Q8VDG5
Gene name |
Ppcs (Coab) |
Protein name |
Phosphopantothenate--cysteine ligase |
Names |
Phosphopantothenoylcysteine synthetase, PPC synthetase |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:106564 |
EC number |
6.3.2.51: Acid--amino-acid ligases (peptide synthases) |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8VDG5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8VDG5-F1 | Predicted | AlphaFoldDB |
11 variants for Q8VDG5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388707521 | 9 | E>A | No | EVA | |
| rs3411998081 | 22 | V>I | No | EVA | |
| rs3394745211 | 64 | R>Q | No | EVA | |
| rs3394483080 | 65 | R>H | No | EVA | |
| rs3388700512 | 67 | A>S | No | EVA | |
| rs3394762080 | 113 | S>T | No | EVA | |
| rs3394607659 | 117 | S>G | No | EVA | |
| rs3394607656 | 118 | L>Q | No | EVA | |
| rs3394789531 | 119 | E>K | No | EVA | |
| rs3394496089 | 122 | E>G | No | EVA | |
| rs48790246 | 220 | D>H | No | EVA |
No associated diseases with Q8VDG5
2 regional properties for Q8VDG5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | DNA/pantothenate metabolism flavoprotein, C-terminal | 36 - 83 | IPR007085-1 |
| domain | DNA/pantothenate metabolism flavoprotein, C-terminal | 159 - 262 | IPR007085-2 |
Functions
| Description | ||
|---|---|---|
| EC Number | 6.3.2.51 | Acid--amino-acid ligases (peptide synthases) |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| identical protein binding | Binding to an identical protein or proteins. |
| phosphopantothenate--cysteine ligase activity | Catalysis of the reaction: CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + (R)-4'-phosphopantothenoyl-L-cysteine. Cysteine can be replaced by some of its derivatives. |
| protein homodimerization activity | Binding to an identical protein to form a homodimer. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| acetyl-CoA biosynthetic process | The chemical reactions and pathways resulting in the formation of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated. |
| coenzyme A biosynthetic process | The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. |
| heart process | A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P40506 | CAB2 | Phosphopantothenate--cysteine ligase CAB2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAEMDLVAEL | PRPAGAARWA | EVMARFAARL | GEQGRRVVLI | TSGGTKVPLE | ARAVRFLDNF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SSGRRGAASA | EVFLAAGYGV | LFLYRARSAF | PYAHRFPPQA | WLSALRPSGP | AQSGKLSLEA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EENALPGFAA | ALQSYQEAAA | AGTFLAVEFT | TLADYLHLLQ | AAALALSPLG | SSAMFYLAAA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VSDFYIPVSE | MPEHKIHSSG | GPLQITMKMV | PKMLSPLVKD | WAPKAFVVSF | KLETDPDIII |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SRARNALEVY | QHQVVVANIL | ESIKSFVIIV | TKDSETELLL | SEEEVAKGLV | IEEKIVDDLR |
| 310 | |||||
| SRHTAFICDK | N |