AiPD: Autoinhibited Protein Database

Gene name	Ess2 (Dgcr14, Dgsi, Es2, Es2el)
Protein name	Splicing factor ESS-2 homolog
Names	ES2 protein, Expressed sequence 2 embryonic lethal
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:27886
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

391-466 (Predicted disordered autoinhibitory region) PR

391-466 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-O70279-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3405834173	16	A>P	No	EVA
rs3389402635	84	R>L	No	EVA
rs3389405126	97	I>T	No	EVA
rs3389374070	106	V>D	No	EVA
rs3389398507	123	L>M	No	EVA
rs3389409602	193	K>E	No	EVA
rs3389413276	233	G>D	No	EVA
rs3389402248	236	D>G	No	EVA
rs3389374088	255	L>P	No	EVA
rs3389395050	258	P>S	No	EVA
rs3389384362	262	A>G	No	EVA
rs3389374028	267	Q>L	No	EVA
rs3389402638	282	K>Q	No	EVA
rs3389374092	345	P>L	No	EVA
rs3389365235	380	R>T	No	EVA
rs3389398535	404	L>I	No	EVA
rs3389405119	428	S>Y	No	EVA
rs3389394998	434	P>R	No	EVA
rs3389374004	446	A>V	No	EVA
rs3389384365	455	L>P	No	EVA

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for O70279

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
catalytic step 2 spliceosome	A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

Name	Definition
No GO annotations for molecular function

Name	Definition
mRNA processing	Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
nervous system development	The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
RNA splicing	The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q96DF8	ESS2	Splicing factor ESS-2 homolog	Homo sapiens (Human)	PR