Q8VI88
Gene name |
Odf4 (Oppo1) |
Protein name |
Outer dense fiber protein 4 |
Names |
Outer dense fiber of sperm tails protein 4, Testis-specific protein oppo 1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:252868 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8VI88
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8VI88-F1 | Predicted | AlphaFoldDB |
19 variants for Q8VI88
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs13481085 | 11 | E>G | No | EVA | |
| rs230203304 | 22 | L>P | No | EVA | |
| rs3389167235 | 59 | L>F | No | EVA | |
| rs3389181647 | 67 | K>Q | No | EVA | |
| rs3402369636 | 82 | Q>L | No | EVA | |
| rs3389140386 | 83 | N>D | No | EVA | |
| rs3389167652 | 97 | T>I | No | EVA | |
| rs3389167444 | 118 | F>Y | No | EVA | |
| rs3389167630 | 123 | I>L | No | EVA | |
| rs240849878 | 127 | F>L | No | EVA | |
| rs3389166970 | 129 | V>M | No | EVA | |
| rs3412804461 | 133 | S>R | No | EVA | |
| rs3389167604 | 143 | V>I | No | EVA | |
| rs3389170310 | 162 | F>L | No | EVA | |
| rs3389166908 | 180 | T>A | No | EVA | |
| rs3389106936 | 259 | S>R | No | EVA | |
| rs3389170322 | 261 | Q>* | No | EVA | |
| rs3389181594 | 261 | Q>P | No | EVA | |
| rs3389180221 | 273 | K>R | No | EVA |
No associated diseases with Q8VI88
1 regional properties for Q8VI88
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Domain of unknown function DUF3456 | 43 - 199 | IPR021852 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| motile cilium | A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell. |
| outer dense fiber | A supramolecular fiber found in the flagella of mammalian sperm that surrounds the nine microtubule doublets. These dense fibers are stiff and noncontractile. In human, they consist of about 10 major and at least 15 minor proteins, where all major proteins are ODF1, ODF2 or ODF2-related proteins. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| cell differentiation | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| spermatogenesis | The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q0II41 | ODF4 | Outer dense fiber protein 4 | Bos taurus (Bovine) | PR |
| D3Z7H4 | Gsg1l | Germ cell-specific gene 1-like protein | Mus musculus (Mouse) | PR |
| Q6AXT9 | Odf4 | Outer dense fiber protein 4 | Rattus norvegicus (Rat) | PR |
| Q9NGJ7 | clc-5 | Clc-like protein 5 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEPDLNEEES | ERIRTSRNRR | SLEHRRNSLL | PFQWKATNNS | RWMAQVVASE | FSLVAFLLLL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VMVFSKKWLY | PSKSRFHQRY | PQNVTKRVYT | SIHSMSTGLL | YICVSKSCPS | SDNGEDNFKM |
| 130 | 140 | 150 | 160 | 170 | 180 |
| WTIHPVFGVA | KISFTLAIGL | GFVLTTWLHL | PYLPCLQRMP | FFGLIGIILS | FCEVTLIFLT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LLLFPVNLWI | YELRKNISVP | IGWSYFIGWL | VLILYFTCGI | LCYLNHKNYW | SLIMSSTTIN |
| 250 | 260 | 270 | 280 | ||
| TACSSLGPES | LVSPSQTPSS | QENSQESPKD | DQKPSSPDKV | VSPPQPDTTG |