Q8VHW3
Gene name |
Cacng6 |
Protein name |
Voltage-dependent calcium channel gamma-6 subunit |
Names |
Neuronal voltage-gated calcium channel gamma-6 subunit |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:54378 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8VHW3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8VHW3-F1 | Predicted | AlphaFoldDB |
13 variants for Q8VHW3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388856166 | 32 | T>S | No | EVA | |
| rs3388856179 | 50 | A>T | No | EVA | |
| rs3388875223 | 53 | A>T | No | EVA | |
| rs3388856178 | 65 | L>F | No | EVA | |
| rs3388846959 | 77 | E>K | No | EVA | |
| rs3388877986 | 79 | A>V | No | EVA | |
| rs3388873501 | 94 | A>V | No | EVA | |
| rs3397566741 | 158 | C>F | No | EVA | |
| rs3397429948 | 158 | C>S | No | EVA | |
| rs3397641855 | 159 | V>L | No | EVA | |
| rs3388853562 | 165 | K>R | No | EVA | |
| rs3388874853 | 203 | V>F | No | EVA | |
| rs3388869600 | 242 | T>N | No | EVA |
No associated diseases with Q8VHW3
No regional properties for Q8VHW3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q8VHW3 | |||
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| L-type voltage-gated calcium channel complex | A type of voltage-dependent calcium channel responsible for excitation-contraction coupling of skeletal, smooth, and cardiac muscle. 'L' stands for 'long-lasting' referring to the length of activation. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium channel activity | Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
| calcium channel regulator activity | Modulates the activity of a calcium channel. |
| voltage-gated ion channel activity | Enables the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| regulation of calcium ion transmembrane transport via high voltage-gated calcium channel | Any process that modulates the frequency, rate or extent of generation of calcium ion transmembrane transport via high voltage-gated calcium channel. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9BXT2 | CACNG6 | Voltage-dependent calcium channel gamma-6 subunit | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MMWSNFFMQE | EDRRRTAVGR | RRAQEQQNLG | LTPEREGKIK | LGLLVAIVGA | TLAVLAVGTE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FWVELNTYKT | NGSAVCEAAH | LGLWKVCIKR | LWQADVPAGR | ETCGPAELPG | EANCTYFKFF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TTGENARIFQ | RTTKKEVNLA | AAVIAVLGLT | AMALGCLCVI | MVLSKGAESL | LRLGAVCFGL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SGLLLFVSLE | VFRHSVGALL | QGVNPETPPA | PRLAYEYSWS | LGCGVGAGLI | LLLGGVCFLL |
| 250 | |||||
| LTLPSWPWRS | LCPKWGGPTA |