AiPD: Autoinhibited Protein Database

Q96NT0

Gene name	CCDC115
Protein name	Coiled-coil domain-containing protein 115
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:84317
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

67-142 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

67-142 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q96NT0

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q96NT0-F1	Predicted				AlphaFoldDB

182 variants for Q96NT0

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
VAR_075752 RCV000210765 RCV000208588 CA352168 rs869025583	11	D>Y	CCDC115-CDG Congenital disorders of glycosylation type II CDG2O [ClinVar, UniProt]	Yes	ClinGen ClinVar UniProt TOPMed dbSNP
RCV000208585 RCV001570443 RCV000210795 CA351426 VAR_075753 rs751325113	31	L>S	CCDC115-CDG Congenital disorders of glycosylation type II CDG2O [ClinVar, UniProt]	Yes	ClinGen ClinVar UniProt ExAC TOPMed dbSNP gnomAD
rs752919660 RCV000514149	1	M>V		No	ClinVar dbSNP
rs767209846 CA1871407	2	A>E		No	ClinGen ExAC gnomAD
rs1247164424 CA348488155	3	A>T		No	ClinGen gnomAD
CA55520823 rs966809969	4	L>F		No	ClinGen TOPMed gnomAD
CA1871405 rs759432544	4	L>P		No	ClinGen ExAC gnomAD
CA348488113 rs766377161	5	D>A		No	ClinGen ExAC gnomAD
rs751429407 CA1871404	5	D>H		No	ClinGen ExAC gnomAD
CA1871403 rs766377161	5	D>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA348488102 rs763011464	6	L>V		No	ClinGen ExAC TOPMed gnomAD
CA1871401 rs374624586	7	R>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA348488082 COSM336164 rs1384694356	7	R>L	lung [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA348488083 rs1384694356 COSM397162	7	R>P	lung [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA348488073 rs1427199474	8	A>G		No	ClinGen TOPMed
CA348488061 rs769438903	9	E>G		No	ClinGen ExAC TOPMed gnomAD
CA1871400 rs769438903	9	E>V		No	ClinGen ExAC TOPMed gnomAD
CA348488034 rs869025583	11	D>H		No	ClinGen TOPMed
CA1871398 rs776405320	12	S>L		No	ClinGen ExAC gnomAD
CA348487977 rs1478332727	16	Q>*		No	ClinGen gnomAD
rs746287541 CA1871396	16	Q>H		No	ClinGen ExAC gnomAD
CA55520765 rs976330400	16	Q>R		No	ClinGen Ensembl
rs201206111 CA1871394	19	G>E		No	ClinGen ExAC gnomAD
CA1871391 rs756251999	24	L>P		No	ClinGen ExAC gnomAD
rs1404268290 CA348487823	25	E>K		No	ClinGen TOPMed
CA348487786 rs1271656812	26	G>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs748303723 CA1871390	27	K>N		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	27	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1871389 rs781526342	28	R>*		No	ClinGen ExAC gnomAD
CA348487743 rs1573828602	29	T>K		No	ClinGen Ensembl
rs150332171 CA1871387	31	L>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA348487681 rs1466551163	33	A>P		No	ClinGen gnomAD
CA1871385 rs750387342	35	V>M		No	ClinGen ExAC gnomAD
CA1871383 rs761461065	36	E>D		No	ClinGen ExAC TOPMed gnomAD
rs764828737 CA1871384	36	E>G		No	ClinGen ExAC TOPMed gnomAD
rs757177047 CA1871366	38	G>D		No	ClinGen ExAC gnomAD
rs757177047 CA348487553	38	G>V		No	ClinGen ExAC gnomAD
CA348487536 rs1441684745	39	W>C		No	ClinGen gnomAD
TCGA novel	39	W>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs753340310 CA1871365	40	L>F		No	ClinGen ExAC gnomAD
CA348487508 rs1288188319	42	L>F		No	ClinGen TOPMed
rs775073648 CA1871362	43	A>P		No	ClinGen ExAC TOPMed gnomAD
rs775073648 CA348487497	43	A>S		No	ClinGen ExAC TOPMed gnomAD
rs775073648 CA1871363	43	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1279004969 CA348487473	44	K>N		No	ClinGen gnomAD
rs766713863 CA1871361	45	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA1871358 rs151154806	46	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs151154806 CA1871359	46	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs748620732 CA348487449	46	R>L		No	ClinGen ExAC gnomAD
CA1871357 rs748620732	46	R>P		No	ClinGen ExAC gnomAD
CA1871360 rs151154806	46	R>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs776711440 CA1871356	47	Y>N		No	ClinGen ExAC gnomAD
CA348487405 rs1341606858	49	M>I		No	ClinGen gnomAD
rs576449724 CA1871354	49	M>K		No	ClinGen ExAC TOPMed gnomAD
rs1281955724 CA348487414	49	M>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs780475360 CA1871353	50	G>C		No	ClinGen ExAC gnomAD
rs771965486 CA1871352	51	A>T		No	ClinGen ExAC gnomAD
CA348487346 rs1159526997	53	S>L		No	ClinGen gnomAD
rs1266096197 CA348487326	55	G>E		No	ClinGen TOPMed
CA348487332 rs1218167117	55	G>R		No	ClinGen TOPMed
rs914098043 CA55520479	56	P>H		No	ClinGen gnomAD
rs914098043 CA55520478	56	P>L		No	ClinGen gnomAD
rs914098043 CA348487315	56	P>R		No	ClinGen gnomAD
rs1179518664 CA348487317	56	P>S		No	ClinGen TOPMed gnomAD
rs1179518664 CA348487319	56	P>T		No	ClinGen TOPMed gnomAD
CA348487285 rs1487215977	59	Y>H		No	ClinGen gnomAD
rs1158374036 CA348487265	60	A>T		No	ClinGen TOPMed
CA1871346 rs755635296	60	A>V		No	ClinGen ExAC gnomAD
rs865959683 CA55520449	61	S>C		No	ClinGen TOPMed
CA55520425 rs865959683	61	S>F		No	ClinGen TOPMed
CA348487219 rs1287058157	63	M>L		No	ClinGen gnomAD
rs1227246917 CA348487206	63	M>R		No	ClinGen gnomAD
CA348487197 rs750733183	64	E>*		No	ClinGen ExAC gnomAD
rs750733183 CA1871342	64	E>K		No	ClinGen ExAC gnomAD
CA1871343 rs750733183	64	E>Q		No	ClinGen ExAC gnomAD
CA55520410 rs910788027	65	P>T		No	ClinGen TOPMed
rs1295713813 CA348487151	67	V>I		No	ClinGen gnomAD
CA55520405 rs985824030	69	L>F		No	ClinGen Ensembl
rs375016127 CA1871341	71	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs556226856 CA348487070	72	S>G		No	ClinGen 1000Genomes gnomAD
CA55520398 rs556226856	72	S>R		No	ClinGen 1000Genomes gnomAD
CA1871303 rs756622601	73	E>*		No	ClinGen ExAC gnomAD
rs756622601 CA1871302	73	E>Q		No	ClinGen ExAC gnomAD
rs753324332 CA1871301	75	Q>*		No	ClinGen ExAC gnomAD
CA55520103 rs900139948	76	E>K		No	ClinGen TOPMed gnomAD
rs767693253 CA1871299	77	G>*		No	ClinGen ExAC gnomAD
rs767693253 CA348486888	77	G>R		No	ClinGen ExAC gnomAD
rs1463302180 CA348486868	78	L>V		No	ClinGen TOPMed gnomAD
rs1175115970 CA348486828	80	K>M		No	ClinGen gnomAD
CA348486790 rs1558824052	82	K>E		No	ClinGen Ensembl
CA348486783 rs1458922873	82	K>R		No	ClinGen TOPMed
CA348486732 rs1176223874	85	R>K		No	ClinGen gnomAD
CA348486708 rs1438596735	86	A>S		No	ClinGen gnomAD
CA348486656 rs1251835017	90	A>T		No	ClinGen gnomAD
rs766470497 CA1871295	93	E>D		No	ClinGen ExAC TOPMed gnomAD
rs369013898 CA55520014	94	V>M		No	ClinGen ESP
CA348486530 rs1183700794	96	P>L		No	ClinGen TOPMed
TCGA novel	98	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	98	E>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1350318989 CA348486470	100	G>R		No	ClinGen gnomAD
CA1871280 rs756608136	101	L>V		No	ClinGen ExAC gnomAD
rs537888072 CA1871278	102	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1871277 rs537888072	102	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs149024810 CA1871279	102	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA1871275 rs201563607	104	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1290112347 CA348486328	104	R>H		No	ClinGen TOPMed gnomAD
rs764934750 CA55519508	105	K>T		No	ClinGen Ensembl
CA348486276 rs1477919871	106	G>D		No	ClinGen TOPMed
CA1871274 rs369536260	106	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA1871272 rs773550144	107	P>H		No	ClinGen ExAC gnomAD
rs146642670 CA55519482	108	T>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs146642670 CA1871271	108	T>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA348486214 rs1426913550	109	K>N		No	ClinGen TOPMed
rs1193406868 CA348486217	109	K>R		No	ClinGen gnomAD
rs1366861462 CA348486205	110	T>N		No	ClinGen TOPMed gnomAD
rs761643164 CA348486195	111	P>A		No	ClinGen ExAC TOPMed gnomAD
rs761643164 CA1871270	111	P>S		No	ClinGen ExAC TOPMed gnomAD
rs1208119028 CA348486159	113	P>A		No	ClinGen gnomAD
rs199817813 CA1871269	113	P>L		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	117	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs771683316 CA1871266	121	D>E		No	ClinGen ExAC TOPMed gnomAD
CA1871264 rs368444053	122	P>L		No	ClinGen ExAC TOPMed gnomAD
rs368444053 CA348485922	122	P>R		No	ClinGen ExAC TOPMed gnomAD
rs770254912 CA1871262	125	W>*		No	ClinGen ExAC gnomAD
CA348485821 rs1191278801	128	I>F		No	ClinGen TOPMed gnomAD
rs1234689786 CA348485779	130	V>G		No	ClinGen TOPMed
rs776504160 CA55519409	131	P>S		No	ClinGen TOPMed
rs752107581 CA1871258	133	S>G		No	ClinGen ExAC TOPMed gnomAD
rs1558823073 CA348485718	133	S>N		No	ClinGen Ensembl
rs1170400086 COSM1006489 CA348485692	135	R>C	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs141848427 CA1871257	135	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA1871256 rs147226112	136	Q>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1432847228 CA348485632	137	A>V		No	ClinGen gnomAD
rs752987968 CA1871254	140	S>R		No	ClinGen ExAC gnomAD
CA348485509 rs771007243	142	R>L		No	ClinGen ExAC TOPMed gnomAD
rs771007243 CA1871252	142	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs762047473 CA1871253 COSM1006488	142	R>W	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA348485497 rs1451493908	143	D>G		No	ClinGen TOPMed
rs1284345073	145	L>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1871215 rs574461175	147	L>P		No	ClinGen ExAC TOPMed gnomAD
CA348484476 rs1418691405	148	A>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1043988997 CA55518151	149	A>E		No	ClinGen TOPMed
CA1871213 rs756325067	149	A>T		No	ClinGen ExAC TOPMed gnomAD
rs752490144 CA55518147	151	I>L		No	ClinGen ExAC TOPMed gnomAD
rs556764590 CA55518145	151	I>T		No	ClinGen gnomAD
rs752490144 CA1871212	151	I>V		No	ClinGen ExAC TOPMed gnomAD
CA1871211 rs767228003	154	L>F		No	ClinGen ExAC gnomAD
CA348484334 rs1418314912	155	Q>H		No	ClinGen gnomAD
rs1371551675 CA348484342	155	Q>P		No	ClinGen TOPMed
CA1871210 rs372325329	157	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs765974155 CA1871208	157	R>H		No	ClinGen ExAC TOPMed gnomAD
CA348484292 rs765974155	157	R>L		No	ClinGen ExAC TOPMed gnomAD
CA1871209 rs765974155	157	R>P		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	159	D>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA348484262 rs1192470250	159	D>H		No	ClinGen gnomAD
CA348484206 rs1469301256	160	W>*		No	ClinGen gnomAD
CA55518088 rs1028451832	160	W>R		No	ClinGen Ensembl
COSM3787851 rs1275658715 CA348484198	161	G>S	pancreas [Cosmic]	No	ClinGen cosmic curated gnomAD
CA1871207 rs762600469	161	G>V		No	ClinGen ExAC TOPMed gnomAD
CA348484181 rs772966334	162	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA1871206 rs772966334	162	R>G		No	ClinGen ExAC TOPMed gnomAD
rs764901188 CA1871205	164	Q>E		No	ClinGen ExAC gnomAD
rs1254184186 CA348484127	165	L>F		No	ClinGen TOPMed
CA348484105 rs1465308778	166	R>Q		No	ClinGen TOPMed gnomAD
rs368677023 CA1871204	166	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA55517989 rs934048566	167	G>*		No	ClinGen TOPMed
rs1462276996 CA348484068	168	L>F		No	ClinGen Ensembl
rs772385622 CA55517974	168	L>H		No	ClinGen ExAC TOPMed gnomAD
CA1871202 rs772385622	168	L>R		No	ClinGen ExAC TOPMed gnomAD
rs1573822535 CA348484056	169	Q>E		No	ClinGen Ensembl
CA1871199 rs546945492	170	E>G		No	ClinGen ExAC TOPMed gnomAD
CA1871200 rs546945492	170	E>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	173	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA348483939 rs1376832060	174	Q>E		No	ClinGen TOPMed gnomAD
rs375063387 CA1871197	174	Q>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA348483924 rs1170894329	175	L>V		No	ClinGen gnomAD
rs1004157116 CA348483885	177	P>A		No	ClinGen TOPMed
rs1004157116 CA55517946	177	P>S		No	ClinGen TOPMed
rs1004157116 CA348483890	177	P>T		No	ClinGen TOPMed
rs1392950988 CA348483858	178	G>E		No	ClinGen gnomAD
CA1871195 rs148689294	180	A>T		No	ClinGen 1000Genomes ExAC gnomAD
CA1871194 rs140831651	180	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD

1 associated diseases with Q96NT0

[MIM: 616828]: Congenital disorder of glycosylation 2O (CDG2O)

A form of congenital disorder of glycosylation, a genetically heterogeneous group of autosomal recessive, multisystem disorders caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. CDG2O is characterized by hepatosplenomegaly, liver failure, hypotonia, and psychomotor disability. {ECO:0000269|PubMed:26833332}. Note=The disease is caused by variants affecting the gene represented in this entry.

Without disease ID

A form of congenital disorder of glycosylation, a genetically heterogeneous group of autosomal recessive, multisystem disorders caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. CDG2O is characterized by hepatosplenomegaly, liver failure, hypotonia, and psychomotor disability. {ECO:0000269|PubMed:26833332}. Note=The disease is caused by variants affecting the gene represented in this entry.

12 regional properties for Q96NT0

Type	Name	Position	InterPro Accession
domain	RNA recognition motif domain	2 - 75	IPR000504-1
domain	RNA recognition motif domain	81 - 156	IPR000504-2
domain	K Homology domain	194 - 265	IPR004087-1
domain	K Homology domain	275 - 348	IPR004087-2
domain	K Homology domain	404 - 475	IPR004087-3
domain	K Homology domain	486 - 558	IPR004087-4
domain	K Homology domain, type 1	198 - 262	IPR004088-1
domain	K Homology domain, type 1	280 - 344	IPR004088-2
domain	K Homology domain, type 1	409 - 471	IPR004088-3
domain	K Homology domain, type 1	490 - 554	IPR004088-4
domain	IGF2BP1, RNA recognition motif 1	1 - 77	IPR034837
domain	IGF2BP1, RNA recognition motif 2	81 - 156	IPR034842

Functions

		Description
EC Number
Subcellular Localization	Endosome Lysosome Endoplasmic reticulum-Golgi intermediate compartment Cytoplasmic vesicle, COPI-coated vesicle Endoplasmic reticulum
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

8 GO annotations of cellular component

Name	Definition
COPI-coated vesicle	A vesicle with a coat formed of the COPI coat complex proteins. COPI-coated vesicles are found associated with Golgi membranes at steady state, are involved in Golgi to endoplasmic reticulum (retrograde) vesicle transport, and possibly also in intra-Golgi transport.
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum-Golgi intermediate compartment	A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport.
endosome	A vacuole to which materials ingested by endocytosis are delivered.
extrinsic component of endoplasmic reticulum membrane	The component of the endoplasmic reticulum membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
lysosome	A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
vacuolar proton-transporting V-type ATPase complex	A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen.

1 GO annotations of molecular function

Name	Definition
unfolded protein binding	Binding to an unfolded protein.

5 GO annotations of biological process

Name	Definition
cellular iron ion homeostasis	Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.
cellular response to increased oxygen levels	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting an increase in the level of oxygen.
lysosomal lumen acidification	Any process that reduces the pH of the lysosomal lumen, measured by the concentration of the hydrogen ion.
lysosomal protein catabolic process	Any cellular protein catabolic process that takes place in a lysosome.
vacuolar proton-transporting V-type ATPase complex assembly	The aggregation, arrangement and bonding together of a vacuolar proton-transporting V-type ATPase complex, proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across the vacuolar membrane.

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q8VE99	Ccdc115	Coiled-coil domain-containing protein 115	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MAALDLRAEL	DSLVLQLLGD	LEELEGKRTV	LNARVEEGWL	SLAKARYAMG	AKSVGPLQYA
70	80	90	100	110	120
SHMEPQVCLH	ASEAQEGLQK	FKVVRAGVHA	PEEVGPREAG	LRRRKGPTKT	PEPESSEAPQ
130	140	150	160	170
DPLNWFGILV	PHSLRQAQAS	FRDGLQLAAD	IASLQNRIDW	GRSQLRGLQE	KLKQLEPGAA