AiPD: Autoinhibited Protein Database

Gene name	Frs3 (Frs2b)
Protein name	Fibroblast growth factor receptor substrate 3
Names	FGFR substrate 3, FRS2-beta
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:107971
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

155-230 (Predicted disordered autoinhibitory region) PR

155-230 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q91WJ0-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389463592	158	R>W	No	EVA
rs237466632	162	A>T	No	EVA
rs263113781	164	R>C	No	EVA
rs3389381535	172	R>P	No	EVA
rs3389485730	204	G>D	No	EVA
rs3389460589	208	H>L	No	EVA
rs3389476429	225	Q>H	No	EVA
rs3389437254	231	D>G	No	EVA
rs3389468139	242	K>N	No	EVA
rs241100008	250	A>V	No	EVA
rs3389427083	285	C>F	No	EVA
rs3389381494	328	L>F	No	EVA
rs3389461606	329	P>S	No	EVA
rs3389485739	330	P>Q	No	EVA
rs3389471951	338	Q>*	No	EVA
rs3407749373	353	L>V	No	EVA
rs3407796422	354	T>S	No	EVA
rs3407683053	373	P>H	No	EVA
rs3389485781	398	R>Q	No	EVA
rs237997064	411	P>S	No	EVA
rs3389470113	423	K>M	No	EVA
rs3389461642	424	G>D	No	EVA
rs3389463608	434	Q>P	No	EVA
rs3389448325	435	N>K	No	EVA
rs265503267	437	S>P	No	EVA

Type	Name	Position	InterPro Accession
domain	IRS-type PTB domain	13 - 115	IPR002404
domain	FRS2, PTB domain	15 - 106	IPR038742

		Description
EC Number
Subcellular Localization	Membrane; Lipid-anchor
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

Name	Definition
fibroblast growth factor receptor binding	Binding to a fibroblast growth factor receptor (FGFR).
identical protein binding	Binding to an identical protein or proteins.
transmembrane receptor protein tyrosine kinase adaptor activity	The binding activity of a molecule that brings together a transmembrane receptor protein tyrosine kinase and one or more other molecules, permitting them to function in a coordinated way.

Name	Definition
fibroblast growth factor receptor signaling pathway	The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands.
transmembrane receptor protein tyrosine kinase signaling pathway	The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q8WU20	FRS2	Fibroblast growth factor receptor substrate 2	Homo sapiens (Human)	PR
O43559	FRS3	Fibroblast growth factor receptor substrate 3	Homo sapiens (Human)	PR
Q8C180	Frs2	Fibroblast growth factor receptor substrate 2	Mus musculus (Mouse)	PR