Q8BXS7
Gene name |
Gpr152 |
Protein name |
Probable G-protein coupled receptor 152 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:269053 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8BXS7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8BXS7-F1 | Predicted | AlphaFoldDB |
27 variants for Q8BXS7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389530571 | 73 | L>V | No | EVA | |
| rs3389527528 | 164 | V>M | No | EVA | |
| rs3408837464 | 171 | E>Q | No | EVA | |
| rs3389525045 | 204 | P>S | No | EVA | |
| rs3389519568 | 221 | R>K | No | EVA | |
| rs3389424842 | 224 | C>Y | No | EVA | |
| rs3389515677 | 256 | L>P | No | EVA | |
| rs3389525021 | 267 | D>N | No | EVA | |
| rs3389481250 | 273 | L>M | No | EVA | |
| rs3389472050 | 316 | A>V | No | EVA | |
| rs3389507699 | 331 | P>S | No | EVA | |
| rs3389507687 | 380 | V>A | No | EVA | |
| rs3389495328 | 381 | A>T | No | EVA | |
| rs3389525080 | 383 | P>L | No | EVA | |
| rs3389527508 | 386 | G>S | No | EVA | |
| rs3389515908 | 395 | T>I | No | EVA | |
| rs3389508261 | 418 | N>K | No | EVA | |
| rs3389508269 | 436 | L>P | No | EVA | |
| rs3389424830 | 437 | T>S | No | EVA | |
| rs3389515720 | 438 | Q>H | No | EVA | |
| rs3389510884 | 448 | Q>H | No | EVA | |
| rs3389508225 | 457 | A>P | No | EVA | |
| rs3389514788 | 470 | N>D | No | EVA | |
| rs3389519596 | 476 | P>A | No | EVA | |
| rs3389530514 | 487 | D>G | No | EVA | |
| rs3389424898 | 488 | R>I | No | EVA | |
| rs3407886946 | 512 | T>W | No | EVA |
No associated diseases with Q8BXS7
1 regional properties for Q8BXS7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | GPCR, rhodopsin-like, 7TM | 46 - 296 | IPR017452 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| G protein-coupled receptor activity | Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
| identical protein binding | Binding to an identical protein or proteins. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| G protein-coupled receptor signaling pathway | The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDTAVEANLG | AAGHGPRTEL | SDEDYYPQGS | WDTVFLVALL | LLGLPANGLM | AWLAGSQARH |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GAGTRLALLL | LSLALSDFLF | LAAATFQILE | IQHGGHWPLG | TAACRFYYFL | WGVSYSSGLF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LLTALSLDRC | LLALCPRWYP | GHRPARLPLW | VCAGVWVLAT | LFSVPWLVFP | EAAVWWYDLV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ICLDFWDTEE | LPLRMLEILG | GFLPFLLLLV | CHVLTQATAC | RTCCGHQPRR | MACHGFARVA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KTILSAYVVL | RLPYQLAQLL | YLAFLWDVYP | GYLLWEALVY | SDYLILLNSC | LSPFLCLAAS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ADLRALLRTV | LSSFAAAVCE | ERPGSFIPAE | PQTLPGPTSE | GQSRLDSVVQ | PQVNPSVQLQ |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SDSVVQPEVS | PSAQPQSDSV | AQPTVGSLIQ | PPLDTVVQLE | VNPLTQPQLD | PMAQPQVNPS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| AQPQSKSVVQ | PQVDPLTQPQ | LDPVAQPQSN | TETPIPAFGD | ESASNPGEEN | SSGPCPDPTP |
| 490 | 500 | 510 | |||
| GTPENLDRPA | VPQEKSPSNV | PPEEAPSAGP | T |