AiPD: Autoinhibited Protein Database

Q15035

Gene name	TRAM2 (KIAA0057)
Protein name	Translocating chain-associated membrane protein 2
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:9697
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

292-370 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

292-370 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q15035

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q15035-F1	Predicted				AlphaFoldDB

255 variants for Q15035

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA139015206 rs917481116	3	F>C		No	ClinGen TOPMed gnomAD
CA364457256 rs1166280675	4	R>C		No	ClinGen TOPMed
CA139015190 rs893631122	6	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1055026180 CA139015180	7	T>M		No	ClinGen Ensembl
rs1014827136 CA139015166	10	Y>S		No	ClinGen Ensembl
CA3856787 rs774335373	11	P>A		No	ClinGen ExAC gnomAD
rs940205416 CA139015165	11	P>R		No	ClinGen TOPMed
rs910017104 CA139015160	12	L>P		No	ClinGen TOPMed gnomAD
rs558653246 CA3856785	15	Q>P		No	ClinGen 1000Genomes ExAC gnomAD
CA139015151 rs927602746	16	E>K		No	ClinGen Ensembl
CA139015150 rs984557992	17	F>L		No	ClinGen TOPMed
CA3856784 rs538768694	19	I>F		No	ClinGen 1000Genomes ExAC gnomAD
CA139015145 rs951849587	19	I>T		No	ClinGen TOPMed
rs867466047 CA139015122	21	N>D		No	ClinGen Ensembl
CA364457059 rs1240870080	22	H>Q		No	ClinGen gnomAD
rs1471352083 CA364457054	23	A>P		No	ClinGen gnomAD
rs747547607 CA3856782	23	A>V		No	ClinGen ExAC TOPMed gnomAD
rs780770976 CA3856781	24	D>E		No	ClinGen ExAC gnomAD
CA3856780 rs754507968	25	I>L		No	ClinGen ExAC TOPMed gnomAD
rs929039181 CA139015109	25	I>M		No	ClinGen Ensembl
rs1271467688 CA364457010	27	F>L		No	ClinGen TOPMed
rs746383393 CA3856779	28	C>F		No	ClinGen ExAC gnomAD
rs1234316964 CA364457004	28	C>G		No	ClinGen TOPMed gnomAD
CA139015106 rs200909798	28	C>W		No	ClinGen Ensembl
rs1456940013 CA364456986	30	V>L		No	ClinGen gnomAD
CA364456977 rs1379030210	31	L>F		No	ClinGen gnomAD
CA3856776 rs370828858	34	L>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs764342345 CA364456942	35	I>F		No	ClinGen ExAC TOPMed gnomAD
rs756371697 CA3856774	35	I>T		No	ClinGen ExAC gnomAD
rs764342345 CA3856775	35	I>V		No	ClinGen ExAC TOPMed gnomAD
rs965982443 CA139015086	36	G>R		No	ClinGen TOPMed
CA3856772 rs767626471	38	M>L		No	ClinGen ExAC TOPMed
CA364456919 rs767626471	38	M>V		No	ClinGen ExAC TOPMed
CA3856771 rs759570092	39	F>S		No	ClinGen ExAC gnomAD
CA364456895 rs1352843512	40	E>Q		No	ClinGen gnomAD
TCGA novel	48	L>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3856752 rs766240970	49	F>C		No	ClinGen ExAC TOPMed gnomAD
rs1397053532 CA364453996	49	F>L		No	ClinGen gnomAD
rs931001562 CA138989973	51	L>S		No	ClinGen Ensembl
rs1010491529 CA138989970	54	Y>C		No	ClinGen TOPMed
CA138989967 rs754061972	55	N>D		No	ClinGen Ensembl
rs975184079 CA138989964	56	I>N		No	ClinGen gnomAD
rs975184079 CA138989961	56	I>T		No	ClinGen gnomAD
CA3856751 rs762893969	56	I>V		No	ClinGen ExAC TOPMed gnomAD
rs202012771 CA138989958	57	S>N		No	ClinGen Ensembl
CA138989955 rs537957321	58	V>L		No	ClinGen ExAC TOPMed gnomAD
CA3856750 rs537957321	58	V>M		No	ClinGen ExAC TOPMed gnomAD
rs912079339 CA138989944	59	P>R		No	ClinGen gnomAD
rs765079698 CA3856749	59	P>S		No	ClinGen ExAC
CA138989941 rs936039667	60	T>K		No	ClinGen TOPMed
CA364452455 rs1330162868	64	E>*		No	ClinGen gnomAD
rs769069443 CA3856718	66	V>M		No	ClinGen ExAC TOPMed gnomAD
rs950895673 CA364452435	67	H>D		No	ClinGen TOPMed gnomAD
rs1361062693 CA364452431	67	H>Q		No	ClinGen TOPMed gnomAD
CA138982027 rs950895673	67	H>Y		No	ClinGen TOPMed gnomAD
CA3856716 rs780299078	70	Y>C		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	71	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1427276969 CA364452384	72	P>S		No	ClinGen gnomAD
CA364452381 rs1427276969	72	P>T		No	ClinGen gnomAD
CA364452365 rs1173244715	73	K>R		No	ClinGen TOPMed gnomAD
rs1187064516 CA364452346	75	L>M		No	ClinGen gnomAD
CA3856715 rs758451152	78	I>V		No	ClinGen ExAC gnomAD
rs745957040 CA3856714	82	I>V		No	ClinGen ExAC TOPMed gnomAD
CA3856713 rs183224983	84	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA3856712 rs142881233	85	T>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs753870579 CA3856711	87	I>L		No	ClinGen ExAC
rs148442567 CA138981993	88	L>F		No	ClinGen ESP gnomAD
TCGA novel	90	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1314466949 CA364452179	91	V>G		No	ClinGen gnomAD
rs756014107 CA3856709	92	V>G		No	ClinGen ExAC gnomAD
rs752372265 CA3856708	93	Q>E		No	ClinGen ExAC gnomAD
CA3856687 rs200215792	100	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA3856686 rs762568731	102	K>R		No	ClinGen ExAC gnomAD
rs764607461 CA3856684	103	R>Q		No	ClinGen ExAC gnomAD
CA3856685 rs754282909	103	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA364451885 rs1298062508	107	S>F		No	ClinGen gnomAD
CA138981773 rs1044975984	112	S>G		No	ClinGen TOPMed
CA3856683 rs371068659	115	N>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA3856682 rs371068659	115	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1415140260 CA364451821	116	E>A		No	ClinGen gnomAD
rs772225939 CA3856681	116	E>K		No	ClinGen ExAC TOPMed gnomAD
CA364451802 rs1472098189	119	Q>*		No	ClinGen gnomAD
CA3856676 rs144551889	122	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs769855429 CA3856675	124	H>P		No	ClinGen ExAC
CA364451751 rs1277278604	126	T>I		No	ClinGen TOPMed
rs1338179962 CA364451745	127	S>L		No	ClinGen TOPMed
rs985212766 CA138981729	130	W>C		No	ClinGen TOPMed
TCGA novel	131	C>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs754872581 CA3856672	133	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA3856670 rs377433311	134	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA3856669 rs775044926	135	V>M		No	ClinGen ExAC TOPMed gnomAD
rs749967299 CA3856668	136	V>E		No	ClinGen ExAC TOPMed gnomAD
CA364451690 rs1223918888	136	V>M		No	ClinGen TOPMed
CA364451682 rs201183470	137	T>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3856667 rs201183470	137	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA364461136 rs1581869311	143	N>T		No	ClinGen Ensembl
CA139015691 rs868432779	144	P>L		No	ClinGen Ensembl
rs773637375 CA3856640	144	P>S		No	ClinGen ExAC gnomAD
rs765378412 CA3856639	145	R>G		No	ClinGen ExAC TOPMed gnomAD
CA3856638 rs762034798	146	S>G		No	ClinGen ExAC gnomAD
CA3856637 rs568794165 CA364461102	146	S>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1292347028 CA364461056	150	D>H		No	ClinGen TOPMed
rs768675125 CA3856636	151	Y>C		No	ClinGen ExAC gnomAD
rs1581869276 CA364461018	153	H>Y		No	ClinGen Ensembl
rs775372010 CA3856634	155	H>Y		No	ClinGen ExAC gnomAD
CA3856632 rs745487573	157	P>H		No	ClinGen ExAC gnomAD
rs745487573 CA3856633	157	P>L		No	ClinGen ExAC gnomAD
CA3856609 rs777322963	159	Q>R		No	ClinGen ExAC gnomAD
CA364460857 rs1356926341	166	C>*		No	ClinGen TOPMed
rs373265077 CA139014928	170	Y>C		No	ClinGen ESP TOPMed
rs373265077 CA364460818	170	Y>S		No	ClinGen ESP TOPMed
rs1467856073 CA364460795	172	L>M		No	ClinGen gnomAD
CA364460779 rs1380533431	173	H>L		No	ClinGen TOPMed
rs780476024 CA3856606	174	A>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	183	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1189616958 CA364460665	183	V>I		No	ClinGen gnomAD
CA3856604 rs750849216	184	R>Q	Variant assessed as Somatic; 0.0001849 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA364460445 rs1355312163	186	E>K		No	ClinGen TOPMed gnomAD
rs754061993 CA3856584	187	E>G		No	ClinGen ExAC gnomAD
TCGA novel	188	I>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA364460427 rs1440944636	188	I>T		No	ClinGen gnomAD
CA3856582 COSM1080263 rs189107930	190	R>H	endometrium Variant assessed as Somatic; 4.621e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs189107930 CA3856583	190	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA364460393 rs1438297950	193	Q>H		No	ClinGen TOPMed
rs1276275635 CA364460372	196	C>Y		No	ClinGen Ensembl
rs767380220 CA3856580	198	Y>H		No	ClinGen ExAC gnomAD
CA3856577 rs766129844	200	V>G		No	ClinGen ExAC TOPMed gnomAD
rs1251522557 CA364460337	202	I>V		No	ClinGen gnomAD
rs1322421654 CA364460257	212	R>C		No	ClinGen gnomAD
rs61734483 CA3856554	212	R>H		No	ClinGen ESP ExAC gnomAD
TCGA novel	214	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs774955626 CA3856550	216	I>T		No	ClinGen ExAC gnomAD
CA139012979 rs912416825	216	I>V		No	ClinGen TOPMed gnomAD
CA3856549 rs143406018	218	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA139012964 rs893253877	220	L>M		No	ClinGen TOPMed gnomAD
rs1243324020 CA364460214	220	L>P		No	ClinGen TOPMed
CA364460205 rs1419410585	221	Q>H		No	ClinGen TOPMed gnomAD
rs770260250 CA3856546	222	Y>F		No	ClinGen ExAC gnomAD
rs748336277 CA3856545	223	S>L		No	ClinGen ExAC TOPMed gnomAD
CA3856544 rs781441095	224	T>P		No	ClinGen ExAC TOPMed gnomAD
CA3856543 rs755003212	229	H>N		No	ClinGen ExAC gnomAD
rs747125419 CA3856542	230	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs758282274 CA3856540	231	A>V		No	ClinGen ExAC gnomAD
TCGA novel	232	R>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	232	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1562474489 CA364460118	235	Y>H		No	ClinGen Ensembl
CA364460099 rs1315770162	237	A>G		No	ClinGen gnomAD
TCGA novel	237	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1380831193 CA364460070	241	N>S		No	ClinGen gnomAD
CA3856536 rs757118859	242	E>K		No	ClinGen ExAC TOPMed
rs370377745 CA3856534	243	K>N		No	ClinGen ESP ExAC gnomAD
rs1392040143 CA364460054	243	K>R		No	ClinGen TOPMed
rs1300458260 CA364460048	244	L>P		No	ClinGen TOPMed
CA3856516 rs534669213	246	S>R		No	ClinGen 1000Genomes ExAC gnomAD
CA3856515 rs755811306	247	A>T		No	ClinGen ExAC gnomAD
CA3856514 rs752460433	247	A>V		No	ClinGen ExAC gnomAD
CA364460000 rs1221568437	250	A>T		No	ClinGen gnomAD
CA364459990 rs1489844209	251	V>A		No	ClinGen gnomAD
rs766905278 CA3856513	253	G>V		No	ClinGen ExAC
CA364459975 rs1288199379	254	V>I		No	ClinGen gnomAD
rs1000386345 CA139012487	255	T>P		No	ClinGen gnomAD
CA364459930 rs1239903526	261	T>A		No	ClinGen gnomAD
CA364459931 rs1239903526	261	T>P		No	ClinGen gnomAD
rs1316531007 CA364459923	262	L>F		No	ClinGen gnomAD
rs1045731447 CA139012477	263	A>V		No	ClinGen TOPMed
CA139012474 rs377045665	264	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3856511 rs377045665 COSM1080262	264	V>M	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA364459905 rs1351084702	266	A>T		No	ClinGen TOPMed gnomAD
CA364459898 rs1346467917	267	I>V		No	ClinGen gnomAD
rs772435370 CA3856510	273	R>C		No	ClinGen ExAC TOPMed gnomAD
COSM742536 CA3856509 rs776994347	273	R>H	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs776994347 CA364459859	273	R>L		No	ClinGen ExAC TOPMed gnomAD
rs776994347 CA3856508	273	R>P		No	ClinGen ExAC TOPMed gnomAD
CA3856504 rs772025878	274	M>K		No	ClinGen ExAC gnomAD
rs200739725 CA3856506 CA3856505	274	M>L		No	ClinGen ExAC TOPMed gnomAD
rs772025878 CA364459858	274	M>T		No	ClinGen ExAC gnomAD
CA3856507 rs200739725	274	M>V		No	ClinGen ExAC TOPMed gnomAD
CA3856503 rs745986308	275	E>G		No	ClinGen ExAC
rs778645164 CA3856502	276	N>K		No	ClinGen ExAC gnomAD
rs771002999 CA3856501	278	A>S		No	ClinGen ExAC gnomAD
rs1429665105 CA364459809	281	P>A		No	ClinGen gnomAD
TCGA novel	282	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs373852555 CA3856499	282	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs756012347 CA3856498	284	G>R		No	ClinGen ExAC gnomAD
TCGA novel	286	F>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3856497 COSM1080260 rs752268807	287	N>S	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA364459760 rs1462797146	288	T>A		No	ClinGen TOPMed
CA364459729 rs1485621272	292	R>K		No	ClinGen gnomAD
rs369134558 CA364459698	295	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs369134558 CA3856480	295	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA364459693 rs1292776142	296	L>V		No	ClinGen gnomAD
CA3856477 rs780643582	302	A>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	302	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	304	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs754674541 CA3856476	305	W>G		No	ClinGen ExAC gnomAD
rs137922566 CA364459632	306	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA3856475 rs137922566	306	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs757947724 CA3856473	309	R>C		No	ClinGen ExAC gnomAD
rs754324999 CA3856472	309	R>H		No	ClinGen ExAC TOPMed gnomAD
CA364459569 rs1251629972	314	Q>H		No	ClinGen gnomAD
CA3856469 rs753115513	316	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA3856470 rs548071187	316	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1247520552 CA364459540	319	R>Q		No	ClinGen gnomAD
CA364459542 rs1398927396	319	R>W		No	ClinGen TOPMed
rs74773325 CA3856468	320	E>G		No	ClinGen ExAC gnomAD
CA3856467 rs759795709	321	Y>N		No	ClinGen ExAC
rs886356394 CA139011492	322	W>C		No	ClinGen Ensembl
rs774474008 CA3856466	323	N>D	Variant assessed as Somatic; 4.752e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA364459509 rs1329260514	324	E>K		No	ClinGen TOPMed gnomAD
CA139011469 rs1047643328	325	Q>R		No	ClinGen Ensembl
rs763148177 CA3856464	328	K>E		No	ClinGen ExAC gnomAD
rs1455685003 CA364459477	328	K>R		No	ClinGen TOPMed gnomAD
rs773242168 CA3856463	329	R>Q		No	ClinGen ExAC gnomAD
CA364459472 rs1304952977	329	R>W		No	ClinGen TOPMed gnomAD
CA364459465 rs1373221419	330	R>K		No	ClinGen TOPMed
CA364459467 rs1373221419	330	R>T		No	ClinGen TOPMed
CA3856460 rs200755793	331	V>A		No	ClinGen ExAC gnomAD
rs200755793 CA364459458	331	V>G		No	ClinGen ExAC gnomAD
CA364459461 rs1161776027	331	V>L		No	ClinGen gnomAD
CA364459455 rs1364642890	332	P>S		No	ClinGen TOPMed gnomAD
CA364459451 rs1290597997	333	A>T		No	ClinGen TOPMed
rs1181513124 CA3856459	334	T>A		No	ClinGen TOPMed gnomAD
rs199535862 CA3856457	334	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA364459445 rs1181513124	334	T>P		No	ClinGen TOPMed gnomAD
CA364459439 rs1271495744	335	P>S		No	ClinGen gnomAD
rs757859864 CA3856455	338	P>L		No	ClinGen ExAC gnomAD
rs972572216 CA139011383	338	P>T		No	ClinGen TOPMed
rs1226155634 CA364459418	339	A>P		No	ClinGen gnomAD
rs1226155634 CA364459419	339	A>T		No	ClinGen gnomAD
rs778188890 CA3856453	340	R>M		No	ClinGen ExAC TOPMed gnomAD
CA364459410 rs778188890	340	R>T		No	ClinGen ExAC TOPMed gnomAD
CA364459405 rs1184328930	341	L>F		No	ClinGen TOPMed
rs1238056237 CA364459403	341	L>P		No	ClinGen gnomAD
CA364459397 rs1412359278	342	I>T		No	ClinGen TOPMed
rs1284950460 CA364459376	345	E>A		No	ClinGen gnomAD
rs1479989918 CA364459379	345	E>K		No	ClinGen TOPMed
CA3856449 rs755344750	346	S>C		No	ClinGen ExAC TOPMed gnomAD
rs1414732764 CA364459366	347	G>S		No	ClinGen TOPMed
rs781570575 CA3856430	348	Y>S		No	ClinGen ExAC TOPMed gnomAD
rs140201298 CA139009936	352	G>E		No	ClinGen ESP gnomAD
TCGA novel	357	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3856429 rs755327656	358	N>H		No	ClinGen ExAC gnomAD
rs748744364 CA139009930	359	G>A		No	ClinGen TOPMed gnomAD
CA139009925 rs748744364	359	G>E		No	ClinGen TOPMed gnomAD
rs780364997 CA3856427	359	G>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs758681632 CA3856426	360	T>I		No	ClinGen ExAC TOPMed gnomAD
rs1250137853 CA364459260	361	S>Y		No	ClinGen TOPMed
COSM1080255 rs1160106138 CA364459249	363	R>Q	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA364459250 rs750740962	363	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1337717228 CA364459245	364	T>A		No	ClinGen TOPMed gnomAD
rs765330900 CA3856424	364	T>I		No	ClinGen ExAC gnomAD
CA3856422 rs575072618	367	L>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA364459219 rs1409199594	368	K>Q		No	ClinGen TOPMed
rs775281396 CA3856419	369	S>F		No	ClinGen ExAC gnomAD
rs986726316 CA139009880	370	P>L		No	ClinGen TOPMed

No associated diseases with Q15035

2 regional properties for Q15035

Type	Name	Position	InterPro Accession
domain	TRAM/LAG1/CLN8 homology domain	112 - 321	IPR006634
domain	TRAM1-like protein	49 - 110	IPR013599

Functions

		Description
EC Number
Subcellular Localization	Membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

1 GO annotations of cellular component

Name	Definition
integral component of endoplasmic reticulum membrane	The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

No GO annotations of molecular function

Name	Definition
No GO annotations for molecular function

3 GO annotations of biological process

Name	Definition
collagen biosynthetic process	The chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).
protein insertion into ER membrane	The process that results in incorporation of a protein into an endoplasmic reticulum (ER) membrane. It depends on specific topogenic sequences of amino acids that ensure that a protein acquires the proper orientation during its insertion into the ER membrane.
SRP-dependent cotranslational protein targeting to membrane, translocation	The process during cotranslational membrane targeting wherein proteins move across a membrane. SRP and its receptor initiate the transfer of the nascent chain across the endoplasmic reticulum (ER) membrane; they then dissociate from the chain, which is transferred to a set of transmembrane proteins, collectively called the translocon. Once the nascent chain translocon complex is assembled, the elongating chain passes directly from the large ribosomal subunit into the centers of the translocon, a protein-lined channel within the membrane. The growing chain is never exposed to the cytosol and does not fold until it reaches the ER lumen.

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q924Z5	Tram2	Translocating chain-associated membrane protein 2	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MAFRRRTKSY	PLFSQEFVIH	NHADIGFCLV	LCVLIGLMFE	VTAKTAFLFI	LPQYNISVPT
70	80	90	100	110	120
ADSETVHYHY	GPKDLVTILF	YIFITIILHA	VVQEYILDKI	SKRLHLSKVK	HSKFNESGQL
130	140	150	160	170	180
VVFHFTSVIW	CFYVVVTEGY	LTNPRSLWED	YPHVHLPFQV	KFFYLCQLAY	WLHALPELYF
190	200	210	220	230	240
QKVRKEEIPR	QLQYICLYLV	HIAGAYLLNL	SRLGLILLLL	QYSTEFLFHT	ARLFYFADEN
250	260	270	280	290	300
NEKLFSAWAA	VFGVTRLFIL	TLAVLAIGFG	LARMENQAFD	PEKGNFNTLF	CRLCVLLLVC
310	320	330	340	350	360
AAQAWLMWRF	IHSQLRHWRE	YWNEQSAKRR	VPATPRLPAR	LIKRESGYHE	NGVVKAENGT

SPRTKKLKSP