P40506

PR
Gene name
CAB2 (YIL083C)
Protein name
Phosphopantothenate--cysteine ligase CAB2
Names
Coenzyme A biosynthesis protein 2, Phosphopantothenoylcysteine synthetase, PPC synthetase
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YIL083C
EC number
6.3.2.5: Acid--amino-acid ligases (peptide synthases)
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

196-277 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

6 structures for P40506

Entry ID Method Resolution Chain Position Source
6AI8 X-ray 230 A A/B 1-365 PDB
6AI9 X-ray 209 A A/B 1-365 PDB
6AIK X-ray 183 A A/B 1-365 PDB
6AIM X-ray 204 A A/B 1-365 PDB
6AIP X-ray 199 A A/B 1-365 PDB
AF-P40506-F1 Predicted AlphaFoldDB

3 variants for P40506

Variant ID(s) Position Change Description Diseaes Association Provenance
s09-204148 168 D>G No SGRP
s09-204068 195 I>V No SGRP
s09-203716 312 T>K No SGRP

No associated diseases with P40506

10 regional properties for P40506

Type Name Position InterPro Accession
domain DNA topoisomerase, type IA, domain 2 104 - 192 IPR003601
domain DNA topoisomerase, type IA, DNA-binding domain 242 - 508 IPR003602
domain TOPRIM domain 3 - 113 IPR006171
domain DNA topoisomerase, type IA, central 77 - 90 IPR013497-1
domain DNA topoisomerase, type IA, central 128 - 556 IPR013497-2
domain DNA topoisomerase, type IA, zn finger 574 - 611 IPR013498-1
domain DNA topoisomerase, type IA, zn finger 614 - 653 IPR013498-2
domain DNA topoisomerase, type IA, zn finger 655 - 688 IPR013498-3
active_site DNA topoisomerase, type IA, active site 279 - 302 IPR023406
domain DNA topoisomerase 1, TOPRIM domain 4 - 125 IPR034149

Functions

Description
EC Number 6.3.2.5 Acid--amino-acid ligases (peptide synthases)
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
CoA-synthesizing protein complex A multisubunit complex likely involved in the synthesis of coenzyme A (CoA). In S. cerevisiae, the complex consists of at least Cab2, Cab3, Cab4 and Cab5 but may also include Sis2 and Vhs3. The latter subunits are shared by the GO:0071513 phosphopantothenoylcysteine decarboxylase complex that catalyses the third step of the coenzyme A (CoA) biosynthetic pathway.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name Definition
phosphopantothenate--cysteine ligase activity Catalysis of the reaction: CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + (R)-4'-phosphopantothenoyl-L-cysteine. Cysteine can be replaced by some of its derivatives.

1 GO annotations of biological process

Name Definition
coenzyme A biosynthetic process The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8VDG5 Ppcs Phosphopantothenate--cysteine ligase Mus musculus (Mouse) PR
10 20 30 40 50 60
MPPLPVLNRP QIHTSVTEIS HAIDRTIKEE LFPVAYTTEE EQYFKTNPKP AYIDELIKDA
70 80 90 100 110 120
KEFIDLQYSL KRNKIVLITS GGTTVPLENN TVRFIDNFSA GTRGASSAEQ FLANGYSVIF
130 140 150 160 170 180
LHREFSLTPY NRSFSHSINT LFLDYIDSEG KIKPEFAENV LKNKKLYDKY MEKEEKLLLL
190 200 210 220 230 240
PFTTVNQYLW SLKSIAKLLN NSGCLFYLAA AVSDFFVPYS RLPQHKIQSG DNGKMGANND
250 260 270 280 290 300
TEGTTRTTPD GKLIVNLDPV PKFLRRLVES WATQAMIVSF KLETDESMLL YKCTQALDRY
310 320 330 340 350 360
NHQLVIGNLL QTRNKQVIFV SPENRKGDWV RLDEKHHSIE EMIIPEVIAR HDKWVAHSKT
KLATK