AiPD: Autoinhibited Protein Database

Q96FX7

Gene name	TRMT61A (C14orf172, TRM61)
Protein name	tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A
Names	mRNA methyladenosine-N(1)-methyltransferase catalytic subunit TRMT61A, tRNA(m1A58)-methyltransferase subunit TRMT61A, tRNA(m1A58)MTase subunit TRMT61A
Species	Homo sapiens (Human)
KEGG Pathway	hsa:115708
EC number	2.1.1.220: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

226-289 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

226-289 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

4 structures for Q96FX7

Entry ID	Method	Resolution	Chain	Position	Source
5CCB	X-ray	200 A	A	1-289	PDB
5CCX	X-ray	210 A	A	1-289	PDB
5CD1	X-ray	360 A	A/D	1-289	PDB
AF-Q96FX7-F1	Predicted				AlphaFoldDB

262 variants for Q96FX7

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs761068650 CA7364771	6	Y>C		No	ClinGen ExAC gnomAD
CA391099449 rs1595999253	12	E>D		No	ClinGen Ensembl
TCGA novel	14	D>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs754364939 CA7364773	15	T>M		No	ClinGen ExAC gnomAD
CA391099530 rs1177017098	17	I>V		No	ClinGen gnomAD
CA391099567 rs1409110452	19	S>L		No	ClinGen TOPMed gnomAD
rs755526697 CA7364774	20	L>V		No	ClinGen ExAC gnomAD
CA391099584 rs1160756318	21	G>D		No	ClinGen gnomAD
rs1169496906 CA391099580	21	G>S		No	ClinGen TOPMed gnomAD
rs1433539750 CA391099593	22	H>N		No	ClinGen TOPMed gnomAD
rs1433539750 CA391099598	22	H>Y		No	ClinGen TOPMed gnomAD
CA267199925 rs1015959998	23	G>V		No	ClinGen gnomAD
rs1310750477 CA391099637	24	A>S		No	ClinGen TOPMed
CA391099641 rs1446903310	24	A>V		No	ClinGen TOPMed
rs1053740482 CA267199928	25	M>V		No	ClinGen TOPMed gnomAD
CA7364780 rs777614755	29	R>H		No	ClinGen ExAC gnomAD
rs770693525 CA7364782	30	V>A		No	ClinGen ExAC TOPMed gnomAD
rs746626061 CA7364781 CA267199946	30	V>L		No	ClinGen ExAC TOPMed gnomAD
CA391099773 rs1299453853	31	Q>E		No	ClinGen TOPMed gnomAD
TCGA novel	32	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA391099806 rs1347302827	32	R>L		No	ClinGen gnomAD
CA7364783 rs781028110	34	A>T		No	ClinGen ExAC gnomAD
rs906582729 CA267199989	35	Q>R		No	ClinGen TOPMed
CA267200007 rs879400235	36	T>N		No	ClinGen gnomAD
CA7364785 rs769773824	37	Q>E		No	ClinGen ExAC gnomAD
TCGA novel	38	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1160460352 CA391099886	38	T>P		No	ClinGen TOPMed
rs775243452 CA7364786	39	R>L		No	ClinGen ExAC TOPMed gnomAD
CA391099902 rs775243452	39	R>P		No	ClinGen ExAC TOPMed gnomAD
CA7364787 rs775243452	39	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA7364789 COSM1368423 rs773491301	41	G>S	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs867972068 CA267200048	44	R>Q		No	ClinGen Ensembl
rs200167911 CA7364790	44	R>W		No	ClinGen ExAC TOPMed gnomAD
CA391099997 rs1173744772	47	V>L		No	ClinGen gnomAD
CA7364792 rs777061390	48	D>G		No	ClinGen ExAC gnomAD
CA7364793 COSM138951 rs759781932	49	L>F	skin [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1449356725 CA391100054	52	R>C		No	ClinGen TOPMed gnomAD
CA7364795 rs753230778	52	R>L		No	ClinGen ExAC TOPMed gnomAD
CA7364798 rs751315445	55	G>S		No	ClinGen ExAC TOPMed gnomAD
CA7364799 rs370903427	57	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1595999339 CA391100112	58	V>G		No	ClinGen Ensembl
CA391100105 rs1025459974	58	V>L		No	ClinGen TOPMed gnomAD
rs1025459974 CA267200081	58	V>M		No	ClinGen TOPMed gnomAD
rs780641430 CA7364800	59	T>A		No	ClinGen ExAC gnomAD
rs1240239856 CA391100123	59	T>M		No	ClinGen TOPMed
rs1222522166 CA391100135	60	C>Y		No	ClinGen TOPMed
CA391100156 rs1230227834	62	R>*		No	ClinGen TOPMed gnomAD
rs1274305713 CA391100165	63	G>C		No	ClinGen gnomAD
CA391100185 rs1309675533	64	G>V		No	ClinGen gnomAD
rs1252710810 CA391100189	65	W>R		No	ClinGen gnomAD
VAR_026053	66	V>A		No	UniProt
rs1595999354 CA391100215	66	V>G		No	ClinGen Ensembl
rs1595999357 CA391100260	70	H>P		No	ClinGen Ensembl
rs749220064 CA7364805	70	H>Y		No	ClinGen ExAC TOPMed gnomAD
rs1474135564 CA391100281	71	P>S		No	ClinGen gnomAD
TCGA novel	72	T>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1360026528 CA391100321	73	P>S		No	ClinGen TOPMed
rs923564404 CA267200139	74	E>K		No	ClinGen Ensembl
CA391100358 rs1162551813	75	L>V		No	ClinGen gnomAD
rs776671417 CA7364810	79	N>T		No	ClinGen ExAC gnomAD
CA7364811 rs759991995	80	L>V		No	ClinGen ExAC gnomAD
CA7364813 rs765484716	81	P>L		No	ClinGen ExAC gnomAD
rs765484716 CA7364812	81	P>R		No	ClinGen ExAC gnomAD
rs984025691 CA267200160	84	T>M		No	ClinGen TOPMed
CA7364815 rs764638376	86	I>L		No	ClinGen ExAC gnomAD
CA7364816 rs751119248	88	Y>C		No	ClinGen ExAC gnomAD
CA7364817 rs756680077	89	S>F		No	ClinGen ExAC gnomAD
rs1227048614 CA391100607	90	T>A		No	ClinGen gnomAD
CA391100656 rs1388982778	93	A>P		No	ClinGen Ensembl
CA391100689 rs1274643478	95	I>L		No	ClinGen gnomAD
rs1476358213 CA391100720	97	M>T		No	ClinGen gnomAD
rs756005027 CA7364822	97	M>V		No	ClinGen ExAC gnomAD
CA391100744 rs1460619061	98	M>I		No	ClinGen Ensembl
rs373763921 CA7364823	98	M>T		No	ClinGen ESP ExAC
CA7364824 rs749028868	101	L>F		No	ClinGen ExAC gnomAD
rs754918409 CA391100785	102	R>P		No	ClinGen ExAC TOPMed gnomAD
CA7364825 rs754918409	102	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA391100780 rs1216954046	102	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA7364828 rs375622926	103	P>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA7364827 rs375622926	103	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1185709260 CA391100799	104	G>S		No	ClinGen TOPMed gnomAD
rs746069691 CA7364830	105	S>F		No	ClinGen ExAC gnomAD
CA7364831 rs746069691	105	S>Y		No	ClinGen ExAC gnomAD
rs1356563065 CA391100837	107	V>D		No	ClinGen gnomAD
CA7364835 rs774949247	107	V>F		No	ClinGen ExAC gnomAD
rs766933931 CA7364837	108	C>*		No	ClinGen ExAC TOPMed gnomAD
rs374883444 CA7364836	108	C>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs1166656830 CA391101302	114	S>N		No	ClinGen gnomAD
rs1566965868 CA391101317	116	S>C		No	ClinGen Ensembl
rs1439207524 CA391101314	116	S>P		No	ClinGen TOPMed gnomAD
rs750500071 CA7364866	118	S>C		No	ClinGen ExAC gnomAD
COSM1230471 rs1566965877 CA391101338	120	A>T	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated Ensembl NCI-TCGA
CA7364868 rs780471368	121	I>S		No	ClinGen ExAC TOPMed gnomAD
CA267201971 rs534908470	122	I>F		No	ClinGen 1000Genomes gnomAD
rs749517669 CA7364869	123	R>C		No	ClinGen ExAC TOPMed gnomAD
rs368720777 CA7364870	123	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA7364871 rs779158678	125	I>T		No	ClinGen ExAC gnomAD
CA391101367 rs1249524293	125	I>V		No	ClinGen gnomAD
CA7364872 rs748480452	126	A>T		No	ClinGen ExAC gnomAD
rs1259701038 CA391101375	126	A>V		No	ClinGen gnomAD
rs772491014 CA7364873	128	T>M		No	ClinGen ExAC TOPMed gnomAD
rs1455630646 CA391101388	129	G>S		No	ClinGen TOPMed gnomAD
CA7364877 rs778902763	133	T>M	Variant assessed as Somatic; 4.639e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1435043877 CA391101427	135	E>Q		No	ClinGen TOPMed
rs901137937 CA267202043	138	Q>R		No	ClinGen TOPMed
COSM1368425 CA267202058 rs997419700	140	R>Q	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA391101465 rs369292682	140	R>W		No	ClinGen ESP TOPMed gnomAD
CA7364881 rs764882612	142	E>K		No	ClinGen ExAC gnomAD
CA391101514 rs762768998	144	A>G		No	ClinGen ExAC TOPMed gnomAD
CA7364882 rs537191569	144	A>S		No	ClinGen 1000Genomes ExAC gnomAD
rs762768998 CA7364883	144	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA7364885 rs373651893	145	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs763960359 CA7364884	145	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1259753689 CA391101533	146	E>G		No	ClinGen gnomAD
CA7364887 rs557071436	148	F>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7364888 rs753912375	148	F>S		No	ClinGen ExAC TOPMed gnomAD
rs1244674336 CA391101573	149	Q>*		No	ClinGen TOPMed
rs1244674336 CA391101575	149	Q>E		No	ClinGen TOPMed
rs200065262 CA7364889	149	Q>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1203499344 CA391101616	151	H>Q		No	ClinGen gnomAD
rs1566965933 CA391101610	151	H>R		No	ClinGen Ensembl
CA391101620 rs376660789	152	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs376660789 CA7364891	152	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs758770178 CA7364893	152	R>H		No	ClinGen ExAC TOPMed gnomAD
CA7364892 rs758770178	152	R>L		No	ClinGen ExAC TOPMed gnomAD
CA7364890 rs376660789	152	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs931727832 CA267202116	153	V>L		No	ClinGen TOPMed gnomAD
rs931727832 CA391101626	153	V>M		No	ClinGen TOPMed gnomAD
rs747508008 CA7364894	155	R>C		No	ClinGen ExAC TOPMed gnomAD
CA7364896 rs542612707	155	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
CA391101656 rs542612707	155	R>L		No	ClinGen 1000Genomes ExAC gnomAD
CA7364895 rs747508008	155	R>S		No	ClinGen ExAC TOPMed gnomAD
CA7364898 rs745307285	159	V>M		No	ClinGen ExAC gnomAD
rs769362508 CA7364899	160	R>C		No	ClinGen ExAC gnomAD
rs1383534911 CA391101716	160	R>H		No	ClinGen gnomAD
CA7364900 rs775159038	161	T>N		No	ClinGen ExAC TOPMed gnomAD
CA7364901 rs762704130	162	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs1353386009 CA391101751	163	D>N		No	ClinGen gnomAD
CA7364903 rs774489533	164	V>M		No	ClinGen ExAC TOPMed gnomAD
rs761857212 CA7364904	165	C>Y		No	ClinGen ExAC gnomAD
CA391101795 rs1237071462	166	R>C		No	ClinGen gnomAD
rs767496789 CA7364905	166	R>H		No	ClinGen ExAC TOPMed gnomAD
rs767496789 CA391101798	166	R>L		No	ClinGen ExAC TOPMed gnomAD
CA391101846 rs1486226850	170	G>S		No	ClinGen gnomAD
CA267202157 rs373210459	171	V>A		No	ClinGen gnomAD
CA7364907 rs559412988	171	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs559412988 CA7364908	171	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA267202163 rs947583538	172	S>N		No	ClinGen Ensembl
rs573048606 CA7364909	174	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	175	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA391101907 rs1425196207	175	A>T		No	ClinGen gnomAD
TCGA novel	175	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7364911 rs778183539	176	D>N		No	ClinGen ExAC TOPMed gnomAD
CA7364913 rs757761969	177	A>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	177	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs769325334 CA7364916	178	V>A		No	ClinGen ExAC gnomAD
CA7364915 rs373346624	178	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA7364918 rs748964962	182	I>T		No	ClinGen ExAC gnomAD
rs1317635039 CA391102024 COSM3814292	184	S>L	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA267202265 rs1001612874	185	P>T		No	ClinGen TOPMed gnomAD
rs1057390847 CA267202271	187	E>D		No	ClinGen TOPMed
CA7364920 rs376392701	189	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA7364921 rs761662772	190	G>S		No	ClinGen ExAC gnomAD
CA391102109 rs1479857418	191	H>D		No	ClinGen gnomAD
rs1479857418 CA391102107	191	H>N		No	ClinGen gnomAD
CA267202297 rs1047674008	192	A>G		No	ClinGen TOPMed gnomAD
CA267202294 rs772161793	192	A>S		No	ClinGen ExAC gnomAD
CA7364922 rs772161793	192	A>T		No	ClinGen ExAC gnomAD
rs765359264 CA391102163	195	A>P		No	ClinGen ExAC TOPMed gnomAD
rs765359264 CA7364925	195	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1367332209 CA391102166	195	A>V		No	ClinGen TOPMed
CA391102170 rs1176685926	196	L>P		No	ClinGen TOPMed gnomAD
CA7364927 rs569343687	199	E>K		No	ClinGen ExAC TOPMed gnomAD
CA267203782 rs368193988	200	G>D		No	ClinGen ESP
CA7364946 rs764319234	201	G>R		No	ClinGen ExAC gnomAD
rs774532983 CA7364947	202	R>C		No	ClinGen ExAC TOPMed gnomAD
rs762203562 CA7364948	202	R>H		No	ClinGen ExAC TOPMed gnomAD
CA267203802 rs774532983	202	R>S		No	ClinGen ExAC TOPMed gnomAD
rs1478669697 CA391103077	203	F>L		No	ClinGen gnomAD
rs767863051 CA7364949	208	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1399457096 CA391103173	211	E>K		No	ClinGen TOPMed
CA7364951 rs756650011	212	Q>*		No	ClinGen ExAC gnomAD
CA391103189 rs1299321554	213	V>L		No	ClinGen gnomAD
rs1231875850 CA391103196	214	Q>*		No	ClinGen gnomAD
rs766756858 CA7364952	215	R>C		No	ClinGen ExAC TOPMed gnomAD
rs753411953 CA7364953	215	R>H		No	ClinGen ExAC TOPMed gnomAD
CA7364956 rs747802952	219	A>E		No	ClinGen ExAC TOPMed gnomAD
rs778750446 CA7364955	219	A>T		No	ClinGen ExAC gnomAD
CA391103231 rs747802952	219	A>V		No	ClinGen ExAC TOPMed gnomAD
CA7364959 rs746711512	220	L>P		No	ClinGen ExAC gnomAD
CA7364961 rs201788463	222	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7364963 rs201492241	223	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs199930951 CA7364964	223	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA7364967 rs201170066	224	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA267203932 rs561568871	224	G>V		No	ClinGen 1000Genomes gnomAD
CA7364968 rs760901356	226	S>P		No	ClinGen ExAC TOPMed gnomAD
CA391103320 rs1312655879	227	E>G		No	ClinGen gnomAD
rs1214778753 CA391103331	228	L>P		No	ClinGen TOPMed
rs1341439003 CA391103337	229	S>C		No	ClinGen gnomAD
rs1596001042 CA391103349	230	T>P		No	ClinGen Ensembl
rs754272698 CA7364970	233	V>A		No	ClinGen ExAC TOPMed
CA7364973 rs752200679	236	Q>H		No	ClinGen ExAC gnomAD
CA7364972 rs764830770	236	Q>L		No	ClinGen ExAC gnomAD
rs1256625423 CA391103455	238	Y>C		No	ClinGen gnomAD
rs375546923 CA7364975	240	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA7364976 rs369826418	241	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
COSM3689953 rs1469772640 CA391103496	241	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA391103504 rs1159339947	242	T>A		No	ClinGen TOPMed gnomAD
CA7364977 rs756976706	244	S>G		No	ClinGen ExAC gnomAD
rs781229023 CA7364978	244	S>I		No	ClinGen ExAC gnomAD
CA267204013 rs1049343188	246	P>L		No	ClinGen TOPMed
rs1403411541 CA391103548	246	P>T		No	ClinGen gnomAD
CA7364979 rs560567167	247	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7364980 rs560567167	247	P>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs761144714 CA7364985	249	D>E		No	ClinGen ExAC gnomAD
CA7364984 rs773286176	249	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1378467886 CA391103608	251	G>R		No	ClinGen gnomAD
CA7364986 rs551888141	252	T>I		No	ClinGen 1000Genomes ExAC gnomAD
CA267204098 rs900487687	253	G>D		No	ClinGen Ensembl
rs1053803719 CA267204082	253	G>S		No	ClinGen Ensembl
CA7364988 rs760137498	254	T>I		No	ClinGen ExAC gnomAD
rs760137498 CA7364989	254	T>K		No	ClinGen ExAC gnomAD
rs1270549744 CA391103671	256	G>A		No	ClinGen gnomAD
rs865787956 CA267204133	258	A>V		No	ClinGen Ensembl
rs763853129 CA267204149	259	G>R		No	ClinGen ExAC TOPMed gnomAD
CA7364992 rs763853129	259	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1452629728 CA391103710	260	S>T		No	ClinGen gnomAD
CA391103721 rs1378754793	261	D>N		No	ClinGen gnomAD
rs757141410 CA7364995	262	T>A		No	ClinGen ExAC gnomAD
rs750159828 CA7364996	262	T>I		No	ClinGen ExAC TOPMed gnomAD
rs757141410 CA7364994	262	T>P		No	ClinGen ExAC gnomAD
rs756077573 CA7364997	266	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1464841410 CA391103790	266	R>H		No	ClinGen TOPMed gnomAD
CA267204203 rs890991684	267	S>G		No	ClinGen Ensembl
CA391103806 rs372778660	267	S>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA391103818 rs778126531	268	G>A		No	ClinGen ExAC TOPMed gnomAD
rs778126531 CA7365001	268	G>D		No	ClinGen ExAC TOPMed gnomAD
rs202234480 CA7365000	268	G>S		No	ClinGen ExAC TOPMed gnomAD
rs377517086 CA7365002 COSM1230470	269	T>M	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA391103841 rs1268264682	270	P>L		No	ClinGen gnomAD
rs1026682603 CA267204220	270	P>T		No	ClinGen Ensembl
rs759937029 CA7365005	271	M>I		No	ClinGen ExAC TOPMed gnomAD
CA7365004 rs776868185	271	M>V		No	ClinGen ExAC gnomAD
CA391103860 rs1260198552	272	K>E		No	ClinGen gnomAD
CA391103888 rs1467281832	273	E>G		No	ClinGen gnomAD
rs1268079363 CA391103915	274	A>V		No	ClinGen gnomAD
rs34277813 CA267204256	275	V>G		No	ClinGen Ensembl
CA7365008 rs762588533	277	H>Q		No	ClinGen ExAC gnomAD
rs1478340677 CA391103976	278	T>A		No	ClinGen TOPMed gnomAD
rs767129800 CA7365012	279	G>D		No	ClinGen ExAC gnomAD
CA391104000 rs1425354966	279	G>R		No	ClinGen TOPMed gnomAD
CA391103997 rs1425354966	279	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs371063129 CA7365013	280	Y>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs1596001151 CA391104040	281	L>P		No	ClinGen Ensembl
rs978272575 CA267204335	284	A>P		No	ClinGen TOPMed gnomAD
rs978272575 CA391104090	284	A>T		No	ClinGen TOPMed gnomAD
rs1330631462 CA391104108	285	T>I		No	ClinGen TOPMed
CA7365016 rs753772153	287	T>I		No	ClinGen ExAC gnomAD
CA7365017 rs758567109	288	P>Q		No	ClinGen ExAC gnomAD
rs1444703883 CA391104139	288	P>S		No	ClinGen gnomAD
rs34161283 CA267204370	289	G>S		No	ClinGen Ensembl
rs1372979325 CA391104162	290	G>Q		No	ClinGen TOPMed

No associated diseases with Q96FX7

No regional properties for Q96FX7

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q96FX7

Functions

		Description
EC Number	2.1.1.220	Methyltransferases
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
tRNA (m1A) methyltransferase complex	A protein complex involved in the catalysis of the formation of the modified nucleotide 1-methyladenosine (m1A) in tRNA. In yeast, it is a heterotetramer of two subunits, Gcd10p and Gcd14p, while in bacteria and archaea it is a homotetramer.

2 GO annotations of molecular function

Name	Definition
mRNA (adenine-N1-)-methyltransferase activity	Catalysis of the reaction: S-adenosyl-L-methionine + adenine in mRNA = S-adenosyl-L-homocysteine + N(1)-methyladenine in mRNA.
tRNA (adenine-N1-)-methyltransferase activity	Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methyladenine.

2 GO annotations of biological process

Name	Definition
mRNA methylation	The posttranscriptional addition of methyl groups to specific residues in an mRNA molecule.
tRNA methylation	The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule.

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P46959	GCD14	tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR

10	20	30	40	50	60
MSFVAYEELI	KEGDTAILSL	GHGAMVAVRV	QRGAQTQTRH	GVLRHSVDLI	GRPFGSKVTC
70	80	90	100	110	120
GRGGWVYVLH	PTPELWTLNL	PHRTQILYST	DIALITMMLE	LRPGSVVCES	GTGSGSVSHA
130	140	150	160	170	180
IIRTIAPTGH	LHTVEFHQQR	AEKAREEFQE	HRVGRWVTVR	TQDVCRSGFG	VSHVADAVFL
190	200	210	220	230	240
DIPSPWEAVG	HAWDALKVEG	GRFCSFSPCI	EQVQRTCQAL	AARGFSELST	LEVLPQVYNV
250	260	270	280
RTVSLPPPDL	GTGTDGPAGS	DTSPFRSGTP	MKEAVGHTGY	LTFATKTPG