AiPD: Autoinhibited Protein Database

Gene name	Uroc1
Protein name	Urocanate hydratase
Names	Urocanase, Imidazolonepropionate hydrolase
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:243537
EC number	4.2.1.49: Hydro-lyases
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-68 (Predicted disordered autoinhibitory region) PR

1-68 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8VC12-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3397100438	23	W>*	No	EVA
rs3388845564	120	Q>*	No	EVA
rs3388827669	130	Q>R	No	EVA
rs3388841199	135	W>R	No	EVA
rs3388839388	146	S>*	No	EVA
rs244063825	173	R>Q	No	EVA
rs3388830027	195	F>Y	No	EVA
rs3388833959	219	V>L	No	EVA
rs3388851055	224	L>F	No	EVA
rs3388843111	237	E>*	No	EVA
rs3388843084	242	K>N	No	EVA
rs3388833878	278	V>A	No	EVA
rs29881042	295	R>H	No	EVA
rs3388809244	315	H>Y	No	EVA
rs3388839402	317	N>S	No	EVA
rs29973304	327	H>R	No	EVA
rs3388844619	366	S>T	No	EVA
rs3388849579	373	A>T	No	EVA
rs3388841188	374	A>P	No	EVA
rs3388845644	376	K>N	No	EVA
rs246030939	388	A>S	No	EVA
rs46858114	422	G>R	No	EVA
rs3388839389	445	G>D	No	EVA
rs52060890	459	Q>L	No	EVA
rs3388822439	471	V>L	No	EVA
rs248468409	481	K>E	No	EVA
rs3388827742	525	A>V	No	EVA
rs3388833917	528	Q>H	No	EVA
rs3388809177	532	S>I	No	EVA
rs3388845627	535	I>F	No	EVA
rs3388839382	610	D>V	No	EVA
rs3388844594	614	E>*	No	EVA
rs3396783171	620	R>W	No	EVA
rs3397029151	621	M>L	No	EVA
rs3397097812	651	Q>L	No	EVA
rs265586306	676	P>S	No	EVA

Type	Name	Position	InterPro Accession
conserved_site	Urocanase conserved site	543 - 558	IPR023636
domain	Urocanase, Rossmann-like domain	214 - 437	IPR035085
domain	Urocanase, N-terminal domain	85 - 211	IPR035400
domain	Urocanase, C-terminal domain	440 - 646	IPR035401

		Description
EC Number	4.2.1.49	Hydro-lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

Name	Definition
urocanate hydratase activity	Catalysis of the reaction: 4-imidazolone-5-propanoate + H(+) = trans-urocanate + H(2)O.

Name	Definition
histidine catabolic process	The chemical reactions and pathways resulting in the breakdown of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid.
histidine catabolic process to glutamate and formamide	The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including glutamate and formamide.
histidine catabolic process to glutamate and formate	The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including glutamate and formate.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q96N76	UROC1	Urocanate hydratase	Homo sapiens (Human)	PR