Q12204
Gene name |
YOR022C (OR26.12) |
Protein name |
Probable phospholipase YOR022C, mitochondrial |
Names |
|
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YOR022C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q12204
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q12204-F1 | Predicted | AlphaFoldDB |
16 variants for Q12204
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s15-375845 | 5 | T>A | No | SGRP | |
| s15-375812 | 16 | R>G | No | SGRP | |
| s15-375730 | 43 | P>R | No | SGRP | |
| s15-375713 | 49 | H>N | No | SGRP | |
| s15-375700 | 53 | K>R | No | SGRP | |
| s15-375649 | 70 | K>R | No | SGRP | |
| s15-375633 | 75 | R>S | No | SGRP | |
| s15-375517 | 114 | S>F | No | SGRP | |
| s15-375158 | 234 | S>P | No | SGRP | |
| s15-375023 | 279 | L>F | No | SGRP | |
| s15-374981 | 293 | A>T | No | SGRP | |
| s15-374882 | 326 | I>L | No | SGRP | |
| s15-374879 | 327 | E>K | No | SGRP | |
| s15-374669 | 397 | P>S | No | SGRP | |
| s15-373970 | 630 | L>V | No | SGRP | |
| s15-373886 | 658 | T>A | No | SGRP |
No associated diseases with Q12204
1 regional properties for Q12204
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | DDHD domain | 519 - 700 | IPR004177 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| mitochondrial matrix | The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| metal ion binding | Binding to a metal ion. |
| phospholipase A1 activity | Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate. |
| phospholipase activity | Catalysis of the hydrolysis of a glycerophospholipid. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| cardiolipin metabolic process | The chemical reactions and pathways involving cardiolipin, 1,3-bis(3-phosphatidyl)glycerol. |
| lipid catabolic process | The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. |
| phosphatidylethanolamine metabolic process | The chemical reactions and pathways involving phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. It is a major structural phospholipid in mammalian systems. It tends to be more abundant than phosphatidylcholine in the internal membranes of the cell and is an abundant component of prokaryotic membranes. |
| phospholipid metabolic process | The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLRFTHRGLP | SSTRFRNIFV | RLNHIYVPWF | YAIDVPNSKP | YLPTYQTLHS | PKKFKPFSVD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DSNRLEKASK | RQERRPVLVN | EDYLFKVDLS | HMELSPTYWE | GPTYQVRRGV | WFDSSNQPLS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SDLTSEIEGL | YKQLKFDDSN | DDPTTTPPAE | SQDIFRLKGK | YPVDKENEGE | QKNGSSNKDE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NESTFKFILF | ANKQTAFLLS | DLDGGKLQLA | FLRSNLAQSL | PINATMITRS | YKYSSSATTK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QTSTSFKAAK | TPQTEVADGS | NSSKSRSIET | KLEKKVSNLF | NLSDFLQLFN | GNASKDQDDA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QSLEKQMETD | YNNADNSQGA | NASSKIEDGK | NSGASDRQIR | SNRRDVDNLI | LCVHGIGQTL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GKKYEYVNFA | HTVNLLRSNM | KKIYNNSEKL | QSLNTAPDYK | SNCNVQVLPI | TWRHSISFQT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DAKEENIENP | DLPTLSQVTV | NGVLPLRKLL | ADGLLDILLY | VEPYYQDMIL | QQVTSQLNKT |
| 490 | 500 | 510 | 520 | 530 | 540 |
| YRIFKEFNPE | FDGKVHLVGH | SLGSMILFDI | LSKQKKYELE | FQVDNLFFIG | SPIGLLKLIQ |
| 550 | 560 | 570 | 580 | 590 | 600 |
| RTKIGDRPEF | PNDLERKLTV | QRPQCKDIYN | VYHVCDPISY | RMEPLVSKEM | AHYEQTYLPH |
| 610 | 620 | 630 | 640 | 650 | 660 |
| CSEAYGLTSK | VLEFGENIWK | DLPGTDENNL | QSKKTSPEKK | EVKLSENLTR | MLTGLNYTGR |
| 670 | 680 | 690 | 700 | 710 | |
| LDYAMSPSLL | EVDFISAIKS | HVSYFEEPDI | AAFILKEILS | KHENASEIYV | KRKTG |