AiPD: Autoinhibited Protein Database

Gene name	Tram2
Protein name	Translocating chain-associated membrane protein 2
Names
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:170829
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

292-370 (Predicted disordered autoinhibitory region) PR

292-370 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q924Z5-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388459091	42	T>I	No	EVA
rs3388460166	59	P>S	No	EVA
rs3389711843	65	T>S	No	EVA
rs3388459238	68	Y>F	No	EVA
rs3388459192	95	Y>N	No	EVA
rs3389688220	101	S>*	No	EVA
rs3389688220	101	S>L	No	EVA
rs3389649974	104	L>H	No	EVA
rs3388459872	130	W>L	No	EVA
rs3388460173	132	F>I	No	EVA
rs36818066	136	V>I	No	EVA
rs3388461301	140	Y>F	No	EVA
rs3388460040	194	Y>*	No	EVA
rs3388460187	206	Y>H	No	EVA
rs3389711811	228	F>L	No	EVA
rs3389722244	228	F>Y	No	EVA
rs3388459049	233	L>F	No	EVA
rs3388459009	245	F>Y	No	EVA
rs3413018967	278	V>L	No	EVA
rs3388459806	290	P>T	No	EVA
rs864262112	291	C>S	No	EVA
rs3388460124	326	S>N	No	EVA
rs260142904	329	R>H	No	EVA
rs236000505	334	V>A	No	EVA
rs220774931	337	P>L	No	EVA
rs3388459335	349	H>Q	No	EVA

Type	Name	Position	InterPro Accession
domain	TRAM/LAG1/CLN8 homology domain	112 - 321	IPR006634
domain	TRAM1-like protein	49 - 110	IPR013599

		Description
EC Number
Subcellular Localization	Membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
integral component of endoplasmic reticulum membrane	The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

Name	Definition
No GO annotations for molecular function

Name	Definition
collagen biosynthetic process	The chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).
protein insertion into ER membrane	The process that results in incorporation of a protein into an endoplasmic reticulum (ER) membrane. It depends on specific topogenic sequences of amino acids that ensure that a protein acquires the proper orientation during its insertion into the ER membrane.
SRP-dependent cotranslational protein targeting to membrane, translocation	The process during cotranslational membrane targeting wherein proteins move across a membrane. SRP and its receptor initiate the transfer of the nascent chain across the endoplasmic reticulum (ER) membrane; they then dissociate from the chain, which is transferred to a set of transmembrane proteins, collectively called the translocon. Once the nascent chain translocon complex is assembled, the elongating chain passes directly from the large ribosomal subunit into the centers of the translocon, a protein-lined channel within the membrane. The growing chain is never exposed to the cytosol and does not fold until it reaches the ER lumen.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q15035	TRAM2	Translocating chain-associated membrane protein 2	Homo sapiens (Human)	PR