Q8VIM4

PR
Gene name
Bsnd
Protein name
Barttin
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:140475
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

40-307 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8VIM4

Entry ID Method Resolution Chain Position Source
AF-Q8VIM4-F1 Predicted AlphaFoldDB

15 variants for Q8VIM4

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388686384 22 G>A No EVA
rs3388694807 53 M>I No EVA
rs3388698954 57 Y>* No EVA
rs257865509 85 L>I No EVA
rs3388699830 98 L>M No EVA
rs3388693578 118 V>F No EVA
rs3394622995 140 V>G No EVA
rs3388697212 151 W>C No EVA
rs3388693639 152 M>R No EVA
rs3388694022 159 H>L No EVA
rs3388693591 209 R>G No EVA
rs213832645 251 A>T No EVA
rs247444392 251 A>V No EVA
rs32775485 292 N>D No EVA
rs3388676812 298 E>D No EVA

No associated diseases with Q8VIM4

No regional properties for Q8VIM4

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q8VIM4

Functions

Description
EC Number
Subcellular Localization
  • Basolateral cell membrane ; Multi-pass membrane protein
  • Staining in membranes of the renal tubule is basolateral
  • Also detected in basolateral membranes of intercalated cells of the collecting duct, which are known to express CLCNKB as well
  • Both acid-secreting alpha-intercalated cells and base-secreting beta-intercalated cells express this protein basolaterally, but intervening AQP2-expressing principal cells appear devoid of protein expression
  • In the inner ear, colocalizes with CLCNK in K(+)-secreting marginal cells of the stria vascularis
  • The basolateral staining contrasts with the apical localization of the KCNQ1 K(+) channel
  • Also found in K(+)-secreting vestibular dark cells, where it colocalized in basolateral membranes with CLCNK below apical membranes that expressed KCNQ1
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
basolateral plasma membrane The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.

1 GO annotations of molecular function

Name Definition
chloride channel regulator activity Binds to and modulates the activity of a chloride channel.

6 GO annotations of biological process

Name Definition
cellular chloride ion homeostasis Any process involved in the maintenance of an internal steady state of chloride ions at the level of a cell.
cellular ion homeostasis Any process involved in the maintenance of an internal steady state of ions at the level of a cell.
cellular potassium ion homeostasis Any process involved in the maintenance of an internal steady state of potassium ions at the level of a cell.
chloride transmembrane transport The process in which chloride is transported across a membrane.
chloride transport The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
sensory perception of sound The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8R2H3 Bsnd Barttin Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MADEKTFRIG FIVLGLFLLS LGTFLMSHDR PQVYGTFYAM GSVMVIGGVI WSMCQCYPKI
70 80 90 100 110 120
TFVPADSDFQ GILSPKALSL LETGLSEVKS PQPPYVRLWE EAAYDQSLPD FTHIQMKVMG
130 140 150 160 170 180
YSEDPRPLLA PELKTGASSV REGEPRTAQA WMEAPVVVHR GSDENEGEKS HSQSSPSVGP
190 200 210 220 230 240
QGSAPLASFH DDLDVGSSEG SSLQPSPNRD EPHRQVPWAS RGPLDRFSDF ALIDDTPTSE
250 260 270 280 290 300
DTVLDGQARE AALPRKQQWS LRMKGETVQA RAEEPEQEEE DLYYGLPDSP GNPLPDKELG
FEPDIQG