Q91ZC0

PR
Gene name
Mrgprb4 (Mrgb4)
Protein name
Mas-related G-protein coupled receptor member B4
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:233230
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

269-321 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q91ZC0

Entry ID Method Resolution Chain Position Source
AF-Q91ZC0-F1 Predicted AlphaFoldDB

69 variants for Q91ZC0

Variant ID(s) Position Change Description Diseaes Association Provenance
rs586929806 7 A>D No EVA
rs581282402 8 W>L No EVA
rs583555280 8 W>R No EVA
rs32832175 18 S>N No EVA
rs3397812858 34 F>C No EVA
rs51667020 34 F>L No EVA
rs50338380 35 L>F No EVA
rs233702444 40 A>S No EVA
rs215273835 40 A>V No EVA
rs251573737 44 L>V No EVA
rs32839209 45 A>V No EVA
rs229124940 58 L>R No EVA
rs252443232 58 L>V No EVA
rs1134746148 59 H>P No EVA
rs241094735 68 L>F No EVA
rs32838411 79 F>C No EVA
rs32838407 91 Q>* No EVA
rs32838407 91 Q>E No EVA
rs46698011 94 N>Y No EVA
rs48050489 99 I>F No EVA
rs32838405 104 T>S No EVA
rs32837733 105 M>T No EVA
rs3388892654 106 F>I No EVA
rs46931320 113 C>S No EVA
rs583677282 115 I>T No EVA
rs580462193 116 A>T No EVA
rs48848346 117 A>T No EVA
rs32837731 122 R>C No EVA
rs583006312 139 H>N No EVA
rs262517883 139 H>P No EVA
rs236274333 143 I>F No EVA
rs213317351 146 A>T No EVA
rs32837729 158 V>L No EVA
rs216588031 162 G>S No EVA
rs227173817 167 F>S No EVA
rs262661287 170 Y>D No EVA
rs32837727 171 D>E No EVA
rs3388915179 173 Y>F No EVA
rs264469854 176 I>T No EVA
rs228302967 176 I>V No EVA
rs223072339 183 A>V No EVA
rs252837267 186 L>I No EVA
rs258045657 188 V>E No EVA
rs258045657 188 V>G No EVA
rs220953478 188 V>L No EVA
rs3388911762 192 V>G No EVA
rs1132240629 194 S>T No EVA
rs1133726561 195 V>E No EVA
rs212925836 197 S>C No EVA
rs32837725 198 L>M No EVA
rs260926947 199 A>T No EVA
rs32836913 207 G>E No EVA
rs247172520 226 V>I No EVA
rs214935446 229 Y>F No EVA
rs227234079 229 Y>N No EVA
rs3388904438 233 P>S No EVA
rs32836909 243 R>S No EVA
rs241231673 244 I>S No EVA
rs229604188 246 E>Q No EVA
rs240369853 248 D>E No EVA
rs259421236 248 D>H No EVA
rs224466404 252 F>S No EVA
rs265355156 281 R>K No EVA
rs243367587 285 L>F No EVA
rs221279349 286 R>Q No EVA
rs3388914115 305 E>V No EVA
rs3388909878 307 G>D No EVA
rs3388916335 309 R>W No EVA
rs32836161 317 E>D No EVA

No associated diseases with Q91ZC0

1 regional properties for Q91ZC0

Type Name Position InterPro Accession
domain GPCR, rhodopsin-like, 7TM 46 - 274 IPR017452

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

3 GO annotations of molecular function

Name Definition
G protein-coupled receptor activity Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
neuropeptide binding Interacting selectively and non-covalently and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators).
transmembrane signaling receptor activity Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.

4 GO annotations of biological process

Name Definition
G protein-coupled receptor signaling pathway The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane.
mast cell activation The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors.
mast cell degranulation The regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell.
positive regulation of cytokinesis Any process that activates or increases the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8BXS7 Gpr152 Probable G-protein coupled receptor 152 Mus musculus (Mouse) PR
10 20 30 40 50 60
MGTTTLAWNI NNTAENGSYT EMFSCITKFN TLNFLTVIIA VVGLAGNGIV LWLLAFHLHR
70 80 90 100 110 120
NAFSVYVLNL AGADFLYLFT QVVHSLECVL QLDNNSFYIL LIVTMFAYLA GLCMIAAISA
130 140 150 160 170 180
ERCLSVMWPI WYHCQRPRHT SAIMCALVWV SSLLLSLVVG LGCGFLFSYY DYYFCITLNF
190 200 210 220 230 240
ITAAFLIVLS VVLSVSSLAL LVKIVWGSHR IPVTRFFVTI ALTVVVFIYF GMPFGICWFL
250 260 270 280 290 300
LSRIMEFDSI FFNNVYEIIE FLSCVNSCAN PIIYFLVGSI RQHRLRWQSL KLLLQRAMQD
310 320
TPEEESGERG PSQRSGELET V