Q8VE99
Gene name |
Ccdc115 |
Protein name |
Coiled-coil domain-containing protein 115 |
Names |
B7 homolog 3, B7-H3, Costimulatory molecule, Coiled-coil protein 1, Ccp1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:69668 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8VE99
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8VE99-F1 | Predicted | AlphaFoldDB |
5 variants for Q8VE99
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs227286291 | 19 | S>R | No | EVA | |
| rs3388463352 | 106 | G>D | No | EVA | |
| rs3389744695 | 137 | A>T | No | EVA | |
| rs3388462762 | 157 | R>G | No | EVA | |
| rs580531373 | 174 | E>D | No | EVA |
No associated diseases with Q8VE99
8 regional properties for Q8VE99
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Oxidoreductase FAD/NAD(P)-binding | 181 - 288 | IPR001433 |
| domain | Flavoprotein pyridine nucleotide cytochrome reductase | 96 - 103 | IPR001709-1 |
| domain | Flavoprotein pyridine nucleotide cytochrome reductase | 128 - 137 | IPR001709-2 |
| domain | Flavoprotein pyridine nucleotide cytochrome reductase | 180 - 199 | IPR001709-3 |
| domain | Flavoprotein pyridine nucleotide cytochrome reductase | 218 - 229 | IPR001709-4 |
| domain | Flavoprotein pyridine nucleotide cytochrome reductase | 274 - 282 | IPR001709-5 |
| domain | Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain | 49 - 155 | IPR008333 |
| domain | FAD-binding domain, ferredoxin reductase-type | 44 - 156 | IPR017927 |
Functions
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| COPI-coated vesicle | A vesicle with a coat formed of the COPI coat complex proteins. COPI-coated vesicles are found associated with Golgi membranes at steady state, are involved in Golgi to endoplasmic reticulum (retrograde) vesicle transport, and possibly also in intra-Golgi transport. |
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| endoplasmic reticulum-Golgi intermediate compartment | A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport. |
| endosome | A vacuole to which materials ingested by endocytosis are delivered. |
| extrinsic component of endoplasmic reticulum membrane | The component of the endoplasmic reticulum membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. |
| lysosome | A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. |
| vacuolar proton-transporting V-type ATPase complex | A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| unfolded protein binding | Binding to an unfolded protein. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular iron ion homeostasis | Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell. |
| cellular response to increased oxygen levels | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting an increase in the level of oxygen. |
| lysosomal lumen acidification | Any process that reduces the pH of the lysosomal lumen, measured by the concentration of the hydrogen ion. |
| lysosomal protein catabolic process | Any cellular protein catabolic process that takes place in a lysosome. |
| vacuolar proton-transporting V-type ATPase complex assembly | The aggregation, arrangement and bonding together of a vacuolar proton-transporting V-type ATPase complex, proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across the vacuolar membrane. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q96NT0 | CCDC115 | Coiled-coil domain-containing protein 115 | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAVQALREEL | DSKCLQLLSD | LEELEAKRAA | LNARVEEGWL | SLAKARYAMG | AKSVGPLQYA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SRMEPQVCVR | ASEAQDGPQT | FRVIKADAQT | PEEVGPSEAS | LRRRKGPTKT | KELGSAVVPQ |
| 130 | 140 | 150 | 160 | 170 | |
| DPLNWFGILV | PHSLRQAQAS | FRDGLQLAAD | IASLQTRINW | GQSQLRGLQK | KLKELDPGPA |