P47051
Gene name |
AIM22 (YJL046W, J1171) |
Protein name |
Putative lipoate-protein ligase A |
Names |
Altered inheritance rate of mitochondria protein 22 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YJL046W |
EC number |
6.3.1.20: Acid--ammonia (or amine) ligases (amide synthases) |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P47051
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P47051-F1 | Predicted | AlphaFoldDB |
7 variants for P47051
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s10-352444 | 22 | H>D | No | SGRP | |
| s10-352517 | 46 | S>L | No | SGRP | |
| s10-352603 | 75 | A>T | No | SGRP | |
| s10-352615 | 79 | E>Q | No | SGRP | |
| s10-352837 | 153 | L>V | No | SGRP | |
| s10-352849 | 157 | N>D | No | SGRP | |
| s10-352906 | 176 | A>P | No | SGRP |
No associated diseases with P47051
No regional properties for P47051
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P47051 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 6.3.1.20 | Acid--ammonia (or amine) ligases (amide synthases) |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| lipoate-protein ligase activity | Catalysis of the lipoylation of a protein in two steps: ATP + (R)-lipoate + a -N6-(lipoyl)lysine + AMP + diphosphate (overall reaction): (1) ATP + (R)-lipoate = lipoyl-AMP + diphosphate; (2) lipoyl-AMP + a -N6-(lipoyl)lysine + AMP. |
| lipoyltransferase activity | Catalysis of the reaction: (R)-lipoyl-5'-AMP + L-lysyl- = (R)-N6-lipoyl-L-lysyl- |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| protein lipoylation | The lipoylation of peptidyl-lysine to form peptidyl-N6-lipoyl-L-lysine. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8VCM4 | Lipt1 | Lipoyltransferase 1, mitochondrial | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSMMLSNWAL | SPRYVGQRNL | IHCTTLFHTL | TRWAKDADDK | YHDINSMYEN | MFTPSNDNVS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ILQDEGKSDY | DTTKASSMEE | DISAFNKDLY | NFYNIGYAKQ | IMSASQLENI | VKAKGRFVIQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SLSTSPYYNL | ALENYVFKNT | PRAKRGPDNC | RLLFYINDRC | AVIGKNQNLW | QEVDLAKLKS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KNFELLRRFS | GGGTVLHDLG | NVNYSYLTSR | EKFETKFFNK | MIIKWLNSLN | PELRLDLNER |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GDIIQDGFKI | SGSAYKIAGG | KAYHHATMLL | NADLEQFSGL | LEPSLPNNME | WESSGVHSVK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SKIKNVGIIT | PNQFIAVVSE | RFQKTFKVDG | EIPIYYCDEF | KSINDEIKDA | MNTLQSEQWK |
| 370 | 380 | 390 | 400 | ||
| YFSGPKFSVK | IKDKGLTIKV | EKGMIYDCDR | NDLIGLEFKG | FLENIDSYT |