Q8VCM4

PR
Gene name
Lipt1
Protein name
Lipoyltransferase 1, mitochondrial
Names
Lipoate biosynthesis protein, Lipoate-protein ligase, Lipoyl ligase
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:623661
EC number
2.3.1.200: Transferring groups other than amino-acyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

146-234 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8VCM4

Entry ID Method Resolution Chain Position Source
AF-Q8VCM4-F1 Predicted AlphaFoldDB

25 variants for Q8VCM4

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389862567 23 G>LLKPAAETLC* No EVA
rs3388466018 25 K>* No EVA
rs3388465232 29 T>A No EVA
rs259353771 47 F>I No EVA
rs219530398 47 F>L No EVA
rs3388464892 50 W>* No EVA
rs226884021 56 H>N No EVA
rs3388465904 122 T>S No EVA
rs3388464270 129 N>D No EVA
rs3388465745 163 S>L No EVA
rs3388465769 172 T>I No EVA
rs3389845033 237 A>S No EVA
rs239411223 241 V>I No EVA
rs264077545 243 G>D No EVA
rs220850427 244 H>Q No EVA
rs3388465768 249 N>D No EVA
rs241091479 261 R>S No EVA
rs3388465438 293 H>L No EVA
rs3388465606 293 H>N No EVA
rs240051731 295 E>K No EVA
rs3388464298 334 S>I No EVA
rs3388463823 335 K>* No EVA
rs3388464969 342 T>S No EVA
rs3388465166 361 K>R No EVA
rs3388465753 362 W>R No EVA

No associated diseases with Q8VCM4

1 regional properties for Q8VCM4

Type Name Position InterPro Accession
domain Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL), catalytic domain 57 - 243 IPR004143

Functions

Description
EC Number 2.3.1.200 Transferring groups other than amino-acyl groups
Subcellular Localization
  • Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

1 GO annotations of molecular function

Name Definition
lipoyltransferase activity Catalysis of the reaction: (R)-lipoyl-5'-AMP + L-lysyl- = (R)-N6-lipoyl-L-lysyl-

1 GO annotations of biological process

Name Definition
protein lipoylation The lipoylation of peptidyl-lysine to form peptidyl-N6-lipoyl-L-lysine.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P47051 AIM22 Putative lipoate-protein ligase A Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
10 20 30 40 50 60
MLIPLSMKNC FRLLCQHKVP AAGFKSPPTH GLILQSISND VYENLAFEDW IHDHIHLEGK
70 80 90 100 110 120
PILFLWRNSP SVVIGRHQNP WQECNLHLMR QEGIKLARRK SGGGAVYHDM GNINLTFFTT
130 140 150 160 170 180
KTKYDRMENL KLIVRALNAV QPQLDVQPTK KFDLLLDGQF KISGTASKIG RTAAYHHCTL
190 200 210 220 230 240
LCSTNRTALS SSLKSPYCGI KSNATPSIPS AVKNLLERDS TLTCEVLMSA VAAEYAAHHQ
250 260 270 280 290 300
VDGHVNLINP ADETMFPGIN RKVKELQSWE WVYGRTPKFT VDTTFHVPYE QAHLEIQVFM
310 320 330 340 350 360
DVKNGRIETC AIKAPDHWLP LEIGEKLNSS FIGSKFCPVE TTLLTNVLLR TCPGDHHLHS
370
KWYILCEKIR GIM