AiPD: Autoinhibited Protein Database

Q96EU6

Gene name	RRP36 (C6orf153, HSPC253)
Protein name	Ribosomal RNA processing protein 36 homolog
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:88745
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-259 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-259 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q96EU6

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q96EU6-F1	Predicted				AlphaFoldDB

233 variants for Q96EU6

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA3812754 rs748570963	2	P>L		No	ClinGen ExAC TOPMed gnomAD
rs748570963 CA3812755	2	P>R		No	ClinGen ExAC TOPMed gnomAD
CA364160422 rs1214721926	2	P>T		No	ClinGen gnomAD
CA138223505 rs575703356	4	A>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA138223504 rs982409640	4	A>T		No	ClinGen TOPMed
CA3812757 rs575703356	4	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs776622419 CA3812759	5	N>S		No	ClinGen ExAC TOPMed gnomAD
CA3812761 rs769916609	6	Y>*		No	ClinGen ExAC gnomAD
rs759483520 CA3812760	6	Y>C		No	ClinGen ExAC gnomAD
rs374693217 CA3812762	7	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs374693217 CA3812763	7	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs199544375 CA138223583 CA364160573	9	G>R		No	ClinGen gnomAD
rs1376616487 CA364160596	10	A>D		No	ClinGen gnomAD
CA364160606 rs1437080322	11	G>W		No	ClinGen gnomAD
CA3812773 rs751251366	13	G>R		No	ClinGen ExAC TOPMed gnomAD
CA3812774 rs761423447	14	A>T		No	ClinGen ExAC
rs982280354 CA138223618	14	A>V		No	ClinGen Ensembl
rs937110331 CA138223638	15	G>R		No	ClinGen Ensembl
rs755464919 CA3812778	16	A>D		No	ClinGen ExAC
rs749969788 CA3812777	16	A>T		No	ClinGen ExAC gnomAD
CA364160708 rs1458618014	17	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA364160705 rs1458618014	17	R>G		No	ClinGen TOPMed gnomAD
rs1349971012 CA364160716	17	R>P		No	ClinGen TOPMed gnomAD
CA364160714 rs1349971012	17	R>Q		No	ClinGen TOPMed gnomAD
CA364160728 rs1371022659	18	R>G		No	ClinGen TOPMed
CA364160741 rs1282320063	18	R>H		No	ClinGen gnomAD
CA364160733 rs1282320063	18	R>L		No	ClinGen gnomAD
CA364160780 rs1581882302	20	R>P		No	ClinGen Ensembl
CA364160803 rs1581882316	22	A>G		No	ClinGen Ensembl
rs984160436 CA138223652	22	A>T		No	ClinGen TOPMed
CA364160810 rs1446052199	23	R>G		No	ClinGen TOPMed gnomAD
CA364160821 rs1163533827	23	R>L		No	ClinGen gnomAD
rs1446052199 CA364160813	23	R>W		No	ClinGen TOPMed gnomAD
rs779407305 CA3812779	25	R>C		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	28	D>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1453885134 CA364160944	31	G>S		No	ClinGen TOPMed
rs540615157 CA3812780	37	V>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA364161076 rs540615157	37	V>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1187538698 CA364161099	38	A>D		No	ClinGen TOPMed
rs1400865037 CA364161082	38	A>P		No	ClinGen TOPMed gnomAD
rs1400865037 CA364161081	38	A>T		No	ClinGen TOPMed gnomAD
CA364161097 rs1187538698	38	A>V		No	ClinGen TOPMed
rs1451847072 CA364161116	39	R>H		No	ClinGen TOPMed gnomAD
CA364161860 rs1210716306	40	D>N		No	ClinGen TOPMed
rs931194093 CA138223682	41	L>V		No	ClinGen Ensembl
rs1384771967 CA364161951	43	R>K		No	ClinGen TOPMed gnomAD
CA3812796 rs765692189	45	T>I		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	46	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1160753881 CA364164002	47	N>K		No	ClinGen gnomAD
CA3812797 rs753224465	48	M>V		No	ClinGen ExAC TOPMed gnomAD
rs758951086 CA364164089	49	S>*		No	ClinGen ExAC TOPMed gnomAD
rs758951086 CA3812798	49	S>L		No	ClinGen ExAC TOPMed gnomAD
CA3812799 rs764487570	50	F>L		No	ClinGen ExAC gnomAD
TCGA novel	50	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1389437670 CA364164205	52	E>D		No	ClinGen gnomAD
rs201407458 CA3812800	52	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA3812801 rs757485192	53	L>V		No	ClinGen ExAC
rs1336309190 CA364164278	54	L>S		No	ClinGen gnomAD
rs1336309190 CA364164275	54	L>W		No	ClinGen gnomAD
rs1241013486 CA364164284	55	E>K		No	ClinGen gnomAD
TCGA novel rs1332746049 CA364164399	57	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen gnomAD NCI-TCGA
rs781279874 CA3812802	57	Q>P		No	ClinGen ExAC gnomAD
rs1053772743 CA138226532	59	Q>R		No	ClinGen TOPMed gnomAD
rs1561862738 CA364164509	61	G>R		No	ClinGen Ensembl
rs745872992 CA3812803	62	T>A		No	ClinGen ExAC gnomAD
TCGA novel	63	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs140642066 CA364164668	64	T>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs140642066 CA3812804	64	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs780334417 CA3812805	65	Y>H		No	ClinGen ExAC gnomAD
CA364164725 rs1184953523	66	K>E		No	ClinGen gnomAD
CA364164752 rs1423754739	66	K>N		No	ClinGen gnomAD
rs1469800765 COSM1621675 CA364164924	70	A>T	liver [Cosmic]	No	ClinGen cosmic curated TOPMed
CA3812808 rs774183025	75	K>E		No	ClinGen ExAC TOPMed gnomAD
CA3812809 rs747910957	75	K>N		No	ClinGen ExAC gnomAD
rs138428694 CA3812810	77	Q>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
VAR_027786 CA3812811 rs3749903	78	A>G		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA364165280 rs3749903	78	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3812812 rs553943818	79	S>C		No	ClinGen ExAC gnomAD
rs1353683272 CA364165336	80	R>I		No	ClinGen gnomAD
rs1015458496 CA138226602	81	P>A		No	ClinGen TOPMed
CA364165438 rs1317379967	82	P>S		No	ClinGen gnomAD
CA364165459 rs1465946895	83	I>T		No	ClinGen TOPMed
rs149918001 CA3812814	83	I>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA364165580 rs1581885462	86	A>G		No	ClinGen Ensembl
rs371308817 CA3812817	89	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs374211157 CA3812818	90	D>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA364165810 rs1207972132	92	H>L		No	ClinGen TOPMed gnomAD
CA3812832 rs776101412	94	P>S		No	ClinGen ExAC gnomAD
TCGA novel	96	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs759055516 CA3812833	97	M>T		No	ClinGen ExAC TOPMed gnomAD
rs769137460 CA3812834	98	S>T		No	ClinGen ExAC gnomAD
rs774748587 CA3812835	99	A>V		No	ClinGen ExAC gnomAD
CA3812836 rs762434217	100	K>N		No	ClinGen ExAC gnomAD
CA364166324 rs1444878881	102	R>*		No	ClinGen gnomAD
CA3812837 rs149161868	102	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA364166365 rs1245743539	103	V>E		No	ClinGen TOPMed
rs760969484 CA3812839	107	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs760969484 CA364166524	107	R>G		No	ClinGen ExAC TOPMed gnomAD
rs766723130 CA3812841	107	R>H		No	ClinGen ExAC gnomAD
CA3812840 rs766723130	107	R>P		No	ClinGen ExAC gnomAD
rs755046273 CA3812842	108	Q>*		No	ClinGen ExAC gnomAD
CA364166562 rs1396387494	108	Q>L		No	ClinGen TOPMed
rs552159549 CA3812844	111	P>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
rs868082733 CA138226873	112	I>V		No	ClinGen Ensembl
rs1220375008 CA364166712	113	S>G		No	ClinGen gnomAD
rs376172874 CA3812846	115	K>M		No	ClinGen ESP ExAC gnomAD
rs145019013 CA138229542	117	A>T		No	ClinGen ESP TOPMed gnomAD
rs367634568 CA364168497	118	R>G		No	ClinGen TOPMed gnomAD
COSM1079404 CA3812874 rs146780269	118	R>Q	endometrium [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
COSM1444615 CA138229545 rs367634568	118	R>W	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs1322861578 CA364168529	119	D>N		No	ClinGen TOPMed
CA3812875 rs140481362	120	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA138229560 rs944793469	121	R>C		No	ClinGen TOPMed
CA3812876 rs371656429	121	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA3812877 rs773886777	123	D>H		No	ClinGen ExAC gnomAD
CA364168797 rs1351852896	125	L>P		No	ClinGen gnomAD
CA3812879 CA364168821 rs771399305	126	S>*		No	ClinGen ExAC TOPMed gnomAD
rs1388047801 CA364168802	126	S>T		No	ClinGen TOPMed
CA364168853 rs1458177933	127	G>R		No	ClinGen TOPMed
rs998897931 CA138229600	128	E>K		No	ClinGen TOPMed gnomAD
CA3812881 rs777173464	130	N>S		No	ClinGen ExAC gnomAD
rs1276658063 CA364169089	132	E>Q		No	ClinGen gnomAD
CA364169115 rs1484620039 CA364169120	133	V>L		No	ClinGen gnomAD
CA3812883 rs759672264	134	F>S		No	ClinGen ExAC TOPMed gnomAD
CA364169317 rs1473283640	138	Y>*		No	ClinGen gnomAD
rs145903817 CA3812885	139	Q>R		No	ClinGen ESP ExAC TOPMed
CA3812887 rs763977082	140	F>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs148154536 CA3812888 COSM159639	141	L>F	breast [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA3812890 rs374850944	145	R>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs750295495 CA3812892	145	R>L		No	ClinGen ExAC TOPMed gnomAD
rs750295495 CA3812891	145	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs779762073 CA3812894	146	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA364169800 rs1561863286	148	E>D		No	ClinGen Ensembl
CA3812897 rs754559538	148	E>Q		No	ClinGen ExAC gnomAD
CA3812898 rs778617196	149	K>R		No	ClinGen ExAC gnomAD
CA364170445 rs1277917772	153	K>R		No	ClinGen gnomAD
CA3812923 rs749509939	155	Q>R		No	ClinGen ExAC gnomAD
TCGA novel	155	Q>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs768928093 CA364170565 CA3812924	156	L>F		No	ClinGen ExAC gnomAD
rs1373137582 CA364170606	157	K>R		No	ClinGen TOPMed
rs1332886019 CA364170612	158	K>Q		No	ClinGen gnomAD
rs1268411911 CA364170842	162	G>E		No	ClinGen gnomAD
rs150243178 CA3812925	163	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	163	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs761890283 CA3812926	166	E>Q		No	ClinGen ExAC gnomAD
rs771864584 CA3812927	169	Q>*		No	ClinGen ExAC TOPMed gnomAD
rs138000931 CA3812928	169	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA364171088 rs1159213886	169	Q>R		No	ClinGen TOPMed
CA3812929 rs201033484	170	Q>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs753750744 CA3812931	171	L>R		No	ClinGen ExAC TOPMed gnomAD
rs759248834 CA3812932	172	L>P		No	ClinGen ExAC gnomAD
rs1307302054 CA364171182	173	Q>*		No	ClinGen gnomAD
rs1350000708 CA364171228	174	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA3812933 rs201667467	174	R>Q	Variant assessed as Somatic; 4.62e-05 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA364171448 rs1356509094	176	E>G		No	ClinGen TOPMed gnomAD
CA3812959 rs371077361	177	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA364171475 rs1195152813	177	Q>R		No	ClinGen TOPMed gnomAD
rs562969123 CA138230606	178	Q>*		No	ClinGen gnomAD
CA364171557 rs1320377422	180	M>V		No	ClinGen gnomAD
CA364171626 rs1366376083	183	Q>E		No	ClinGen gnomAD
TCGA novel	183	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3812960 rs766804064	184	E>G		No	ClinGen ExAC gnomAD
COSM188578 rs575586322 CA3812961	185	R>*	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs117415551 CA3812962	185	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1561863771 CA364171702	186	K>E		No	ClinGen Ensembl
CA3812964 rs748340079	187	Q>H		No	ClinGen ExAC gnomAD
rs1248483023 CA364171949	192	H>Y		No	ClinGen gnomAD
CA138230664 rs750147388	194	A>G		No	ClinGen Ensembl
CA364172017 rs747071318	195	L>M		No	ClinGen ExAC TOPMed gnomAD
CA3812967 rs747071318	195	L>V		No	ClinGen ExAC TOPMed gnomAD
CA364172104 rs1271900092	197	Q>R		No	ClinGen TOPMed
rs1176901871 CA364172177	199	R>C		No	ClinGen gnomAD
CA3812968 rs770834773	199	R>H		No	ClinGen ExAC TOPMed gnomAD
COSM1246908 rs180946521 CA3812971	200	R>Q	oesophagus [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA3812970 rs745605375	200	R>W		No	ClinGen ExAC gnomAD
rs1437750358 CA364172299	201	A>P		No	ClinGen gnomAD
rs1377445166 CA364172304	201	A>V		No	ClinGen TOPMed
rs775462988 CA3812972	203	A>T		No	ClinGen ExAC gnomAD
rs1306591350 CA364172433	204	Q>*		No	ClinGen TOPMed
CA3812973 rs762660786	205	Q>*		No	ClinGen ExAC gnomAD
CA364172468 rs762660786	205	Q>K		No	ClinGen ExAC gnomAD
rs1387795345 CA364172540	206	G>D		No	ClinGen gnomAD
CA3812974 rs763669657	207	H>Y		No	ClinGen ExAC TOPMed gnomAD
rs761263930 CA364172630	208	R>P		No	ClinGen ExAC gnomAD
rs761263930 CA3812976	208	R>Q		No	ClinGen ExAC gnomAD
rs773848628 CA3812975 COSM3777681	208	R>W	Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA364172710 rs1330724262	211	F>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA3812998 rs765745200	217	Q>*		No	ClinGen ExAC gnomAD
rs140316056 CA3812999	218	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA3813000 rs763256930	218	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1424627594 CA364174295	219	Q>H		No	ClinGen TOPMed gnomAD
rs199956173 CA3813001	222	L>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1400219658 CA364174372	223	A>T		No	ClinGen TOPMed
CA3813002 rs751704275	223	A>V		No	ClinGen ExAC TOPMed gnomAD
CA3813003 rs757590627	224	E>D		No	ClinGen ExAC TOPMed gnomAD
rs1369251295 CA364174393	224	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA364174457 CA3813004 rs371847127	226	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA3813005 rs750587298	227	K>E		No	ClinGen ExAC gnomAD
CA3813006 rs371459242	227	K>M		No	ClinGen ESP ExAC gnomAD
CA3813007 rs780172948	227	K>N		No	ClinGen ExAC gnomAD
CA138232372 rs750587298	227	K>Q		No	ClinGen ExAC gnomAD
rs1379387048 CA364174514	228	E>G		No	ClinGen gnomAD
CA3813008 rs749063179	229	L>V		No	ClinGen ExAC gnomAD
rs934029119 CA138232399	231	R>C		No	ClinGen TOPMed gnomAD
CA3813009 rs374907155	232	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	233	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs201588473 CA3813010	233	K>Q		No	ClinGen 1000Genomes ExAC gnomAD
COSM1079406 rs771772252 CA3813012	238	F>L	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs772653926 CA3813013	238	F>Y		No	ClinGen ExAC gnomAD
rs201561865 CA3813014	240	S>N		No	ClinGen ExAC TOPMed gnomAD
rs759948925 CA3813015	241	R>*		No	ClinGen ExAC TOPMed gnomAD
rs759948925 CA364174853	241	R>G		No	ClinGen ExAC TOPMed gnomAD
CA3813016 rs775879581	241	R>Q		No	ClinGen ExAC gnomAD
CA3813017 rs528827718	244	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA3813018 rs764334710	244	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs142677240 CA3813019	245	R>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3813020 rs572074645	245	R>Q		No	ClinGen 1000Genomes ExAC gnomAD
CA3813022 rs750491646	247	A>T		No	ClinGen ExAC TOPMed gnomAD
CA364175069 rs1022559034	250	D>N		No	ClinGen TOPMed gnomAD
CA138232503 rs1022559034	250	D>Y		No	ClinGen TOPMed gnomAD
CA3813023 rs144610442	251	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs148480237 CA3813024	252	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3813025 rs753692615	252	R>I		No	ClinGen ExAC TOPMed gnomAD
rs1319494474 CA364175170	253	H>N		No	ClinGen TOPMed
CA138232575 rs1002368059	253	H>R		No	ClinGen TOPMed
rs1319494474 CA364175174	253	H>Y		No	ClinGen TOPMed
CA364175193 rs1246619653	254	L>F		No	ClinGen gnomAD
CA3813029 rs376655454	257	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA364175307 rs1477286080	258	K>N		No	ClinGen gnomAD
CA364175300 rs1244368971	258	K>R		No	ClinGen gnomAD
rs376410795 CA3813031	259	E>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	260	E>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3813032 rs529652316	260	E>S		No	ClinGen 1000Genomes ExAC

No associated diseases with Q96EU6

No regional properties for Q96EU6

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q96EU6

Functions

		Description
EC Number
Subcellular Localization	Nucleus, nucleolus	Concentrated in the fibrillar region of the nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
90S preribosome	A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.
nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.

1 GO annotations of molecular function

Name	Definition
RNA binding	Binding to an RNA molecule or a portion thereof.

4 GO annotations of biological process

Name	Definition
cleavage involved in rRNA processing	Any phosphodiester bond hydrolysis involved in the conversion of a primary ribosomal RNA (rRNA) transcript into a mature rRNA molecule.
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.
ribosomal small subunit biogenesis	A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis.
rRNA processing	Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
A6QNR1	RRP36	Ribosomal RNA processing protein 36 homolog	Bos taurus (Bovine)	PR
Q3UFY0	Rrp36	Ribosomal RNA processing protein 36 homolog	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MPGANYRAGA	GAGAGARRPR	GARDREEDGG	GLEPAAVARD	LLRGTSNMSF	EELLELQSQV
70	80	90	100	110	120
GTKTYKQLVA	GNSPKKQASR	PPIQNACVAD	KHRPLEMSAK	IRVPFLRQVV	PISKKVARDP
130	140	150	160	170	180
RFDDLSGEYN	PEVFDKTYQF	LNDIRAKEKE	LVKKQLKKHL	SGEEHEKLQQ	LLQRMEQQEM
190	200	210	220	230	240
AQQERKQQQE	LHLALKQERR	AQAQQGHRPY	FLKKSEQRQL	ALAEKFKELK	RSKKLENFLS
250
RKRRRNAGKD	RRHLPLSKE