AiPD: Autoinhibited Protein Database

Q96P16

Gene name	RPRD1A (P15RS)
Protein name	Regulation of nuclear pre-mRNA domain-containing protein 1A
Names	Cyclin-dependent kinase inhibitor 2B-related protein, p15INK4B-related protein
Species	Homo sapiens (Human)
KEGG Pathway	hsa:55197
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

105-189 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

105-189 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

3 structures for Q96P16

Entry ID	Method	Resolution	Chain	Position	Source
4JXT	X-ray	190 A	A	1-137	PDB
4NAC	X-ray	200 A	A/B	1-131	PDB
AF-Q96P16-F1	Predicted				AlphaFoldDB

166 variants for Q96P16

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs774131938 CA8938891	3	A>V		No	ClinGen ExAC gnomAD
rs748892078 CA8938889	5	S>F		No	ClinGen ExAC gnomAD
CA8938887 rs769263531	7	A>V		No	ClinGen ExAC TOPMed gnomAD
CA402200626 rs1432641941	8	A>T		No	ClinGen gnomAD
rs78759517 CA298663329	10	E>G		No	ClinGen Ensembl
rs1319625006 CA402200591	11	K>R		No	ClinGen gnomAD
CA402200574 rs1432889368	12	K>N		No	ClinGen gnomAD
COSM1264566 rs757714667 CA8938884	14	S>L	oesophagus [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed
CA298663318 rs1029427212	14	S>T		No	ClinGen TOPMed
CA298663304 rs757714667	14	S>W		No	ClinGen ExAC TOPMed
rs76432625 CA298663283	16	L>V		No	ClinGen Ensembl
rs1598686244 CA402200527	17	S>T		No	ClinGen Ensembl
CA402200517 rs1389798761	18	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA402200503 rs1447718530	19	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA8938882 rs138029311	20	Q>*		No	ClinGen ESP ExAC TOPMed gnomAD
VAR_037229	21	Q>H	a breast cancer sample; somatic mutation [UniProt]	No	UniProt
CA8938878 rs759516825	28	L>Q		No	ClinGen ExAC gnomAD
CA402200297 rs1216019007	38	R>C		No	ClinGen gnomAD
CA8938875 rs761774077	38	R>H		No	ClinGen ExAC gnomAD
CA402200260 rs1303294462	42	T>A		No	ClinGen gnomAD
TCGA novel	43	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA402200225 rs1362664771	45	E>V		No	ClinGen TOPMed
rs762635649 CA8938872	49	R>W		No	ClinGen ExAC TOPMed gnomAD
CA402198991 rs1328384016	60	L>F		No	ClinGen gnomAD
CA402198984 rs1598636974	61	Y>S		No	ClinGen Ensembl
rs764828851 CA8938852	67	I>L		No	ClinGen ExAC gnomAD
rs111706297 CA298678950	79	K>E		No	ClinGen Ensembl
CA298678943 rs1028905977	83	P>S		No	ClinGen TOPMed
rs1198164144 CA402198814	85	I>M		No	ClinGen TOPMed gnomAD
rs897472561 CA298678934	85	I>V		No	ClinGen Ensembl
CA402198736 rs1412325021	95	E>*		No	ClinGen TOPMed gnomAD
rs772741025 CA8938814	95	E>A		No	ClinGen ExAC gnomAD
CA402198738 rs1412325021	95	E>K		No	ClinGen TOPMed gnomAD
CA402198726 rs1308186217	96	T>I		No	ClinGen gnomAD
CA402198727 rs1308186217	96	T>S		No	ClinGen gnomAD
CA402198725 rs1428882166	97	D>N		No	ClinGen gnomAD
CA8938813 rs762363915	99	S>G		No	ClinGen ExAC gnomAD
CA402198707 rs1164754566	99	S>N		No	ClinGen gnomAD
CA402198676 rs1458394091	103	H>Y		No	ClinGen gnomAD
rs749541565 CA8938811	107	V>L		No	ClinGen ExAC gnomAD
CA8938810 rs749541565	107	V>M		No	ClinGen ExAC gnomAD
CA8938809 rs780310615	109	S>T		No	ClinGen ExAC TOPMed gnomAD
rs769850382 CA8938808	110	I>V		No	ClinGen ExAC gnomAD
CA8938806 rs781199117 COSM3422155 COSM3422157	120	D>N	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA8938805 rs758378117	121	V>I		No	ClinGen ExAC gnomAD
CA298676408 rs924893698	123	E>D		No	ClinGen TOPMed
CA8938803 rs778636902	124	Q>E		No	ClinGen ExAC gnomAD
CA402198519 rs1568133544	126	K>R		No	ClinGen Ensembl
rs753515329 CA8938801	127	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs1234568122 CA402198507	128	A>T		No	ClinGen TOPMed gnomAD
rs760366747 CA8938799	130	Y>H		No	ClinGen ExAC gnomAD
rs1028191023 CA298676310	131	G>D		No	ClinGen gnomAD
rs1288805715 CA402198464	133	K>Q		No	ClinGen TOPMed
rs778919387 CA8938785	133	K>R		No	ClinGen ExAC TOPMed gnomAD
rs753702057 CA8938783	135	P>A		No	ClinGen ExAC gnomAD
CA402198447 rs1384300502	135	P>L		No	ClinGen TOPMed
rs779668769 CA8938782	136	R>K		No	ClinGen ExAC gnomAD
CA8938781 rs755883351	137	K>M		No	ClinGen ExAC gnomAD
CA402198430 rs1406061908	138	R>*		No	ClinGen TOPMed gnomAD
CA402198431 rs1406061908	138	R>G		No	ClinGen TOPMed gnomAD
COSM988186 rs1174471975 CA402198429	138	R>Q	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1377484096 CA402198418	140	Y>C		No	ClinGen gnomAD
CA8938780 rs750072530	140	Y>H		No	ClinGen ExAC gnomAD
CA8938778 rs767204777	143	I>V		No	ClinGen ExAC gnomAD
CA8938777 rs761397530	144	K>N		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	144	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1207562987 CA402198379	145	V>G		No	ClinGen gnomAD
rs1294731184 CA402198372	146	D>E		No	ClinGen TOPMed
CA298676248 rs982502014	148	N>D		No	ClinGen TOPMed
rs750975524 CA8938776	151	C>S		No	ClinGen ExAC gnomAD
rs750975524 CA402198336	151	C>Y		No	ClinGen ExAC gnomAD
rs951298795 CA298676224	155	G>E		No	ClinGen TOPMed
TCGA novel	158	S>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs758982237 CA8938754	163	T>I		No	ClinGen ExAC gnomAD
rs142970983 CA298672425	164	L>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP NCI-TCGA
CA402198240 rs1316859387	165	D>N		No	ClinGen TOPMed
CA402198227 rs1212802214	167	V>I		No	ClinGen TOPMed gnomAD
rs1381211447 CA402198215	168	R>S		No	ClinGen gnomAD
CA402198214 rs1286054840	169	A>T		No	ClinGen gnomAD
CA8938750 rs776910476	169	A>V		No	ClinGen ExAC gnomAD
CA402198195 rs1431846788	171	Q>H		No	ClinGen TOPMed gnomAD
CA402198169 rs1207447477	175	N>S		No	ClinGen TOPMed
rs773394858 CA8938747	176	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1408764022 CA402198152	178	S>L		No	ClinGen TOPMed gnomAD
rs772016009 CA8938746	178	S>P		No	ClinGen ExAC TOPMed gnomAD
rs1181968143 CA402198125	182	A>G		No	ClinGen gnomAD
CA402198113 rs1568130590	184	H>R		No	ClinGen Ensembl
rs775556895 CA298672367	186	R>G		No	ClinGen ExAC gnomAD
rs935340069 CA298672343	188	A>G		No	ClinGen TOPMed gnomAD
rs935340069 CA402198084	188	A>V		No	ClinGen TOPMed gnomAD
CA8938742 rs745662634	190	L>F		No	ClinGen ExAC TOPMed gnomAD
CA8938741 rs371752785	191	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA8938740 rs746611301	193	E>D		No	ClinGen ExAC TOPMed gnomAD
CA298672269 rs866790806	195	Q>*		No	ClinGen Ensembl
rs1334338184 CA402198001	201	D>E		No	ClinGen gnomAD
rs1103 CA298672252	204	T>A		No	ClinGen Ensembl
rs1158606173 CA402197982	204	T>R		No	ClinGen TOPMed
CA402197960 rs1427980742	206	K>E		No	ClinGen TOPMed
TCGA novel	207	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8938717 rs747685598	207	E>V		No	ClinGen ExAC gnomAD
CA298672098 rs1102	208	S>P		No	ClinGen Ensembl
CA402197939 rs1457250427	209	G>R		No	ClinGen gnomAD
CA402197931 rs1362882196	210	E>A		No	ClinGen gnomAD
CA402197925 rs1178424972	211	R>G		No	ClinGen TOPMed
rs755531779 CA8938715	211	R>S		No	ClinGen ExAC gnomAD
CA298672063 rs370259374	216	V>L		No	ClinGen ESP
rs1434540090 CA402197878	218	D>N		No	ClinGen gnomAD
rs754314786 COSM1480314 CA8938714	219	A>V	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA8938711 rs750743635	220	C>R		No	ClinGen ExAC gnomAD
CA402197835 rs1296220201	224	A>T		No	ClinGen TOPMed
rs767638938 CA8938710	226	Y>F		No	ClinGen ExAC gnomAD
CA402197812 rs1394682621	227	N>S		No	ClinGen TOPMed
TCGA novel	229	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA402197788 rs1486201477	231	A>T		No	ClinGen gnomAD
COSM988184 rs369471626 CA8938709	231	A>V	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs1314128793 CA402197765	234	I>T		No	ClinGen TOPMed gnomAD
rs568270468 CA8938707	235	D>V		No	ClinGen 1000Genomes ExAC gnomAD
CA8938705 rs368751642	241	T>I		No	ClinGen ExAC gnomAD
CA8938704 rs770843027	242	R>*		No	ClinGen ExAC gnomAD
CA8938703 rs768166102	242	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs771643524 CA8938701	245	A>T		No	ClinGen ExAC gnomAD
rs1359330723 CA402197681	247	F>I		No	ClinGen gnomAD
CA402197664 rs1172813385	249	R>H		No	ClinGen gnomAD
CA298671953 rs961747482	250	C>G		No	ClinGen gnomAD
rs778437944 CA8938699	250	C>S		No	ClinGen ExAC gnomAD
rs778437944 CA8938700	250	C>Y		No	ClinGen ExAC gnomAD
CA298671941 rs887529279	251	Q>R		No	ClinGen TOPMed
CA8938696 rs780443035	254	A>T		No	ClinGen ExAC TOPMed gnomAD
CA402197627 rs1184829975	255	L>V		No	ClinGen gnomAD
rs756578040 CA8938695	260	H>R		No	ClinGen ExAC TOPMed gnomAD
rs544990628 CA298809447	266	K>E		No	ClinGen Ensembl
rs767361358 CA402290618	267	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs767361358 CA8938663	267	R>G		No	ClinGen ExAC gnomAD
CA8938662 rs149833712	267	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs1383003363 CA402290572	275	V>M		No	ClinGen gnomAD
COSM277114 CA402290564 rs1198214970	276	R>C	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA402290563 rs918462703	276	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA298809445 rs918462703	276	R>L		No	ClinGen gnomAD
rs140057019 CA8938657	277	K>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1261646240 CA402290558	277	K>R		No	ClinGen TOPMed gnomAD
CA298809444 rs984205975	278	E>D		No	ClinGen Ensembl
CA402290554 rs1395020730	278	E>K		No	ClinGen gnomAD
rs747405130 CA8938652	282	R>Q		No	ClinGen ExAC gnomAD
CA8938653 rs771497563	282	R>W		No	ClinGen ExAC TOPMed gnomAD
rs948620722 CA402290512 CA298809443	284	Q>H		No	ClinGen TOPMed gnomAD
rs778230833 CA8938651	285	S>R		No	ClinGen ExAC gnomAD
rs1219865966 CA402290498	287	P>A		No	ClinGen gnomAD
rs1568108598 CA402290474	290	S>F		No	ClinGen Ensembl
CA8938650 rs758740817	290	S>P	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
TCGA novel	290	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs971830369 CA298809442	291	R>Q		No	ClinGen TOPMed gnomAD
rs748368061 CA8938649	292	L>F		No	ClinGen ExAC gnomAD
rs146097569 CA8938648	294	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA8938645 rs781114893	296	T>A		No	ClinGen ExAC TOPMed gnomAD
rs757146784 CA402290426	298	S>R		No	ClinGen ExAC gnomAD
rs751377732 CA8938643	299	H>P		No	ClinGen ExAC gnomAD
CA8938642 rs763856571	301	H>N		No	ClinGen ExAC gnomAD
rs762553843 CA402290407	301	H>P		No	ClinGen ExAC gnomAD
rs762553843 CA8938641	301	H>R		No	ClinGen ExAC gnomAD
rs1412155283 CA402290396	303	P>H		No	ClinGen gnomAD
rs1056979561 CA298809441	303	P>S		No	ClinGen TOPMed gnomAD
rs752379681 CA298809440	305	A>E		No	ClinGen ExAC TOPMed gnomAD
CA8938640 rs752379681	305	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs907942364 CA298809439	307	D>G		No	ClinGen TOPMed
CA402290328 rs771583595	313	D>G		No	ClinGen ExAC TOPMed gnomAD
CA8938636 rs771583595	313	D>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD

No associated diseases with Q96P16

2 regional properties for Q96P16

Type	Name	Position	InterPro Accession
domain	CID domain	1 - 133	IPR006569
domain	Regulation of nuclear pre-mRNA domain-containing protein 1A/B	165 - 310	IPR032337

Functions

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
RNA polymerase II, holoenzyme	A nuclear DNA-directed RNA polymerase complex containing an RNA polymerase II core enzyme as well as additional proteins and transcription factor complexes, that are capable of promoter recognition and transcription initiation from an RNA polymerase II promoter in vivo. These additional components may include general transcription factor complexes TFIIA, TFIID, TFIIE, TFIIF, or TFIIH, as well as Mediator, SWI/SNF, GCN5, or SRBs and confer the ability to recognize promoters.

2 GO annotations of molecular function

Name	Definition
identical protein binding	Binding to an identical protein or proteins.
RNA polymerase II complex binding	Binding to an RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits.

2 GO annotations of biological process

Name	Definition
dephosphorylation of RNA polymerase II C-terminal domain	The process of removing a phosphate group from an amino acid residue in the C-terminal domain of RNA polymerase II. Some dephosphorylation occurs during transcription while some may occur after the enzyme is released from the template in order to prepare it for the beginning of the transcription cycle again. RNA polymerase II with little or no phosphorylation is referred to as the hypophosphorylated or II(A) form.
mRNA 3'-end processing	Any process involved in forming the mature 3' end of an mRNA molecule.

3 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9NQG5	RPRD1B	Regulation of nuclear pre-mRNA domain-containing protein 1B	Homo sapiens (Human)	PR
Q9CSU0	Rprd1b	Regulation of nuclear pre-mRNA domain-containing protein 1B	Mus musculus (Mouse)	PR
Q8VDS4	Rprd1a	Regulation of nuclear pre-mRNA domain-containing protein 1A	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MSAFSEAALE	KKLSELSNSQ	QSVQTLSLWL	IHHRKHSRPI	VTVWERELRK	AKPNRKLTFL
70	80	90	100	110	120
YLANDVIQNS	KRKGPEFTKD	FAPVIVEAFK	HVSSETDESC	KKHLGRVLSI	WEERSVYEND
130	140	150	160	170	180
VLEQLKQALY	GDKKPRKRTY	EQIKVDENEN	CSSLGSPSEP	PQTLDLVRAL	QDLENAASGD
190	200	210	220	230	240
AAVHQRIASL	PVEVQEVSLL	DKITDKESGE	RLSKMVEDAC	MLLADYNGRL	AAEIDDRKQL
250	260	270	280	290	300
TRMLADFLRC	QKEALAEKEH	KLEEYKRKLA	RVSLVRKELR	SRIQSLPDLS	RLPNVTGSHM
310
HLPFAGDIYS	ED