AiPD: Autoinhibited Protein Database

Q8TBF2

Gene name	PRXL2B
Protein name	Prostamide/prostaglandin F synthase
Names	Prostamide/PG F synthase, Prostamide/PGF synthase, Peroxiredoxin-like 2B, Protein FAM213B
Species	Homo sapiens (Human)
KEGG Pathway	hsa:127281
EC number	1.11.1.20: Peroxidases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

85-156 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

85-156 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q8TBF2

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8TBF2-F1	Predicted				AlphaFoldDB

184 variants for Q8TBF2

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs1465149695 CA337972836	2	S>G	No	ClinGen gnomAD
rs757860802 CA541653	4	V>A	No	ClinGen ExAC TOPMed gnomAD
CA16974963 rs374181306	5	D>V	No	ClinGen Ensembl
rs375491063 CA541656	7	A>D	No	ClinGen ESP ExAC TOPMed gnomAD
CA541654 rs542158618	7	A>P	No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA541655 rs375491063	7	A>V	No	ClinGen ESP ExAC TOPMed gnomAD
CA541657 rs779628951	8	R>C	No	ClinGen ExAC TOPMed gnomAD
CA337972913 rs1468165836	9	V>L	No	ClinGen gnomAD
CA337972940 rs1412292027	11	A>E	No	ClinGen TOPMed gnomAD
CA337972935 rs1159867442	11	A>T	No	ClinGen TOPMed gnomAD
CA337972944 rs1412292027	11	A>V	No	ClinGen TOPMed gnomAD
rs866041846 CA16974993	12	C>Y	No	ClinGen gnomAD
rs947664073 CA16975008	15	K>N	No	ClinGen TOPMed
rs369950133 CA541658	15	K>Q	No	ClinGen ESP ExAC TOPMed gnomAD
CA16975009 rs866708289	17	A>V	No	ClinGen gnomAD
CA16975010 rs888753734	18	V>L	No	ClinGen TOPMed gnomAD
CA337973061 rs866108678 CA16975012	20	G>R	No	ClinGen TOPMed
CA16975016 rs868012424	21	E>D	No	ClinGen Ensembl
rs768402718 CA541659	21	E>G	No	ClinGen ExAC gnomAD
CA337973179 rs1274818008	22	A>S	No	ClinGen gnomAD
CA16975198 rs991913588	23	V>M	No	ClinGen TOPMed gnomAD
rs980348599 CA16975215	26	R>Q	No	ClinGen TOPMed
rs549244493 CA16975212	26	R>W	No	ClinGen 1000Genomes TOPMed gnomAD
CA16975218 rs927541533	27	S>I	No	ClinGen TOPMed gnomAD
CA541677 rs754642361	28	L>Q	No	ClinGen ExAC gnomAD
rs1374870231 CA337973287	29	W>R	No	ClinGen gnomAD
CA16975236 rs938862761	30	R>P	No	ClinGen TOPMed gnomAD
rs1403203760 CA337973346	31	E>*	No	ClinGen gnomAD
CA337973356 rs1396366421	31	E>G	No	ClinGen TOPMed gnomAD
rs373997233 CA541679	32	H>R	No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA16975291 rs907939346	33	A>V	No	ClinGen TOPMed gnomAD
rs1265042181 CA337973455	36	V>G	No	ClinGen TOPMed
rs772034526 CA541680	36	V>L	No	ClinGen ExAC TOPMed gnomAD
rs972180026 CA16975310	38	G>R	No	ClinGen Ensembl
CA337973474 rs1298259058	38	G>V	No	ClinGen gnomAD
CA337973479 rs1346469260	39	L>P	No	ClinGen TOPMed gnomAD
CA337973478 rs1346469260	39	L>Q	No	ClinGen TOPMed gnomAD
rs777621960 CA337973495	41	R>H	No	ClinGen ExAC TOPMed gnomAD
rs777621960 CA541681	41	R>L	No	ClinGen ExAC TOPMed gnomAD
CA337973496 rs777621960	41	R>P	No	ClinGen ExAC TOPMed gnomAD
CA16975355 rs868467311	43	G>W	No	ClinGen Ensembl
CA337973541 rs1368736488	44	C>Y	No	ClinGen TOPMed
rs1197959042 CA337973555	45	V>A	No	ClinGen TOPMed gnomAD
rs1487134558 CA337973547	45	V>M	No	ClinGen gnomAD
rs745931744 CA541683	48	R>S	No	ClinGen ExAC gnomAD
rs1479848044 CA337973600	49	W>*	No	ClinGen gnomAD
rs769719500 CA541684	51	A>T	No	ClinGen ExAC gnomAD
rs377736173 CA541685	51	A>V	No	ClinGen ESP ExAC TOPMed gnomAD
CA337973648 rs1557500508	53	D>N	No	ClinGen Ensembl
CA337973665 rs1175654003	54	L>F	No	ClinGen gnomAD
rs774847353 CA541688	56	S>I	No	ClinGen ExAC gnomAD
CA337973713 rs1049300628	58	A>P	No	ClinGen TOPMed gnomAD
CA16975422 rs1049300628	58	A>S	No	ClinGen TOPMed gnomAD
CA337973720 rs1288055462	58	A>V	No	ClinGen gnomAD
CA541689 rs774372262	59	G>E	No	ClinGen ExAC TOPMed gnomAD
rs1370219132 CA337973732	60	L>F	No	ClinGen gnomAD
rs768043662 CA541690	62	D>E	No	ClinGen ExAC TOPMed gnomAD
CA541692 rs761269474	65	G>S	No	ClinGen ExAC TOPMed gnomAD
rs1258591076 CA337973811	66	V>G	No	ClinGen gnomAD
rs1237812057 CA337973807	66	V>M	No	ClinGen gnomAD
rs765751080 CA541693	67	R>H	No	ClinGen ExAC gnomAD
rs899128712 CA337973839	69	V>L	No	ClinGen TOPMed gnomAD
CA16975444 rs899128712	69	V>M	No	ClinGen TOPMed gnomAD
CA337973857 rs1570616272	70	G>V	No	ClinGen Ensembl
rs1467553598 CA337973860	71	V>I	No	ClinGen gnomAD
rs1257410433 CA337973876	72	G>E	No	ClinGen TOPMed
CA337973889 rs1157106971	73	P>H	No	ClinGen gnomAD
rs148467351 CA541697	73	P>S	No	ClinGen ESP ExAC TOPMed gnomAD
CA16975475 rs868334952	74	E>D	No	ClinGen gnomAD
rs1458596474 CA337973895	74	E>Q	No	ClinGen gnomAD
rs867145894 CA16975484	75	A>S	No	ClinGen Ensembl
rs758169588 CA541698	75	A>V	No	ClinGen ExAC gnomAD
CA541699 rs373829099	76	L>R	No	ClinGen ESP ExAC TOPMed gnomAD
rs1438701056 CA337973926	77	G>R	No	ClinGen gnomAD
CA541700 rs746870840	79	Q>*	No	ClinGen ExAC gnomAD
rs757231520 CA541701	80	E>G	No	ClinGen ExAC gnomAD
CA337973990 rs1330832939	83	D>Y	No	ClinGen gnomAD
CA16975516 rs1009264446	84	G>R	No	ClinGen TOPMed gnomAD
CA337974004 rs1009264446	84	G>S	No	ClinGen TOPMed gnomAD
rs1333318228 CA337974011	84	G>V	No	ClinGen gnomAD
CA541704 rs371479642	85	D>E	No	ClinGen 1000Genomes ExAC gnomAD
rs1020669430 CA16975521	85	D>N	No	ClinGen Ensembl
rs1224350440 CA337974022	85	D>V	No	ClinGen gnomAD
rs1478391483 CA337974031	86	Y>C	No	ClinGen TOPMed
rs868041940 CA16975522	88	A>S	No	ClinGen Ensembl
rs1480322328 CA337974061	88	A>V	No	ClinGen TOPMed gnomAD
CA337974138 rs1340311124	90	E>D	No	ClinGen TOPMed
rs1300456302 CA337974142	91	L>I	No	ClinGen gnomAD
CA337974143 rs1300456302	91	L>V	No	ClinGen gnomAD
CA541726 rs747468915	92	Y>S	No	ClinGen ExAC gnomAD
CA337974163 rs1210292027	93	L>M	No	ClinGen gnomAD
rs976291040 CA16976317	94	D>H	No	ClinGen Ensembl
CA337974183 rs1444380818	95	E>K	No	ClinGen gnomAD
CA337974194 rs1277179118	96	S>G	No	ClinGen TOPMed
rs368813313 CA541729	96	S>N	No	ClinGen ESP ExAC TOPMed gnomAD
rs1485428554 CA337974204	97	K>Q	No	ClinGen gnomAD
rs1218762765 CA337974225	98	Q>R	No	ClinGen TOPMed
rs775077232 CA541731	100	Y>*	No	ClinGen ExAC gnomAD
CA541730 rs764680301	100	Y>H	No	ClinGen ExAC gnomAD
rs764680301 CA337974246	100	Y>N	No	ClinGen ExAC gnomAD
rs1172520727 CA337974260	101	K>*	No	ClinGen gnomAD
CA337974296 rs1334418066	103	L>P	No	ClinGen gnomAD
rs1344910272 CA337974298	104	G>S	No	ClinGen gnomAD
CA337974346 rs751294709	107	R>P	No	ClinGen ExAC TOPMed gnomAD
CA541734 rs751294709	107	R>Q	No	ClinGen ExAC TOPMed gnomAD
rs1429105266 CA337974342	107	R>W	No	ClinGen gnomAD
CA16977151 rs370507648	108	Y>C	No	ClinGen ESP TOPMed
CA337974756 rs370507648	108	Y>S	No	ClinGen ESP TOPMed
rs1333081743 CA337974768	109	N>D	No	ClinGen TOPMed
CA337974776 rs1557503436	109	N>S	No	ClinGen Ensembl
CA16977160 rs981819573	112	S>G	No	ClinGen Ensembl
CA337974822 rs1263591284	112	S>N	No	ClinGen gnomAD
rs1259190557 CA337974856	113	I>T	No	ClinGen TOPMed
CA337974837 rs1358438861	113	I>V	No	ClinGen gnomAD
CA541765 rs757485721	114	L>F	No	ClinGen ExAC TOPMed gnomAD
rs867635647 CA16977165	115	P>T	No	ClinGen Ensembl
rs746930692 CA541764	117	A>*	No	ClinGen ExAC TOPMed
rs1271744172 CA337974921	117	A>S	No	ClinGen gnomAD
CA337974937 rs1481792573	118	L>P	No	ClinGen TOPMed gnomAD
rs918359258 CA16977205	121	P>L	No	ClinGen gnomAD
CA337974978 rs1483683431	121	P>S	No	ClinGen TOPMed
rs770271771 CA541768	122	V>G	No	ClinGen ExAC gnomAD
rs1416914009 CA337974993	122	V>L	No	ClinGen TOPMed
rs144215612 CA541769	123	R>C	No	ClinGen ESP ExAC TOPMed gnomAD
rs144215612 CA337975006	123	R>G	No	ClinGen ESP ExAC TOPMed gnomAD
rs748716490 CA541770	123	R>H	No	ClinGen ExAC gnomAD
CA337975036 rs768170711	124	D>G	No	ClinGen ExAC gnomAD
CA541771 rs768170711	124	D>V	No	ClinGen ExAC gnomAD
rs773754249 CA541772	125	V>M	No	ClinGen ExAC gnomAD
rs771918774 CA541774	127	A>S	No	ClinGen ExAC TOPMed gnomAD
CA337975078 rs1184412610	128	K>R	No	ClinGen Ensembl
rs141104076 CA541798	129	A>S	No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA337975189 rs1431513613	131	A>G	No	ClinGen gnomAD
rs1178451370 CA337975196	132	V>I	No	ClinGen TOPMed gnomAD
rs148988402 CA541801	134	I>V	No	ClinGen ESP ExAC TOPMed gnomAD
rs1053863687 CA16977529	136	G>R	No	ClinGen Ensembl
CA541805 rs750602949	139	S>F	No	ClinGen ExAC TOPMed gnomAD
CA541807 rs766706557	141	D>H	No	ClinGen ExAC gnomAD
rs766706557 CA541808	141	D>Y	No	ClinGen ExAC gnomAD
rs1228164389 CA337975372	142	L>V	No	ClinGen TOPMed gnomAD
CA541811 rs779613731	145	S>R	No	ClinGen ExAC TOPMed gnomAD
rs757946334 CA541813	146	G>R	No	ClinGen ExAC gnomAD
rs777451341 CA541814	147	G>R	No	ClinGen ExAC gnomAD
rs770497087 CA541816	149	L>V	No	ClinGen ExAC gnomAD
CA337975521 rs1392922105	150	V>G	No	ClinGen TOPMed
CA541817 rs781034373	150	V>M	No	ClinGen ExAC gnomAD
CA337975586 rs1458645619	154	G>S	No	ClinGen gnomAD
CA541854 rs779756816	155	G>S	No	ClinGen ExAC TOPMed gnomAD
CA337976205 rs1448329219	161	H>R	No	ClinGen TOPMed gnomAD
rs200164303 CA541857	163	V>I	No	ClinGen ExAC TOPMed gnomAD
rs200164303 CA337976245	163	V>L	No	ClinGen ExAC TOPMed gnomAD
CA541858 rs748149450	164	Q>*	No	ClinGen ExAC gnomAD
rs770867206 CA541859	164	Q>R	No	ClinGen ExAC TOPMed gnomAD
rs371656711 CA541860	167	P>L	No	ClinGen ESP ExAC TOPMed gnomAD
CA337976343 rs1260244640	167	P>S	No	ClinGen TOPMed
CA337976365 rs1450660380	168	G>C	No	ClinGen gnomAD
CA337976360 rs1450660380	168	G>R	No	ClinGen gnomAD
rs770211827 CA541862	169	D>A	No	ClinGen ExAC gnomAD
rs746014507 CA541861	169	D>N	No	ClinGen ExAC gnomAD
CA541863 rs544710926	170	Y>C	No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA541865 rs565565761	171	V>F	No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA541866 rs565565761	171	V>I	No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA541867 rs565565761	171	V>L	No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs749952576 CA541869	173	K>R	No	ClinGen ExAC TOPMed gnomAD
rs778792541 CA541874	178	Q>H	No	ClinGen ExAC gnomAD
CA337976552 rs1475459013	179	V>I	No	ClinGen gnomAD
CA541878 rs746005922	182	I>V	No	ClinGen ExAC TOPMed gnomAD
rs770115843 CA541879	183	S>P	No	ClinGen ExAC gnomAD
rs374933565 CA16980431	184	A>V	No	ClinGen ESP TOPMed
CA337976629 rs1323139908	185	E>G	No	ClinGen gnomAD
rs1365966803 CA337976646	187	C>S	No	ClinGen gnomAD
CA16980434 rs141147759	188	A>V	No	ClinGen ESP
CA337976669 rs1220736576	190	D>A	No	ClinGen gnomAD
rs369682917 CA541883	190	D>N	No	ClinGen ESP ExAC TOPMed gnomAD
rs762160893 CA541884	191	P>L	No	ClinGen ExAC TOPMed gnomAD
CA541886 rs551150393	193	Q>*	No	ClinGen 1000Genomes ExAC gnomAD
CA16980539 rs1047355667	193	Q>R	No	ClinGen Ensembl
rs1185997291 CA337976773	194	C>R	No	ClinGen gnomAD
rs780215273 CA541914	195	D>N	No	ClinGen ExAC gnomAD
CA541916 rs754038181	197	E>*	No	ClinGen ExAC gnomAD
CA337976849 rs754038181	197	E>K	No	ClinGen ExAC gnomAD
CA541917 rs754038181	197	E>Q	No	ClinGen ExAC gnomAD
CA337976881 rs1431798360	198	V>A	No	ClinGen gnomAD
rs1388534375 CA337976871	198	V>M	No	ClinGen gnomAD

No associated diseases with Q8TBF2

2 regional properties for Q8TBF2

Type	Name	Position	InterPro Accession
domain	Proteasome component (PCI) domain	286 - 483	IPR000717
domain	26S proteasome regulatory subunit, C-terminal	465 - 531	IPR013586

Functions

		Description
EC Number	1.11.1.20	Peroxidases
Subcellular Localization	Cytoplasm, cytosol
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

5 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
myelin sheath	An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.

3 GO annotations of molecular function

Name	Definition
antioxidant activity	Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage.
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP.
prostaglandin-F synthase activity	Catalysis of the reaction: NADP+ + (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate = NADPH + H+ + (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate.

1 GO annotations of biological process

Name	Definition
prostaglandin biosynthetic process	The chemical reactions and pathways resulting in the formation of prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring.

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q58CY6	PRXL2B	Prostamide/prostaglandin F synthase	Bos taurus (Bovine)	PR

10	20	30	40	50	60
MSTVDLARVG	ACILKHAVTG	EAVELRSLWR	EHACVVAGLR	RFGCVVCRWI	AQDLSSLAGL
70	80	90	100	110	120
LDQHGVRLVG	VGPEALGLQE	FLDGDYFAGE	LYLDESKQLY	KELGFKRYNS	LSILPAALGK
130	140	150	160	170	180
PVRDVAAKAK	AVGIQGNLSG	DLLQSGGLLV	VSKGGDKVLL	HFVQKSPGDY	VPKEHILQVL
190
GISAEVCASD	PPQCDREV