AiPD: Autoinhibited Protein Database

Q96DF8

Gene name	ESS2
Protein name	Splicing factor ESS-2 homolog
Names	DiGeorge syndrome critical region 13, DiGeorge syndrome critical region 14, DiGeorge syndrome protein H, DGS-H, Protein ES2
Species	Homo sapiens (Human)
KEGG Pathway	hsa:8220
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

380-470 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

380-470 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

2 structures for Q96DF8

Entry ID	Method	Resolution	Chain	Position	Source
8C6J	EM	280 A	4	1-476	PDB
AF-Q96DF8-F1	Predicted				AlphaFoldDB

461 variants for Q96DF8

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1302025516 CA410656625	2	E>D		No	ClinGen gnomAD
CA321377871 rs375321180	3	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA10097089 rs375321180	3	T>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA410656581 rs537105916	4	P>A		No	ClinGen gnomAD
CA10097087 rs755430853	4	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA410656572 rs755430853	4	P>R		No	ClinGen ExAC TOPMed gnomAD
CA321377866 rs537105916	4	P>S		No	ClinGen gnomAD
CA410656585 rs537105916	4	P>T		No	ClinGen gnomAD
CA10097085 rs780536698	5	G>D		No	ClinGen ExAC gnomAD
CA10097086 rs749850729	5	G>S		No	ClinGen ExAC gnomAD
rs756509847 CA410656536	6	A>G		No	ClinGen ExAC TOPMed gnomAD
CA410656550 rs1200030269	6	A>T		No	ClinGen TOPMed gnomAD
CA10097084 rs756509847	6	A>V		No	ClinGen ExAC TOPMed gnomAD
rs114771984 RCV000880692 CA10097083	7	S>A		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA10097082 rs145030716	7	S>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs114771984 CA410656530	7	S>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs532703283 CA10097079	8	A>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs532703283 CA321377839	8	A>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1322065209 CA410656502	8	A>V	Variant assessed as Somatic; 5.586e-05 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs201845619 CA410656492	9	S>L		No	ClinGen ExAC TOPMed gnomAD
CA10097076 rs145246090	9	S>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA10097077 rs145246090	9	S>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs201845619 CA10097075	9	S>W		No	ClinGen ExAC TOPMed gnomAD
CA10097074 rs370561261	10	S>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA410656478 rs370561261	10	S>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs1316988424 CA410656486	10	S>P		No	ClinGen TOPMed gnomAD
rs768822340 CA10097070	13	L>F		No	ClinGen ExAC TOPMed gnomAD
rs768822340 CA10097071	13	L>I		No	ClinGen ExAC TOPMed gnomAD
rs749359650 CA10097069	13	L>P		No	ClinGen ExAC gnomAD
CA10097068 rs367802920	14	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs367802920 CA410656414	14	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA321377811 rs983454485	16	A>P		No	ClinGen Ensembl
CA321377808 rs960245551	16	A>V		No	ClinGen TOPMed gnomAD
CA10097065 rs781727502	18	R>K		No	ClinGen ExAC TOPMed gnomAD
rs781727502 CA410656324	18	R>T		No	ClinGen ExAC TOPMed gnomAD
CA10097063 rs530916835	19	P>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs551093700 CA10097064	19	P>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs777318051 CA10097062	20	P>L		No	ClinGen ExAC gnomAD
rs1288488136 CA410656261	21	R>K		No	ClinGen TOPMed
rs1460293541 CA410656224	23	R>G		No	ClinGen TOPMed gnomAD
rs752214453 CA410656185	25	A>G		No	ClinGen ExAC TOPMed gnomAD
rs752214453 CA10097060	25	A>V		No	ClinGen ExAC TOPMed gnomAD
CA410656173 rs1326204746	26	G>E		No	ClinGen gnomAD
CA10097059 rs765094825	27	E>G		No	ClinGen ExAC gnomAD
CA410656141 rs1433805214	28	A>V		No	ClinGen gnomAD
CA10097058 rs544823271	29	G>E		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	29	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA410656132 rs1422837448	30	A>P		No	ClinGen TOPMed gnomAD
rs766214563 CA10097056	30	A>V		No	ClinGen ExAC TOPMed gnomAD
VAR_015117 rs113904207 CA10097055	31	A>V		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA10097053 rs768784402	35	Q>P		No	ClinGen ExAC gnomAD
CA10097052 rs763021146	36	R>G		No	ClinGen ExAC gnomAD
CA410656028 rs1156924914	36	R>Q		No	ClinGen TOPMed gnomAD
rs780419082 CA321377766	37	V>G		No	ClinGen Ensembl
rs1569115426 CA410655994	39	D>E		No	ClinGen Ensembl
rs746425961 CA10097049	41	E>A		No	ClinGen ExAC gnomAD
rs1442997855 CA410655966	41	E>D		No	ClinGen TOPMed gnomAD
rs1242934528 CA410655964	42	E>Q		No	ClinGen gnomAD
rs201081961 CA321376861	47	L>F		No	ClinGen 1000Genomes TOPMed
COSM1641489 CA10097027 rs375829121	49	T>M	stomach [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs1305839151 CA410655478	50	V>A		No	ClinGen TOPMed
CA410655483 rs1431413489	50	V>L		No	ClinGen gnomAD
CA410655469 rs1328060994	51	I>F		No	ClinGen gnomAD
rs1300151959 CA410655452	52	Q>*		No	ClinGen gnomAD
rs1300151959 CA410655454	52	Q>E		No	ClinGen gnomAD
TCGA novel	54	D>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10097024 rs372370162	54	D>G		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	55	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA321376850 rs977468788	57	P>A		No	ClinGen Ensembl
rs368156510 CA10097023	57	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA10097021 rs756071081	60	E>*		No	ClinGen ExAC gnomAD
CA321376839 rs11542546	61	K>E		No	ClinGen Ensembl
CA410655343 rs1264845622	61	K>R		No	ClinGen TOPMed
CA410655336 rs1197872057	62	L>V		No	ClinGen gnomAD
rs374006759 CA321376834	63	Q>R		No	ClinGen ESP
rs1029580611 CA321376830	65	Q>*		No	ClinGen Ensembl
rs967639937 CA321376820	65	Q>R		No	ClinGen TOPMed
CA321376816 rs998604062	66	K>R		No	ClinGen Ensembl
rs1555916281 CA410655287	67	E>K		No	ClinGen Ensembl
rs1555916281 CA410655286	67	E>Q		No	ClinGen Ensembl
rs535319919 CA10097017	69	L>P		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	70	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs752924065 CA10097016	71	A>G		No	ClinGen ExAC TOPMed gnomAD
CA410655232 rs559394479	72	E>*		No	ClinGen ExAC TOPMed gnomAD
CA10097013 rs559394479	72	E>K		No	ClinGen ExAC TOPMed gnomAD
CA10097012 rs766906980	73	E>Q		No	ClinGen ExAC gnomAD
CA321376770 rs144603309	79	R>P		No	ClinGen ESP ExAC gnomAD
CA10097008 rs144603309	79	R>Q		No	ClinGen ESP ExAC gnomAD
CA10097009 rs772367223	79	R>W		No	ClinGen ExAC TOPMed gnomAD
CA410655134 rs773947416	81	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA10097007 rs773947416	81	R>G		No	ClinGen ExAC gnomAD
rs1408770768 CA410655129	81	R>H		No	ClinGen TOPMed
CA10097005 rs569930086 CA410655115	82	Q>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC gnomAD NCI-TCGA
TCGA novel	83	I>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	85	I>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10097004 rs779486009	86	K>T		No	ClinGen ExAC gnomAD
rs756053981 CA10097003	89	S>P		No	ClinGen ExAC gnomAD
CA321376748 rs745829152	90	A>P		No	ClinGen ExAC TOPMed gnomAD
CA10097002 rs745829152	90	A>T		No	ClinGen ExAC TOPMed gnomAD
rs139706843 CA10097000	93	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs201700740 CA321376722	95	S>T		No	ClinGen 1000Genomes
CA10096996 rs200418708	96	R>Q		No	ClinGen ExAC gnomAD
rs549848339 CA10096997 COSM444694	96	R>W	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA410654959 rs766419391	97	E>D		No	ClinGen ExAC TOPMed gnomAD
CA321376715 rs949777513	97	E>Q		No	ClinGen TOPMed
rs915598787 CA321376708	98	P>L		No	ClinGen TOPMed gnomAD
rs761214188 CA410654952	98	P>S		No	ClinGen ExAC gnomAD
rs761214188 CA10096994	98	P>T		No	ClinGen ExAC gnomAD
CA10096993 rs111488352 RCV000951355	99	P>L		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA321376706 rs1056088337	99	P>S		No	ClinGen Ensembl
rs774706476 CA410654929	101	P>A		No	ClinGen ExAC TOPMed gnomAD
rs774706476 CA10096990	101	P>S		No	ClinGen ExAC TOPMed gnomAD
CA10096954 rs142891341	102	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA10096989 rs768281956	102	Y>D		No	ClinGen ExAC TOPMed gnomAD
rs1361818462 CA410654863	104	T>N		No	ClinGen TOPMed gnomAD
CA10096953 rs781310248	104	T>P		No	ClinGen ExAC gnomAD
rs1569113298 CA410654843	106	A>T		No	ClinGen Ensembl
rs752018276 CA10096951	106	A>V		No	ClinGen ExAC gnomAD
CA10096949 rs764603196	110	T>S		No	ClinGen ExAC gnomAD
CA10096948 rs758631784	111	P>S		No	ClinGen ExAC gnomAD
rs1369995654 CA410654784	112	E>A		No	ClinGen gnomAD
rs1314325579 CA410654770	113	V>E		No	ClinGen TOPMed
rs753109294 CA10096947	114	H>R		No	ClinGen ExAC TOPMed gnomAD
rs1025308104 CA321376598	115	A>V		No	ClinGen TOPMed
CA410654740 rs1195728748	116	G>D		No	ClinGen gnomAD
rs759289271 CA10096945	116	G>R		No	ClinGen ExAC gnomAD
CA410654735 rs1195728748	116	G>V		No	ClinGen gnomAD
CA10096943 rs766028339	117	T>S		No	ClinGen ExAC gnomAD
CA10096941 rs773235843 COSM1616228	121	G>S	liver [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA10096940 rs563995948	122	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10096939 rs375055751	124	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs746126476 CA10096936	126	P>L		No	ClinGen ExAC TOPMed gnomAD
rs746126476 CA10096937	126	P>R		No	ClinGen ExAC TOPMed gnomAD
CA410654599 rs1220996257	126	P>S		No	ClinGen gnomAD
rs757275424 COSM332379 CA10096934	127	R>C	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs889267913 CA321376566	127	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs759010652 CA10096931	128	G>A		No	ClinGen ExAC gnomAD
CA10096932 rs778186461	128	G>S		No	ClinGen ExAC TOPMed gnomAD
CA10096929 rs765680928	129	R>*		No	ClinGen ExAC gnomAD
CA10096928 rs754557180	129	R>Q		No	ClinGen ExAC gnomAD
CA410654548 rs1452426012	130	G>D		No	ClinGen gnomAD
CA321376555 rs71328292	130	G>S		No	ClinGen TOPMed
CA410654518 rs767355139	132	E>A		No	ClinGen ExAC TOPMed gnomAD
CA10096922 rs767355139	132	E>V		No	ClinGen ExAC TOPMed gnomAD
rs773997518 COSM1193507 CA10096921	133	D>G	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs773997518 CA10096920	133	D>V		No	ClinGen ExAC TOPMed gnomAD
CA410653571 rs1306774936	135	E>D		No	ClinGen gnomAD
CA410653566 rs1355795208	136	A>G		No	ClinGen TOPMed
rs775330452 CA10096898	136	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1448767739 CA410653564	137	G>R		No	ClinGen gnomAD
rs1601358728 CA410653546	139	E>G		No	ClinGen Ensembl
CA410653550 rs1188925213	139	E>K		No	ClinGen gnomAD
CA410653539 rs1462095227	140	E>A		No	ClinGen TOPMed
CA321372992 rs142163076	140	E>D		No	ClinGen ESP
CA410653538 rs1462095227	140	E>G		No	ClinGen TOPMed
rs1434321467 CA410653520	142	K>N		No	ClinGen TOPMed gnomAD
rs1601358674 CA410653524	142	K>R		No	ClinGen Ensembl
CA10096895 rs773132543 COSM135908	144	P>L	skin [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1284509039 CA410653486	148	L>V		No	ClinGen gnomAD
CA410653478 rs1450136035	149	D>G		No	ClinGen gnomAD
rs935395053 CA321372980	150	V>I		No	ClinGen TOPMed
rs953742022 CA321372970	153	S>N		No	ClinGen TOPMed
CA10096891 rs769291624	154	R>C		No	ClinGen ExAC TOPMed gnomAD
rs749669668 CA10096890	154	R>H		No	ClinGen ExAC TOPMed gnomAD
rs749669668 CA410653447	154	R>P		No	ClinGen ExAC TOPMed gnomAD
CA410653435 rs1361211971	156	T>A		No	ClinGen gnomAD
rs780626777 CA10096889	156	T>M	Variant assessed as Somatic; 0.0003235 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA10096887 rs552696210	158	E>D		No	ClinGen 1000Genomes ExAC gnomAD
CA410653423 rs1413544743	158	E>K		No	ClinGen gnomAD
CA410653399 rs1422234608	160	N>S		No	ClinGen Ensembl
CA410653379 rs1474071742	161	A>V		No	ClinGen gnomAD
CA410653346 rs1410462491	164	Q>R		No	ClinGen TOPMed
CA10096886 rs780727355	165	E>D		No	ClinGen ExAC TOPMed gnomAD
COSM579525 rs756730455 CA10096885	167	M>T	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1601358355 CA410653315	167	M>V		No	ClinGen Ensembl
CA410653288 rs1264686682	169	V>A		No	ClinGen TOPMed gnomAD
CA410653278 rs1219811264	170	A>G		No	ClinGen TOPMed gnomAD
rs1219811264 CA410653277	170	A>V		No	ClinGen TOPMed gnomAD
rs534119591 CA10096884 COSM3842173	173	R>K	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA321372923 rs992474455	174	S>N		No	ClinGen TOPMed
CA10096880 rs200671779	175	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs367983628 COSM1241072 CA10096881	175	R>W	oesophagus [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs1302773116 CA410653205	176	A>V		No	ClinGen TOPMed
CA10096879 rs200014767 COSM1032019	177	R>C	endometrium [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA10096878 rs146164647	177	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA10096876 rs149239809	178	H>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10096877 rs772197640	178	H>R		No	ClinGen ExAC gnomAD
CA10096874 rs62223875	179	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA10096873 rs374567546	180	W>*		No	ClinGen ESP ExAC gnomAD
rs1221719354 CA410653159	181	L>V		No	ClinGen gnomAD
rs770232270 CA10096871	182	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA410653135 rs1243621185	183	Q>*		No	ClinGen TOPMed
rs370949168 CA10096870	185	E>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA410653014 rs1221159241	191	R>K		No	ClinGen gnomAD
rs200196233 CA10096849	192	Q>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs200196233 CA10096850	192	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA410652988 rs1159895423	194	D>E		No	ClinGen TOPMed
CA410652978 rs1410648525	196	L>F		No	ClinGen TOPMed
CA10096845 rs182094450 CA410652968	197	E>D		No	ClinGen 1000Genomes ExAC gnomAD
rs370053001 CA10096846	197	E>K	Variant assessed as Somatic; 4.62e-05 impact. [NCI-TCGA]	No	ClinGen ESP NCI-TCGA TOPMed
rs746678849 CA10096844	199	P>L		No	ClinGen ExAC TOPMed gnomAD
rs777432584 CA10096843	203	H>D		No	ClinGen ExAC gnomAD
CA10096842 rs757856073	203	H>R		No	ClinGen ExAC TOPMed gnomAD
CA410652909 rs747673537	204	Q>*		No	ClinGen ExAC gnomAD
rs747673537 CA10096841	204	Q>E		No	ClinGen ExAC gnomAD
rs778756650 CA10096840	206	I>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA321372591 rs761756482	207	E>D		No	ClinGen gnomAD
CA10096838 rs753657160	207	E>K		No	ClinGen ExAC TOPMed gnomAD
CA10096837 rs766141099	208	S>I		No	ClinGen ExAC TOPMed gnomAD
rs766141099 CA321372581	208	S>T		No	ClinGen ExAC TOPMed gnomAD
CA10096836 rs757472646	211	A>D		No	ClinGen ExAC TOPMed gnomAD
CA410652816 rs1238153125	212	S>G		No	ClinGen TOPMed gnomAD
TCGA novel	214	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA410652772 rs1214175175	215	T>A		No	ClinGen TOPMed
rs201686898 CA321372560	215	T>I		No	ClinGen Ensembl
rs530140096 CA10096833	216	W>*		No	ClinGen 1000Genomes ExAC gnomAD
rs1183321082 CA410652683	219	K>T		No	ClinGen TOPMed
CA410652660 rs775775567	220	A>G		No	ClinGen ExAC gnomAD
CA410652678 rs1233141080	220	A>T		No	ClinGen TOPMed
CA10096832 rs775775567	220	A>V		No	ClinGen ExAC gnomAD
TCGA novel	221	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	222	N>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1187751346 CA410652562	224	L>V		No	ClinGen TOPMed
CA410652524 rs1569110213	225	M>I		No	ClinGen Ensembl
rs947942799 CA321372555	226	Y>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1395967101 CA410652475	227	Y>C		No	ClinGen gnomAD
rs983667719 CA321372553	227	Y>H		No	ClinGen Ensembl
rs1569110187 CA410652465	228	P>S		No	ClinGen Ensembl
rs777022646 CA10096829	229	E>D		No	ClinGen ExAC gnomAD
CA410652293 rs1375125536	231	V>F		No	ClinGen gnomAD
CA10096799 RCV000961728 rs62619780	234	E>K		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA10096798 rs752926171	237	L>P		No	ClinGen ExAC gnomAD
CA410652127 rs1207237361	239	K>E		No	ClinGen TOPMed
rs1249231695 CA410652057	241	P>A		No	ClinGen TOPMed
CA10096797 rs779218622	241	P>L		No	ClinGen ExAC gnomAD
CA321372150 COSM1203429 rs890258477	242	R>Q	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
COSM1414857 CA10096796 rs754954476	242	R>W	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1254904381 CA410652006	243	Q>H		No	ClinGen TOPMed
rs1375981910 CA410651986	244	V>A		No	ClinGen gnomAD
rs1467305981 CA410651994	244	V>L		No	ClinGen gnomAD
rs1433988204 CA410651975	245	V>I		No	ClinGen TOPMed
CA10096794 rs766791880	246	H>P		No	ClinGen ExAC TOPMed gnomAD
rs766791880 CA410651944	246	H>R		No	ClinGen ExAC TOPMed gnomAD
CA410651949 rs1433916302	246	H>Y		No	ClinGen TOPMed gnomAD
rs996255657 CA321372126	248	N>K		No	ClinGen TOPMed
CA10096793 rs761230219	249	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA410651870 rs1259317061	250	R>C		No	ClinGen TOPMed gnomAD
rs140756028 CA10096791	250	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs566826089 CA321372070	252	L>V		No	ClinGen 1000Genomes gnomAD
rs1254846532 CA410651787	254	D>E		No	ClinGen gnomAD
rs1233531282 CA410651750	257	S>G		No	ClinGen gnomAD
rs968116729 CA410651745	257	S>N		No	ClinGen TOPMed gnomAD
rs968116729 CA321372063	257	S>T		No	ClinGen TOPMed gnomAD
CA10096790 rs762199335	258	Q>*		No	ClinGen ExAC gnomAD
CA10096789 rs773829984	259	A>V		No	ClinGen ExAC gnomAD
CA321372043 rs780719893	260	L>V		No	ClinGen TOPMed gnomAD
rs1394154916 CA410651678	261	S>N		No	ClinGen TOPMed gnomAD
rs768372613 CA10096788	262	R>K		No	ClinGen ExAC gnomAD
CA10096787 rs762361491	263	C>R		No	ClinGen ExAC TOPMed gnomAD
rs1466764172 CA410651624	264	Q>K		No	ClinGen gnomAD
rs1569109602 CA410651561	267	Q>E		No	ClinGen Ensembl
rs1439543152 CA410651520	268	A>V		No	ClinGen gnomAD
rs776739459 CA410651504	270	A>S		No	ClinGen ExAC TOPMed gnomAD
CA10096783 rs776739459	270	A>T	Variant assessed as Somatic; 0.0001621 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs770800622 CA10096782	271	L>F		No	ClinGen ExAC TOPMed gnomAD
rs770800622 CA410651497	271	L>V		No	ClinGen ExAC TOPMed gnomAD
CA321371965 rs1037688310	272	N>S		No	ClinGen gnomAD
CA321371958 rs1022711974	273	A>D		No	ClinGen TOPMed gnomAD
CA410650514 rs1248663967	276	K>N		No	ClinGen TOPMed
CA410650521 rs1190601531	276	K>Q		No	ClinGen TOPMed
CA10096740 rs770011574	277	Q>*		No	ClinGen ExAC gnomAD
CA321371121 rs1055826827	277	Q>R		No	ClinGen TOPMed gnomAD
CA10096738 rs781293974	283	D>N		No	ClinGen ExAC TOPMed gnomAD
CA410650284 rs1234692962	285	K>N		No	ClinGen gnomAD
TCGA novel	286	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1441883104 CA410650193	291	E>*		No	ClinGen gnomAD
rs1441883104 CA410650197	291	E>Q		No	ClinGen gnomAD
CA321371086 rs146974447	292	S>C		No	ClinGen ESP TOPMed gnomAD
CA10096734 rs148317214	294	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA410650104 rs1376107867	296	G>A		No	ClinGen TOPMed gnomAD
CA410650109 rs1247296989	296	G>C		No	ClinGen gnomAD
CA410650044 rs1446707118	301	V>I		No	ClinGen gnomAD
rs1359234759 CA410650032	302	A>T		No	ClinGen TOPMed gnomAD
rs1234515125 CA410650011	303	T>A		No	ClinGen TOPMed
CA410650000 rs1260442989	303	T>I		No	ClinGen TOPMed
CA410649977 rs1417422785	305	S>C		No	ClinGen gnomAD
rs893421219 CA321371007	306	P>L		No	ClinGen Ensembl
TCGA novel	306	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs982092347 CA321371014	306	P>T		No	ClinGen TOPMed gnomAD
CA10096729 rs753377366	307	A>V		No	ClinGen ExAC gnomAD
CA410649922 rs1181202280	308	P>S		No	ClinGen TOPMed gnomAD
rs528925233 CA321370959	309	G>R		No	ClinGen 1000Genomes
rs1336035873 CA410649688	310	V>L		No	ClinGen gnomAD
rs117976088 CA321370141	311	N>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA321370147 rs993590982	311	N>S		No	ClinGen TOPMed
rs1319331770 CA410649653	312	E>A		No	ClinGen TOPMed
COSM182020 rs202175079 CA10096704	312	E>K	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA410649607 rs1383497874	314	P>L		No	ClinGen TOPMed gnomAD
rs766513749 CA10096702	315	M>L		No	ClinGen ExAC gnomAD
rs1458368861 CA410649561	317	T>I		No	ClinGen gnomAD
CA321370099 rs1027716692	318	W>C		No	ClinGen TOPMed
CA10096701 rs760804299	318	W>L		No	ClinGen ExAC gnomAD
rs1464199559 CA410649526	320	E>*		No	ClinGen gnomAD
rs1179182223 CA410649522	320	E>G		No	ClinGen TOPMed gnomAD
TCGA novel	320	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA410649511 rs1171417356	321	V>F		No	ClinGen gnomAD
rs1347763873 CA410649496	322	E>G		No	ClinGen TOPMed
rs142149550 CA410649481	323	N>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10096698 rs748705227	324	T>A		No	ClinGen ExAC gnomAD
rs775031102 CA10096697	324	T>I		No	ClinGen ExAC gnomAD
rs775031102 CA410649472	324	T>K		No	ClinGen ExAC gnomAD
CA10096694 rs755792682	325	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA10096693 rs755792682	325	P>R		No	ClinGen ExAC gnomAD
rs749686222 CA10096695	325	P>S		No	ClinGen ExAC gnomAD
CA10096692 rs549781957	327	R>S		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	328	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1310026727 CA410649427	328	V>I		No	ClinGen gnomAD
rs1300140911 CA410649393	330	G>E		No	ClinGen gnomAD
CA10096691 rs780602798	331	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs533003983 CA10096689	333	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
CA410649333 rs1463567466	335	Y>F		No	ClinGen gnomAD
rs758121446 CA10096687	335	Y>H		No	ClinGen ExAC TOPMed gnomAD
CA410649323 rs17743887 CA10096685	336	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10096684 rs17743887 VAR_015118	336	V>M		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1386332094 CA410649302	338	R>G		No	ClinGen TOPMed
CA410649300 rs1455019924	338	R>K		No	ClinGen gnomAD
rs1177317678 CA410649277	340	P>R		No	ClinGen gnomAD
CA321369973 rs949975061	340	P>S		No	ClinGen gnomAD
rs767457150 CA410649269	341	G>C		No	ClinGen ExAC gnomAD
rs767457150 CA10096682	341	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA410649263 rs1197088174	341	G>V		No	ClinGen gnomAD
TCGA novel	342	P>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA410648893 rs1160816383	347	L>P		No	ClinGen gnomAD
CA410648889 rs1456783061	348	E>K		No	ClinGen gnomAD
CA10096660 rs764689359	349	P>A		No	ClinGen ExAC TOPMed gnomAD
rs776091656 CA10096658	351	R>C		No	ClinGen ExAC gnomAD
CA321368017 rs968360558	351	R>H		No	ClinGen TOPMed gnomAD
CA410648829 rs968360558	351	R>L		No	ClinGen TOPMed gnomAD
rs200861284 CA10096654	354	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA10096655 rs776077837	354	R>W		No	ClinGen ExAC TOPMed gnomAD
CA10096652 rs777313231	358	K>R		No	ClinGen ExAC TOPMed gnomAD
rs771966191 CA10096651	359	M>V		No	ClinGen ExAC gnomAD
rs1320758640 CA410648701	361	N>S		No	ClinGen TOPMed
CA10096649 rs747995432	362	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs747995432 CA410648683	362	E>Q		No	ClinGen ExAC gnomAD
CA10096647 rs754673515	364	A>S		No	ClinGen ExAC gnomAD
COSM1032017 rs754673515 CA410648651	364	A>T	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA410648613 rs1166965917	366	K>R		No	ClinGen gnomAD
CA10096642 rs540493772	368	R>P		No	ClinGen 1000Genomes ExAC gnomAD
CA10096643 rs540493772	368	R>Q		No	ClinGen 1000Genomes ExAC gnomAD
rs757615100 CA10096644	368	R>W		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	373	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs753084383 CA10096640	373	E>K		No	ClinGen ExAC gnomAD
rs1253620886 CA410648475	374	A>S		No	ClinGen gnomAD
CA321367866 rs368257897 COSM1641488	376	R>Q	stomach [Cosmic]	No	ClinGen cosmic curated gnomAD
rs369834780 CA321367873	376	R>W		No	ClinGen ESP gnomAD
CA10096639 rs574659489	378	V>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs759812764 CA10096638	379	T>M		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	380	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	380	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs777110426 CA10096637	381	N>S		No	ClinGen ExAC TOPMed gnomAD
rs140145367 CA10096634	383	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA410647527 rs1601342736	385	L>F		No	ClinGen Ensembl
rs1378096431 CA410647511	386	T>A		No	ClinGen TOPMed
CA410647502 rs1438233431	386	T>I		No	ClinGen TOPMed
CA410647514 rs1378096431	386	T>P		No	ClinGen TOPMed
rs1234617963 CA410647485	387	P>R		No	ClinGen TOPMed gnomAD
CA410647489 rs1470558412	387	P>S		No	ClinGen gnomAD
CA10096614 rs773975522	388	K>R		No	ClinGen ExAC gnomAD
TCGA novel	389	G>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA410647459 rs1457810365	389	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1601342603 CA410647434	390	L>R		No	ClinGen Ensembl
rs146152930 CA10096613	390	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1601342558 CA410647351	394	M>T		No	ClinGen Ensembl
CA10096612 rs142030383	394	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs775604081 CA10096611	395	S>L		No	ClinGen ExAC gnomAD
rs745674810 CA10096609	396	P>S		No	ClinGen ExAC TOPMed gnomAD
rs1281871091 CA410647275	397	A>S		No	ClinGen gnomAD
rs1413819655 CA410647258	398	L>P		No	ClinGen gnomAD
rs778130843 CA10096608	399	Q>E		No	ClinGen ExAC gnomAD
rs534156960 CA10096607	399	Q>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs748146654 CA10096606	400	R>C		No	ClinGen ExAC gnomAD
CA10096605 rs575074091	400	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA410647227 rs575074091	400	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1159765342 CA410647188	403	S>R		No	ClinGen gnomAD
COSM1414855 CA410647170 rs1410300640	405	T>M	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs766875280 CA10096602	406	A>D		No	ClinGen ExAC gnomAD
rs750843358 CA10096600	408	K>T		No	ClinGen ExAC gnomAD
CA10096598 rs761563805	411	D>N		No	ClinGen ExAC gnomAD
CA410647068 rs186717850	412	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10096595 rs763606714	412	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA10096596 rs186717850	412	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10096593 rs775514047 COSM1032016	415	R>Q	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs377464869 CA10096594	415	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1361045054 CA410646962	418	Y>F		No	ClinGen gnomAD
rs769912652 CA10096592	420	P>S		No	ClinGen ExAC gnomAD
rs712965 CA321367056	423	A>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs712965 CA321367050	423	A>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs712965 CA10096591 VAR_015119	423	A>V		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs751194608 CA321367028	424	R>C		No	ClinGen TOPMed gnomAD
rs776531141 CA10096590	424	R>H		No	ClinGen ExAC TOPMed gnomAD
rs776531141 CA410646892	424	R>L		No	ClinGen ExAC TOPMed gnomAD
CA410646889 rs776531141	424	R>P		No	ClinGen ExAC TOPMed gnomAD
rs200592269 CA10096589	426	T>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA410646876 rs1601342185	426	T>P		No	ClinGen Ensembl
rs779035330 CA10096587	427	H>D		No	ClinGen ExAC gnomAD
rs768714246 CA10096586	427	H>Q		No	ClinGen ExAC TOPMed gnomAD
CA10096585 rs749383026	428	L>F		No	ClinGen ExAC TOPMed gnomAD
CA410646853 rs749383026	428	L>V		No	ClinGen ExAC TOPMed gnomAD
CA321366981 rs991861629	429	K>E		No	ClinGen TOPMed
CA10096584 rs137995273	430	T>S		No	ClinGen ESP ExAC
CA10096583 rs756678975	431	P>L		No	ClinGen ExAC TOPMed gnomAD
rs781653916 CA10096581	432	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA321366953 rs1036269035	432	A>V		No	ClinGen TOPMed
rs1468552242 CA410646796	433	S>G		No	ClinGen gnomAD
rs751161380 CA10096579	434	G>R		No	ClinGen ExAC TOPMed gnomAD
CA10096577 rs762542001	437	T>A		No	ClinGen ExAC gnomAD
rs765237389 CA10096575	437	T>I		No	ClinGen ExAC TOPMed gnomAD
CA10096576 rs765237389	437	T>N		No	ClinGen ExAC TOPMed gnomAD
CA410646746 rs762542001	437	T>P		No	ClinGen ExAC gnomAD
CA321366896 COSM1714140 rs533285660	438	P>L	skin [Cosmic]	No	ClinGen cosmic curated Ensembl
rs1325145831 CA410646716	439	T>I		No	ClinGen gnomAD
rs146964365 CA10096571	440	S>G		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	440	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs368459829 CA10096570	441	T>A		No	ClinGen ESP ExAC gnomAD
COSM1032015 CA10096569 rs768922267	442	P>L	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA10096567 rs780144981 COSM3842170	443	A>V	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs746322500 CA10096565	444	P>S		No	ClinGen ExAC gnomAD
CA10096564 rs377733215	445	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs962807666 CA410646672	446	S>C		No	ClinGen gnomAD
CA321366812 rs962807666	446	S>F		No	ClinGen gnomAD
rs975182762 CA321366820	446	S>P		No	ClinGen Ensembl
CA410646662 rs1206100325	448	T>I		No	ClinGen TOPMed gnomAD
CA321366800 rs367552506	448	T>P		No	ClinGen ExAC TOPMed gnomAD
rs367552506 CA10096562	448	T>S		No	ClinGen ExAC TOPMed gnomAD
rs551191358 CA10096560	449	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs551191358 CA10096561	449	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs142803658 CA10096559	449	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs142803658 CA410646659	449	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs138868865 CA10096557	454	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs766241326 CA10096555	456	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs753742890 CA10096556	456	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs772946229 CA10096553	457	A>S		No	ClinGen ExAC TOPMed gnomAD
rs1431813963 CA410646606	458	S>F		No	ClinGen gnomAD
CA410646602 rs1402865145	459	I>F		No	ClinGen TOPMed
rs113582836 CA321366717	462	N>S		No	ClinGen Ensembl
CA10096549 rs769820225	465	Q>*		No	ClinGen ExAC gnomAD
CA410646541 rs375484595	469	R>G		No	ClinGen ESP TOPMed gnomAD
CA10096548 rs745952527	469	R>Q		No	ClinGen ExAC gnomAD
CA321366661 rs375484595	469	R>W		No	ClinGen ESP TOPMed gnomAD
rs200628413 CA10096546	470	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs777185987 CA10096547	470	R>S		No	ClinGen ExAC gnomAD
rs747371131 CA10096545 COSM1032013	472	A>T	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1349762892 CA410646522	472	A>V		No	ClinGen gnomAD
rs61737477 CA10096544	473	S>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA321366636 rs61737477	473	S>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1168613190 CA410646520	473	S>P		No	ClinGen gnomAD
CA10096543 rs61737477	473	S>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs778713377 CA10096541	474	D>N		No	ClinGen ExAC gnomAD
CA410646517 rs778713377	474	D>Y		No	ClinGen ExAC gnomAD
rs1411710864 CA410646490	477	F>W		No	ClinGen gnomAD

No associated diseases with Q96DF8

No regional properties for Q96DF8

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q96DF8

Functions

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

2 GO annotations of cellular component

Name	Definition
catalytic step 2 spliceosome	A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

No GO annotations of molecular function

Name	Definition
No GO annotations for molecular function

2 GO annotations of biological process

Name	Definition
mRNA splicing, via spliceosome	The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
nervous system development	The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
O70279	Ess2	Splicing factor ESS-2 homolog	Mus musculus (Mouse)	PR

10	20	30	40	50	60
METPGASASS	LLLPAASRPP	RKREAGEAGA	ATSKQRVLDE	EEYIEGLQTV	IQRDFFPDVE
70	80	90	100	110	120
KLQAQKEYLE	AEENGDLERM	RQIAIKFGSA	LGKMSREPPP	PYVTPATFET	PEVHAGTGVV
130	140	150	160	170	180
GNKPRPRGRG	LEDGEAGEEE	EKEPLPSLDV	FLSRYTSEDN	ASFQEIMEVA	KERSRARHAW
190	200	210	220	230	240
LYQAEEEFEK	RQKDNLELPS	AEHQAIESSQ	ASVETWKYKA	KNSLMYYPEG	VPDEEQLFKK
250	260	270	280	290	300
PRQVVHKNTR	FLRDPFSQAL	SRCQLQQAAA	LNAQHKQGKV	GPDGKELIPQ	ESPRVGGFGF
310	320	330	340	350	360
VATPSPAPGV	NESPMMTWGE	VENTPLRVEG	SETPYVDRTP	GPAFKILEPG	RRERLGLKMA
370	380	390	400	410	420
NEAAAKNRAK	KQEALRRVTE	NLASLTPKGL	SPAMSPALQR	LVSRTASKYT	DRALRASYTP
430	440	450	460	470
SPARSTHLKT	PASGLQTPTS	TPAPGSATRT	PLTQDPASIT	DNLLQLPARR	KASDFF