular component

Name	Definition
adherens junction	A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name	Definition
cadherin binding	Binding to cadherin, a type I membrane protein involved in cell adhesion.
transcription coactivator activity	A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator.

15 GO annotations of biological process

Name	Definition
axon guidance	The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
cell differentiation	The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
gonadotropin secretion	The regulated release of a gonadotropin, any hormone that stimulates the gonads, especially follicle-stimulating hormone and luteinizing hormone.
hypomethylation of CpG island	An decrease in the epigenetic methylation of cytosine and adenosine residues in a CpG island in DNA. CpG islands are genomic regions that contain a high frequency of the CG dinucleotide and are often associated with the transcription start site of genes.
negative regulation of angiogenesis	Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
negative regulation of apoptotic process	Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
negative regulation of cell population proliferation	Any process that stops, prevents or reduces the rate or extent of cell proliferation.
negative regulation of DNA biosynthetic process	Any process that stops, prevents or reduces the frequency, rate or extent of DNA biosynthetic process.
negative regulation of DNA-templated transcription	Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
negative regulation of Notch signaling pathway	Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway.
negative regulation of vascular endothelial growth factor receptor signaling pathway	Any process that stops, prevents, or reduces the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity.
positive regulation of DNA-templated transcription	Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
positive regulation of embryonic development	Any process that activates or increases the frequency, rate or extent of embryonic development.
positive regulation of skeletal muscle fiber development	Any process that activates, maintains or increases the rate of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.
positive regulation of transcription regulatory region DNA binding	Any process that activates or increases the frequency, rate or extent of transcription regulatory region DNA binding.

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q3UW53	Niban1	Protein Niban 1	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MGDVLSTHLD	DARRQHIAEK	TGKILTEFLQ	FYEDQYGVAL	FNSMRHEIEG	TGLPQAQLLW
70	80	90	100	110	120
RKVPLDERIV	FSGNLFQHQE	DSKKWRNRFS	LVPHNYGLVL	YENKAAYERQ	VPPRAVINSA
130	140	150	160	170	180
GYKILTSVDQ	YLELIGNSLP	GTTAKSGSAP	ILKCPTQFPL	ILWHPYARHY	YFCMMTEAEQ
190	200	210	220	230	240
DKWQAVLQDC	IRHCNNGIPE	DSKVEGPAFT	DAIRMYRQSK	ELYGTWEMLC	GNEVQILSNL
250	260	270	280	290	300
VMEELGPELK	AELGPRLKGK	PQERQRQWIQ	ISDAVYHMVY	EQAKARFEEV	LSKVQQVQPA
310	320	330	340	350	360
MQAVIRTDMD	QIITSKEHLA	SKIRAFILPK	AEVCVRNHVQ	PYIPSILEAL	MVPTSQGFTE
370	380	390	400	410	420
VRDVFFKEVT	DMNLNVINEG	GIDKLGEYME	KLSRLAYHPL	KMQSCYEKME	SLRLDGLQQR
430	440	450	460	470	480
FDVSSTSVFK	QRAQIHMREQ	MDNAVYTFET	LLHQELGKGP	TKEELCKSIQ	RVLERVLKKY
490	500	510	520	530	540
DYDSSSVRKR	FFREALLQIS	IPFLLKKLAP	TCKSELPRFQ	ELIFEDFARF	ILVENTYEEV
550	560	570	580	590	600
VLQTVMKDIL	QAVKEAAVQR	KHNLYRDSMV	MHNSDPNLHL	LAEGAPIDWG	EEYSNSGGGG
610	620	630	640	650	660
SPSPSTPESA	TLSEKRRRAK	QVVSVVQDEE	VGLPFEASPE	SPPPASPDGV	TEIRGLLAQG
670	680	690	700	710	720
LRPESPPPAG	PLLNGAPAGE	SPQPKAAPEA	SSPPASPLQH	LLPGKAVDLG	PPKPSDQETG
730	740
EQVSSPSSHP	ALHTTTEDSA	GVQTEF