Q8VDM4

PR
Gene name
Psmd2
Protein name
26S proteasome non-ATPase regulatory subunit 2
Names
26S proteasome regulatory subunit RPN1, 26S proteasome regulatory subunit S2, 26S proteasome subunit p97
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:21762
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-59 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8VDM4

Entry ID Method Resolution Chain Position Source
AF-Q8VDM4-F1 Predicted AlphaFoldDB

31 variants for Q8VDM4

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389417905 3 E>G No EVA
rs3389367989 6 R>L No EVA
rs3389356021 59 L>I No EVA
rs3389403609 81 Q>* No EVA
rs3389413383 84 S>Y No EVA
rs13464948 88 S>P No EVA
rs3389404754 96 L>H No EVA
rs3389407531 101 P>Q No EVA
rs3389413336 102 H>Y No EVA
rs3389423088 113 M>V No EVA
rs3389409852 142 Y>N No EVA
rs3389409861 154 W>* No EVA
rs3406788104 213 Q>LDLIEADLAIGVLINVLL* No EVA
rs3406788104 218 E>ADLGVGVLINVLL* No EVA
rs3406788013 222 D>G No EVA
rs3389401313 265 A>S No EVA
rs3389356006 291 Q>* No EVA
rs3389413316 314 Y>N No EVA
rs3389407500 401 K>* No EVA
rs3389401297 435 S>Y No EVA
rs3389401048 436 S>T No EVA
rs3389409816 451 V>L No EVA
rs3389413322 497 V>D No EVA
rs3389367970 508 S>F No EVA
rs3389409810 577 L>P No EVA
rs3389401018 584 S>L No EVA
rs3389407552 634 K>R No EVA
rs3389387151 662 M>K No EVA
rs13464949 849 A>V No EVA
rs3389413384 860 K>* No EVA
rs3389367996 864 G>R No EVA

No associated diseases with Q8VDM4

4 regional properties for Q8VDM4

Type Name Position InterPro Accession
repeat Proteasome/cyclosome repeat 443 - 478 IPR002015-1
repeat Proteasome/cyclosome repeat 480 - 512 IPR002015-2
domain RPN1, N-terminal 56 - 354 IPR040892
domain 26S proteasome non-ATPase regulatory subunit RPN1, C-terminal 853 - 906 IPR041433

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
proteasome accessory complex A protein complex, that caps one or both ends of the proteasome core complex and regulates entry into, or exit from, the proteasome core complex.
proteasome complex A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core.
proteasome regulatory particle A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex.
proteasome regulatory particle, base subcomplex The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex.
proteasome storage granule An aggregation of proteasome core protease (CP) and regulatory particle (RP) complexes that localizes in the cytoplasm as dot-like structures when cells are in a quiescent state.

1 GO annotations of molecular function

Name Definition
enzyme regulator activity Binds to and modulates the activity of an enzyme.

2 GO annotations of biological process

Name Definition
proteasome-mediated ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
regulation of protein catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 Homo sapiens (Human) PR
10 20 30 40 50 60
MEEGGRDKTP VQSQQPSATT PSGADEKSSG KERRDAGEKD KEQELSEEDK QLQDELEMLV
70 80 90 100 110 120
ERLGEKDTSL YRPALEELRR QIRSSTTSMT SVPKPLKFLR PHYGKLKEIY ENMAPGENKC
130 140 150 160 170 180
FAADIISVLA MTMSGERECL KYRLVGSQEE LASWGHEYVR HLAGEVAKEW QELDDAEKAQ
190 200 210 220 230 240
REPLLTLVKE IVPYNMAHNA EHEACDLLME IEQVDMLEKD IDENAYAKVC LYLTSCVNYV
250 260 270 280 290 300
PEPENSALLR CALGVFRKFS RFPEALRLAL MLNDMELVED IFTSCKDVVV QKQMAFMLGR
310 320 330 340 350 360
HGVFLELSED VEEYEDLTEI MSNVQLNSNF LALARELDIM EPKVPDDIYK THLENNRFGG
370 380 390 400 410 420
SGSQVDSARM NLASSFVNGF VNAAFGQDKL LTDDGNKWLY KNKDHGMLSA AASLGMILLW
430 440 450 460 470 480
DVDGGLTQID KYLYSSEDYI KSGALLACGI VNSGVRNECD PALALLSDYV LHNSNTMRLG
490 500 510 520 530 540
SIFGLGLAYA GSNREDVLTL LLPVMGDSKS SMEVAGVTAL ACGMIAVGSC NGDVTSTILQ
550 560 570 580 590 600
TIMEKSETEL KDTYARWLPL GLGLNHLGKG EAIEAILAAL EVVSEPFRSF ANTLVDVCAY
610 620 630 640 650 660
AGSGNVLKVQ QLLHICSEHF DSKEKEEDKD KKEKKDKDKK EAPADMGAHQ GVAVLGIALI
670 680 690 700 710 720
AMGEEIGAEM ALRTFGHLLR YGEPTLRRAV PLALALISVS NPRLNILDTL SKFSHDADPE
730 740 750 760 770 780
VSYNSIFAMG MVGSGTNNAR LAAMLRQLAQ YHAKDPNNLF MVRLAQGLTH LGKGTLTLCP
790 800 810 820 830 840
YHSDRQLMSQ VAVAGLLTVL VSFLDVRNII LGKSHYVLYG LVAAMQPRML VTFDEELRPL
850 860 870 880 890 900
PVSVRVGQAV DVVGQAGKPK TITGFQTHTT PVLLAHGERA ELATEEFLPV TPILEGFVIL
RKNPNYDL