P00861
Gene name |
lysA |
Protein name |
Diaminopimelate decarboxylase |
Names |
DAP decarboxylase, DAPDC |
Species |
Escherichia coli (strain K12) |
KEGG Pathway |
eco:b2838 |
EC number |
4.1.1.20: Carboxy-lyases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
3 structures for P00861
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1KNW | X-ray | 210 A | A | 1-420 | PDB |
| 1KO0 | X-ray | 220 A | A | 1-420 | PDB |
| AF-P00861-F1 | Predicted | AlphaFoldDB |
No variants for P00861
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P00861 | |||||
No associated diseases with P00861
4 regional properties for P00861
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Orn/DAP/Arg decarboxylase 2, C-terminal | 32 - 376 | IPR022643 |
| domain | Orn/DAP/Arg decarboxylase 2, N-terminal | 33 - 275 | IPR022644 |
| binding_site | Orn/DAP/Arg decarboxylase 2, pyridoxal-phosphate binding site | 51 - 69 | IPR022653 |
| conserved_site | Orn/DAP/Arg decarboxylase 2, conserved site | 216 - 229 | IPR022657 |
Functions
| Description | ||
|---|---|---|
| EC Number | 4.1.1.20 | Carboxy-lyases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| diaminopimelate decarboxylase activity | Catalysis of the reaction: meso-2,6-diaminopimelate + H(+) = L-lysine + CO(2). |
| pyridoxal phosphate binding | Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| lysine biosynthetic process via diaminopimelate | The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q949X7 | LYSA1 | Diaminopimelate decarboxylase 1, chloroplastic | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPHSLFSTDT | DLTAENLLRL | PAEFGCPVWV | YDAQIIRRQI | AALKQFDVVR | FAQKACSNIH |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ILRLMREQGV | KVDSVSLGEI | ERALAAGYNP | QTHPDDIVFT | ADVIDQATLE | RVSELQIPVN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AGSVDMLDQL | GQVSPGHRVW | LRVNPGFGHG | HSQKTNTGGE | NSKHGIWYTD | LPAALDVIQR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| HHLQLVGIHM | HIGSGVDYAH | LEQVCGAMVR | QVIEFGQDLQ | AISAGGGLSV | PYQQGEEAVD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TEHYYGLWNA | AREQIARHLG | HPVKLEIEPG | RFLVAQSGVL | ITQVRSVKQM | GSRHFVLVDA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GFNDLMRPAM | YGSYHHISAL | AADGRSLEHA | PTVETVVAGP | LCESGDVFTQ | QEGGNVETRA |
| 370 | 380 | 390 | 400 | 410 | |
| LPEVKAGDYL | VLHDTGAYGA | SMSSNYNSRP | LLPEVLFDNG | QARLIRRRQT | IEELLALELL |