Q8VDS4
Gene name |
Rprd1a (Kiaa4077, P15rs) |
Protein name |
Regulation of nuclear pre-mRNA domain-containing protein 1A |
Names |
Cyclin-dependent kinase inhibitor 2B-related protein, p15INK4B-related protein |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:225283 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8VDS4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8VDS4-F1 | Predicted | AlphaFoldDB |
11 variants for Q8VDS4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389483098 | 103 | H>D | No | EVA | |
| rs3389499649 | 104 | L>R | No | EVA | |
| rs3389493775 | 155 | G>E | No | EVA | |
| rs3389457238 | 161 | P>S | No | EVA | |
| rs3412696409 | 183 | V>I | No | EVA | |
| rs3389438416 | 186 | R>S | No | EVA | |
| rs3389469701 | 210 | E>D | No | EVA | |
| rs3389469632 | 227 | N>I | No | EVA | |
| rs3389469628 | 238 | K>N | No | EVA | |
| rs3389457256 | 259 | E>* | No | EVA | |
| rs3408503194 | 295 | V>D | No | EVA |
No associated diseases with Q8VDS4
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| RNA polymerase II, holoenzyme | A nuclear DNA-directed RNA polymerase complex containing an RNA polymerase II core enzyme as well as additional proteins and transcription factor complexes, that are capable of promoter recognition and transcription initiation from an RNA polymerase II promoter in vivo. These additional components may include general transcription factor complexes TFIIA, TFIID, TFIIE, TFIIF, or TFIIH, as well as Mediator, SWI/SNF, GCN5, or SRBs and confer the ability to recognize promoters. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| identical protein binding | Binding to an identical protein or proteins. |
| RNA polymerase II complex binding | Binding to an RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| dephosphorylation of RNA polymerase II C-terminal domain | The process of removing a phosphate group from an amino acid residue in the C-terminal domain of RNA polymerase II. Some dephosphorylation occurs during transcription while some may occur after the enzyme is released from the template in order to prepare it for the beginning of the transcription cycle again. RNA polymerase II with little or no phosphorylation is referred to as the hypophosphorylated or II(A) form. |
| mRNA 3'-end processing | Any process involved in forming the mature 3' end of an mRNA molecule. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9NQG5 | RPRD1B | Regulation of nuclear pre-mRNA domain-containing protein 1B | Homo sapiens (Human) | PR |
| Q96P16 | RPRD1A | Regulation of nuclear pre-mRNA domain-containing protein 1A | Homo sapiens (Human) | PR |
| Q9CSU0 | Rprd1b | Regulation of nuclear pre-mRNA domain-containing protein 1B | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSAFSEAALE | KKLSELSNSQ | QSVQTLSLWL | IHHRKHSRPI | VTVWERELRK | AKPNRKLTFL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YLANDVIQNS | KRKGPEFTKD | FAPVIVEAFK | HVSSETDESC | KKHLGRVLSI | WEERSVYEND |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VLEQLKHALY | GDKKARKRTY | EQIKVDENEN | CSSLGSPSEP | PQTLDLVRAL | QDLENAASGD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AAVHQRIASL | PVEVQEVSLL | EKITDKESGE | RLSKMVEDAC | MLLADYNGRL | AAEIDDRKQL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TRMLADFLRC | QKEALAEKEH | KLEEYKRKLA | RVSLVRKELR | ARIQSLPDLS | RLPNVTGSHM |
| 310 | |||||
| HLPFAGDIYS | ED |