Q91X85

PR
Gene name
Flvcr2 (Mfsd7c)
Protein name
Feline leukemia virus subgroup C receptor-related protein 2
Names
Calcium-chelate transporter, CCT
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:217721
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-127 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q91X85

Entry ID Method Resolution Chain Position Source
AF-Q91X85-F1 Predicted AlphaFoldDB

No variants for Q91X85

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q91X85

No associated diseases with Q91X85

1 regional properties for Q91X85

Type Name Position InterPro Accession
domain Major facilitator superfamily domain 110 - 515 IPR020846

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion membrane ; Multi-pass membrane protein
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
  • Cell membrane ; Multi-pass membrane protein
  • Primarily resides in mitochondria where it interacts with components of the electron transfer complexes III, IV and V (By similarity)
  • Colocalizes with ATP2A2 at the mitochondrial-ER contact junction (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
heme binding Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
heme transmembrane transporter activity Enables the transfer of heme from one side of a membrane to the other.

1 GO annotations of biological process

Name Definition
heme export The directed movement of heme out of a cell or organelle.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9Y5Y0 FLVCR1 Feline leukemia virus subgroup C receptor-related protein 1 Homo sapiens (Human) PR
Q9UPI3 FLVCR2 Feline leukemia virus subgroup C receptor-related protein 2 Homo sapiens (Human) PR
P60815 Flvcr2 Feline leukemia virus subgroup C receptor-related protein 2 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MVNESLNQEE SNDRPAPESE FQMDTSYSTQ PSGSIHPSVS GHPSVSGHPS VSGHPSVSIH
70 80 90 100 110 120
PSVSIDPSVS VRPSSSALPS TLAQPSGLTH HSSLVREDSV IKVSKRRWVV VLVFSCYSLC
130 140 150 160 170 180
NAFQWIQYGS INNIFMNFYG VSAFAIDWLS MCYMLTYIPL LLPVAWMLEK FGLRTIAITG
190 200 210 220 230 240
SALNCLGAWV KLGSLEPHLF PVTMVGQVIC SVAQVFILGM PSRIASVWFG ADEVSTACSV
250 260 270 280 290 300
AVFGNQLGIA IGFLVPPVLV PNIKDPEKLA YHISIMFYII GGVATFLFIL VIIVFKEKPK
310 320 330 340 350 360
HPPSRAQSLS YALATTDASY LSSIVRLFKN LNFVLLVITY GLNAGAFYAL STLLNRMVIL
370 380 390 400 410 420
HFPGEEVNAG RIGLTIVIAG MFGAMISGIW LDKSKTYKET TLVVYIMTLV GMVVYTFTLN
430 440 450 460 470 480
LNHLWIVFIT AGTLGFFMTG YLPLGFEFAV EFTYPESEGV SSGLLNVSAQ VFGIVFTISQ
490 500 510 520 530 540
GQIIDNHGTM FGNIFLCVFL ALGSALTAFI KSDLRRQRAN KDAPETKVQE EEEEEEGSNT
550
SKVPVVSEAH L