F4JGR5
PR
Gene name |
PFP-BETA2 |
Protein name |
Pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit beta 2 |
Names |
PFP 2, 6-phosphofructokinase, pyrophosphate dependent 2, PPi-PFK 2, Protein MATERNAL EFFECT EMBRYO ARREST 51, Pyrophosphate-dependent 6-phosphofructose-1-kinase 2 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT4G04040 |
EC number |
2.7.1.90: Phosphotransferases with an alcohol group as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for F4JGR5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-F4JGR5-F1 | Predicted | AlphaFoldDB |
78 variants for F4JGR5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_4_1939254_C_A | 2 | A>E | No | 1000Genomes | |
| ENSVATH00460232 | 4 | Q>H | No | 1000Genomes | |
| tmp_4_1939265_G_A | 6 | D>N | No | 1000Genomes | |
| ENSVATH10657504 | 12 | Y>F | No | 1000Genomes | |
| ENSVATH06448901 | 15 | G>E | No | 1000Genomes | |
| ENSVATH10657526 | 22 | T>A | No | 1000Genomes | |
| tmp_4_1939364_G_A | 39 | D>N | No | 1000Genomes | |
| tmp_4_1939370_A_C | 41 | T>P | No | 1000Genomes | |
| ENSVATH02643463 | 47 | V>L | No | 1000Genomes | |
| ENSVATH06448902 | 52 | F>S | No | 1000Genomes | |
| tmp_4_1939573_C_A | 74 | P>H | No | 1000Genomes | |
| ENSVATH10657546 | 74 | P>S | No | 1000Genomes | |
| ENSVATH06448910 | 82 | A>G | No | 1000Genomes | |
| tmp_4_1939620_A_G | 90 | N>D | No | 1000Genomes | |
| ENSVATH10657548 | 90 | N>S | No | 1000Genomes | |
| ENSVATH10657549 | 97 | K>N | No | 1000Genomes | |
| ENSVATH06448914 | 125 | E>D | No | 1000Genomes | |
| ENSVATH10657550 | 128 | R>S | No | 1000Genomes | |
| tmp_4_1939835_G_A | 131 | S>N | No | 1000Genomes | |
| tmp_4_1939880_A_G | 146 | K>R | No | 1000Genomes | |
| ENSVATH06448916 | 147 | Y>F | No | 1000Genomes | |
| ENSVATH10657552 | 153 | E>G | No | 1000Genomes | |
| ENSVATH02643466 | 154 | F>I | No | 1000Genomes | |
| tmp_4_1940499_G_T | 165 | D>Y | No | 1000Genomes | |
| ENSVATH02643479 | 179 | Q>K | No | 1000Genomes | |
| ENSVATH02643480 | 179 | Q>L | No | 1000Genomes | |
| tmp_4_1940660_A_G | 189 | K>E | No | 1000Genomes | |
| ENSVATH06448939 | 195 | L>F | No | 1000Genomes | |
| ENSVATH13913982 | 198 | I>V | No | 1000Genomes | |
| tmp_4_1940732_C_T | 213 | H>Y | No | 1000Genomes | |
| tmp_4_1940830_A_G | 217 | K>E | No | 1000Genomes | |
| tmp_4_1940842_A_T | 221 | T>S | No | 1000Genomes | |
| ENSVATH02643483 | 222 | L>V | No | 1000Genomes | |
| tmp_4_1940919_T_A | 246 | D>E | No | 1000Genomes | |
| tmp_4_1941060_G_A | 267 | G>E | No | 1000Genomes | |
| tmp_4_1941066_A_T | 269 | Y>F | No | 1000Genomes | |
| ENSVATH13914015 | 278 | R>C | No | 1000Genomes | |
| ENSVATH06448956 | 304 | E>* | No | 1000Genomes | |
| ENSVATH06448957 | 304 | E>A | No | 1000Genomes | |
| tmp_4_1941356_C_T | 307 | L>F | No | 1000Genomes | |
| tmp_4_1941399_A_G | 321 | Y>C | No | 1000Genomes | |
| ENSVATH06448958 | 322 | K>Q | No | 1000Genomes | |
| tmp_4_1941415_T_A | 326 | N>K | No | 1000Genomes | |
| ENSVATH10657699 | 352 | E>K | No | 1000Genomes | |
| ENSVATH06448962 | 357 | L>I | No | 1000Genomes | |
| tmp_4_1941603_C_T | 358 | A>V | No | 1000Genomes | |
| ENSVATH06448964 | 367 | Q>R | No | 1000Genomes | |
| tmp_4_1941645_T_G | 372 | L>R | No | 1000Genomes | |
| ENSVATH10657700 | 377 | L>S | No | 1000Genomes | |
| tmp_4_1941662_G_A | 378 | E>K | No | 1000Genomes | |
| tmp_4_1941711_A_C | 394 | E>A | No | 1000Genomes | |
| ENSVATH08221012 | 400 | N>T | No | 1000Genomes | |
| ENSVATH10657702 | 413 | I>S | No | 1000Genomes | |
| ENSVATH06448966 | 419 | E>K | No | 1000Genomes | |
| ENSVATH02643491 | 424 | K>T | No | 1000Genomes | |
| ENSVATH10657703 | 428 | T>A | No | 1000Genomes | |
| tmp_4_1941926_C_A | 428 | T>K | No | 1000Genomes | |
| ENSVATH10657703 | 428 | T>P | No | 1000Genomes | |
| tmp_4_1942132_C_G | 470 | S>R | No | 1000Genomes | |
| tmp_4_1942133_G_A | 471 | G>R | No | 1000Genomes | |
| ENSVATH06448975 | 480 | G>E | No | 1000Genomes | |
| tmp_4_1942270_G_A | 487 | E>K | No | 1000Genomes | |
| ENSVATH13914021 | 498 | S>L | No | 1000Genomes | |
| tmp_4_1942327_C_A | 506 | H>N | No | 1000Genomes | |
| ENSVATH10657728 | 514 | K>T | No | 1000Genomes | |
| tmp_4_1942448_C_A | 520 | L>I | No | 1000Genomes | |
| ENSVATH00460245 | 521 | E>D | No | 1000Genomes | |
| ENSVATH10657730 | 526 | K>N | No | 1000Genomes | |
| ENSVATH00460246 | 527 | K>N | No | 1000Genomes | |
| ENSVATH00460247 | 552 | P>T | No | 1000Genomes | |
| ENSVATH06448994 | 553 | G>R | No | 1000Genomes | |
| ENSVATH00460248 | 555 | D>Y | No | 1000Genomes | |
| ENSVATH13914022 | 557 | R>I | No | 1000Genomes | |
| tmp_4_1942726_A_T | 557 | R>S | No | 1000Genomes | |
| tmp_4_1942733_A_T | 560 | T>S | No | 1000Genomes | |
| ENSVATH10657747 | 562 | M>L | No | 1000Genomes | |
| tmp_4_1942752_G_T | 566 | G>V | No | 1000Genomes | |
| tmp_4_1942757_C_T | 568 | Q>* | No | 1000Genomes |
No associated diseases with F4JGR5
1 regional properties for F4JGR5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Phosphofructokinase domain | 99 - 464 | IPR000023 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.1.90 | Phosphotransferases with an alcohol group as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| 6-phosphofructokinase activity | Catalysis of the reaction: ATP + D-fructose-6-phosphate = ADP + D-fructose 1,6-bisphosphate. |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| diphosphate-fructose-6-phosphate 1-phosphotransferase activity | Catalysis of the reaction: fructose-6-phosphate + diphosphate = phosphate + fructose-1,6-bisphosphate. |
| metal ion binding | Binding to a metal ion. |
| phosphofructokinase activity | Catalysis of the transfer of a phosphate group, usually from ATP, to a phosphofructose substrate molecule. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| embryo development ending in seed dormancy | The process whose specific outcome is the progression of the embryo over time, from zygote formation to the end of seed dormancy. An example of this process is found in Arabidopsis thaliana. |
| fructose 6-phosphate metabolic process | The chemical reactions and pathways involving fructose 6-phosphate, also known as F6P. The D-enantiomer is an important intermediate in glycolysis, gluconeogenesis, and fructose metabolism. |
| photosynthesis | The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. |
| response to glucose | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8W4M5 | PFP-BETA1 | Pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit beta 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MASQLDLIGG | DYIAGISINP | PTNSRVTSVY | SEVQASRIDH | TLPLPSVFKT | PFKIIDGPPS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SSAGHPEEIE | KLFPNLFGQP | SALLVPNQSN | EVSSDQKLKI | GVVLSGGQAP | GGHNVICGIF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DYLQEYARGS | SLFGFRGGPA | GIMKGKYIEL | TSEFVYPYRN | QGGFDMICSG | RDKIETPEQF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KQAEETVTKM | DLDGLVVIGG | DDSNTNACLL | AEHFRAKNMK | TLVIGCPKTI | DGDLKSKEVP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TSFGFDTACK | IYSEMIGNVM | IDARSTGKYY | HFVRLMGRAA | SHITLECALQ | THPNITIIGE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EVFEKKLTLK | NVTDNIVDVI | YKRAENGYNY | GVILVPEGLI | DFIPEVQQLI | SELNEVLAEG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NVDEEGQWKK | NLKKETLEIF | EFLPQTIQEQ | LMLERDPHGN | VQVAKIETEK | MLIQMVETEL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EKKKTEGTYE | REFMGKSHFF | GYEGRCGLPT | NFDATYCYAL | GYGAGSLLQS | GKTGLISSVG |
| 490 | 500 | 510 | 520 | 530 | 540 |
| NLAAPVEEWT | VGGTALTSLM | DVERRHGKFK | PVIKKAMVEL | EGAPFKKFAS | QREEWALKNR |
| 550 | 560 | ||||
| YISPGPIQFK | GPGSDARNHT | LMLELGAQA |