Q8W2F3
PR
Gene name |
PIF4 (BHLH9, EN102, SRL2, At2g43010, MFL8.13) |
Protein name |
Transcription factor PIF4 |
Names |
Basic helix-loop-helix protein 9, AtbHLH9, bHLH 9, Phytochrome-interacting factor 4, Short under red-light 2, Transcription factor EN 102, bHLH transcription factor bHLH009 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT2G43010 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8W2F3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8W2F3-F1 | Predicted | AlphaFoldDB |
32 variants for Q8W2F3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH05707682 | 44 | H>R | No | 1000Genomes | |
| tmp_2_17887293_A_C | 67 | E>D | No | 1000Genomes | |
| ENSVATH00272202 | 123 | P>H | No | 1000Genomes | |
| ENSVATH13623283 | 128 | D>H | No | 1000Genomes | |
| ENSVATH00272203 | 131 | P>S | No | 1000Genomes | |
| ENSVATH14610674 | 146 | S>L | No | 1000Genomes | |
| ENSVATH05707684 | 150 | E>G | No | 1000Genomes | |
| ENSVATH05707685 | 160 | T>N | No | 1000Genomes | |
| ENSVATH00272205 | 179 | M>I | No | 1000Genomes | |
| tmp_2_17887694_G_A | 201 | G>D | No | 1000Genomes | |
| tmp_2_17887693_G_A | 201 | G>S | No | 1000Genomes | |
| tmp_2_17887742_G_C | 217 | G>A | No | 1000Genomes | |
| tmp_2_17887748_G_A | 219 | C>Y | No | 1000Genomes | |
| ENSVATH00272207 | 226 | R>K | No | 1000Genomes | |
| ENSVATH00272208 | 231 | H>D | strain: cv. Bla-6, cv. Et-0, cv. Li-5:3, cv. Mt-0, cv. Pa-2 and cv. Tsu-1 [UniProt] | No | 1000Genomes |
| ENSVATH05707690 | 276 | R>K | No | 1000Genomes | |
| ENSVATH13623326 | 320 | A>S | No | 1000Genomes | |
| tmp_2_17888353_G_T | 321 | A>S | No | 1000Genomes | |
| ENSVATH05707692 | 324 | A>V | No | 1000Genomes | |
| ENSVATH05707694 | 342 | I>M | No | 1000Genomes | |
| ENSVATH13623328 | 357 | S>F | No | 1000Genomes | |
| ENSVATH05707695 | 370 | P>R | No | 1000Genomes | |
| ENSVATH05707696 | 378 | D>A | No | 1000Genomes | |
| ENSVATH05707696 | 378 | D>G | No | 1000Genomes | |
| tmp_2_17888718_G_T | 396 | M>I | No | 1000Genomes | |
| ENSVATH01982429 | 399 | M>T | No | 1000Genomes | |
| tmp_2_17888738_G_T | 403 | R>I | No | 1000Genomes | |
| ENSVATH00272209 | 405 | S>G | No | 1000Genomes | |
| ENSVATH01982430 | 413 | Q>H | No | 1000Genomes | |
| ENSVATH00272210 | 414 | Q>E | No | 1000Genomes | |
| tmp_2_17888782_G_C | 418 | V>L | No | 1000Genomes | |
| tmp_2_17888795_C_A | 422 | T>N | No | 1000Genomes |
No associated diseases with Q8W2F3
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA-binding transcription factor activity | A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. |
| promoter-specific chromatin binding | Binding to a section of chromatin that is associated with gene promoter sequences of DNA. |
| protein dimerization activity | The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| de-etiolation | The greening response of plants grown in the dark (etiolated) as a result of chloroplast biogenesis and the accumulation of chlorophyll. |
| phototropism | The movement of an organism, or part of an organism, in response to a light stimulus, usually toward or away from it. |
| red light signaling pathway | The series of molecular signals initiated upon sensing of red light by a photoreceptor molecule. Red light is electromagnetic radiation of wavelength of 580-700nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs. |
| red or far-red light signaling pathway | The series of molecular signals initiated upon sensing by photoreceptor molecules of red light or far red light. Red light is electromagnetic radiation of wavelength of 580-700nm. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs. |
| red, far-red light phototransduction | The sequence of reactions within a cell required to convert absorbed photons from red or far-red light into a molecular signal; the red, far-red light range is defined as having a wavelength within the range 660-730 nm. |
| regulation of auxin biosynthetic process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of auxins, plant hormones that regulate aspects of plant growth. |
| regulation of auxin mediated signaling pathway | Any process that modulates the rate, frequency or extent of auxin mediated signaling pathway. Auxin mediated signaling pathway is the series of molecular signals generated in response to detection of auxin. |
| response to low fluence blue light stimulus by blue low-fluence system | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of a low fluence blue light stimulus by the blue low-fluence system. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm. The blue low-fluence system responds to blue light at or below 0.1 micromols/m2. In certain species excitation of the blue low fluence system induces the transcription of a number of nuclear and plastid coded genes. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEHQGWSFEE | NYSLSTNRRS | IRPQDELVEL | LWRDGQVVLQ | SQTHREQTQT | QKQDHHEEAL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RSSTFLEDQE | TVSWIQYPPD | EDPFEPDDFS | SHFFSTMDPL | QRPTSETVKP | KSSPEPPQVM |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VKPKACPDPP | PQVMPPPKFR | LTNSSSGIRE | TEMEQYSVTT | VGPSHCGSNP | SQNDLDVSMS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| HDRSKNIEEK | LNPNASSSSG | GSSGCSFGKD | IKEMASGRCI | TTDRKRKRIN | HTDESVSLSD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AIGNKSNQRS | GSNRRSRAAE | VHNLSERRRR | DRINERMKAL | QELIPHCSKT | DKASILDEAI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DYLKSLQLQL | QVMWMGSGMA | AAAASAPMMF | PGVQPQQFIR | QIQSPVQLPR | FPVMDQSAIQ |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NNPGLVCQNP | VQNQIISDRF | ARYIGGFPHM | QAATQMQPME | MLRFSSPAGQ | QSQQPSSVPT |
| KTTDGSRLDH |