Q96FV9
PR
Gene name |
THOC1 (HPR1) |
Protein name |
THO complex subunit 1 |
Names |
Tho1, Nuclear matrix protein p84, p84N5, hTREX84 |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:9984 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
5 structures for Q96FV9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1WXP | NMR | - | A | 561-657 | PDB |
| 7APK | EM | 330 A | A/I/a/i | 2-657 | PDB |
| 7ZNK | EM | 390 A | A/I/a/i | 1-657 | PDB |
| 7ZNL | EM | 345 A | A/I/a/i | 1-657 | PDB |
| AF-Q96FV9-F1 | Predicted | AlphaFoldDB |
383 variants for Q96FV9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
rs751229459 CA401653790 |
2 | S>A | No |
ClinGen ExAC gnomAD |
|
|
rs763798964 CA8866632 |
2 | S>F | No |
ClinGen ExAC gnomAD |
|
|
rs751229459 CA8866633 |
2 | S>T | No |
ClinGen ExAC gnomAD |
|
|
rs759934263 CA401653783 |
3 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs759934263 CA8866631 |
3 | P>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs759934263 CA401653784 |
3 | P>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA295363378 rs377273560 |
4 | T>A | No |
ClinGen ESP TOPMed |
|
|
CA401653778 rs1228949025 |
4 | T>M | No |
ClinGen TOPMed gnomAD |
|
|
CA401653782 rs377273560 |
4 | T>P | No |
ClinGen ESP TOPMed |
|
|
rs761201235 CA8866627 |
5 | P>L | No |
ClinGen ExAC gnomAD |
|
|
rs771236334 CA8866628 |
5 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA401653771 rs1315272526 |
6 | P>A | No |
ClinGen gnomAD |
|
|
rs534593142 CA8866626 |
6 | P>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs534593142 CA295363365 |
6 | P>Q | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs534593142 CA401653770 |
6 | P>R | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs772056461 CA401653768 |
7 | L>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA401653766 rs1412061837 |
7 | L>P | No |
ClinGen gnomAD |
|
|
rs772056461 CA8866625 |
7 | L>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA401653755 rs779066227 |
9 | S>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs779066227 CA8866623 |
9 | S>R | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 9 | S>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA8866621 rs749476495 |
10 | L>F | No |
ClinGen ExAC gnomAD |
|
|
CA8866620 rs755908137 |
11 | P>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs750401436 CA8866618 |
11 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA401653741 rs750401436 |
11 | P>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs755908137 CA8866619 |
11 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA401653740 rs1256764842 |
12 | E>K | No |
ClinGen gnomAD |
|
|
rs567290635 CA8866616 |
13 | A>V | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs369145062 CA8866614 |
15 | T>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs369145062 CA295363303 |
15 | T>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1214242206 CA401653716 |
16 | R>Q | No |
ClinGen gnomAD |
|
|
CA8866612 rs752304581 |
17 | F>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8866611 rs766732205 |
18 | T>M | No |
ClinGen ExAC gnomAD |
|
|
rs1420787676 CA401653306 |
19 | K>N | No |
ClinGen gnomAD |
|
|
rs767729011 CA8866587 |
20 | S>P | No |
ClinGen ExAC gnomAD |
|
|
CA8866586 rs762417829 |
21 | T>I | No |
ClinGen ExAC gnomAD |
|
|
rs1363121476 CA401653251 |
23 | E>G | No |
ClinGen TOPMed |
|
|
CA401653242 rs1454594740 |
24 | A>S | No |
ClinGen TOPMed gnomAD |
|
|
rs1255057456 CA401653230 |
24 | A>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs774656714 CA8866585 |
25 | L>S | No |
ClinGen ExAC gnomAD |
|
|
CA401653193 rs764286658 |
26 | N>K | No |
ClinGen ExAC gnomAD |
|
|
rs763113630 CA8866583 |
27 | N>I | No |
ClinGen ExAC gnomAD |
|
|
CA401653178 rs763113630 |
27 | N>S | No |
ClinGen ExAC gnomAD |
|
|
CA401653185 rs1268872517 |
27 | N>Y | No |
ClinGen gnomAD |
|
| TCGA novel | 28 | K>E | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs369266525 CA295361479 |
28 | K>R | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 29 | N>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA401653087 rs1325536370 |
32 | P>L | No |
ClinGen TOPMed |
|
|
rs1315621481 CA401653034 |
36 | T>A | No |
ClinGen gnomAD |
|
|
CA401653026 rs1306991741 |
36 | T>S | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 37 | F>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1393457893 CA401653019 |
37 | F>V | No |
ClinGen TOPMed |
|
|
rs775923064 CA8866582 |
39 | Q>H | No |
ClinGen ExAC gnomAD |
|
|
CA401652961 rs1373658274 |
40 | V>A | No |
ClinGen gnomAD |
|
|
CA295361469 rs974649860 |
40 | V>L | No |
ClinGen Ensembl |
|
|
CA295361459 rs374704085 |
41 | P>L | No |
ClinGen Ensembl |
|
|
rs965858807 CA295361463 |
41 | P>S | No |
ClinGen gnomAD |
|
|
CA401652939 rs1369855844 |
42 | G>C | No |
ClinGen gnomAD |
|
|
CA401652943 rs1369855844 |
42 | G>S | No |
ClinGen gnomAD |
|
|
rs1171489023 CA401652893 |
43 | S>R | No |
ClinGen gnomAD |
|
| TCGA novel | 44 | E>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA401652889 rs1433937819 |
44 | E>K | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA401652878 rs1172820776 |
45 | N>K | No |
ClinGen gnomAD |
|
|
CA295361346 rs538490417 |
45 | N>S | No |
ClinGen 1000Genomes TOPMed gnomAD |
|
|
CA401652876 rs1426737606 |
46 | E>K | No |
ClinGen gnomAD |
|
| rs746975641 | 48 | K>N | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
| rs746975641 | 49 | C>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA8866564 rs369918372 |
49 | C>S | No |
ClinGen ESP ExAC |
|
| TCGA novel | 49 | C>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs765360001 CA8866561 |
49 | C>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA295361315 rs571166091 |
50 | T>I | No |
ClinGen 1000Genomes |
|
|
CA295361304 rs376345000 |
55 | F>L | No |
ClinGen ESP TOPMed gnomAD |
|
|
CA401652804 rs1229196623 |
56 | R>K | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs760373126 CA8866557 |
58 | I>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA401652786 rs1232110006 |
59 | L>V | No |
ClinGen TOPMed |
|
|
CA401652765 rs1233408716 |
62 | E>K | No |
ClinGen gnomAD |
|
|
CA401652755 rs1357282922 |
63 | I>N | No |
ClinGen gnomAD |
|
|
rs1567858811 CA401652736 |
64 | I>V | No |
ClinGen Ensembl |
|
|
CA8866542 rs367948771 |
66 | H>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA8866541 rs754145701 |
66 | H>Q | No |
ClinGen ExAC |
|
|
CA295360641 rs769210811 |
66 | H>Y | No |
ClinGen Ensembl |
|
|
rs1250920577 CA401652707 |
68 | S>* | No |
ClinGen TOPMed |
|
|
rs1202796912 CA401652709 |
68 | S>A | No |
ClinGen TOPMed |
|
|
CA401652702 rs1567858786 |
69 | C>Y | No |
ClinGen Ensembl |
|
|
rs1485963871 CA401652697 |
70 | E>K | No |
ClinGen TOPMed |
|
|
rs766503377 CA8866540 |
71 | N>D | No |
ClinGen ExAC gnomAD |
|
|
CA8866539 rs760556024 |
72 | V>I | No |
ClinGen ExAC gnomAD |
|
|
rs772965492 CA8866538 |
74 | A>S | No |
ClinGen ExAC gnomAD |
|
|
CA8866537 rs189891584 |
75 | I>V | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs761747275 CA295360624 |
77 | S>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8866536 rs761747275 |
77 | S>F | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 77 | S>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA8866535 rs774220742 |
79 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1194429512 CA401652634 |
80 | I>T | No |
ClinGen gnomAD |
|
|
CA8866533 rs748747249 |
80 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1270748074 CA401652624 |
82 | G>R | No |
ClinGen gnomAD |
|
|
rs200172012 CA8866531 |
84 | T>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA401652205 rs1235117996 |
88 | C>S | No |
ClinGen TOPMed gnomAD |
|
|
CA295358559 rs1028033970 |
89 | T>S | No |
ClinGen Ensembl |
|
|
CA401652193 rs769308809 |
90 | A>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8866511 rs769308809 |
90 | A>T | Variant assessed as Somatic; 0.0001025 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs745519348 CA8866510 |
92 | T>I | No |
ClinGen ExAC gnomAD |
|
|
CA401652164 rs1471178830 |
93 | P>L | No |
ClinGen TOPMed |
|
|
rs1376643800 CA401652149 |
95 | V>I | No |
ClinGen TOPMed gnomAD |
|
|
CA401652137 rs1567857398 |
96 | L>F | No |
ClinGen Ensembl |
|
|
CA401652123 rs1175916495 |
98 | G>E | No |
ClinGen gnomAD |
|
|
rs965150596 CA295358540 |
105 | P>S | No |
ClinGen Ensembl |
|
| TCGA novel | 107 | D>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1271500599 CA401651958 |
112 | I>V | No |
ClinGen TOPMed |
|
|
rs916035648 CA295358531 |
113 | F>Y | No |
ClinGen TOPMed |
|
|
CA401651929 rs772620511 |
115 | F>C | No |
ClinGen ExAC gnomAD |
|
|
rs772620511 CA8866508 |
115 | F>S | No |
ClinGen ExAC gnomAD |
|
|
CA401651922 rs1475434358 |
116 | V>A | No |
ClinGen gnomAD |
|
| TCGA novel | 117 | E>Q | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs755414662 CA8866505 |
122 | T>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1263393932 CA401651853 |
124 | K>R | No |
ClinGen TOPMed |
|
|
rs866540485 CA295358184 |
130 | S>Y | No |
ClinGen Ensembl |
|
|
CA401651781 rs1204724969 |
131 | A>S | No |
ClinGen TOPMed |
|
|
rs866320130 CA401651773 |
132 | G>R | No |
ClinGen gnomAD |
|
|
rs868645265 CA295358174 |
132 | G>V | No |
ClinGen Ensembl |
|
|
rs866320130 CA295358178 |
132 | G>W | No |
ClinGen gnomAD |
|
|
CA8866491 rs770675786 |
135 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
CA401651732 rs1189987332 |
137 | L>V | No |
ClinGen gnomAD |
|
| TCGA novel | 138 | R>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1474078520 CA401651722 |
138 | R>H | No |
ClinGen gnomAD |
|
|
CA295358160 rs993702361 |
140 | C>S | No |
ClinGen TOPMed gnomAD |
|
|
CA295357894 rs758285014 |
146 | R>I | No |
ClinGen Ensembl |
|
|
CA8866470 rs768962290 |
148 | S>F | No |
ClinGen ExAC gnomAD |
|
|
CA401651627 rs1281964584 |
149 | K>E | No |
ClinGen TOPMed |
|
|
rs1377966217 CA401651618 |
150 | S>P | No |
ClinGen TOPMed |
|
|
CA8866468 rs745665555 |
153 | T>R | No |
ClinGen ExAC gnomAD |
|
|
CA8866467 rs770267483 |
154 | V>I | No |
ClinGen ExAC gnomAD |
|
|
rs1371339098 CA401651586 |
155 | F>V | No |
ClinGen gnomAD |
|
|
rs201162385 CA8866464 |
158 | R>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA8866465 rs781280898 |
158 | R>W | No |
ClinGen ExAC gnomAD |
|
|
CA401651501 rs1197789287 |
167 | F>L | No |
ClinGen TOPMed |
|
| TCGA novel | 175 | L>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA295355154 rs891429156 |
178 | Q>E | No |
ClinGen Ensembl |
|
|
rs867300638 CA295355150 |
179 | S>I | No |
ClinGen Ensembl |
|
|
CA401651388 rs1435167473 |
182 | N>S | No |
ClinGen gnomAD |
|
|
rs747105570 CA8866444 |
184 | E>G | No |
ClinGen ExAC gnomAD |
|
|
CA401651336 rs1420342503 |
190 | N>Y | No |
ClinGen gnomAD |
|
|
rs1188403824 CA401651327 |
191 | T>K | No |
ClinGen gnomAD |
|
|
CA8866441 rs748265210 |
192 | N>D | No |
ClinGen ExAC gnomAD |
|
|
CA401651321 rs1263180649 |
192 | N>S | No |
ClinGen gnomAD |
|
|
rs1267842369 CA401651312 |
193 | E>A | No |
ClinGen TOPMed |
|
|
CA295355120 rs867029873 |
194 | Q>H | No |
ClinGen Ensembl |
|
|
CA295355123 rs878879539 |
194 | Q>K | No |
ClinGen gnomAD |
|
|
CA295355105 rs866359458 |
196 | S>R | No |
ClinGen Ensembl |
|
|
CA401651283 rs1472828942 |
197 | T>S | No |
ClinGen TOPMed |
|
|
rs1257357000 CA401651275 |
199 | G>C | No |
ClinGen TOPMed gnomAD |
|
|
rs1230641660 CA401651274 |
199 | G>D | No |
ClinGen gnomAD |
|
|
CA401651277 rs1257357000 |
199 | G>S | No |
ClinGen TOPMed gnomAD |
|
|
rs1311304274 CA401651267 |
200 | Q>R | No |
ClinGen gnomAD |
|
| TCGA novel | 201 | K>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA401651213 rs1475519476 |
202 | H>R | No |
ClinGen TOPMed gnomAD |
|
|
rs1315535615 CA401651203 |
203 | T>A | No |
ClinGen gnomAD |
|
|
rs1243699806 CA401651156 |
206 | R>G | No |
ClinGen TOPMed gnomAD |
|
|
CA401651152 rs1357343156 |
206 | R>K | No |
ClinGen gnomAD |
|
|
rs1444815594 CA401651115 |
208 | E>G | No |
ClinGen TOPMed |
|
|
CA401651088 rs1185105678 |
210 | M>T | No |
ClinGen TOPMed |
|
|
CA401651077 rs1374308514 |
211 | D>H | No |
ClinGen gnomAD |
|
|
CA8866421 rs773364121 |
214 | E>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs760717085 CA8866422 |
214 | E>G | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 216 | E>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1165816026 CA401651000 |
216 | E>Q | No |
ClinGen gnomAD |
|
|
CA401650933 rs1367304344 |
220 | E>G | No |
ClinGen gnomAD |
|
|
CA401650905 rs1460407913 |
222 | A>P | No |
ClinGen TOPMed |
|
|
rs1296482811 CA401650897 |
222 | A>V | No |
ClinGen TOPMed |
|
|
CA8866417 rs768627342 |
223 | P>S | No |
ClinGen ExAC gnomAD |
|
|
CA401650881 rs1273745289 |
224 | T>A | No |
ClinGen TOPMed gnomAD |
|
|
CA401650863 COSM172322 rs1250711792 |
225 | T>M | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
|
CA401650849 rs1456033317 |
226 | C>F | No |
ClinGen gnomAD |
|
|
CA401650279 rs1364352129 |
228 | I>V | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 229 | P>Q | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 229 | P>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA401650266 rs1265860043 |
230 | I>V | No |
ClinGen TOPMed |
|
|
rs1268575439 CA401650222 COSM264029 |
236 | R>* | large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
|
rs775390511 CA8866397 |
236 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA8866394 rs780980533 |
252 | Y>H | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 254 | K>missing | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA401650055 rs1173878862 |
258 | K>N | No |
ClinGen TOPMed gnomAD |
|
|
CA8866393 rs373006315 |
259 | T>I | No |
ClinGen ESP ExAC gnomAD |
|
|
CA8866392 rs373006315 |
259 | T>S | No |
ClinGen ESP ExAC gnomAD |
|
|
CA8866391 rs777449755 |
262 | K>R | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 265 | E>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs548902228 CA8866375 |
265 | E>Q | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA8866372 rs771499996 |
269 | A>D | No |
ClinGen ExAC gnomAD |
|
|
CA401649970 rs1286319225 |
270 | V>I | No |
ClinGen gnomAD |
|
| TCGA novel | 271 | F>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs530768782 CA8866370 |
273 | S>G | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA8866369 rs756565871 |
273 | S>N | No |
ClinGen ExAC gnomAD |
|
|
rs1487448966 CA401649930 |
275 | K>R | No |
ClinGen TOPMed gnomAD |
|
|
rs1293605333 CA401649914 |
277 | D>V | No |
ClinGen TOPMed |
|
|
rs1465656285 CA401649904 |
278 | D>E | No |
ClinGen gnomAD |
|
| TCGA novel | 279 | T>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs750734146 CA8866368 |
281 | A>G | No |
ClinGen ExAC gnomAD |
|
|
CA401649874 rs1414526722 |
283 | R>K | No |
ClinGen gnomAD |
|
|
CA401649857 rs1471695835 |
285 | K>N | No |
ClinGen gnomAD |
|
| TCGA novel | 286 | M>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs140658412 CA8866365 |
286 | M>I | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs757874733 CA8866366 |
286 | M>V | No |
ClinGen ExAC gnomAD |
|
|
rs1459105703 CA401649844 |
287 | E>G | No |
ClinGen gnomAD |
|
|
CA8866364 rs377620376 |
288 | E>K | No |
ClinGen ESP ExAC gnomAD |
|
|
rs758539672 CA8866363 |
290 | K>E | No |
ClinGen ExAC gnomAD |
|
|
rs1336092339 CA401649824 |
290 | K>T | No |
ClinGen gnomAD |
|
|
CA8866362 rs753031558 |
292 | G>R | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 293 | G>E | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA295350692 rs986317244 |
294 | E>G | No |
ClinGen TOPMed |
|
| TCGA novel | 300 | K>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA8866347 rs768218042 |
309 | D>G | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 312 | L>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1478754847 CA401647827 |
312 | L>V | No |
ClinGen TOPMed |
|
| TCGA novel | 313 | S>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1378629176 CA401647803 |
315 | S>N | No |
ClinGen gnomAD |
|
|
rs757641974 CA8866344 COSM3388401 |
318 | R>C | Variant assessed as Somatic; 0.0 impact. pancreas urinary_tract [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
|
rs1299185012 CA401647777 |
319 | R>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA401647776 rs1442306530 |
319 | R>Q | No |
ClinGen gnomAD |
|
|
CA401647771 rs1421537132 |
320 | H>Y | No |
ClinGen TOPMed |
|
|
rs747576873 CA8866343 |
322 | L>V | No |
ClinGen ExAC gnomAD |
|
|
CA295339396 rs369391941 |
327 | I>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA8866340 rs369391941 |
327 | I>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 333 | K>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1277329442 CA401647601 |
342 | N>S | No |
ClinGen gnomAD |
|
|
rs1396446152 CA401647594 |
343 | Y>C | No |
ClinGen gnomAD |
|
|
rs1396446152 CA401647593 |
343 | Y>S | No |
ClinGen gnomAD |
|
|
rs199869012 CA8866321 |
344 | V>I | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs374747865 CA295338377 |
351 | L>F | No |
ClinGen ESP |
|
|
CA8866319 rs755027192 |
357 | T>A | No |
ClinGen ExAC gnomAD |
|
|
CA401647494 rs1474687858 |
357 | T>I | No |
ClinGen TOPMed |
|
|
CA401647448 rs1170893401 |
361 | Y>H | No |
ClinGen TOPMed |
|
|
CA401647067 rs1443630671 |
367 | N>K | No |
ClinGen gnomAD |
|
| rs778021280 | 370 | D>M | Variant assessed as Somatic; 5.315e-05 impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA8866300 rs749332430 |
370 | D>N | No |
ClinGen ExAC TOPMed |
|
|
rs1249678965 CA401647026 |
373 | R>G | No |
ClinGen TOPMed gnomAD |
|
|
CA8866297 rs756362305 |
373 | R>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1414311034 COSM3403476 CA401646991 |
376 | K>E | Variant assessed as Somatic; impact. central_nervous_system [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA TOPMed |
|
rs1263423968 CA401646975 |
378 | V>I | No |
ClinGen gnomAD |
|
|
CA401646946 rs1376818984 |
380 | H>Y | No |
ClinGen TOPMed gnomAD |
|
|
CA8866282 rs201689148 |
383 | N>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA8866281 rs769182418 |
384 | T>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA295338037 rs865911913 |
385 | E>* | No |
ClinGen Ensembl |
|
|
CA8866280 rs376053242 |
390 | S>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1475538109 CA401646828 |
396 | C>G | No |
ClinGen TOPMed gnomAD |
|
|
rs1417446775 CA401646822 |
397 | P>T | No |
ClinGen gnomAD |
|
| TCGA novel | 400 | V>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA8866253 rs745933882 |
404 | T>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8866254 rs769928528 |
404 | T>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA401646742 rs1214281676 |
405 | S>P | No |
ClinGen TOPMed gnomAD |
|
|
CA401646713 rs1175627221 |
409 | P>S | No |
ClinGen TOPMed |
|
|
rs890667182 CA295337212 |
410 | T>M | No |
ClinGen TOPMed gnomAD |
|
|
CA8866249 rs200887739 |
412 | I>V | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs377169666 CA8866248 |
414 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA295337162 rs947264802 COSM264028 |
414 | R>W | Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
|
CA401646665 rs1297278231 |
417 | T>P | No |
ClinGen TOPMed |
|
|
CA8866247 rs748150928 |
417 | T>R | No |
ClinGen ExAC TOPMed |
|
|
CA8866246 rs778985342 |
418 | A>T | No |
ClinGen ExAC gnomAD |
|
|
rs1455345197 CA401646639 |
419 | P>L | No |
ClinGen gnomAD |
|
|
CA401646623 rs1311032627 |
420 | E>D | No |
ClinGen TOPMed |
|
|
rs753364989 CA8866244 |
420 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA401646571 rs1384908220 |
424 | G>E | No |
ClinGen gnomAD |
|
|
rs749988119 CA8866241 |
426 | G>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8866242 rs755820555 |
426 | G>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA401646538 rs1452736563 |
427 | P>T | No |
ClinGen gnomAD |
|
|
CA8866240 rs764502807 |
428 | T>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs763303870 CA8866239 |
429 | K>R | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 430 | K>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 431 | I>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1356755845 | 431 | I>N | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 431 | I>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs776017441 CA8866238 |
435 | N>S | No |
ClinGen ExAC gnomAD |
|
|
CA401646304 rs1298624257 |
436 | E>* | No |
ClinGen gnomAD |
|
|
CA401646298 rs1421750825 |
437 | E>K | No |
ClinGen gnomAD |
|
|
rs1158408949 CA401646228 |
446 | P>L | No |
ClinGen gnomAD |
|
|
CA401646210 rs1450363559 |
449 | M>L | No |
ClinGen TOPMed |
|
|
rs866623318 CA295336541 |
450 | E>* | No |
ClinGen Ensembl |
|
| TCGA novel | 454 | S>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA401646161 rs1427825706 |
455 | E>D | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 457 | R>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA401646042 rs1244441201 |
459 | H>P | No |
ClinGen gnomAD |
|
|
CA8866209 rs772400295 |
460 | M>V | No |
ClinGen ExAC gnomAD |
|
|
rs1201294802 CA401646015 |
461 | P>A | No |
ClinGen gnomAD |
|
|
rs1380081623 CA401645985 |
465 | E>G | No |
ClinGen TOPMed |
|
|
rs1598286379 CA401645954 |
469 | E>A | No |
ClinGen Ensembl |
|
|
CA401645945 rs1230419699 |
470 | A>G | No |
ClinGen TOPMed |
|
|
CA401645936 rs1305577350 |
472 | E>Q | No |
ClinGen gnomAD |
|
|
rs1229070882 CA401645919 |
474 | A>T | No |
ClinGen TOPMed gnomAD |
|
|
rs1381697316 CA401645908 |
475 | D>E | No |
ClinGen gnomAD |
|
|
rs1334768586 CA401645904 |
476 | P>S | No |
ClinGen gnomAD |
|
|
rs768267123 CA8866205 |
478 | N>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs749307095 CA8866204 |
479 | M>I | No |
ClinGen ExAC gnomAD |
|
|
rs189055293 CA8866202 |
482 | N>K | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA8866203 rs779852649 |
482 | N>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8866201 rs745360942 |
485 | K>Q | No |
ClinGen ExAC gnomAD |
|
|
rs1256645404 CA401645817 |
487 | V>M | No |
ClinGen TOPMed |
|
|
COSM1388113 CA8866185 rs775547853 |
502 | R>Q | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
|
CA8866186 rs762624783 |
502 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1289801390 CA401645702 |
504 | S>I | No |
ClinGen gnomAD |
|
|
rs895075446 CA295331089 |
510 | P>A | No |
ClinGen TOPMed |
|
|
CA295331084 rs1054076229 |
510 | P>L | No |
ClinGen TOPMed |
|
|
CA401645375 rs1436910640 |
531 | K>R | No |
ClinGen TOPMed |
|
|
rs746719209 CA8866179 |
532 | E>Q | No |
ClinGen ExAC |
|
| rs755407022 | 534 | P>= | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA295331034 rs377720582 |
534 | P>L | No |
ClinGen ESP gnomAD |
|
|
CA8866155 rs138671246 |
535 | P>S | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA401645083 rs1194862191 |
536 | P>S | No |
ClinGen gnomAD |
|
|
CA8866153 rs746446174 |
537 | S>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs756487622 CA8866154 |
537 | S>P | No |
ClinGen ExAC gnomAD |
|
|
rs781756311 CA8866152 |
538 | E>G | No |
ClinGen ExAC TOPMed |
|
|
rs751614194 CA8866150 |
548 | E>D | No |
ClinGen ExAC gnomAD |
|
|
CA8866149 rs764197569 |
551 | N>S | No |
ClinGen ExAC gnomAD |
|
|
CA8866147 rs752909026 |
555 | L>Q | No |
ClinGen ExAC gnomAD |
|
|
CA401644936 rs1219585933 |
557 | E>A | No |
ClinGen gnomAD |
|
|
CA8866146 rs765003260 |
559 | E>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA295330066 rs7343043 |
561 | P>L | No |
ClinGen Ensembl |
|
|
rs988418371 CA295330061 |
564 | R>P | No |
ClinGen TOPMed gnomAD |
|
|
CA401644875 rs988418371 |
564 | R>Q | No |
ClinGen TOPMed gnomAD |
|
|
CA8866128 rs752932820 |
564 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1304075550 CA401644873 |
565 | R>* | No |
ClinGen TOPMed |
|
|
rs370144365 CA8866127 |
565 | R>Q | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1598284174 CA401644858 |
567 | K>R | No |
ClinGen Ensembl |
|
|
CA295330053 rs749979436 |
570 | T>R | No |
ClinGen Ensembl |
|
|
COSM3692094 CA8866126 rs754814035 |
571 | G>R | large_intestine [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
|
rs1179413090 CA401644829 |
572 | E>A | No |
ClinGen TOPMed gnomAD |
|
|
rs1179413090 CA401644828 |
572 | E>G | No |
ClinGen TOPMed gnomAD |
|
|
CA295330029 rs958265112 |
572 | E>K | No |
ClinGen Ensembl |
|
|
rs753651519 CA8866125 |
574 | I>M | No |
ClinGen ExAC gnomAD |
|
|
CA8866124 rs766121793 |
575 | E>G | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 577 | F>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1330590537 CA401644780 |
579 | N>S | No |
ClinGen TOPMed |
|
| TCGA novel | 582 | G>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs750315921 CA8866122 |
582 | G>V | No |
ClinGen ExAC gnomAD |
|
|
rs200603522 CA295330006 |
583 | E>K | No |
ClinGen 1000Genomes |
|
|
CA8866120 rs201476225 |
584 | Q>H | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA8866121 rs201737592 |
584 | Q>R | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA8866118 rs768445844 |
585 | W>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs777142821 CA8866116 |
587 | I>T | No |
ClinGen ExAC gnomAD |
|
|
CA401644706 rs1272911508 |
590 | P>L | No |
ClinGen Ensembl |
|
|
CA401644662 rs1473573815 |
596 | D>A | No |
ClinGen TOPMed |
|
|
rs772081290 CA8866112 |
598 | E>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1458581066 CA401644642 |
599 | I>F | No |
ClinGen TOPMed |
|
|
rs1458581066 CA401644644 |
599 | I>L | No |
ClinGen TOPMed |
|
|
rs1422973174 CA401644639 |
599 | I>T | No |
ClinGen gnomAD |
|
|
rs1159849616 CA401644637 |
600 | R>G | No |
ClinGen gnomAD |
|
|
CA295329969 rs1028039225 |
600 | R>T | No |
ClinGen Ensembl |
|
|
CA8866111 rs748233567 |
601 | Q>E | No |
ClinGen ExAC gnomAD |
|
|
CA401644614 rs1389025779 |
603 | E>G | No |
ClinGen TOPMed |
|
|
CA8866110 rs778910404 |
603 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8866108 rs753991890 |
604 | C>G | No |
ClinGen ExAC |
|
|
rs1481072213 CA401644607 |
604 | C>S | No |
ClinGen gnomAD |
|
|
CA401644608 rs1481072213 |
604 | C>Y | No |
ClinGen gnomAD |
|
|
rs779836882 CA8866107 |
605 | D>A | No |
ClinGen ExAC gnomAD |
|
|
rs1271486053 CA401644603 |
605 | D>H | No |
ClinGen gnomAD |
|
|
CA401644567 rs1215838101 |
609 | M>I | No |
ClinGen gnomAD |
|
|
CA8866106 rs755923145 |
609 | M>T | No |
ClinGen ExAC gnomAD |
|
|
rs767468917 CA8866104 |
611 | M>L | No |
ClinGen ExAC gnomAD |
|
|
rs1223116538 CA401644547 |
612 | R>G | No |
ClinGen gnomAD |
|
| TCGA novel | 613 | A>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1284947013 CA401644533 |
614 | K>E | No |
ClinGen gnomAD |
|
|
rs1402886345 CA401644529 |
614 | K>T | No |
ClinGen gnomAD |
|
|
rs371637037 CA295329925 |
615 | Q>H | No |
ClinGen ESP |
|
|
CA401644502 rs1287348208 |
619 | A>P | No |
ClinGen TOPMed |
|
|
rs555128357 CA295329918 |
626 | V>I | No |
ClinGen Ensembl |
|
|
rs762712809 CA8866100 |
629 | T>I | No |
ClinGen ExAC gnomAD |
|
|
CA401644412 rs1470579967 |
631 | E>D | No |
ClinGen gnomAD |
|
|
CA401644414 rs1317802839 |
631 | E>G | No |
ClinGen gnomAD |
|
|
CA8866099 rs775272891 |
635 | N>K | No |
ClinGen ExAC gnomAD |
|
|
rs1040203185 CA295329911 |
635 | N>S | No |
ClinGen TOPMed |
|
|
rs1480334384 CA401644380 |
636 | A>G | No |
ClinGen gnomAD |
|
|
rs761073200 CA8866097 |
638 | N>D | No |
ClinGen ExAC gnomAD |
|
|
CA401644370 rs1486666763 |
638 | N>T | No |
ClinGen gnomAD |
|
|
rs1598283995 CA401644337 |
643 | S>G | No |
ClinGen Ensembl |
|
| TCGA novel | 644 | D>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA401644300 rs1264933178 |
648 | S>G | No |
ClinGen TOPMed gnomAD |
|
|
rs773637900 CA8866095 |
649 | L>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA628030827 rs1567840057 |
652 | D>* | No |
ClinGen Ensembl |
|
|
CA401644276 rs1322533426 |
652 | D>H | No |
ClinGen gnomAD |
|
|
CA8866093 rs657541 |
653 | N>D | No |
ClinGen ExAC gnomAD |
|
|
CA295329851 rs657541 |
653 | N>H | No |
ClinGen ExAC gnomAD |
|
|
CA401644266 rs1216542754 |
653 | N>S | No |
ClinGen gnomAD |
|
| TCGA novel | 654 | E>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA295329837 rs774415125 |
656 | N>K | No |
ClinGen ExAC gnomAD |
|
|
CA401644246 rs1269606971 |
656 | N>Y | No |
ClinGen gnomAD |
No associated diseases with Q96FV9
1 regional properties for Q96FV9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Tubulin epsilon and delta complex protein 1 domain | 86 - 256 | IPR027996 |
Functions
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nuclear matrix | The dense fibrillar network lying on the inner side of the nuclear membrane. |
| nuclear speck | A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| THO complex | The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1p, Tho2p, Thp1p, and Mft1p, while the human complex is composed of 7 subunits. |
| THO complex part of transcription export complex | The THO complex when it is part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp1, and Mft1, while the human complex is composed of 7 subunits. |
| transcription export complex | The transcription export (TREX) complex couples transcription elongation by RNA polymerase II to mRNA export. The complex associates with the polymerase and travels with it along the length of the transcribed gene. TREX is composed of the THO transcription elongation complex as well as other proteins that couple THO to mRNA export proteins. The TREX complex is known to be found in a wide range of eukaryotes, including S. cerevisiae and metazoans. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
13 GO annotations of biological process
| Name | Definition |
|---|---|
| apoptotic process | A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. |
| mRNA export from nucleus | The directed movement of mRNA from the nucleus to the cytoplasm. |
| mRNA processing | Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. |
| negative regulation of DNA damage checkpoint | Any process that stops, prevents, or reduces the frequency, rate or extent of a DNA damage checkpoint. |
| negative regulation of isotype switching to IgA isotypes | Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching to IgA isotypes. |
| positive regulation of DNA-templated transcription, elongation | Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase. |
| regulation of DNA recombination | Any process that modulates the frequency, rate or extent of DNA recombination, a DNA metabolic process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. |
| regulation of DNA-templated transcription elongation | Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase. |
| replication fork processing | The process in which a DNA replication fork that has stalled is restored to a functional state and replication is restarted. The stalling may be due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes. |
| RNA processing | Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. |
| RNA splicing | The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
| viral mRNA export from host cell nucleus | The directed movement of intronless viral mRNA from the host nucleus to the cytoplasm for translation. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSPTPPLFSL | PEARTRFTKS | TREALNNKNI | KPLLSTFSQV | PGSENEKKCT | LDQAFRGILE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EEIINHSSCE | NVLAIISLAI | GGVTEGICTA | STPFVLLGDV | LDCLPLDQCD | TIFTFVEKNV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ATWKSNTFYS | AGKNYLLRMC | NDLLRRLSKS | QNTVFCGRIQ | LFLARLFPLS | EKSGLNLQSQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FNLENVTVFN | TNEQESTLGQ | KHTEDREEGM | DVEEGEMGDE | EAPTTCSIPI | DYNLYRKFWS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LQDYFRNPVQ | CYEKISWKTF | LKYSEEVLAV | FKSYKLDDTQ | ASRKKMEELK | TGGEHVYFAK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FLTSEKLMDL | QLSDSNFRRH | ILLQYLILFQ | YLKGQVKFKS | SNYVLTDEQS | LWIEDTTKSV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| YQLLSENPPD | GERFSKMVEH | ILNTEENWNS | WKNEGCPSFV | KERTSDTKPT | RIIRKRTAPE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DFLGKGPTKK | ILMGNEELTR | LWNLCPDNME | ACKSETREHM | PTLEEFFEEA | IEQADPENMV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ENEYKAVNNS | NYGWRALRLL | ARRSPHFFQP | TNQQFKSLPE | YLENMVIKLA | KELPPPSEEI |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KTGEDEDEED | NDALLKENES | PDVRRDKPVT | GEQIEVFANK | LGEQWKILAP | YLEMKDSEIR |
| 610 | 620 | 630 | 640 | 650 | |
| QIECDSEDMK | MRAKQLLVAW | QDQEGVHATP | ENLINALNKS | GLSDLAESLT | NDNETNS |