Q949X7
Gene name |
LYSA1 (At3g14390, MLN21.17) |
Protein name |
Diaminopimelate decarboxylase 1, chloroplastic |
Names |
DAP decarboxylase 1, DAPDC 1 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G14390 |
EC number |
4.1.1.20: Carboxy-lyases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q949X7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 6N2A | X-ray | 188 A | A/B | 63-484 | PDB |
| AF-Q949X7-F1 | Predicted | AlphaFoldDB |
25 variants for Q949X7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH02143834 | 26 | R>L | No | 1000Genomes | |
| tmp_3_4806868_T_G | 33 | L>W | No | 1000Genomes | |
| tmp_3_4806900_C_G | 44 | R>G | No | 1000Genomes | |
| ENSVATH13917140 | 46 | S>P | No | 1000Genomes | |
| tmp_3_4806919_C_A | 50 | A>D | No | 1000Genomes | |
| ENSVATH10673423 | 51 | V>A | No | 1000Genomes | |
| ENSVATH05829438 | 99 | K>R | No | 1000Genomes | |
| ENSVATH05829439 | 117 | S>N | No | 1000Genomes | |
| ENSVATH10673424 | 162 | T>K | No | 1000Genomes | |
| ENSVATH05829440 | 176 | L>I | No | 1000Genomes | |
| ENSVATH02143837 | 195 | N>T | No | 1000Genomes | |
| tmp_3_4807564_C_T | 220 | P>S | No | 1000Genomes | |
| tmp_3_4807717_A_G | 239 | N>D | No | 1000Genomes | |
| ENSVATH10673439 | 249 | V>I | No | 1000Genomes | |
| tmp_3_4807802_C_T | 267 | S>F | No | 1000Genomes | |
| tmp_3_4808018_G_A | 290 | R>Q | No | 1000Genomes | |
| tmp_3_4808034_A_C | 295 | E>D | No | 1000Genomes | |
| ENSVATH13917141 | 314 | A>T | No | 1000Genomes | |
| ENSVATH10673442 | 320 | M>I | No | 1000Genomes | |
| ENSVATH13917142 | 328 | E>G | No | 1000Genomes | |
| ENSVATH05829448 | 334 | D>N | No | 1000Genomes | |
| tmp_3_4808353_G_A | 375 | A>T | No | 1000Genomes | |
| ENSVATH05829450 | 398 | E>D | No | 1000Genomes | |
| ENSVATH05829449 | 398 | E>G | No | 1000Genomes | |
| ENSVATH10673476 | 400 | E>D | No | 1000Genomes |
No associated diseases with Q949X7
4 regional properties for Q949X7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Orn/DAP/Arg decarboxylase 2, C-terminal | 98 - 438 | IPR022643 |
| domain | Orn/DAP/Arg decarboxylase 2, N-terminal | 101 - 347 | IPR022644 |
| binding_site | Orn/DAP/Arg decarboxylase 2, pyridoxal-phosphate binding site | 122 - 140 | IPR022653 |
| conserved_site | Orn/DAP/Arg decarboxylase 2, conserved site | 293 - 306 | IPR022657 |
Functions
| Description | ||
|---|---|---|
| EC Number | 4.1.1.20 | Carboxy-lyases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| chloroplast | A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. |
| chloroplast stroma | The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| diaminopimelate decarboxylase activity | Catalysis of the reaction: meso-2,6-diaminopimelate + H(+) = L-lysine + CO(2). |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| lysine biosynthetic process via diaminopimelate | The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P00861 | lysA | Diaminopimelate decarboxylase | Escherichia coli (strain K12) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAAATQFLSQ | PSSLNPHQLK | NQTSQRSRSI | PVLSLKSTLK | PLKRLSVKAA | VVSQNSSKTV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TKFDHCFKKS | SDGFLYCEGT | KVEDIMESVE | RRPFYLYSKP | QITRNLEAYK | EALEGVSSVI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GYAIKANNNL | KILEHLRSLG | CGAVLVSGNE | LRLALRAGFD | PTKCIFNGNG | KSLEDLVLAA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QEGVFVNVDS | EFDLNNIVEA | SRISGKQVNV | LLRINPDVDP | QVHPYVATGN | KNSKFGIRNE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KLQWFLDQVK | AHPKELKLVG | AHCHLGSTIT | KVDIFRDAAV | LMIEYIDEIR | RQGFEVSYLN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| IGGGLGIDYY | HAGAVLPTPM | DLINTVRELV | LSRDLNLIIE | PGRSLIANTC | CFVNHVTGVK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TNGTKNFIVI | DGSMAELIRP | SLYDAYQHIE | LVSPPPAEAE | VTKFDVVGPV | CESADFLGKD |
| 430 | 440 | 450 | 460 | 470 | 480 |
| RELPTPPQGA | GLVVHDAGAY | CMSMASTYNL | KMRPPEYWVE | EDGSITKIRH | AETFDDHLRF |
| FEGL |