P60815

PR
Gene name
Flvcr2
Protein name
Feline leukemia virus subgroup C receptor-related protein 2
Names
Calcium-chelate transporter, CCT
Species
Rattus norvegicus (Rat)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-125 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P60815

Entry ID Method Resolution Chain Position Source
AF-P60815-F1 Predicted AlphaFoldDB

No variants for P60815

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P60815

No associated diseases with P60815

1 regional properties for P60815

Type Name Position InterPro Accession
domain Major facilitator superfamily domain 104 - 509 IPR020846

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion membrane ; Multi-pass membrane protein
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
  • Cell membrane ; Multi-pass membrane protein
  • Primarily resides in mitochondria where it interacts with components of the electron transfer chain complexes III, IV and V
  • Colocalizes with ATP2A2 at the mitochondrial-ER contact junction
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
heme binding Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
heme transmembrane transporter activity Enables the transfer of heme from one side of a membrane to the other.

1 GO annotations of biological process

Name Definition
heme export The directed movement of heme out of a cell or organelle.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9Y5Y0 FLVCR1 Feline leukemia virus subgroup C receptor-related protein 1 Homo sapiens (Human) PR
Q9UPI3 FLVCR2 Feline leukemia virus subgroup C receptor-related protein 2 Homo sapiens (Human) PR
Q91X85 Flvcr2 Feline leukemia virus subgroup C receptor-related protein 2 Mus musculus (Mouse) PR
10 20 30 40 50 60
MVNESLNQEE SNDRPVPESE FQADTSYSTQ PSVSIHPSVS GHPSVSIHPS VSGHPSVSID
70 80 90 100 110 120
PSVSVHPSSS AHPSTLAQPS GLTHPNELVK EDSVIKVSKR RWAVVLVFSC YSLCNAFQWI
130 140 150 160 170 180
QYGSINNIFM NFYGVSAFAI DWLSMCYMLT YIPLLLPVAW MLEKFGLRTI AITGSALNCL
190 200 210 220 230 240
GAWVKLGSLE PHLFPVTMVG QVICSVAQVF ILGMPSRIAS VWFGANEVST ACSMAVFGNQ
250 260 270 280 290 300
LGIAIGFLVP PVLVPNIKDQ EKLAYHISIM FYIIGGVATL LFILVIIVFK EKPKYPPSRA
310 320 330 340 350 360
QSLSYALATT DASYLSSIVR LFKNLNFVLL VITYGLNAGA FYALSTLLNR MVIMHFPGQE
370 380 390 400 410 420
VNAGRIGLTI VIAGMFGAMI SGIWLDKSKT YKETTLVVYI MTLVGMVVYT FTLNLNHLWI
430 440 450 460 470 480
VFITADSLGF FMTGYLPLGF EFAVELTYPE SEGVSSGLLN VSAQVFGIIF TISQGQIIDN
490 500 510 520 530 540
YGSVPGNIFL CVFLALGSAL TAFIKSDLRR QRANKDAPET KVQEEEEEEE ESNTSKVPTV
LSEAHL