Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q8W5R2

Entry ID Method Resolution Chain Position Source
AF-Q8W5R2-F1 Predicted AlphaFoldDB

114 variants for Q8W5R2

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_1_11266243_C_G 7 H>D No 1000Genomes
ENSVATH00055181 7 H>R No 1000Genomes
ENSVATH12526587 10 T>A No 1000Genomes
ENSVATH12526590 39 H>Y No 1000Genomes
tmp_1_11266348_C_A 42 Q>K No 1000Genomes
tmp_1_11266361_C_T 46 A>V No 1000Genomes
ENSVATH00055185 64 V>I No 1000Genomes
ENSVATH12526638 75 V>I No 1000Genomes
tmp_1_11266573_G_T 77 R>L No 1000Genomes
ENSVATH12526639 97 I>T No 1000Genomes
ENSVATH12526706 120 S>T No 1000Genomes
ENSVATH00055191 124 K>R No 1000Genomes
ENSVATH01141848 127 V>I No 1000Genomes
ENSVATH00055193 145 S>R No 1000Genomes
tmp_1_11267169_T_A 190 F>Y No 1000Genomes
tmp_1_11267232_T_C 211 V>A No 1000Genomes
tmp_1_11267235_C_T 212 A>V No 1000Genomes
ENSVATH04690104 238 S>P No 1000Genomes
ENSVATH00055200 239 S>T No 1000Genomes
ENSVATH04690106 244 A>T No 1000Genomes
ENSVATH04690107 257 L>V No 1000Genomes
ENSVATH12526777 258 N>I No 1000Genomes
tmp_1_11267697_G_A 268 V>I No 1000Genomes
ENSVATH12526812 294 L>F No 1000Genomes
ENSVATH14027920 335 G>V No 1000Genomes
ENSVATH14027921 336 N>D No 1000Genomes
tmp_1_11268184_C_A 336 N>K No 1000Genomes
ENSVATH14027922 347 R>C No 1000Genomes
tmp_1_11268230_C_T 352 H>Y No 1000Genomes
ENSVATH00055206 373 S>N No 1000Genomes
tmp_1_11268502_C_A 411 A>D No 1000Genomes
ENSVATH00055210 463 P>T No 1000Genomes
ENSVATH04690140 467 D>N No 1000Genomes
tmp_1_11268993_C_A 480 P>H No 1000Genomes
tmp_1_11269010_G_C 486 A>P No 1000Genomes
ENSVATH12527038 487 D>V No 1000Genomes
ENSVATH12527039 489 P>S No 1000Genomes
ENSVATH04690142 490 C>Y No 1000Genomes
ENSVATH14027966 507 N>K No 1000Genomes
ENSVATH00055211 508 N>S No 1000Genomes
ENSVATH12527040 509 P>L No 1000Genomes
ENSVATH00055212 511 K>R No 1000Genomes
ENSVATH04690143 513 T>I No 1000Genomes
tmp_1_11269091_A_C 513 T>P No 1000Genomes
ENSVATH04690144 514 G>D No 1000Genomes
ENSVATH04690145 519 T>M No 1000Genomes
ENSVATH14027967 529 H>Y No 1000Genomes
tmp_1_11269157_G_C 535 E>Q No 1000Genomes
ENSVATH14027968 536 D>N No 1000Genomes
ENSVATH01141902 537 P>L No 1000Genomes
ENSVATH04690147 544 V>F No 1000Genomes
ENSVATH00055213 546 A>D No 1000Genomes
ENSVATH12527042 548 V>M No 1000Genomes
tmp_1_11269205_G_A 551 E>K No 1000Genomes
ENSVATH14027969 557 E>G No 1000Genomes
ENSVATH12527043 560 H>Y No 1000Genomes
ENSVATH01141904 572 V>G No 1000Genomes
ENSVATH04690148 573 P>Q No 1000Genomes
ENSVATH14027970 575 G>E No 1000Genomes
ENSVATH14027971 576 A>V No 1000Genomes
ENSVATH12527115 584 P>A No 1000Genomes
ENSVATH12527116 585 S>L No 1000Genomes
ENSVATH04690150 594 K>E No 1000Genomes
ENSVATH14027972 597 V>L No 1000Genomes
ENSVATH00055217 598 N>K No 1000Genomes
ENSVATH04690151 600 N>D No 1000Genomes
tmp_1_11269356_A_G 601 N>S No 1000Genomes
tmp_1_11269594_A_C 613 N>T No 1000Genomes
ENSVATH00055221 616 R>S No 1000Genomes
tmp_1_11269614_G_T 620 A>S No 1000Genomes
ENSVATH00055223 623 L>Q No 1000Genomes
ENSVATH12527121 624 S>A No 1000Genomes
ENSVATH04690161 627 A>T No 1000Genomes
tmp_1_11269648_C_T 631 S>L No 1000Genomes
ENSVATH01141918 640 A>P No 1000Genomes
ENSVATH01141919 640 A>V No 1000Genomes
ENSVATH04690166 649 V>L No 1000Genomes
ENSVATH04690167 655 D>Y No 1000Genomes
ENSVATH12527123 658 T>I No 1000Genomes
ENSVATH04690168 658 T>S No 1000Genomes
tmp_1_11269876_A_G 672 K>E No 1000Genomes
tmp_1_11269976_A_T 675 T>S No 1000Genomes
ENSVATH14028018 688 A>S No 1000Genomes
ENSVATH00055226 692 I>V No 1000Genomes
ENSVATH14028023 704 E>Q No 1000Genomes
ENSVATH04690178 708 A>V No 1000Genomes
ENSVATH14028024 717 R>Q No 1000Genomes
ENSVATH12527240 742 P>A No 1000Genomes
ENSVATH14028026 742 P>L No 1000Genomes
ENSVATH14028026 742 P>R No 1000Genomes
ENSVATH00055231 743 E>K No 1000Genomes
ENSVATH04690181 751 H>Y No 1000Genomes
tmp_1_11270490_G_C 757 L>F No 1000Genomes
ENSVATH00055232 770 A>S No 1000Genomes
ENSVATH04690190 784 T>K No 1000Genomes
ENSVATH01141932 802 E>D No 1000Genomes
ENSVATH04690192 812 S>P No 1000Genomes
tmp_1_11270939_A_C 818 I>L No 1000Genomes
ENSVATH12527391 835 E>D No 1000Genomes
tmp_1_11271315_A_G 864 K>E No 1000Genomes
tmp_1_11271342_G_A 873 G>R No 1000Genomes
ENSVATH04690197 875 N>K No 1000Genomes
ENSVATH04690199 878 T>M No 1000Genomes
ENSVATH00055238 882 E>A No 1000Genomes
ENSVATH00055238 882 E>V No 1000Genomes
ENSVATH14028030 889 D>Y No 1000Genomes
ENSVATH14028031 890 S>L No 1000Genomes
ENSVATH00055239 893 P>T No 1000Genomes
ENSVATH04690203 899 R>S No 1000Genomes
ENSVATH00055240 919 T>A No 1000Genomes
ENSVATH04690206 924 A>V No 1000Genomes
ENSVATH04690207 927 K>N No 1000Genomes
ENSVATH12527394 929 Y>N No 1000Genomes
ENSVATH07537887 933 P>S No 1000Genomes

No associated diseases with Q8W5R2

1 regional properties for Q8W5R2

Type Name Position InterPro Accession
domain DDHD domain 669 - 868 IPR004177

Functions

Description
EC Number
Subcellular Localization
  • Vacuole membrane
  • Detected in small organelles membranes
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
plant-type vacuole membrane The lipid bilayer surrounding a vacuole that retains the same shape regardless of cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this component is found in Arabidopsis thaliana.
plasmodesma A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell.
vacuole A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.

3 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
phospholipase A1 activity Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate.
phospholipase activity Catalysis of the hydrolysis of a glycerophospholipid.

4 GO annotations of biological process

Name Definition
amyloplast organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an amyloplast. An amyloplast is a plastid whose main function is to synthesize and store starch.
detection of gravity The series of events in which a gravitational stimulus is received and converted into a molecular signal.
lipid catabolic process The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
negative gravitropism The orientation of plant parts away from gravity.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q12204 YOR022C Probable phospholipase YOR022C, mitochondrial Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q9Y6Y8 SEC23IP SEC23-interacting protein Homo sapiens (Human) PR
10 20 30 40 50 60
MEDRETHLGT REVNETSPDL LKNTPSNIAR LEDVIEQCHG RQKYLAQTRS PSDGSDVRWY
70 80 90 100 110 120
FCKVPLAENE LAASVPRTDV VGKSEYFRFG MRDSLAIEAS FLQREDELLS LWWKEYAECS
130 140 150 160 170 180
EGPKLQVNSK KKSIETPSEA SVSSSLYEVE EERVGVPVKG GLYEVDLVRR HCFPVYWNGD
190 200 210 220 230 240
NRRVLRGHWF ARKGGLDWLP IPETVSEQLE VAYRNKVWRR RSFQPSGLFA ARIDLQGSSL
250 260 270 280 290 300
GLHALFTGED DTWEAWLNVD PSGFSGIVGY TGNGIKLRRG YAGSYSPKPT QEELRQQKEE
310 320 330 340 350 360
EMDDYCSQVP VRHLVFMVHG IGQKGEKSNL VDDVGNFRQI TAALAERHLT SHQLSTQRVL
370 380 390 400 410 420
FIPCQWRKGL KLSGEAAVDK CTLDGVRRFR EMLSATVHDV LYYMSPIYCQ AIIDSVSKQL
430 440 450 460 470 480
NRLYLKFLKR NPDYVGKISI YGHSLGSVLS YDILCHQHNL SSPFPMDSVY KKFFPDEESP
490 500 510 520 530 540
PTPAKADKPC SSHPSSNFEP EKSDQLNNPE KITGQDNNTM AKEPTVLEHH DVIQEDPSLI
550 560 570 580 590 600
SDSVVANVGL ERRGGQEDDH HDSSGAISSQ DVPDGADCRT PDSPSCSQEQ SWDKESVNSN
610 620 630 640 650 660
NEERIKLLQD EVNSLRSKVA QLLSENARIL SDEKAKTSVA PKELNNEKVQ TEDADAPTSF
670 680 690 700 710 720
TPFIKYQKLE FKVDTFFAVG SPLGVFLALR NIRLGIGKGK DYWEEENAIE EMPACRRMFN
730 740 750 760 770 780
IFHPYDPVAY RVEPLVCKEY LPERPVIIPY HRGGKRLHIG LQDFREDFAA RSQRIMNHFD
790 800 810 820 830 840
SVRTRVLTIC QSKSADNLDE MEETDDEKDD RSYGSLMIER LTGTRDGRID HMLQEKTFEH
850 860 870 880 890 900
PYLQAIGAHT NYWRDQDTAL FIIKHLYREL PDGPNSPTES TEGDDSPKDS SRPHSWIDRR
910 920 930
EADYDDEELP LTFSDKQITR SFSAEAKKYL KKP