A5PK26

SS
Gene name
ACAP1 (CENTB1)
Protein name
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1
Names
Centaurin-beta-1 , Cnt-b1
Species
Bos taurus (Bovine)
KEGG Pathway
bta:508582
EC number
Protein Class

Descriptions

ACAP1 (ArfGAP with coiled-coil, ankyrin repeat, and PH domains protein 1) is an ARF6 GAP that acts as a key component of a defined clathrin complex for endocytic recycling. A flexible linker region between the GAP and ANK domains acts to obstruct cargo binding, with a key residue within this region (Ser-554) regulating this obstruction. The excision of the linker region results in promoting cargo binding and integrin recycling.

Autoinhibitory domains (AIDs)

525-569 (Linker region) SS

Target domain

403-525 (GAP domain)

Relief mechanism

PTM

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A5PK26

Entry ID Method Resolution Chain Position Source
AF-A5PK26-F1 Predicted AlphaFoldDB

No variants for A5PK26

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A5PK26

No associated diseases with A5PK26

5 regional properties for A5PK26

Type Name Position InterPro Accession
conserved_site ATP-dependent RNA helicase DEAD-box, conserved site 189 - 197 IPR000629
domain Helicase, C-terminal 254 - 415 IPR001650
domain DEAD/DEAH box helicase domain 67 - 229 IPR011545
domain Helicase superfamily 1/2, ATP-binding domain 61 - 258 IPR014001
domain RNA helicase, DEAD-box type, Q motif 42 - 70 IPR014014

Functions

Description
EC Number
Subcellular Localization
  • Recycling endosome membrane ; Peripheral membrane protein ; Cytoplasmic side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
recycling endosome membrane The lipid bilayer surrounding a recycling endosome.

2 GO annotations of molecular function

Name Definition
GTPase activator activity Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
metal ion binding Binding to a metal ion.

1 GO annotations of biological process

Name Definition
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

15 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O97902 ASAP1 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 Bos taurus (Bovine) SS
A1Z7A6 Asap ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein Drosophila melanogaster (Fruit fly) SS
O43150 ASAP2 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 Homo sapiens (Human) SS
Q15057 ACAP2 Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 Homo sapiens (Human) PR
Q8TDY4 ASAP3 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 Homo sapiens (Human) SS
Q9ULH1 ASAP1 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 Homo sapiens (Human) EV
Q15027 ACAP1 Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 Homo sapiens (Human) EV
Q5U464 Asap3 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 Mus musculus (Mouse) SS
Q6ZQK5 Acap2 Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 Mus musculus (Mouse) PR
Q7SIG6 Asap2 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 Mus musculus (Mouse) SS
Q9QWY8 Asap1 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 Mus musculus (Mouse) SS
Q8K2H4 Acap1 Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 Mus musculus (Mouse) SS
Q1AAU6 Asap1 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 Rattus norvegicus (Rat) SS
Q9SMX5 AGD4 ADP-ribosylation factor GTPase-activating protein AGD4 Arabidopsis thaliana (Mouse-ear cress) PR
Q9C6C3 AGD2 ADP-ribosylation factor GTPase-activating protein AGD2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MTVKLDFEEC LKDSPRFRAS VELVEAEVSE LETRLEKLLK LGNGLLESGR HYLAASRAFI
70 80 90 100 110 120
VGICDLAHLG PPEPMMAECL DKFTQSLSHK LDSHAELLDA TQHTLQRQIQ TLVKEGLRSF
130 140 150 160 170 180
REAGRDFWRG AESLEAALTH NAEVPRRRAQ EAEEAGAALK VARAGYRGRA LDYALQINVI
190 200 210 220 230 240
EDKRKFDIME FVLRLVEAQA THFQQGHEEL SQLAQYRKEL GGQLHQLVLN SAREKRDMEQ
250 260 270 280 290 300
RHVLLKQKEL GGEEPEPSLK EGPGGLVMEG HLFKRASNAF KTWSRRWFTI QSNQLVYQKR
310 320 330 340 350 360
YKDPVTVVVD DLRLCTVKLC PDSERRFCFE VVSPSKSCLL QSDSERLMQL WVSAVQSSIA
370 380 390 400 410 420
TAFSQARLDD SPRGLGQGSG HLAISSAATL GPGGLTRGRE PGGVGHVAAQ VQSVDGNAQC
430 440 450 460 470 480
CDCREPAPEW ASINLGVTLC IQCSGIHRSL GVHFSKVRSL TLDSWEPELV KLMCELGNVV
490 500 510 520 530 540
INQIYEARVE AMAVKKPGPS CSRQEKEAWI HAKYVEKKFL TKLPEIRGRR GGRGPPRGHP
550 560 570 580 590 600
PVPPKPGLIR PKPGSFRSKP EPPSEDLQSL HPGALLFRAA GHPPSLPTMA DALAHGADVN
610 620 630 640 650 660
WVNGGQENAT PLIQATAAVR VLNSLLACEF LLQNGANVNQ VDNQGRGPLH HATILGHTGL
670 680 690 700 710 720
ACLFLKRGAD LGVRDSEGRD PLTIAVETAN ADIVTLLRLA KMREADAAQG QAGDETYLDI
730 740
FRDFSLMASD DPEKLSRRSH DLHTL