P46959
Gene name |
GCD14 (TRM61, YJL125C, J0710) |
Protein name |
tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 |
Names |
General control non-derepressible protein 14, Protein GCD14, tRNA(m1A58)-methyltransferase subunit TRM61, tRNA(m1A58)MTase subunit TRM61 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YJL125C |
EC number |
2.1.1.220: Methyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
3 structures for P46959
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 5EQJ | X-ray | 220 A | B | 1-383 | PDB |
| 5ERG | X-ray | 220 A | B | 1-383 | PDB |
| AF-P46959-F1 | Predicted | AlphaFoldDB |
7 variants for P46959
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s10-186163 | 172 | G>D | No | SGRP | |
| s10-186125 | 185 | E>Q | No | SGRP | |
| s10-186023 | 219 | S>A | No | SGRP | |
| s10-185770 | 303 | N>S | No | SGRP | |
| s10-185759 | 307 | V>I | No | SGRP | |
| s10-185639 | 347 | M>V | No | SGRP | |
| s10-185536 | 381 | T>M | No | SGRP |
No associated diseases with P46959
No regional properties for P46959
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P46959 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 2.1.1.220 | Methyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| tRNA (m1A) methyltransferase complex | A protein complex involved in the catalysis of the formation of the modified nucleotide 1-methyladenosine (m1A) in tRNA. In yeast, it is a heterotetramer of two subunits, Gcd10p and Gcd14p, while in bacteria and archaea it is a homotetramer. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| tRNA (adenine-N1-)-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methyladenine. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| tRNA methylation | The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q96FX7 | TRMT61A | tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSTNCFSGYK | DLIKEGDLTL | IWVSRDNIKP | VRMHSEEVFN | TRYGSFPHKD | IIGKPYGSQI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AIRTKGSNKF | AFVHVLQPTP | ELWTLSLPHR | TQIVYTPDSS | YIMQRLNCSP | HSRVIEAGTG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SGSFSHAFAR | SVGHLFSFEF | HHIRYEQALE | EFKEHGLIDD | NVTITHRDVC | QGGFLIKKGD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TTSYEFGNNE | TAASLNANVV | FLDLPAPWDA | IPHLDSVISV | DEKVGLCCFS | PCIEQVDKTL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DVLEKYGWTD | VEMVEIQGRQ | YESRRQMVRS | LNDALERLRD | IKRHKLQGVE | RRKRMFNNTI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DSNDEKVGKR | NEDGVPLTEK | AKFNPFGKGS | RIKEGDSNYK | WKEVTKMEAE | IKSHTSYLTF |
| 370 | 380 | ||||
| AFKVVNRSRD | DEKVNEILRS | TEK |