Q91WV0
PR
Gene name |
Dr1 |
Protein name |
Protein Dr1 |
Names |
Down-regulator of transcription 1, Negative cofactor 2-beta, NC2-beta, TATA-binding protein-associated phosphoprotein |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:13486 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q91WV0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q91WV0-F1 | Predicted | AlphaFoldDB |
2 variants for Q91WV0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388780436 | 12 | T>A | No | EVA | |
| rs3388764748 | 54 | A>P | No | EVA |
No associated diseases with Q91WV0
9 regional properties for Q91WV0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | cDENN domain | 116 - 298 | IPR001194 |
| domain | Pleckstrin homology domain | 1743 - 1849 | IPR001849 |
| domain | GRAM domain | 870 - 1006 | IPR004182 |
| domain | dDENN domain | 351 - 420 | IPR005112 |
| domain | uDENN domain | 1 - 86 | IPR005113 |
| domain | Myotubularin-like, phosphatase domain | 1108 - 1584 | IPR010569 |
| domain | SBF1/SBF2 domain | 530 - 754 | IPR022096 |
| domain | Tripartite DENN domain | 7 - 427 | IPR037516 |
| domain | Myotubularin-related protein 13, PH-GRAM domain | 882 - 1000 | IPR037823 |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| ATAC complex | A chromatin remodelling complex that regulates transcription via acetylation primarily of nucleosomal histones H3 and possibly H4. Shares the histone acetylation (HAT) module of GCN5/PCAF-ADA2-ADA3-SGF29 (or orthologs) with the related SAGA complex (GO:0000124). Contains HAT subunits GCN5 or PCAF in a mutually exclusive manner. In addition to the HAT module contains DR1/NC2B, KAT14, MBIP, WDR5, YEATS2 and ZZZ3 or orthologs. Also regulates the activity of non-histone targets and orchestrates mitotic progression by regulating Cyclin A degradation through acetylation. |
| mitotic spindle | A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules. |
| negative cofactor 2 complex | A heterodimeric protein complex that can stably associate with TATA-binding protein on promoters, thereby preventing the assembly of transcription factors TFIIA and TFIIB and leading to repression of RNA polymerase II transcription. The two subunits, NC2alpha (Drap1) and NC2beta (Dr1), dimerize through histone fold domains of the H2A/H2B type present in the amino termini. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| RNA polymerase II transcription regulator complex | A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| core promoter sequence-specific DNA binding | Binding to a sequence of DNA that is part of a core promoter region. The core promoter is composed of the transcription start site and binding sites for the RNA polymerase and the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon. |
| protein heterodimerization activity | Binding to a nonidentical protein to form a heterodimer. |
| RNA polymerase II general transcription initiation factor activity | A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase II. The general transcription factors for RNA polymerase II include TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBP). In most species, RNA polymerase II transcribes all messenger RNAs (mRNAs), most untranslated regulatory RNAs, the majority of the snoRNAs, four of the five snRNAs (U1, U2, U4, and U5), and other small noncoding RNAs. For some small RNAs there is variability between species as to whether it is transcribed by RNA polymerase II or RNA polymerase III. However there are also rare exceptions, such as Trypanosoma brucei, where RNA polymerase I transcribes certain mRNAs in addition to its normal role in rRNA transcription. |
| TBP-class protein binding | Binding to a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs). |
13 GO annotations of biological process
| Name | Definition |
|---|---|
| chromatin remodeling | A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication. |
| histone H3 acetylation | The modification of histone H3 by the addition of an acetyl group. |
| histone H3-K14 acetylation | The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 14 of the histone. |
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| regulation of cell cycle | Any process that modulates the rate or extent of progression through the cell cycle. |
| regulation of cell division | Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells. |
| regulation of DNA-templated transcription | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
| regulation of embryonic development | Any process that modulates the frequency, rate or extent of embryonic development. |
| regulation of histone deacetylation | Any process that modulates the frequency, rate or extent of the removal of acetyl groups from histones. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| regulation of tubulin deacetylation | Any process that modulates the frequency, rate or extent of tubulin deacetylation. Tubulin deacetylation is the removal of an acetyl group from a protein amino acid. |
| RNA polymerase II preinitiation complex assembly | The aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase. |
3 homologous proteins in AiPD
| 10 | 20 | 30 | 40 | 50 | 60 |
| MASSSGNDDD | LTIPRAAINK | MIKETLPNVR | VANDARELVV | NCCTEFIHLI | SSEANEICNK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SEKKTISPEH | VIQALESLGF | GSYISEVKEV | LQECKTVALK | RRKASSRLEN | LGIPEEELLR |
| 130 | 140 | 150 | 160 | 170 | |
| QQQELFAKAR | QQQAELAQQE | WLQMQQAAQQ | AQLAAASASA | STQAGSSQDE | EDDDDI |