Q8TDY4

SS
Gene name
ASAP3 (DDEFL1, UPLC1)
Protein name
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3
Names
Development and differentiation-enhancing factor-like 1 , Protein up-regulated in liver cancer 1
Species
Homo sapiens (Human)
KEGG Pathway
hsa:55616
EC number
Protein Class

Descriptions

ASAP1 is an Arf GTPase-activating protein (GAP) that functions on membrane surfaces to catalyze the hydrolysis of GTP bound to Arf. ASAP1 has a BAR domain which functions as membrane curvature sensors or as inducers of membrane curvature. The BAR domain influences GAP activity by binding to the PH domain and/or Arf GAP domain. The deletion of the entire BAR domain or the N-terminal extension increased GAP activity.

Autoinhibitory domains (AIDs)

0-302 (BAR domain) SS

Target domain

304-391 (PH domain);426-546 (Arf GAP domain)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

4 structures for Q8TDY4

Entry ID Method Resolution Chain Position Source
2B0O X-ray 206 A E/F/G/H 416-697 PDB
3LVQ X-ray 338 A E 416-697 PDB
3LVR X-ray 338 A E 416-697 PDB
AF-Q8TDY4-F1 Predicted AlphaFoldDB

967 variants for Q8TDY4

Variant ID(s) Position Change Description Diseaes Association Provenance
rs929106916 2 P>A No gnomAD
rs1392057705 2 P>L No TOPMed
gnomAD
rs1392057705 2 P>R No TOPMed
gnomAD
rs929106916 2 P>S No gnomAD
rs1642414497 4 Q>K No gnomAD
rs1014533591 5 F>V No TOPMed
rs2148671568 6 S>N No 1000Genomes
rs1455934163 8 A>T No TOPMed
gnomAD
rs1222403992 10 F>L No gnomAD
rs1438624260 12 A>T No gnomAD
rs983085875 13 V>F No TOPMed
gnomAD
rs1200670115 15 A>T No gnomAD
rs2148671519 15 A>V No Ensembl
rs1452158487 16 E>K No gnomAD
rs1642408739 17 D>N No Ensembl
rs1266548307 18 L>F No TOPMed
gnomAD
rs1266548307 18 L>I No TOPMed
gnomAD
rs1343111724 19 S>G No gnomAD
rs1209383711 20 S>F No gnomAD
rs1012385676 21 P>L No TOPMed
gnomAD
rs1012385676 21 P>R No TOPMed
gnomAD
rs764931577 22 A>V No ExAC
TOPMed
gnomAD
rs1570430490 23 G>E No Ensembl
rs1241152128 23 G>W No gnomAD
rs2148671461 24 A>P No Ensembl
rs1642407331 27 F>L No Ensembl
rs1642407209 27 F>S No TOPMed
rs1642406320 30 K>N No TOPMed
gnomAD
rs1032534820 30 K>R No TOPMed
gnomAD
rs1032534820 30 K>T No TOPMed
gnomAD
rs527492071 31 M>K No 1000Genomes
TOPMed
gnomAD
rs1332249550 31 M>V No TOPMed
gnomAD
rs980433406 32 P>L No Ensembl
rs902802355 32 P>S No TOPMed
gnomAD
rs902802355 32 P>T No TOPMed
gnomAD
rs1642405303 33 R>W No TOPMed
rs1403576954 35 R>G No gnomAD
TCGA novel
rs1642404685
 35 R>P Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
Ensembl
rs2148671375 37 A>S No Ensembl
rs1642404260 38 A>G No Ensembl
rs1298232633 40 A>V No gnomAD
rs1042378982 43 E>K No TOPMed
gnomAD
rs1399862351 43 E>V No TOPMed
TCGA novel 44 I>= Variant assessed as Somatic; LOW impact. [NCI-TCGA] No NCI-TCGA
rs1641379667 44 I>F No Ensembl
rs1343138857 44 I>T No gnomAD
rs1414621361 47 G>R No gnomAD
rs755067543 48 D>N No ExAC
TOPMed
gnomAD
TCGA novel 51 I>L Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs980790231 51 I>T No TOPMed
gnomAD
rs1558153725 54 R>G No TOPMed
gnomAD
TCGA novel 54 R>I Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1641378631 55 I>T No Ensembl
rs766886545 57 K>T No ExAC
gnomAD
rs1194566647 58 A>G No TOPMed
gnomAD
rs750796854 59 V>L No ExAC
TOPMed
gnomAD
rs750796854 59 V>M No ExAC
TOPMed
gnomAD
rs765453970
COSM4029988
COSM4906466
 60 R>Q Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
ExAC
NCI-TCGA
TOPMed
gnomAD
COSM1340527
rs370249845
COSM4784477
 60 R>W Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic] No NCI-TCGA Cosmic
cosmic curated
NCI-TCGA
TOPMed
gnomAD
rs1558153630 61 A>V No Ensembl
rs369898744 62 I>V No ESP
ExAC
TOPMed
gnomAD
rs1202143420 63 H>R No gnomAD
rs1003293425 64 S>N No gnomAD
rs763627912 65 S>Y No ExAC
gnomAD
rs142619271 66 G>S No ESP
ExAC
TOPMed
gnomAD
rs141249142 68 G>D No ESP
ExAC
TOPMed
gnomAD
rs1479970825 71 E>D No TOPMed
gnomAD
rs1221740339 74 E>Q No gnomAD
rs768995083 75 Q>* No ExAC
gnomAD
rs747134598 77 R>* No ExAC
gnomAD
rs148331468
COSM906226
COSM4875637
 77 R>Q Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic] No NCI-TCGA Cosmic
cosmic curated
ESP
ExAC
NCI-TCGA
TOPMed
gnomAD
rs771999248 79 A>V No ExAC
gnomAD
rs201389143 80 V>L No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs201389143 80 V>M No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs199778394 81 E>D No 1000Genomes
ExAC
TOPMed
gnomAD
rs755800424 82 S>C No ExAC
gnomAD
rs755800424 82 S>Y No ExAC
gnomAD
rs985873101 84 G>R No TOPMed
gnomAD
rs758935550 85 N>K No ExAC
TOPMed
gnomAD
COSM906225
COSM4871035
 86 S>N Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs372043920 86 S>R No ESP
ExAC
TOPMed
gnomAD
rs1417694845 87 H>P No TOPMed
gnomAD
rs1417694845 87 H>R No TOPMed
gnomAD
rs766403675 90 Q>* No ExAC
gnomAD
rs1056622939 90 Q>H No TOPMed
rs762907646 91 N>I No ExAC
gnomAD
rs764882440 91 N>K No ExAC
TOPMed
gnomAD
rs762907646 91 N>T No ExAC
gnomAD
rs775536140 93 H>Q No 1000Genomes
ExAC
gnomAD
rs537036849 93 H>R No 1000Genomes
ExAC
gnomAD
rs772237023 94 E>G No ExAC
gnomAD
rs774900879 98 G>A No ExAC
gnomAD
COSM4906339
rs774900879
COSM4029987
 98 G>D Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
ExAC
gnomAD
rs749734430 100 L>R No ExAC
gnomAD
rs1641367009 103 A>V No Ensembl
TCGA novel
rs1641366823
 104 V>M Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
TOPMed
gnomAD
rs756392232 106 T>I No ExAC
gnomAD
rs374686646 107 R>C No ESP
ExAC
TOPMed
gnomAD
rs138253513 107 R>H No ESP
ExAC
TOPMed
gnomAD
rs138253513 107 R>L No ESP
ExAC
TOPMed
gnomAD
rs1361297937 108 E>D No gnomAD
rs141822254 108 E>K No ESP
ExAC
TOPMed
gnomAD
rs759839502 111 A>V No ExAC
TOPMed
gnomAD
TCGA novel 112 L>* Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
rs750338035 113 F>L No ExAC
TOPMed
gnomAD
rs1195302448 114 K>R No gnomAD
rs1641365413 116 L>M No TOPMed
rs1388417392 118 Q>E No TOPMed
rs1327158802 118 Q>H No TOPMed
rs763887626 119 N>D No ExAC
gnomAD
rs201194561 120 L>F No ESP
ExAC
TOPMed
gnomAD
rs751737672 121 N>D No ExAC
gnomAD
rs1020860248 122 N>S No TOPMed
gnomAD
rs766482714 125 S>A No ExAC
TOPMed
gnomAD
rs765877713 125 S>F No ExAC
TOPMed
gnomAD
rs766482714 125 S>P No ExAC
TOPMed
gnomAD
rs1641260085 126 F>L No TOPMed
rs1429232807 127 P>S No TOPMed
gnomAD
TCGA novel 128 L>P Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
rs770196583 131 L>V No ExAC
TOPMed
gnomAD
rs1558147385 132 M>I No Ensembl
rs762313460 134 G>E No ExAC
gnomAD
rs1641259281 134 G>R No Ensembl
rs1641259145 135 Q>H No gnomAD
rs1641259042 136 L>P No TOPMed
gnomAD
rs1027917730 138 D>G No TOPMed
gnomAD
rs1162544595 139 G>A No TOPMed
gnomAD
rs553500353 139 G>S No ExAC
TOPMed
gnomAD
rs1162544595 139 G>V No TOPMed
gnomAD
rs746691583 140 R>* No ExAC
TOPMed
gnomAD
rs139815549 140 R>P No ESP
ExAC
TOPMed
gnomAD
rs139815549 140 R>Q No ESP
ExAC
TOPMed
gnomAD
rs1050711146 141 Q>K No TOPMed
gnomAD
rs745461334 144 K>R No ExAC
gnomAD
rs745461334 144 K>T No ExAC
gnomAD
rs1364974639 147 L>M No TOPMed
gnomAD
rs1402553813 150 A>S No TOPMed
gnomAD
rs1402553813 150 A>T No TOPMed
gnomAD
rs770430325 150 A>V No ExAC
gnomAD
rs1641212950 151 W>* No Ensembl
rs976560864 151 W>C No TOPMed
rs541333954 153 D>N No 1000Genomes
rs755791108 154 Y>C No ExAC
gnomAD
rs1372591412 155 E>D No TOPMed
gnomAD
rs1167001974 156 A>S No TOPMed
gnomAD
rs755959425 158 M>R No ExAC
TOPMed
gnomAD
rs755959425 158 M>T No ExAC
TOPMed
gnomAD
TCGA novel 162 E>Q Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
COSM906160
COSM4873422
 163 K>N Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs267598443 163 K>R No Ensembl
COSM4868324
COSM906159
rs372166776
 165 R>C Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic] No NCI-TCGA Cosmic
cosmic curated
ESP
NCI-TCGA
TOPMed
gnomAD
rs368844883 165 R>H No ESP
ExAC
TOPMed
gnomAD
rs372166776 165 R>S No ESP
TOPMed
gnomAD
rs201699410 166 D>E No 1000Genomes
rs769725912 166 D>N No ExAC
TOPMed
gnomAD
rs748019349 166 D>V No ExAC
gnomAD
rs769725912 166 D>Y No ExAC
TOPMed
gnomAD
rs149730721 167 R>L No ESP
ExAC
gnomAD
rs149730721 167 R>Q No ESP
ExAC
gnomAD
rs867093977 167 R>W Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
gnomAD
rs1202172050 168 A>V No TOPMed
gnomAD
rs2148618984 170 V>G No Ensembl
rs561907649 171 T>I No 1000Genomes
ExAC
TOPMed
gnomAD
rs757341327 172 G>R No ExAC
TOPMed
gnomAD
rs1640911822 173 G>R No TOPMed
rs374835567 175 P>R No ESP
ExAC
TOPMed
gnomAD
rs764205375 177 E>K No ExAC
TOPMed
gnomAD
rs756706141 178 V>A No ExAC
gnomAD
rs756706141 178 V>G No ExAC
gnomAD
TCGA novel 179 A>T Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1484349433 182 M>T No gnomAD
rs753210534 182 M>V No ExAC
TOPMed
gnomAD
rs768029130 184 R>K No ExAC
TOPMed
gnomAD
rs768029130 184 R>T No ExAC
TOPMed
gnomAD
TCGA novel 185 E>A Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
rs1272559168 186 R>Q No TOPMed
COSM5077892 186 R>S Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA Cosmic
COSM906158
rs759918483
COSM4872402
 186 R>W Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic] No NCI-TCGA Cosmic
cosmic curated
ExAC
NCI-TCGA
TOPMed
gnomAD
rs773929984 187 R>H No ExAC
TOPMed
gnomAD
rs1640909685 188 I>M No TOPMed
rs762445032 188 I>T No ExAC
gnomAD
rs1204613089 189 F>I No TOPMed
rs772721348 189 F>L No ExAC
gnomAD
rs769243302 190 Q>* No ExAC
gnomAD
rs143888534 192 H>P No ESP
ExAC
TOPMed
gnomAD
rs571052424 193 M>I No ExAC
TOPMed
gnomAD
rs776519575 193 M>V No ExAC
TOPMed
gnomAD
rs1425586324 195 E>K No TOPMed
gnomAD
rs1425586324 195 E>Q No TOPMed
gnomAD
rs1640900049 198 L>I No Ensembl
rs1358455138 199 K>R No TOPMed
rs765029335 200 A>P No ExAC
gnomAD
rs765029335 200 A>T No ExAC
gnomAD
rs148831305 201 G>E No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs145225699 201 G>R No 1000Genomes
ExAC
TOPMed
gnomAD
rs763993163 202 E>D No ExAC
gnomAD
rs1384156799 202 E>G No TOPMed
gnomAD
rs1288724257 203 S>G No gnomAD
rs1429045642 203 S>N No gnomAD
rs1408685045 203 S>R No gnomAD
rs1177797265 204 Q>H No gnomAD
rs1432489440 207 Q>R No TOPMed
gnomAD
rs1469706785 208 G>S No gnomAD
rs184865364 210 D>H No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs1171880370 211 F>L No gnomAD
rs774899692 211 F>L No ExAC
TOPMed
gnomAD
rs771711611 212 L>I No ExAC
TOPMed
gnomAD
rs759278844 212 L>P No ExAC
gnomAD
rs1570350191 214 S>R No Ensembl
rs1262023511 216 I>M No TOPMed
gnomAD
rs780236449 217 K>R No ExAC
TOPMed
gnomAD
rs138247317 218 F>L No ESP
ExAC
TOPMed
gnomAD
rs1243455932 218 F>S No TOPMed
gnomAD
rs149194749 218 F>V No ESP
ExAC
gnomAD
rs1321272065 220 H>R No gnomAD
rs902677114 220 H>Y No TOPMed
gnomAD
rs1229700736 221 A>T Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
TOPMed
gnomAD
rs1308364543 221 A>V No gnomAD
rs867873164 222 Q>R No TOPMed
gnomAD
rs780020089 224 N>H No ExAC
gnomAD
rs377564938 226 F>L No ESP
ExAC
TOPMed
gnomAD
rs1640880962 227 Q>H No Ensembl
rs1640881070 227 Q>R No TOPMed
rs772133678 229 G>V No ExAC
TOPMed
gnomAD
rs779082114 230 W>R No ExAC
gnomAD
rs1558128496 235 S>R No Ensembl
rs777448053 237 F>I No ExAC
TOPMed
gnomAD
rs957067693 238 P>S No Ensembl
rs1221949022 239 F>Y No gnomAD
rs200562976 241 E>K No 1000Genomes
ExAC
TOPMed
gnomAD
rs1240415847 242 K>N No TOPMed
gnomAD
rs767623836 244 A>E No ExAC
TOPMed
gnomAD
rs767623836 244 A>G No ExAC
TOPMed
gnomAD
COSM4786344
COSM1340526
 244 A>T Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs767623836 244 A>V Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No ExAC
NCI-TCGA
TOPMed
gnomAD
rs1640878967 245 A>S No gnomAD
rs1406232862 247 V>A No TOPMed
gnomAD
rs1558128283 247 V>I No Ensembl
rs1174846779 248 H>R No TOPMed
gnomAD
rs751156487 249 A>G No ExAC
gnomAD
rs751066143 250 L>F No ExAC
TOPMed
gnomAD
rs779724669 251 H>R No ExAC
gnomAD
rs1558127821 252 Q>* No Ensembl
COSM1245526
rs1640871077
 253 A>T oesophagus [Cosmic] No cosmic curated
TOPMed
rs1470215991 254 Q>P No TOPMed
gnomAD
rs758002450 255 E>Q No ExAC
rs185053013 257 E>K No 1000Genomes
ExAC
gnomAD
rs1411072031 259 Q>H No TOPMed
gnomAD
rs1308569732 259 Q>R No TOPMed
gnomAD
rs753097677 265 R>Q No ExAC
TOPMed
gnomAD
rs151232489 265 R>W No ESP
ExAC
TOPMed
gnomAD
rs1640869564 268 L>F No TOPMed
rs1206148186 269 R>* No TOPMed
gnomAD
rs1558127593 269 R>Q No Ensembl
rs878948424 270 G>E No Ensembl
rs1378558930 271 T>A No TOPMed
gnomAD
rs1462141855 273 Q>P No gnomAD
rs1640868814 274 L>P No TOPMed
rs760054820 275 E>A No ExAC
gnomAD
rs774353425 275 E>D No ExAC
gnomAD
rs1262011798 275 E>Q No TOPMed
gnomAD
rs1640868340 276 S>G No Ensembl
TCGA novel 278 E>* Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 278 E>D Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1640861110 280 H>Q No TOPMed
rs762139381 280 H>Y No ExAC
TOPMed
gnomAD
rs776502496 282 S>R No ExAC
TOPMed
gnomAD
rs764768097 283 R>Q No ExAC
TOPMed
gnomAD
rs543667188 283 R>W No 1000Genomes
ExAC
TOPMed
gnomAD
TCGA novel 284 K>N Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1640860444 286 S>* No Ensembl
rs778504713 287 G>E No ExAC
gnomAD
rs766940864 287 G>R No ExAC
TOPMed
gnomAD
rs375411165 288 C>Y No ESP
ExAC
TOPMed
gnomAD
rs1244804357 289 G>D No Ensembl
rs12117542 290 Y>* No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs1233000259 290 Y>C No gnomAD
rs1481906513 292 I>M No TOPMed
gnomAD
rs1293473654 293 H>Q No gnomAD
rs1405779262 293 H>Y No TOPMed
gnomAD
rs2148616779 294 Q>* No Ensembl
rs1640858861 294 Q>R No TOPMed
rs755317799 295 H>Y No ExAC
gnomAD
rs1358503365 296 Q>R No gnomAD
rs1640858518 297 G>S No TOPMed
rs1287410261 298 N>H No gnomAD
rs1225443331 298 N>K No gnomAD
rs1287410261 298 N>Y No gnomAD
TCGA novel 299 K>N Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs996978623 299 K>R No Ensembl
rs1640858054 301 F>C No gnomAD
rs1640857922 302 G>R No Ensembl
rs147482690 303 T>M No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs1640857534 305 K>N No TOPMed
gnomAD
rs1004652228 306 V>L No TOPMed
rs1004652228 306 V>M No TOPMed
COSM1283525 307 G>D Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1640857200 307 G>V No TOPMed
gnomAD
rs1348652867 308 F>S No gnomAD
rs1640856552 314 D>G No Ensembl
rs1640856344 315 G>R No Ensembl
COSM4663599
COSM259520
rs760996705
 317 R>* Variant assessed as Somatic; HIGH impact. large_intestine [NCI-TCGA, Cosmic] No NCI-TCGA Cosmic
cosmic curated
ExAC
NCI-TCGA
TOPMed
gnomAD
rs760996705 317 R>G No ExAC
TOPMed
gnomAD
rs1240975876 317 R>Q Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
TOPMed
gnomAD
rs17855027 319 V>A No Ensembl
rs2148613728 319 V>F No Ensembl
TCGA novel 321 Q>* Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
rs752374798 321 Q>H No ExAC
gnomAD
TCGA novel 323 R>G Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
rs865808556 323 R>G No Ensembl
rs1640780515 323 R>K No TOPMed
TCGA novel 324 K>* Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
COSM1183713
rs1234048915
 325 C>R large_intestine [Cosmic] No cosmic curated
gnomAD
rs575123252 329 Y>C No gnomAD
rs74946314 331 C>W No ExAC
gnomAD
rs1216480001
COSM307999
 331 C>Y biliary_tract [Cosmic] No cosmic curated
gnomAD
COSM4948352
COSM1340524
 333 T>I Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1320282388 333 T>N No gnomAD
rs1433578524 334 I>L No gnomAD
rs199508833 337 S>G No ESP
ExAC
TOPMed
gnomAD
rs1558122616 337 S>N No Ensembl
rs772733929 338 T>M No ExAC
TOPMed
gnomAD
rs1640766184 339 I>V No Ensembl
rs746201608 341 R>Q No ExAC
TOPMed
gnomAD
rs768232484 341 R>W No ExAC
gnomAD
rs1640765765 342 P>S No Ensembl
rs767252554 343 P>L No ExAC
TOPMed
gnomAD
rs767252554 343 P>Q No ExAC
TOPMed
gnomAD
rs1266348945 344 V>E No gnomAD
rs1570341625 345 K>R No Ensembl
rs1640765031 346 L>V No Ensembl
rs898562179 347 T>A No TOPMed
rs1244767462 347 T>N No TOPMed
gnomAD
rs778486613 348 L>P No ExAC
gnomAD
rs1409892131 350 T>M No TOPMed
gnomAD
COSM4815921
COSM1473652
 352 Q>K Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1640763921 352 Q>R No Ensembl
rs1640763806 353 V>M No TOPMed
rs1459798391 354 R>G No TOPMed
gnomAD
rs1640763530 355 P>L No Ensembl
rs781440555 355 P>S No ExAC
TOPMed
gnomAD
rs947451884 357 P>L No TOPMed
gnomAD
rs1164705858 358 E>G No TOPMed
rs1640763236 359 E>D No Ensembl
rs1640763143 361 K>N No Ensembl
TCGA novel 363 F>I Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1328713889 363 F>L No TOPMed
gnomAD
rs747558021 364 D>N No ExAC
TOPMed
gnomAD
rs747558021 364 D>Y No ExAC
TOPMed
gnomAD
rs199608986 368 H>Y No ESP
ExAC
TOPMed
gnomAD
rs1558119506 369 N>H No Ensembl
rs1640719734 370 R>G No TOPMed
rs267598442
COSM414557
 370 R>Q skin urinary_tract [Cosmic] No cosmic curated
TOPMed
COSM4782626
COSM3418939
 370 R>W Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs781148535 371 T>M No ExAC
TOPMed
gnomAD
rs1640719516 371 T>S No TOPMed
rs1640719150
COSM4787177
COSM1340523
 372 Y>H Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic] No NCI-TCGA Cosmic
cosmic curated
TOPMed
rs1218745257 373 H>L No TOPMed
gnomAD
rs1640718944 374 F>C No gnomAD
rs902056583 374 F>L No TOPMed
gnomAD
rs747227838 375 Q>* No ExAC
TOPMed
gnomAD
rs747227838 375 Q>E No ExAC
TOPMed
gnomAD
rs1275928793 375 Q>H No TOPMed
gnomAD
TCGA novel
rs747227838
 375 Q>K Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
ExAC
TOPMed
gnomAD
rs1456591683 376 A>T No gnomAD
rs16828486
RCV000974828
VAR_048295
 377 E>A No ClinVar
UniProt
1000Genomes
ESP
ExAC
TOPMed
dbSNP
gnomAD
TCGA novel
rs374474860
 378 D>E Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No ESP
ExAC
TOPMed
gnomAD
NCI-TCGA
rs1157001530 378 D>N No gnomAD
rs750257839
COSM1667255
 379 E>K central_nervous_system [Cosmic] No cosmic curated
ExAC
TOPMed
gnomAD
rs1640716490 381 E>D No Ensembl
rs1450243874 381 E>K No gnomAD
rs1450243874 381 E>Q No gnomAD
rs1022608784 382 C>R No TOPMed
rs757164442 382 C>Y No ExAC
rs1640716139 383 E>D No Ensembl
rs1640716012 384 A>E No Ensembl
rs899616384 386 V>A No TOPMed
rs1362697688 389 L>F No TOPMed
gnomAD
rs1640709621 389 L>W No Ensembl
rs1640709239 394 D>G No TOPMed
rs1448620878 395 E>K Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
gnomAD
rs1341167760 396 A>S No gnomAD
rs1325835739 398 S>G No TOPMed
gnomAD
rs762296900 398 S>R No ExAC
TOPMed
gnomAD
rs776982932 399 S>R No ExAC
gnomAD
rs200129246 400 A>P No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs200129246 400 A>S No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs200129246 400 A>T No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs1640708078 401 F>L No TOPMed
rs1161048318 401 F>L No gnomAD
TCGA novel 402 L>I Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1297800172 403 G>R Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
TOPMed
gnomAD
rs1184132863 404 E>A No gnomAD
rs1346908048 404 E>D No gnomAD
rs775567666 404 E>K Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No ExAC
NCI-TCGA
TOPMed
gnomAD
rs772223774 405 P>S No ExAC
gnomAD
rs2148610616 407 A>G No Ensembl
rs1179019500 407 A>P No TOPMed
rs1179019500 407 A>T No TOPMed
TCGA novel 408 G>D Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1439257454 409 P>A No gnomAD
COSM1172120
rs1570338178
 409 P>L oesophagus [Cosmic] No cosmic curated
Ensembl
rs1570338178 409 P>R No Ensembl
rs1203916884 410 G>A No TOPMed
gnomAD
rs1203916884 410 G>E No TOPMed
gnomAD
rs1403997568 410 G>R No TOPMed
gnomAD
rs770615390 412 W>* No ExAC
TOPMed
gnomAD
rs770615390 412 W>C No ExAC
TOPMed
gnomAD
rs1293612193 413 G>E No gnomAD
rs1640704886 414 S>F No gnomAD
rs1570338054 414 S>P No Ensembl
rs749154152 415 A>T No ExAC
TOPMed
gnomAD
rs987899392 416 G>S No Ensembl
rs570022866 416 G>V No ExAC
TOPMed
gnomAD
rs548083247 417 H>R No 1000Genomes
ExAC
TOPMed
gnomAD
rs752198805 418 D>N No ExAC
gnomAD
rs1640704020 419 G>E No gnomAD
rs1640703913 420 E>K No TOPMed
gnomAD
rs374050468 421 P>L Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No ESP
NCI-TCGA
TOPMed
gnomAD
rs1308897783 422 H>Q No TOPMed
gnomAD
rs1640703208 423 D>N No TOPMed
rs1409385869 424 L>F No gnomAD
COSM4029908
COSM4906777
 425 T>R Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1167304433 427 L>P No gnomAD
rs1017856685 427 L>V No TOPMed
gnomAD
rs780857824 428 L>F No ExAC
gnomAD
rs754606408 429 I>L No ExAC
gnomAD
rs754606408 429 I>V No ExAC
gnomAD
rs146159261 430 A>E No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs146159261 430 A>V No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
TCGA novel 432 V>A Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1390922769 432 V>G No Ensembl
rs766105033 432 V>L No ExAC
TOPMed
gnomAD
rs766105033 432 V>M No ExAC
TOPMed
gnomAD
rs370693470 433 K>N Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No ESP
ExAC
NCI-TCGA
TOPMed
gnomAD
rs58233188 436 P>T No Ensembl
rs1433166891 437 G>E No TOPMed
gnomAD
rs1375059299 438 N>T No TOPMed
gnomAD
rs1287648210 439 S>N No gnomAD
rs1159085013 440 Q>R No TOPMed
rs1421257813 441 C>S No Ensembl
rs1225353539 442 C>* No gnomAD
rs1640700227 442 C>R No Ensembl
rs775481841 443 D>E No ExAC
TOPMed
gnomAD
rs1289039830 444 C>F Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
TOPMed
gnomAD
rs1289039830 444 C>S No TOPMed
gnomAD
rs1640699512 445 G>R No TOPMed
rs1228054866 446 A>T No gnomAD
rs1640699159 446 A>V No Ensembl
rs1640699041 447 A>V No Ensembl
rs1432211584 448 D>E No gnomAD
TCGA novel 448 D>Y Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs535978345 449 P>S No 1000Genomes
ExAC
TOPMed
gnomAD
rs535978345 449 P>T No 1000Genomes
ExAC
TOPMed
gnomAD
rs1640691790 450 T>M No gnomAD
rs1247355325 451 W>* No gnomAD
rs1206672294 452 L>F No gnomAD
rs1211150923 453 S>G No TOPMed
gnomAD
rs1640691008 453 S>N No Ensembl
rs1640690901 454 T>P No TOPMed
rs778264601 455 N>S No Ensembl
COSM4812794
COSM3804489
 458 V>L Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1278723620 458 V>M Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
TOPMed
gnomAD
rs1231055850 459 L>P No gnomAD
rs1297550865 460 T>FF* No gnomAD
rs926573438 461 C>G No gnomAD
rs926573438 461 C>R No gnomAD
rs1640689769 462 I>S No Ensembl
rs547079352 463 Q>R No 1000Genomes
ExAC
TOPMed
gnomAD
rs1640689359 465 S>A No TOPMed
rs759500482 465 S>L No ExAC
gnomAD
rs1430175288 466 G>D No gnomAD
rs1195332557 466 G>S No TOPMed
rs773639283 467 V>A No ExAC
gnomAD
rs773639283 467 V>D No ExAC
gnomAD
rs768411529 467 V>F No ExAC
gnomAD
rs768411529 467 V>I No ExAC
gnomAD
rs769703053 469 R>C No ExAC
TOPMed
gnomAD
rs1182517714 469 R>H No gnomAD
rs1182517714 469 R>P No gnomAD
rs866071019 470 E>K No gnomAD
rs866071019 470 E>Q No gnomAD
rs1640686665 471 L>R No gnomAD
rs776680053 471 L>V No ExAC
TOPMed
gnomAD
rs1343345246 472 G>C No gnomAD
rs1274337752 472 G>V No gnomAD
rs2148609664 473 V>G No Ensembl
rs373421354 474 R>C No ESP
ExAC
gnomAD
rs1357736082 476 S>L No TOPMed
gnomAD
rs1309509905 477 R>C No gnomAD
rs778593616 477 R>H No ExAC
TOPMed
gnomAD
rs778593616 477 R>L No ExAC
TOPMed
gnomAD
rs778593616 477 R>P No ExAC
TOPMed
gnomAD
COSM679950
rs2148609597
 478 M>I lung [Cosmic] No cosmic curated
Ensembl
rs753097379 478 M>L No ExAC
gnomAD
rs753097379 478 M>V Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No ExAC
NCI-TCGA
gnomAD
rs767969077 479 Q>H No 1000Genomes
ExAC
TOPMed
gnomAD
rs1368974647 480 S>L No gnomAD
rs1640684635 480 S>P No Ensembl
rs1640684249 483 L>S No TOPMed
rs751529728 485 L>P No ExAC
gnomAD
rs751529728 485 L>Q No ExAC
gnomAD
rs1255427123 487 G>C No TOPMed
gnomAD
rs766479444 487 G>D No ExAC
gnomAD
COSM4907029
COSM4029907
 489 S>C Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1194418704 490 E>D No gnomAD
rs748937105 493 L>Q No ExAC
gnomAD
rs777351413 494 A>T No ExAC
gnomAD
rs148723559 495 L>F No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs747377864 496 N>S No ExAC
gnomAD
rs758852504 497 M>V No ExAC
gnomAD
COSM4905843
COSM4406187
 499 N>H Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs750474928 500 T>M No ExAC
TOPMed
gnomAD
rs750474928 500 T>R No ExAC
TOPMed
gnomAD
rs757477745 501 S>R No ExAC
TOPMed
gnomAD
rs754099357 503 N>S No ExAC
TOPMed
gnomAD
rs1640665669 504 E>K No Ensembl
rs1640665475 506 M>L No Ensembl
rs764271686 506 M>T No ExAC
gnomAD
rs1462897349 508 A>S No gnomAD
rs1558115674 508 A>V No TOPMed
rs1325983637 509 Q>R No TOPMed
gnomAD
TCGA novel 510 L>P Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1558115603 510 L>R No Ensembl
rs752462758 510 L>V No ExAC
TOPMed
gnomAD
rs759480430 512 S>T No ExAC
gnomAD
rs934970877
COSM318791
 513 H>Q lung [Cosmic] No cosmic curated
TOPMed
gnomAD
rs774341386 515 G>A No ExAC
gnomAD
rs1433253626 515 G>S No gnomAD
rs1223362377 516 P>A No gnomAD
COSM110341
rs140530758
 516 P>L skin [Cosmic] No cosmic curated
ExAC
TOPMed
gnomAD
rs140530758 516 P>R No ExAC
TOPMed
gnomAD
rs201865670 517 K>E No 1000Genomes
ExAC
TOPMed
gnomAD
rs1640662944 518 P>R No Ensembl
rs1446404100 518 P>S No TOPMed
gnomAD
rs2148608642 520 A>P No Ensembl
rs772894513 522 S>R No ExAC
TOPMed
gnomAD
rs769362757 523 D>V No ExAC
gnomAD
rs1393152364 524 M>I No gnomAD
rs1208226628 524 M>T No gnomAD
rs202004624 525 G>A No ExAC
TOPMed
gnomAD
rs202004624 525 G>V No ExAC
TOPMed
gnomAD
rs371915285 527 R>C Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No ESP
ExAC
NCI-TCGA
gnomAD
rs1640640127 527 R>H No TOPMed
gnomAD
rs1640640127 527 R>L No TOPMed
gnomAD
rs1468439191 528 R>K No gnomAD
rs1176202439 528 R>W No gnomAD
rs771591906 529 D>G No ExAC
gnomAD
rs1450958311 530 Y>S No gnomAD
rs749337388 533 A>S No ExAC
gnomAD
rs749337388 533 A>T No ExAC
gnomAD
rs756289914 535 Y>* No ExAC
TOPMed
gnomAD
rs1208575887 535 Y>C No TOPMed
gnomAD
rs1260276184 535 Y>H No TOPMed
gnomAD
rs1640638568 536 V>M No TOPMed
rs1223379693 538 H>D No gnomAD
rs1371689742 538 H>R No gnomAD
rs1223379693 538 H>Y No gnomAD
rs200891347 539 R>S No TOPMed
gnomAD
TCGA novel 540 F>L Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1211868023 541 A>T No TOPMed
gnomAD
rs1640637874 541 A>V No TOPMed
COSM4897974
COSM2048481
rs781443284
 542 R>C Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
ExAC
NCI-TCGA
gnomAD
rs751387661 542 R>H No ExAC
TOPMed
gnomAD
rs751387661 542 R>L No ExAC
TOPMed
gnomAD
rs781443284 542 R>S No ExAC
gnomAD
rs148195646 543 R>Q No 1000Genomes
ExAC
TOPMed
gnomAD
rs766259434
COSM4906991
COSM2048480
 543 R>W Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
ExAC
NCI-TCGA
TOPMed
gnomAD
rs749884891 544 C>G No ExAC
TOPMed
gnomAD
rs2148607484 544 C>Y No Ensembl
rs997600722 545 T>A No TOPMed
gnomAD
rs1252602653 545 T>I No TOPMed
gnomAD
rs764651704 546 P>L No ExAC
TOPMed
gnomAD
rs761441284 547 E>K No ExAC
TOPMed
gnomAD
rs1191541107 548 P>L No TOPMed
gnomAD
rs753407192 550 R>* No ExAC
gnomAD
rs763875974 550 R>Q No ExAC
TOPMed
gnomAD
rs1640634875 553 T>I No gnomAD
rs759935282 553 T>S No ExAC
TOPMed
gnomAD
rs774877977 554 A>V No ExAC
TOPMed
gnomAD
rs144216953 555 I>M No ESP
ExAC
TOPMed
gnomAD
rs1315349029 555 I>V No gnomAD
rs867114979 557 N>S No TOPMed
rs1570332704 559 D>A No TOPMed
rs1570332704 559 D>G No TOPMed
rs773834302 560 L>F No ExAC
gnomAD
rs769741844 562 S>L No ExAC
TOPMed
gnomAD
rs1640633190 563 V>L No TOPMed
rs1428282217 564 L>R No gnomAD
rs1640632565 566 A>D No Ensembl
rs781353121 566 A>T No ExAC
gnomAD
rs1640632565
COSM1718098
 566 A>V NS [Cosmic] No cosmic curated
Ensembl
rs1247642331 568 A>T No gnomAD
rs768889298 568 A>V No ExAC
gnomAD
COSM4924954
COSM4924955
 569 N>T Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1392979876 573 F>C No TOPMed
gnomAD
rs1570332590 573 F>L No Ensembl
rs746752156 573 F>L No ExAC
gnomAD
rs1392979876 573 F>S No TOPMed
gnomAD
rs1170461118 575 Q>H No TOPMed
gnomAD
rs758282757 576 P>L No ExAC
TOPMed
gnomAD
rs779832556 576 P>S No ExAC
gnomAD
rs1383329095 577 L>P No gnomAD
rs889574490 579 G>R No Ensembl
rs1484902922 580 P>R No gnomAD
rs1640630780 580 P>S No Ensembl
rs778956024 583 Q>* No ExAC
TOPMed
gnomAD
rs754323088 584 A>V No ExAC
TOPMed
gnomAD
rs146392307 585 P>S No ESP
ExAC
TOPMed
rs2148605134 589 V>A No Ensembl
COSM5380189
COSM5380188
rs150324380
 589 V>I Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
ESP
ExAC
NCI-TCGA
TOPMed
gnomAD
rs1558110399 591 H>R No Ensembl
COSM906134
COSM4870539
 593 A>D Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs774503253 594 V>I No ExAC
TOPMed
gnomAD
rs774503253 594 V>L No ExAC
TOPMed
gnomAD
rs188720319 595 K>R No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs188720319 595 K>T No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs2148605099 596 V>I No Ensembl
rs769875873 597 A>T No ExAC
TOPMed
gnomAD
rs747605318 597 A>V No ExAC
gnomAD
rs780758516 598 N>K No ExAC
gnomAD
rs1388517844 598 N>S No TOPMed
gnomAD
rs147652133 599 Q>* No ESP
TOPMed
rs1325059983 600 A>P No gnomAD
rs1325059983 600 A>S No gnomAD
rs754516055 601 S>A No ExAC
gnomAD
rs746663718 602 L>P No ExAC
gnomAD
rs146999625 603 P>R No ESP
ExAC
gnomAD
rs1381717326 603 P>S No TOPMed
TCGA novel 604 L>V Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1180088185 605 V>L No gnomAD
rs754228983 611 N>S No ExAC
gnomAD
rs201997487 612 G>A No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs146395542 612 G>C No ESP
ExAC
TOPMed
gnomAD
rs146395542 612 G>S No ESP
ExAC
TOPMed
gnomAD
rs1558109607 613 G>D No Ensembl
rs1270636026 613 G>R No gnomAD
rs1640556624 616 D>N No TOPMed
rs751614263 616 D>V No ExAC
gnomAD
rs1416833360 617 A>S No gnomAD
VAR_035612 617 A>T a colorectal cancer sample; somatic mutation [UniProt] No UniProt
rs1640556161 618 K>Q No Ensembl
rs1001003079 619 A>P No TOPMed
gnomAD
rs1001003079 619 A>S No TOPMed
gnomAD
rs1001003079 619 A>T No TOPMed
gnomAD
rs766652020 620 A>G No ExAC
TOPMed
gnomAD
rs766652020 620 A>V No ExAC
TOPMed
gnomAD
rs142199725 621 D>V No ESP
ExAC
rs1422293595 622 G>R No TOPMed
gnomAD
rs765114680 623 N>K No ExAC
gnomAD
rs1168932160 623 N>S No gnomAD
rs1370816480 624 T>M No TOPMed
gnomAD
TCGA novel 625 A>V Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1256614078 627 H>R No gnomAD
rs1483547288 628 Y>C No TOPMed
gnomAD
rs768510202 628 Y>H No ExAC
gnomAD
rs774990747 629 A>T No ExAC
TOPMed
gnomAD
rs1021198071 629 A>V No Ensembl
rs1226914515 630 A>G No TOPMed
gnomAD
rs1226914515 630 A>V No TOPMed
gnomAD
rs771643051 631 L>F No ExAC
gnomAD
rs745515586 632 Y>C No ExAC
TOPMed
gnomAD
rs745515586 632 Y>S No ExAC
TOPMed
gnomAD
rs1235446816 633 N>S No TOPMed
gnomAD
rs1292843140 634 Q>H No gnomAD
rs778595220 634 Q>K No ExAC
gnomAD
rs1640552706 635 P>R No gnomAD
rs748500137 636 D>G No ExAC
TOPMed
gnomAD
rs113419927 636 D>N Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No ExAC
NCI-TCGA
TOPMed
gnomAD
rs113419927 636 D>Y No ExAC
TOPMed
gnomAD
rs1640551840 637 C>F No Ensembl
rs781690330 637 C>R No ExAC
TOPMed
gnomAD
rs1640551840 637 C>S No Ensembl
rs1166448755 642 L>P No gnomAD
rs1166448755 642 L>R No gnomAD
rs1640551201 643 K>R No gnomAD
TCGA novel 646 A>T Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs2148604365 647 L>F No Ensembl
rs1640550876 648 V>A No Ensembl
rs747044302 649 G>R No ExAC
TOPMed
gnomAD
rs780277335 650 T>I No 1000Genomes
ExAC
TOPMed
gnomAD
rs1640550351 651 V>L No gnomAD
rs758525430 654 A>G No ExAC
gnomAD
rs757431221 656 E>D No ExAC
TOPMed
gnomAD
rs1045499733 656 E>K No TOPMed
gnomAD
rs377297346 658 A>P No ESP
TOPMed
gnomAD
rs144319319 661 I>V No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs1640530621 662 A>T No gnomAD
rs763788327 662 A>V No ExAC
gnomAD
rs1252335611 664 K>Q No TOPMed
rs1285148928 666 H>Q No TOPMed
gnomAD
rs1318939999 666 H>Y No gnomAD
rs755994782 667 H>R No ExAC
TOPMed
gnomAD
rs1640529554 668 K>* No Ensembl
rs1346427181 669 E>G No Ensembl
rs138556791 669 E>K No ESP
ExAC
TOPMed
gnomAD
rs767480290 670 C>Y No ExAC
gnomAD
rs1289784579 671 E>K No TOPMed
gnomAD
rs1323304625 673 L>M No gnomAD
rs1640523580 675 E>K No gnomAD
rs1640523348 676 Q>H No TOPMed
rs751566920 676 Q>P No ExAC
gnomAD
rs1640523246 677 A>T No Ensembl
COSM327590
rs146824903
 678 Q>* haematopoietic_and_lymphoid_tissue [Cosmic] No cosmic curated
1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs199856800 678 Q>H No 1000Genomes
ExAC
TOPMed
gnomAD
rs146824903 678 Q>K No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs750016708 679 A>G No ExAC
TOPMed
gnomAD
rs750016708 679 A>V Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No ExAC
NCI-TCGA
TOPMed
gnomAD
rs1570325855 681 T>A No Ensembl
rs1207185210 681 T>N No TOPMed
gnomAD
rs368585298 682 F>S No ESP
ExAC
TOPMed
gnomAD
rs772638477 683 A>S No ExAC
gnomAD
TCGA novel 684 F>L Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1293453218 685 P>L No gnomAD
rs760113301 685 P>S No ExAC
TOPMed
gnomAD
TCGA novel 686 L>Q Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1558107047 687 H>P No gnomAD
rs1413973552 687 H>Q No TOPMed
gnomAD
rs774976959 688 V>G No ExAC
TOPMed
gnomAD
rs770891821 689 D>H No ExAC
gnomAD
rs1462404837 690 Y>C No gnomAD
rs1640520899 691 S>C No Ensembl
COSM3705666
rs777818177
 692 W>* Variant assessed as Somatic; HIGH impact. liver [NCI-TCGA, Cosmic] No cosmic curated
ExAC
NCI-TCGA
TOPMed
gnomAD
rs1389681761 692 W>L No TOPMed
gnomAD
rs202006565 693 V>I No ESP
TOPMed
gnomAD
rs747871777 698 P>R No ExAC
TOPMed
gnomAD
rs779202932 698 P>S No Ensembl
rs1473752826 699 G>C No TOPMed
gnomAD
rs1025151450 700 S>F No TOPMed
rs1640519887 701 D>N No Ensembl
rs754828129 704 E>D No ExAC
TOPMed
gnomAD
rs1475099269 705 D>A No gnomAD
rs751431631 705 D>N No ExAC
gnomAD
COSM4908107
COSM3984864
 708 E>V Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs780083743 709 K>N No ExAC
gnomAD
rs147016526 710 R>C Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No ESP
ExAC
NCI-TCGA
TOPMed
gnomAD
rs538117231 710 R>H No 1000Genomes
ExAC
gnomAD
rs147016526 710 R>S No ESP
ExAC
TOPMed
gnomAD
rs2148602538 711 C>S No Ensembl
rs775363873 711 C>S No ExAC
gnomAD
rs572873506 711 C>W No gnomAD
rs1372288784 713 L>R No Ensembl
COSM5948358
COSM5948357
 714 K>N Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1447445605 714 K>T No gnomAD
rs867590061 715 L>F No Ensembl
rs745800960 716 P>L No ExAC
TOPMed
gnomAD
rs745800960 716 P>R No ExAC
TOPMed
gnomAD
rs140136454 717 A>D No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs1329364609 717 A>T No gnomAD
rs748837787 718 Q>* No ExAC
gnomAD
TCGA novel 718 Q>P Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs987009902 719 A>V No Ensembl
rs934139379 720 H>D No Ensembl
rs1199115201 720 H>P No TOPMed
rs921563421 721 W>* No Ensembl
rs1360365726 721 W>R No gnomAD
rs777516793 723 S>N No ExAC
TOPMed
gnomAD
rs1025100874 723 S>R No TOPMed
gnomAD
rs1558105763
COSM3485691
COSM4904065
 724 G>E Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
Ensembl
NCI-TCGA
rs182680450 727 D>H No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs1307055619 728 I>F No TOPMed
rs1640506653 728 I>M No Ensembl
rs766753572 729 S>G No ExAC
TOPMed
gnomAD
rs766753572 729 S>R No ExAC
TOPMed
gnomAD
COSM1320338 730 N>K Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1640506199 730 N>S No gnomAD
rs1374272725 731 K>E No TOPMed
gnomAD
rs1343837442 733 Y>C No TOPMed
gnomAD
rs750900769 734 E>K No ExAC
gnomAD
COSM4819232
COSM4819233
 734 E>Q Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs765765843 736 V>I No ExAC
gnomAD
rs1640505012 737 A>G No Ensembl
rs776707855 737 A>T No ExAC
TOPMed
gnomAD
rs760951474 739 L>P No ExAC
TOPMed
gnomAD
rs369920126 742 A>S No ESP
ExAC
TOPMed
gnomAD
rs375702551 742 A>V No ESP
ExAC
TOPMed
gnomAD
rs748749801 744 P>H No ExAC
TOPMed
gnomAD
rs748749801 744 P>L No ExAC
TOPMed
gnomAD
rs1640503905 744 P>T No Ensembl
rs777425342 745 Q>E Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No ExAC
NCI-TCGA
TOPMed
gnomAD
rs1334144738 745 Q>H No gnomAD
rs962892972 745 Q>R No TOPMed
gnomAD
rs1413237225 746 G>S No TOPMed
gnomAD
rs199574094 747 E>* No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs199574094 747 E>K No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs1640502708 748 S>G No gnomAD
rs1640502585 749 E>* No TOPMed
TCGA novel 750 D>G Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
COSM533471
COSM5255773
 752 P>L Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1473082668 752 P>T No TOPMed
rs779337722 753 P>L No ExAC
TOPMed
gnomAD
rs1238161061 755 L>F No TOPMed
gnomAD
rs754412905 757 V>A No ExAC
TOPMed
gnomAD
rs750759674 758 K>I No ExAC
gnomAD
rs750759674 758 K>R No ExAC
gnomAD
rs1640500565
COSM1737694
 760 S>F central_nervous_system [Cosmic] No cosmic curated
TOPMed
rs200686258 761 S>F No ESP
ExAC
TOPMed
gnomAD
rs144367386 761 S>P No 1000Genomes
ExAC
TOPMed
gnomAD
rs774299439 762 R>Q No ExAC
TOPMed
gnomAD
rs144247660 762 R>W No ESP
ExAC
TOPMed
gnomAD
rs770925310 763 T>N No ExAC
gnomAD
rs1390803033 764 L>F No TOPMed
rs1640499606 764 L>S No Ensembl
rs1008324836 764 L>V No TOPMed
rs2148602038 765 V>I No Ensembl
rs1446542381 766 Q>P No TOPMed
gnomAD
rs1446542381 766 Q>R No TOPMed
gnomAD
rs146778835 767 G>R No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs1640498671 769 A>V No Ensembl
rs375020208 771 H>Q No ESP
TOPMed
rs531491670 771 H>R No 1000Genomes
ExAC
TOPMed
gnomAD
rs1397469444 771 H>Y No gnomAD
rs563984060 772 A>T No 1000Genomes
ExAC
TOPMed
gnomAD
rs1458473313 773 S>G No TOPMed
rs1640496905 774 G>E No Ensembl
rs1365961458 774 G>R No Ensembl
rs1174321740 775 D>N No TOPMed
COSM1687202
rs768226542
 776 R>C Variant assessed as Somatic; MODERATE impact. skin [NCI-TCGA, Cosmic] No NCI-TCGA Cosmic
cosmic curated
1000Genomes
ExAC
NCI-TCGA
TOPMed
gnomAD
rs746655789 776 R>H Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No ExAC
NCI-TCGA
TOPMed
gnomAD
rs768226542 776 R>S No 1000Genomes
ExAC
TOPMed
gnomAD
rs775168497 778 E>K No ExAC
gnomAD
rs1439647361 780 S>C No gnomAD
rs1640449252 780 S>P No gnomAD
rs577277489 781 S>R No 1000Genomes
ExAC
gnomAD
rs1558102482 783 S>I No Ensembl
TCGA novel 785 E>D Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1219616113 786 A>V No TOPMed
gnomAD
rs868775351 788 E>G No Ensembl
rs749681544 788 E>K No ExAC
gnomAD
rs778291824 789 T>A No ExAC
TOPMed
gnomAD
rs756590732 789 T>N No ExAC
gnomAD
rs1352166617 790 P>S No gnomAD
rs1293342577 792 S>I No TOPMed
gnomAD
rs1293342577 792 S>N No TOPMed
gnomAD
rs1293342577 792 S>T No TOPMed
gnomAD
COSM3485690
COSM4891773
 796 P>L Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1381586758 797 A>G No TOPMed
rs886162370 799 S>F No Ensembl
rs781127739 800 S>C No ExAC
TOPMed
gnomAD
COSM1687201
rs781127739
 800 S>F skin [Cosmic] No cosmic curated
ExAC
TOPMed
gnomAD
rs565640692 801 S>N No Ensembl
rs1272769597 801 S>R No gnomAD
COSM3485689
COSM4897264
rs372626373
 805 P>L Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
ESP
ExAC
NCI-TCGA
TOPMed
gnomAD
rs1570321477 807 E>D No Ensembl
rs751800679 808 P>S No ExAC
gnomAD
rs1640445409 812 S>G No TOPMed
gnomAD
rs1640445409 812 S>R No TOPMed
gnomAD
rs1174125425 813 Q>* No gnomAD
rs758220211 816 P>R No ExAC
gnomAD
rs766739739 816 P>S No ExAC
gnomAD
rs1640444788 817 N>Y No TOPMed
rs750200318 818 S>P No ExAC
gnomAD
rs765157276 819 E>G No ExAC
gnomAD
COSM3864872 820 E>K Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
COSM4897336
COSM3485688
 822 L>F Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1570321358 822 L>V No Ensembl
rs761654342 823 R>* No ExAC
TOPMed
gnomAD
rs761654342 823 R>G No ExAC
TOPMed
gnomAD
rs199665281 823 R>Q No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs201264216 824 E>A No 1000Genomes
ExAC
TOPMed
gnomAD
rs1487489433 825 P>S No gnomAD
rs1283114763 826 P>L No TOPMed
gnomAD
rs760214231 827 G>A No ExAC
TOPMed
gnomAD
rs760214231 827 G>D No ExAC
TOPMed
gnomAD
rs760214231 827 G>V No ExAC
TOPMed
gnomAD
rs1640442572 828 T>A No gnomAD
rs775080630 829 S>P No ExAC
gnomAD
rs1025786923 831 P>A No gnomAD
rs749606321 831 P>L No ExAC
gnomAD
rs749606321 831 P>R No ExAC
gnomAD
rs994330797 832 S>N No TOPMed
gnomAD
rs773451661 832 S>R No ExAC
gnomAD
rs1357103046 834 T>I No gnomAD
rs1313447704 835 S>A No gnomAD
rs1640441031 835 S>C No TOPMed
rs896085148 836 G>R Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No TOPMed
gnomAD
NCI-TCGA
rs896085148 836 G>W No TOPMed
gnomAD
rs758996848 837 T>I No ExAC
TOPMed
gnomAD
rs755069632 839 P>A No ExAC
TOPMed
gnomAD
rs755069632 839 P>S No ExAC
TOPMed
gnomAD
rs1477075212 840 S>A No gnomAD
COSM4869115
rs1260013457
COSM906123
 840 S>L Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic] No NCI-TCGA Cosmic
cosmic curated
NCI-TCGA
gnomAD
rs780367200 841 E>G No ExAC
gnomAD
rs905864851 842 M>R No TOPMed
gnomAD
rs905864851 842 M>T No TOPMed
gnomAD
rs758700381 842 M>V No ExAC
gnomAD
COSM4029886
COSM4907554
 843 Y>C Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs535583916 843 Y>D No 1000Genomes
ExAC
TOPMed
gnomAD
rs535583916 843 Y>H No 1000Genomes
ExAC
TOPMed
gnomAD
rs1293663910 845 P>H No gnomAD
rs1293663910 845 P>L No gnomAD
rs1336756048 845 P>S Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
gnomAD
rs753354426 846 V>F No ExAC
TOPMed
gnomAD
COSM4029885
rs753354426
COSM4907285
 846 V>I Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
ExAC
NCI-TCGA
TOPMed
gnomAD
COSM4905841
COSM4403907
 847 R>K Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1407664018 847 R>S No gnomAD
COSM4899239
COSM3485687
 848 F>= Variant assessed as Somatic; LOW impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1176257638 850 S>F No gnomAD
rs142945237 851 E>* No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs142945237 851 E>K No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs998339956 852 S>N No TOPMed
gnomAD
rs1570319736 853 T>P No Ensembl
rs554814285 854 R>C No 1000Genomes
ExAC
TOPMed
gnomAD
rs1288158151 854 R>L No TOPMed
gnomAD
rs1173292268 855 S>C No TOPMed
gnomAD
rs1640414932 855 S>P No TOPMed
rs777142418 856 Y>C No ExAC
gnomAD
rs200734272 857 R>G No ExAC
TOPMed
gnomAD
rs761253953 857 R>L No ExAC
TOPMed
gnomAD
rs761253953 857 R>P No ExAC
TOPMed
gnomAD
rs761253953 857 R>Q No ExAC
TOPMed
gnomAD
rs200734272 857 R>W No ExAC
TOPMed
gnomAD
rs143495247 858 R>G No ESP
ExAC
TOPMed
gnomAD
rs745986617 858 R>Q Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No ExAC
NCI-TCGA
TOPMed
gnomAD
rs143495247 858 R>W No ESP
ExAC
TOPMed
gnomAD
rs1553171320 859 G>R No Ensembl
rs749012817 860 A>G No ExAC
TOPMed
gnomAD
rs771194681 860 A>P No 1000Genomes
ExAC
TOPMed
gnomAD
TCGA novel 860 A>R Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
rs771194681 860 A>T No 1000Genomes
ExAC
TOPMed
gnomAD
rs749012817 860 A>V No ExAC
TOPMed
gnomAD
rs568988549 861 R>Q No 1000Genomes
ExAC
gnomAD
rs536081650 861 R>W No 1000Genomes
ExAC
TOPMed
gnomAD
rs1360476972 862 S>G No gnomAD
rs781229291 862 S>I No ExAC
TOPMed
gnomAD
rs781229291 862 S>N No ExAC
TOPMed
gnomAD
rs1377675705 865 D>G No gnomAD
rs1640411755 866 G>D No Ensembl
rs1431089680 867 P>L No gnomAD
rs1197797419 867 P>S No gnomAD
rs765881891 868 S>L No ExAC
TOPMed
gnomAD
rs758067842 869 A>P No ExAC
gnomAD
rs1640410698 871 Q>R No Ensembl
rs1273738355 872 P>S No TOPMed
gnomAD
rs1347294989 874 P>S No gnomAD
rs1442226882 875 R>G No TOPMed
rs532640961 877 N>K No 1000Genomes
ExAC
TOPMed
gnomAD
rs764534286 877 N>S No ExAC
TOPMed
gnomAD
rs764534286 877 N>T No ExAC
TOPMed
gnomAD
rs776104795 878 V>M No ExAC
TOPMed
gnomAD
rs137927599 879 P>L No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
RCV000885106
rs137927599
 879 P>Q No ClinVar
1000Genomes
ESP
ExAC
TOPMed
dbSNP
gnomAD
rs1280286096 879 P>S Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
TOPMed
gnomAD
rs1570316929 880 V>A No TOPMed
rs1416630959 880 V>F No TOPMed
gnomAD
rs1570316929 880 V>G No TOPMed
rs200298634 882 I>V No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs531234229 883 T>I No 1000Genomes
ExAC
TOPMed
gnomAD
rs763061579 885 G>* No ExAC
gnomAD
rs1040517601 885 G>E No TOPMed
gnomAD
rs763061579 885 G>R No ExAC
gnomAD
rs1640363241 886 D>H No TOPMed
gnomAD
rs1640363026 888 S>* No TOPMed
rs1640362915 890 T>A No gnomAD
rs771244024 891 G>E No TOPMed
gnomAD
rs1218407697 892 S>N No TOPMed
gnomAD
rs1212181115 894 P>L No TOPMed
rs773383278 894 P>S No ExAC
TOPMed
gnomAD
rs770017518 895 A>E No ExAC
gnomAD
COSM906122
COSM4864503
 897 S>F Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs747871319 898 V>A No ExAC
gnomAD
rs1230408567 899 Q>P No gnomAD
rs142687246 900 L>F No ESP
ExAC
gnomAD
rs114806866 901 L>S No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs1640360268 902 Q>R No Ensembl
rs1277307525 903 D>G No TOPMed
rs148021104 904 D>W No ESP
ExAC
TOPMed
gnomAD

No associated diseases with Q8TDY4

7 regional properties for Q8TDY4

Type Name Position InterPro Accession
domain Arf GTPase activating protein 426 - 551 IPR001164
domain Pleckstrin homology domain 302 - 396 IPR001849
repeat Ankyrin repeat 585 - 674 IPR002110
domain BAR domain 49 - 260 IPR004148
domain Arf GTPase activating protein 3, BAR domain 35 - 243 IPR028775
domain ASAP, PH domain 294 - 400 IPR037844
domain ASAP3, ArfGAP domain 424 - 546 IPR047006

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
focal adhesion A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ).
intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
ruffle Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.

2 GO annotations of molecular function

Name Definition
GTPase activator activity Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
metal ion binding Binding to a metal ion.

3 GO annotations of biological process

Name Definition
cell migration The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues.
positive regulation of GTPase activity Any process that activates or increases the activity of a GTPase.
regulation of stress fiber assembly Any process that modulates the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.

15 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A5PK26 ACAP1 Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 Bos taurus (Bovine) SS
O97902 ASAP1 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 Bos taurus (Bovine) SS
A1Z7A6 Asap ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein Drosophila melanogaster (Fruit fly) SS
Q15027 ACAP1 Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 Homo sapiens (Human) EV
Q15057 ACAP2 Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 Homo sapiens (Human) PR
O43150 ASAP2 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 Homo sapiens (Human) SS
Q9ULH1 ASAP1 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 Homo sapiens (Human) EV
Q8K2H4 Acap1 Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 Mus musculus (Mouse) SS
Q6ZQK5 Acap2 Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 Mus musculus (Mouse) PR
Q7SIG6 Asap2 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 Mus musculus (Mouse) SS
Q9QWY8 Asap1 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 Mus musculus (Mouse) SS
Q5U464 Asap3 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 Mus musculus (Mouse) SS
Q1AAU6 Asap1 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 Rattus norvegicus (Rat) SS
Q9C6C3 AGD2 ADP-ribosylation factor GTPase-activating protein AGD2 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SMX5 AGD4 ADP-ribosylation factor GTPase-activating protein AGD4 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MPEQFSVAEF LAVTAEDLSS PAGAAAFAAK MPRYRGAALA REEILEGDQA ILQRIKKAVR
70 80 90 100 110 120
AIHSSGLGHV ENEEQYREAV ESLGNSHLSQ NSHELSTGFL NLAVFTREVA ALFKNLIQNL
130 140 150 160 170 180
NNIVSFPLDS LMKGQLRDGR QDSKKQLEKA WKDYEAKMAK LEKERDRARV TGGIPGEVAQ
190 200 210 220 230 240
DMQRERRIFQ LHMCEYLLKA GESQMKQGPD FLQSLIKFFH AQHNFFQDGW KAAQSLFPFI
250 260 270 280 290 300
EKLAASVHAL HQAQEDELQK LTQLRDSLRG TLQLESREEH LSRKNSGCGY SIHQHQGNKQ
310 320 330 340 350 360
FGTEKVGFLY KKSDGIRRVW QKRKCGVKYG CLTISHSTIN RPPVKLTLLT CQVRPNPEEK
370 380 390 400 410 420
KCFDLVTHNR TYHFQAEDEH ECEAWVSVLQ NSKDEALSSA FLGEPSAGPG SWGSAGHDGE
430 440 450 460 470 480
PHDLTKLLIA EVKSRPGNSQ CCDCGAADPT WLSTNLGVLT CIQCSGVHRE LGVRFSRMQS
490 500 510 520 530 540
LTLDLLGPSE LLLALNMGNT SFNEVMEAQL PSHGGPKPSA ESDMGTRRDY IMAKYVEHRF
550 560 570 580 590 600
ARRCTPEPQR LWTAICNRDL LSVLEAFANG QDFGQPLPGP DAQAPEELVL HLAVKVANQA
610 620 630 640 650 660
SLPLVDFIIQ NGGHLDAKAA DGNTALHYAA LYNQPDCLKL LLKGRALVGT VNEAGETALD
670 680 690 700 710 720
IARKKHHKEC EELLEQAQAG TFAFPLHVDY SWVISTEPGS DSEEDEEEKR CLLKLPAQAH
730 740 750 760 770 780
WASGRLDISN KTYETVASLG AATPQGESED CPPPLPVKNS SRTLVQGCAR HASGDRSEVS
790 800 810 820 830 840
SLSSEAPETP ESLGSPASSS SLMSPLEPGD PSQAPPNSEE GLREPPGTSR PSLTSGTTPS
850 860 870 880 890 900
EMYLPVRFSS ESTRSYRRGA RSPEDGPSAR QPLPRRNVPV GITEGDGSRT GSLPASSVQL
LQD