AiPD: Autoinhibited Protein Database

Gene name	PFP-BETA1
Protein name	Pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit beta 1
Names	PFP 1, 6-phosphofructokinase, pyrophosphate dependent 1, PPi-PFK 1, Pyrophosphate-dependent 6-phosphofructose-1-kinase 1
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT1G12000
EC number	2.7.1.90: Phosphotransferases with an alcohol group as acceptor
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-121 (Predicted disordered autoinhibitory region) PR

1-121 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8W4M5-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
ENSVATH11021515	16	S>P	No	1000Genomes
tmp_1_4053609_G_C	40	T>S	No	1000Genomes
tmp_1_4053287_G_A	69	A>V	No	1000Genomes
ENSVATH01038774	82	A>T	No	1000Genomes
ENSVATH00018920	87	Q>H	No	1000Genomes
tmp_1_4052980_G_A	138	A>V	No	1000Genomes
ENSVATH11021446	150	A>G	No	1000Genomes
tmp_1_4052772_C_A	164	M>I	No	1000Genomes
ENSVATH04561820	179	K>Q	No	1000Genomes
ENSVATH04561790	308	K>N	No	1000Genomes
tmp_1_4051571_C_A	325	G>V	No	1000Genomes
ENSVATH04561776	413	M>L	No	1000Genomes
ENSVATH11020026	420	K>T	No	1000Genomes
ENSVATH04561775	426	A>E	No	1000Genomes
tmp_1_4051050_T_A	430	Q>L	No	1000Genomes
tmp_1_4050867_G_A	453	T>I	No	1000Genomes
tmp_1_4050841_C_T	462	A>T	No	1000Genomes
tmp_1_4050681_T_C	479	N>S	No	1000Genomes
ENSVATH04561766	482	A>S	No	1000Genomes
tmp_1_4050652_C_T	489	V>I	No	1000Genomes
tmp_1_4050212_G_T	550	P>T	No	1000Genomes
ENSVATH11019787	551	G>S	No	1000Genomes
tmp_1_4050200_A_T	554	S>T	No	1000Genomes
ENSVATH04561751	564	G>R	No	1000Genomes
ENSVATH04561750	565	A>D	No	1000Genomes

Type	Name	Position	InterPro Accession
domain	Band 7 domain	31 - 216	IPR001107

		Description
EC Number	2.7.1.90	Phosphotransferases with an alcohol group as acceptor
Subcellular Localization	Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
plant-type cell wall	A more or less rigid stucture lying outside the cell membrane of a cell and composed of cellulose and pectin and other organic and inorganic substances.

Name	Definition
6-phosphofructokinase activity	Catalysis of the reaction: ATP + D-fructose-6-phosphate = ADP + D-fructose 1,6-bisphosphate.
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
diphosphate-fructose-6-phosphate 1-phosphotransferase activity	Catalysis of the reaction: fructose-6-phosphate + diphosphate = phosphate + fructose-1,6-bisphosphate.
metal ion binding	Binding to a metal ion.
phosphofructokinase activity	Catalysis of the transfer of a phosphate group, usually from ATP, to a phosphofructose substrate molecule.

Name	Definition
fructose 6-phosphate metabolic process	The chemical reactions and pathways involving fructose 6-phosphate, also known as F6P. The D-enantiomer is an important intermediate in glycolysis, gluconeogenesis, and fructose metabolism.
photosynthesis	The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds.
response to glucose	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
F4JGR5	PFP-BETA2	Pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit beta 2	Arabidopsis thaliana (Mouse-ear cress)	PR