AiPD: Autoinhibited Protein Database

Q8WWU5

Gene name	TCP11
Protein name	T-complex protein 11 homolog
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:6954
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-65 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-65 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q8WWU5

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8WWU5-F1	Predicted				AlphaFoldDB

370 variants for Q8WWU5

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1456414354 CA363750779	2	P>A		No	ClinGen gnomAD
rs899863200 CA137258825	4	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA3769063 rs750735988	5	K>N		No	ClinGen ExAC gnomAD
rs1229709552 CA363750713	6	E>K		No	ClinGen gnomAD
CA363750701 rs1162775199	7	S>R		No	ClinGen TOPMed gnomAD
rs561197879 CA137258820	9	P>L		No	ClinGen 1000Genomes
CA363750672 rs1359571825	9	P>S		No	ClinGen TOPMed
rs1439866290 CA363750659	10	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA363750641 rs1323930663	12	Y>H		No	ClinGen gnomAD
CA3769061 rs762189731	13	P>L		No	ClinGen ExAC gnomAD
CA363750620 rs1381928600	13	P>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA3769060 rs774496499	14	G>C		No	ClinGen ExAC gnomAD
CA3769055 rs543124451	18	G>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs763012661 CA3769056	18	G>S		No	ClinGen ExAC
CA3769053 rs200719262	19	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA3769052 rs772842447	19	R>M		No	ClinGen ExAC gnomAD
rs201851411 CA3769051	20	S>F		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	21	C>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3769049 rs201458023	21	C>R		No	ClinGen 1000Genomes ExAC gnomAD
CA3769045 rs755782847	28	P>A		No	ClinGen ExAC TOPMed gnomAD
CA3769043 rs767710443	28	P>L		No	ClinGen ExAC TOPMed gnomAD
CA3769044 rs767710443	28	P>R		No	ClinGen ExAC TOPMed gnomAD
CA3769046 rs755782847	28	P>S		No	ClinGen ExAC TOPMed gnomAD
CA363750347 rs755782847	28	P>T		No	ClinGen ExAC TOPMed gnomAD
CA3769042 rs757626295	29	P>R		No	ClinGen ExAC gnomAD
CA3769039 rs763065536	30	Q>*		No	ClinGen ExAC gnomAD
CA3769038 rs775498454	30	Q>P		No	ClinGen ExAC TOPMed
rs775498454 CA137258679	30	Q>R		No	ClinGen ExAC TOPMed
rs35693439 CA3769035	32	D>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs765473542 CA3769036	32	D>N		No	ClinGen ExAC gnomAD
CA3769034 rs773071336	35	G>D		No	ClinGen ExAC gnomAD
rs747971863 CA3769032	36	S>C		No	ClinGen ExAC gnomAD
CA3769030 rs768692818	37	E>K		No	ClinGen ExAC gnomAD
rs748833848 CA363750171	38	D>E		No	ClinGen ExAC TOPMed gnomAD
rs779675502 CA363750167	39	P>A		No	ClinGen ExAC TOPMed gnomAD
CA3769028 rs779675502	39	P>T		No	ClinGen ExAC TOPMed gnomAD
CA137258630 rs960823929	40	P>R		No	ClinGen TOPMed
CA3769026 rs745455902	40	P>T		No	ClinGen ExAC TOPMed gnomAD
rs909615555 CA137258613	41	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA137258607 rs1030887195	42	F>V		No	ClinGen TOPMed
CA363748734 rs1393925509	45	V>F		No	ClinGen gnomAD
rs374601449 CA137255795	47	G>D		No	ClinGen ESP TOPMed gnomAD
rs754716204 CA3768945	49	T>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	50	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs370605224 CA3768943	51	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA3768940 rs199809733	52	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3768939 rs767188052	53	N>H		No	ClinGen ExAC gnomAD
CA3768937 rs774597120	56	S>F		No	ClinGen ExAC gnomAD
CA137255728 rs202046288	57	K>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3768936 rs202046288	57	K>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA137255724 rs1024658371	58	L>M		No	ClinGen TOPMed gnomAD
TCGA novel	61	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA363748518 rs904401585	64	M>R		No	ClinGen TOPMed gnomAD
CA137255719 rs904401585	64	M>T		No	ClinGen TOPMed gnomAD
rs1405121684 CA363748498	66	C>S		No	ClinGen gnomAD
rs1170864520 CA363748496	66	C>Y		No	ClinGen TOPMed gnomAD
CA363748458 rs1426080139	69	Y>C		No	ClinGen TOPMed
CA3768933 rs776111702	70	M>T		No	ClinGen ExAC TOPMed gnomAD
CA3768932 rs770373406	71	E>D		No	ClinGen ExAC gnomAD
rs529870463 CA3768931	73	K>E		No	ClinGen ExAC TOPMed gnomAD
CA363748406 rs1562008782	74	V>F		No	ClinGen Ensembl
rs200759685 CA3768930	76	P>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA363748385 rs1345817697	76	P>S		No	ClinGen gnomAD
rs1399436117 CA363748373	77	P>L		No	ClinGen gnomAD
CA3768929 rs771291103	78	S>G		No	ClinGen ExAC gnomAD
CA3768928 rs747313916	79	S>G		No	ClinGen ExAC
CA363748356 rs1174638457	79	S>N		No	ClinGen gnomAD
CA363747770 rs1562000718	80	L>P		No	ClinGen Ensembl
CA363747730 rs1475863816	82	G>D		No	ClinGen TOPMed gnomAD
rs1053898388 CA137252679	86	E>D		No	ClinGen TOPMed gnomAD
rs561528550 CA137252671	87	T>I		No	ClinGen Ensembl
CA3768912 rs147549679	88	V>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA363747592 rs1398339111	88	V>M		No	ClinGen TOPMed
rs760059724 CA3768910	90	N>D		No	ClinGen ExAC gnomAD
CA3768908 rs771201385	90	N>K		No	ClinGen ExAC gnomAD
CA3768909 rs201795646	90	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA363747473 rs1386568512	94	D>E		No	ClinGen TOPMed
rs778104076 CA3768906	102	A>T		No	ClinGen ExAC TOPMed gnomAD
rs145037860 CA3768905	102	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1353997193 CA363747318	104	P>A		No	ClinGen gnomAD
rs1300260237 CA363747312	104	P>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA137252635 rs962728918	105	P>S		No	ClinGen TOPMed gnomAD
TCGA novel	106	D>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3768903 rs368275334	106	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA137252609 rs866816400	108	S>I		No	ClinGen Ensembl
CA137252606 rs1016966105	109	C>R		No	ClinGen TOPMed
CA363747207 rs1167831775	111	L>I		No	ClinGen TOPMed gnomAD
CA363747206 rs1167831775	111	L>V		No	ClinGen TOPMed gnomAD
CA137252605 rs980154902	112	E>G		No	ClinGen TOPMed
rs1462583250 CA363747170	114	L>R		No	ClinGen gnomAD
TCGA novel	120	I>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs894732301 CA137249615	125	L>V		No	ClinGen Ensembl
rs144320775 CA3768880	128	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA3768878 rs746528793	128	R>H		No	ClinGen ExAC TOPMed gnomAD
CA3768879 rs746528793	128	R>L		No	ClinGen ExAC TOPMed gnomAD
rs899153308 CA137249581	129	Q>K		No	ClinGen Ensembl
CA3768876 rs757908827	131	R>C		No	ClinGen ExAC TOPMed gnomAD
rs150752841 CA3768875 COSM186289	131	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs150752841 CA363746599	131	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA3768874 rs558253635	133	R>K		No	ClinGen 1000Genomes ExAC gnomAD
rs1384595465 CA363746565	135	E>A		No	ClinGen TOPMed gnomAD
rs755441742 CA3768873	136	I>T		No	ClinGen ExAC TOPMed gnomAD
rs1289422334 CA363746519	138	E>A		No	ClinGen gnomAD
CA3768872 rs754205823	139	A>V		No	ClinGen ExAC gnomAD
CA3768871 rs539582879	141	D>A		No	ClinGen 1000Genomes ExAC gnomAD
CA363746496 rs1443040177	141	D>Y		No	ClinGen TOPMed
CA3768870 rs200041132	142	M>T		No	ClinGen 1000Genomes ExAC gnomAD
rs940755138 CA137249550	142	M>V		No	ClinGen Ensembl
rs1454501884 CA363746462	143	D>N		No	ClinGen gnomAD
CA363746439 COSM596158 rs142915532	144	L>F	lung [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs1051381139 CA137249540	145	L>F		No	ClinGen Ensembl
CA3768868 rs767553081	146	K>R		No	ClinGen ExAC gnomAD
rs761880060 CA3768867	147	Q>E		No	ClinGen ExAC TOPMed gnomAD
CA363746407 rs1263910503	147	Q>R		No	ClinGen gnomAD
rs1166732028 CA363746379	149	A>S		No	ClinGen TOPMed
rs1327578490 CA363746375	149	A>V		No	ClinGen gnomAD
rs1561992858 CA363746364	150	E>G		No	ClinGen Ensembl
rs768848363 CA3768865	151	H>P		No	ClinGen ExAC gnomAD
CA3768864 rs375000730	153	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA3768863 rs776337343	155	K>R		No	ClinGen ExAC gnomAD
CA363746292 rs1348995170	156	V>I		No	ClinGen TOPMed gnomAD
CA3768862 rs770912471	157	L>P		No	ClinGen ExAC TOPMed gnomAD
rs139258646 CA3768860	158	Y>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs139258646 CA363746263	158	Y>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1295666803 CA363746238	160	S>C		No	ClinGen gnomAD
rs1295666803 CA363746236	160	S>F		No	ClinGen gnomAD
rs757885410 CA3768859	161	K>E		No	ClinGen ExAC gnomAD
CA3768858 rs747639934	161	K>N		No	ClinGen ExAC TOPMed gnomAD
rs754639015 CA3768856	163	V>I		No	ClinGen ExAC TOPMed gnomAD
rs372296449 CA3768855	165	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA363746177 rs199753305	166	M>L		No	ClinGen ExAC TOPMed gnomAD
CA3768854 rs199753305	166	M>V		No	ClinGen ExAC TOPMed gnomAD
CA3768853 rs756489956	167	M>I		No	ClinGen ExAC TOPMed gnomAD
rs1427930390 CA363746147	170	L>Q		No	ClinGen gnomAD
TCGA novel	172	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA363746126 rs1486230309	173	P>L		No	ClinGen gnomAD
rs768039790 CA3768851	173	P>T		No	ClinGen ExAC gnomAD
COSM1078295 rs199835007 CA3768849	175	R>*	endometrium [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA3768850 rs199835007	175	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs750331817 CA137249431	175	R>P		No	ClinGen ExAC gnomAD
rs750331817 CA3768848	175	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA137249428 rs977179353	176	D>G		No	ClinGen Ensembl
rs1191640351 CA363746100	178	A>V		No	ClinGen TOPMed
COSM3366476 CA137249419 rs775764694	179	V>L	kidney [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA3768846 rs775764694	179	V>M		No	ClinGen ExAC gnomAD
CA363746068 rs1456588725	183	E>A		No	ClinGen TOPMed gnomAD
TCGA novel	184	N>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3768844 rs760486424	184	N>S		No	ClinGen ExAC TOPMed gnomAD
rs533808712 CA3768843	185	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA3768842 rs146246778 COSM1443986	186	T>M	pancreas large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs368388208 CA3768841	187	D>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs1411395659 CA363746037	188	P>S		No	ClinGen gnomAD
CA363746039 rs1411395659	188	P>T		No	ClinGen gnomAD
CA363746033 rs1168665163	189	V>I		No	ClinGen gnomAD
rs1232463911 CA363746021	190	W>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA363746026 rs1465184197	190	W>R		No	ClinGen gnomAD
CA3768840 rs778500766	191	L>P		No	ClinGen ExAC gnomAD
CA363746007 rs1581804782	193	R>K		No	ClinGen Ensembl
CA363745967 rs1287665637	197	Q>*		No	ClinGen gnomAD
rs371137302 CA3768814	197	Q>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs371137302 CA3768815	197	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA3768813 rs757600603	200	G>S		No	ClinGen ExAC gnomAD
CA3768811 rs778219246	201	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs200541069 CA3768812	201	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA363745932 rs1328093669	203	K>T		No	ClinGen gnomAD
rs752771922 CA3768809	204	M>T		No	ClinGen ExAC gnomAD
CA3768808 rs765409364	207	V>L		No	ClinGen ExAC TOPMed
rs201092504 CA3768804	210	T>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA3768802 rs774471334	211	I>V		No	ClinGen ExAC gnomAD
CA3768800 rs764104836	213	S>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA3768799 rs762394336	215	Q>R		No	ClinGen ExAC gnomAD
rs1244438506 CA363745839	216	P>R		No	ClinGen gnomAD
CA137248802 rs941436362	216	P>S		No	ClinGen TOPMed
TCGA novel	217	H>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs776259421 CA3768795	221	H>R		No	ClinGen ExAC gnomAD
CA3768796 rs745588245	221	H>Y		No	ClinGen ExAC gnomAD
CA363745766 rs1445164091	224	Q>*		No	ClinGen TOPMed
CA3768794 rs771322225	224	Q>H		No	ClinGen ExAC gnomAD
rs1349735266 CA363745765	224	Q>P		No	ClinGen gnomAD
TCGA novel	224	Q>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA363745747 rs1235260144	225	Y>*		No	ClinGen gnomAD
rs202025517 CA137248784	226	E>G		No	ClinGen 1000Genomes
CA363745726 rs1273142004	227	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA137248781 rs954988108	227	R>W		No	ClinGen gnomAD
CA3768793 rs747350461	228	A>T		No	ClinGen ExAC TOPMed
CA3768791 rs758862942	229	K>E		No	ClinGen ExAC gnomAD
CA3768790 rs748180958	233	L>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	234	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA363745607 rs1377625100	237	Q>*		No	ClinGen gnomAD
CA3768776 rs776312603	239	S>N		No	ClinGen ExAC TOPMed gnomAD
rs770519277 CA3768775	240	L>F		No	ClinGen ExAC gnomAD
CA363745522 rs1482132412	241	L>F		No	ClinGen gnomAD
CA137248664 rs530781724	246	K>R		No	ClinGen gnomAD
CA363745426 rs1217396081	249	T>I		No	ClinGen gnomAD
CA3768770 rs2234045 VAR_039692	253	G>A		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1581799183 CA363745382	254	D>A		No	ClinGen Ensembl
TCGA novel	254	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3768769 rs755127178	255	L>F		No	ClinGen ExAC gnomAD
rs749358203 CA3768768	257	M>V		No	ClinGen ExAC TOPMed gnomAD
rs780448674 CA3768767	259	P>L		No	ClinGen ExAC TOPMed gnomAD
CA3768766 rs756367121	260	P>L		No	ClinGen ExAC TOPMed gnomAD
rs758120624 CA3768763	264	D>A		No	ClinGen ExAC gnomAD
CA363745077 rs1163935151	264	D>E		No	ClinGen gnomAD
rs777657692 CA3768764	264	D>Y		No	ClinGen ExAC gnomAD
CA3768762 rs752717040	265	T>S		No	ClinGen ExAC gnomAD
rs1458376624 CA363745010	270	S>G		No	ClinGen gnomAD
CA363745004 rs1237739096	270	S>T		No	ClinGen gnomAD
rs753303993 CA3768759	272	A>G		No	ClinGen ExAC gnomAD
CA137248597 rs571058019	272	A>S		No	ClinGen 1000Genomes gnomAD
rs766023819 CA3768758	273	G>R		No	ClinGen ExAC
rs766023819 CA363744977	273	G>S		No	ClinGen ExAC
CA3768756 rs760263154	273	G>V		No	ClinGen ExAC gnomAD
rs762054767 CA3768753	275	S>P		No	ClinGen ExAC gnomAD
rs774973172 CA3768752	276	P>L		No	ClinGen ExAC gnomAD
rs768998692 CA3768751	277	N>H		No	ClinGen ExAC gnomAD
rs371115731 CA3768750	277	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1283311776 CA363744906	279	A>T		No	ClinGen TOPMed gnomAD
CA3768749 rs780219572	281	N>S		No	ClinGen ExAC gnomAD
rs1394543395 CA363744853	283	P>A		No	ClinGen gnomAD
CA3768748 rs770158711	283	P>R		No	ClinGen ExAC TOPMed gnomAD
CA3768747 rs376470025	285	P>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs376470025 CA3768746	285	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs758259983 CA3768745	288	P>S		No	ClinGen ExAC gnomAD
rs150437868 CA137248531	290	M>I		No	ClinGen ESP TOPMed gnomAD
rs62404564 CA3768744	290	M>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs753359455 CA3768741	301	L>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs753359455 CA3768742	301	L>I		No	ClinGen ExAC gnomAD
TCGA novel	302	W>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3768739 rs746615964	303	D>G		No	ClinGen ExAC TOPMed gnomAD
CA363744576 rs1209828003	303	D>Y		No	ClinGen gnomAD
CA3768738 rs199758911	305	E>*		No	ClinGen 1000Genomes ExAC
CA3768735 rs767056497	309	F>Y		No	ClinGen ExAC TOPMed gnomAD
rs1347384665 CA363744496	310	P>L		No	ClinGen TOPMed
rs1217845931 CA363744493	311	E>K		No	ClinGen gnomAD
CA363744416 rs1265433800	314	L>P		No	ClinGen TOPMed gnomAD
rs1282083854 CA363744401	315	M>T		No	ClinGen Ensembl
rs754754585 CA3768723	316	D>N		No	ClinGen ExAC gnomAD
rs140505237 CA137248441	317	R>G		No	ClinGen ESP TOPMed gnomAD
CA137248438 rs372979577	318	T>N		No	ClinGen ESP TOPMed gnomAD
CA3768721 rs779936728	319	R>Q		No	ClinGen ExAC gnomAD
rs199729611 CA3768722	319	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
COSM1672330 rs1427129351 CA363744302	320	L>P	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed
rs190225207 CA3768718	322	E>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs966772237 CA137248429	322	E>K		No	ClinGen TOPMed gnomAD
CA363744243 rs1581797591	323	L>M		No	ClinGen Ensembl
rs751971112 CA3768716	326	Q>P		No	ClinGen ExAC TOPMed gnomAD
CA137248422 rs375634528	328	H>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA363744142 rs1375109535	329	Q>*		No	ClinGen TOPMed
rs201387409 CA3768714	329	Q>L		No	ClinGen ExAC TOPMed gnomAD
rs765786893 COSM76696 CA137248399	332	V>F	ovary Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs765786893 CA3768712 COSM241861	332	V>I	Variant assessed as Somatic; 0.0 impact. prostate [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs868637949 CA137248393	333	M>I		No	ClinGen Ensembl
CA3768711 rs759717986	333	M>T		No	ClinGen ExAC gnomAD
rs776505647 CA137248392	335	S>A		No	ClinGen ExAC TOPMed gnomAD
CA3768710 rs776505647	335	S>P		No	ClinGen ExAC TOPMed gnomAD
rs757186529 CA137248366	342	S>C		No	ClinGen Ensembl
TCGA novel	343	F>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs868506529 CA137248358	345	G>D		No	ClinGen Ensembl
CA3768705 rs2234046	345	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3768706 rs2234046	345	G>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1581797311 CA363743861	346	S>R		No	ClinGen Ensembl
CA3768702 rs372743324	352	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA137248353 rs372743324	352	P>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA363743725 rs1164822565	354	F>L		No	ClinGen TOPMed
TCGA novel	355	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1443317790 CA363743710	356	D>N		No	ClinGen TOPMed gnomAD
TCGA novel	356	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1404199363 CA363743669	358	L>V		No	ClinGen TOPMed
CA363743647 rs1017696883	360	R>C		No	ClinGen TOPMed gnomAD
rs1017696883 CA137248350	360	R>G		No	ClinGen TOPMed gnomAD
CA363743645 rs1198350542	360	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs545871773 CA3768701	361	I>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	362	T>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA137248302 rs756781573	364	S>F		No	ClinGen ExAC TOPMed gnomAD
rs756781573 CA3768700	364	S>Y		No	ClinGen ExAC TOPMed gnomAD
CA363743590 rs1315995243	365	L>S		No	ClinGen gnomAD
rs1339627838 CA363743545	368	D>E		No	ClinGen gnomAD
CA363743548 rs1245272171	368	D>G		No	ClinGen gnomAD
TCGA novel	369	F>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs763812558 CA3768698	371	S>T		No	ClinGen ExAC TOPMed gnomAD
CA3768677 rs779470706	374	E>Q		No	ClinGen ExAC gnomAD
rs755339702 CA3768676	375	E>K		No	ClinGen ExAC TOPMed gnomAD
CA3768675 rs754370826	376	A>T		No	ClinGen ExAC gnomAD
CA3768674 rs766896459	377	I>M		No	ClinGen ExAC gnomAD
CA363743372 rs1437319258	377	I>V		No	ClinGen gnomAD
rs1450974523 CA363743347	380	V>M		No	ClinGen TOPMed gnomAD
rs750433913 CA3768672	382	E>K		No	ClinGen ExAC gnomAD
rs750433913 CA363743319	382	E>Q		No	ClinGen ExAC gnomAD
CA363743286 rs1354092680	383	Q>R		No	ClinGen gnomAD
rs761971960 CA3768669	385	S>P		No	ClinGen ExAC TOPMed gnomAD
CA363743197 rs984693096	389	H>L		No	ClinGen TOPMed gnomAD
rs1019823482 CA137247923	389	H>N		No	ClinGen Ensembl
CA137247917 rs984693096	389	H>R		No	ClinGen TOPMed gnomAD
rs1437213857 CA363743105	393	K>Q		No	ClinGen gnomAD
CA3768667 rs769613866	394	N>T		No	ClinGen ExAC gnomAD
rs1219952372 CA363743050	395	M>V		No	ClinGen TOPMed
CA363743014 rs1421955552	396	G>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs759366965 CA3768666	398	V>L		No	ClinGen ExAC gnomAD
CA137247904 COSM108038 rs147061538	399	A>V	skin [Cosmic]	No	ClinGen cosmic curated Ensembl
rs1157743433 CA363742939	400	L>P		No	ClinGen gnomAD
CA363742932 rs1417463614	401	S>G		No	ClinGen gnomAD
rs776451131 CA3768665	402	S>N		No	ClinGen ExAC gnomAD
CA363742885 rs1426635275	403	D>Y		No	ClinGen TOPMed gnomAD
CA3768664 rs770838863	405	T>I		No	ClinGen ExAC TOPMed gnomAD
rs142229547 CA137247889	406	A>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA3768663 rs142229547	406	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA3768662 rs777371930	406	A>V		No	ClinGen ExAC TOPMed gnomAD
rs562902814 CA3768661	407	S>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1351800786 CA363742813	409	M>T		No	ClinGen gnomAD
rs755355317 CA3768658	413	Q>*		No	ClinGen ExAC gnomAD
rs997157057 CA137247854	413	Q>H		No	ClinGen Ensembl
CA137247834 rs932951552	415	I>T		No	ClinGen TOPMed
CA363742616 rs1476974758	422	V>I		No	ClinGen TOPMed
CA3768655 rs754172299	425	V>I		No	ClinGen ExAC TOPMed gnomAD
rs552806919 CA3768653	426	I>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA137247482 rs571410395	427	D>G		No	ClinGen 1000Genomes gnomAD
rs756602426 CA3768652	427	D>H		No	ClinGen ExAC gnomAD
CA363741980 rs1369129582	428	Q>*		No	ClinGen TOPMed gnomAD
CA3768634 rs115171214	428	Q>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs2234051 VAR_039693 CA3768631	429	R>Q		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA3768632 rs746410817	429	R>W		No	ClinGen ExAC TOPMed gnomAD
rs757381332 CA3768630	431	H>D		No	ClinGen ExAC gnomAD
rs1346306432 CA363741879	435	K>N		No	ClinGen TOPMed
rs149685630 CA3768627	437	C>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA3768628 rs149685630	437	C>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA363741815 rs1287526066	440	L>P		No	ClinGen TOPMed
CA363741809 rs1353727033	441	G>D		No	ClinGen TOPMed
TCGA novel	441	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA137247461 rs35507973	442	V>E		No	ClinGen Ensembl
rs569547384 CA3768625	443	Q>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs548056330 CA3768624	444	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs548056330 CA3768622	444	R>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs548056330 CA3768623	444	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA137247454 rs1005525749	444	R>W		No	ClinGen TOPMed
CA137247436 rs374559672	447	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs773869428 CA3768619	448	D>G		No	ClinGen ExAC TOPMed gnomAD
rs768213865 CA137247432	451	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA3768618 rs768213865	451	G>V		No	ClinGen ExAC gnomAD
CA363741673 rs1163810038	453	L>F		No	ClinGen gnomAD
CA363741659 rs1421789485	454	T>S		No	ClinGen gnomAD
rs774971447 CA3768616	455	L>V		No	ClinGen ExAC gnomAD
TCGA novel	456	I>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1193746804 CA363741645	456	I>V		No	ClinGen gnomAD
rs770206514 CA3768615	458	A>V		No	ClinGen ExAC TOPMed gnomAD
rs929158828 CA137247395	461	A>T		No	ClinGen Ensembl
CA363741564 rs1440444651	461	A>V		No	ClinGen gnomAD
rs781669719 CA3768613	463	L>Q		No	ClinGen ExAC TOPMed gnomAD
rs967756304 CA137247390	464	G>D		No	ClinGen TOPMed
rs1376851842 CA363741479	467	F>C		No	ClinGen TOPMed
rs1425287327 CA363741473	468	V>L		No	ClinGen Ensembl
rs1241232875 CA363741455	469	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA363741399 rs1258484423	473	H>R		No	ClinGen TOPMed
TCGA novel	475	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA363741342 rs1479988646	477	V>M		No	ClinGen TOPMed gnomAD
rs747117260 CA3768610	480	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1225352357 CA363741286	481	Y>C		No	ClinGen TOPMed gnomAD
CA3768608 rs758379313	482	Y>C		No	ClinGen ExAC gnomAD
CA3768609 rs777960647	482	Y>H		No	ClinGen ExAC gnomAD
CA3768607 rs753031619	483	T>A		No	ClinGen ExAC TOPMed gnomAD
rs897648182 CA363741260	483	T>N		No	ClinGen gnomAD
CA137247380 rs897648182	483	T>S		No	ClinGen gnomAD
CA363741194 rs1241395500	488	T>I		No	ClinGen TOPMed gnomAD
rs765365117 CA3768606	488	T>S		No	ClinGen ExAC gnomAD
rs755987530 CA3768605	489	L>F		No	ClinGen ExAC gnomAD
CA3768604 rs750176539	493	A>P		No	ClinGen ExAC gnomAD
rs750176539 CA363741146	493	A>T		No	ClinGen ExAC gnomAD
CA3768603 rs767593115	495	A>S		No	ClinGen ExAC gnomAD
CA363741124 rs767593115	495	A>T		No	ClinGen ExAC gnomAD
CA3768600 rs763698528	502	S>P		No	ClinGen ExAC gnomAD
CA3768598 rs765845352	503	V>S		No	ClinGen ExAC gnomAD

No associated diseases with Q8WWU5

No regional properties for Q8WWU5

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q8WWU5

Functions

		Description
EC Number
Subcellular Localization	Membrane ; Single-pass membrane protein Cell projection, cilium, flagellum Cytoplasmic vesicle, secretory vesicle, acrosome	Localizes on the acrosomal cap region of acrosome-intact, but not acrosome-reacted sperm Colocalizes with MROH2B and PRKACA on the acrosome and tail regions in round spermatids and spermatozoa regardless of the capacitation status of the sperm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
acrosomal vesicle	A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
sperm flagellum	A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid.
sperm midpiece	The highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece.

No GO annotations of molecular function

Name	Definition
No GO annotations for molecular function

6 GO annotations of biological process

Name	Definition
adenylate cyclase-activating G protein-coupled receptor signaling pathway	A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity and a subsequent increase in the intracellular concentration of cyclic AMP (cAMP).
germ cell development	The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.
protein kinase A signaling	A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound.
regulation of sperm capacitation	Any process that modulates the frequency, rate or extent of sperm capacitation.
signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
spermatogenesis	The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q8N4U5	TCP11L2	T-complex protein 11-like protein 2	Homo sapiens (Human)	PR
Q5H9J9	TCP11X2	T-complex protein 11 X-linked protein 2	Homo sapiens (Human)	PR

10	20	30	40	50	60
MPDVKESVPP	KYPGDSEGRS	CKPETSGPPQ	EDKSGSEDPP	PFLSVTGLTE	TVNEVSKLSN
70	80	90	100	110	120
KIGMNCDYYM	EEKVLPPSSL	EGKVKETVHN	AFWDHLKEQL	SATPPDFSCA	LELLKEIKEI
130	140	150	160	170	180
LLSLLLPRQN	RLRIEIEEAL	DMDLLKQEAE	HGALKVLYLS	KYVLNMMALL	CAPVRDEAVQ
190	200	210	220	230	240
KLENITDPVW	LLRGIFQVLG	RMKMDMVNYT	IQSLQPHLQE	HSIQYERAKF	QELLNKQPSL
250	260	270	280	290	300
LNHTTKWLTQ	AAGDLTMSPP	TCPDTSDSSS	VAGPSPNEAA	NNPEPLSPTM	VLCQGFLNLL
310	320	330	340	350	360
LWDLENEEFP	ETLLMDRTRL	QELKSQLHQL	TVMASVLLVA	SSFSGSVLFG	SPQFVDKLKR
370	380	390	400	410	420
ITKSLLEDFH	SRPEEAILTV	SEQVSQEIHQ	SLKNMGLVAL	SSDNTASLMG	QLQNIAKKEN
430	440	450	460	470	480
CVCSVIDQRI	HLFLKCCLVL	GVQRSLLDLP	GGLTLIEAEL	AELGQKFVNL	THHNQQVFGP
490	500
YYTEILKTLI	SPAQALETKV	ESV