Q921C1
Gene name |
Gjc3 (Cx29, Gje1) |
Protein name |
Gap junction gamma-3 protein |
Names |
Connexin-29, Cx29, Gap junction epsilon-1 protein |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:118446 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q921C1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q921C1-F1 | Predicted | AlphaFoldDB |
24 variants for Q921C1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388791628 | 2 | L>I | No | EVA | |
| rs32289763 | 8 | I>N | No | EVA | |
| rs3396123074 | 10 | C>R | No | EVA | |
| rs3388802985 | 31 | V>L | No | EVA | |
| rs3396259246 | 39 | L>I | No | EVA | |
| rs3396331630 | 39 | L>R | No | EVA | |
| rs3388802932 | 65 | H>Q | No | EVA | |
| rs3388783249 | 72 | K>E | No | EVA | |
| rs3388808901 | 76 | Y>S | No | EVA | |
| rs220732399 | 106 | T>I | No | EVA | |
| rs3388801623 | 113 | Y>N | No | EVA | |
| rs250436928 | 124 | Q>H | No | EVA | |
| rs32288965 | 127 | Q>R | No | EVA | |
| rs3388798998 | 139 | G>R | No | EVA | |
| rs3388803687 | 143 | L>I | No | EVA | |
| rs3388798990 | 179 | F>I | No | EVA | |
| rs3388793766 | 182 | R>H | No | EVA | |
| rs3388795740 | 194 | Q>* | No | EVA | |
| rs3388803613 | 224 | L>F | No | EVA | |
| rs240489117 | 229 | R>K | No | EVA | |
| rs3388771558 | 231 | W>G | No | EVA | |
| rs218255844 | 243 | K>N | No | EVA | |
| rs3388808948 | 266 | K>* | No | EVA | |
| rs3388788360 | 270 | F>E | No | EVA |
No associated diseases with Q921C1
1 regional properties for Q921C1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| active_site | Glycoside hydrolase family 9, His active site | 390 - 416 | IPR018221 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| connexin complex | An assembly of six molecules of connexin, made in the Golgi apparatus and subsequently transported to the plasma membrane, where docking of two connexons on apposed plasma membranes across the extracellular space forms a gap junction. |
| gap junction | A cell-cell junction composed of pannexins or innexins and connexins, two different families of channel-forming proteins. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| myelin sheath | An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| gap junction channel activity | A wide pore channel activity that enables a direct cytoplasmic connection from one cell to an adjacent cell. The gap junction can pass large solutes as well as electrical signals between cells. Gap junctions consist of two gap junction hemi-channels, or connexons, one contributed by each membrane through which the gap junction passes. |
| identical protein binding | Binding to an identical protein or proteins. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cell-cell signaling | Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions. |
| myelination | The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier. |
| sensory perception of sound | The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P28236 | Gja8 | Gap junction alpha-8 protein | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLLLELPIKC | RMCGRFLRQL | LAQESQHSTP | VGRFLLPMLM | GFRLLILVSS | GPGVFGNDEN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EFICHLGQPG | CKTICYDVFR | PLSPLRFWAF | QVILMAVPSA | IYVAFTLYHV | IGYWEVPGKE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NKEQETQISK | GDHSKDVSGA | KSLKLLWAYV | AHLGVRLALE | GAALGVQYNL | YGFKMSSTFI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| CREDPCIGST | TCFQSHPSEK | TIFLNIMFGI | SGACFLFIFL | ELALLGLGRF | WRIYKHKLSF |
| 250 | 260 | ||||
| LKKLPTSESS | VRSKDTTDEL | SVVEAKEPF |