Q8RXT4

PR
Gene name
NEK4 (At3g63280, F16M2.130)
Protein name
Serine/threonine-protein kinase Nek4
Names
NimA-related protein kinase 4, AtNek4
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT3G63280
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

265-514 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

146-168 (Activation loop from InterPro)

Target domain

4-258 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q8RXT4

Entry ID Method Resolution Chain Position Source
AF-Q8RXT4-F1 Predicted AlphaFoldDB

37 variants for Q8RXT4

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_3_23378790_T_C 37 L>P No 1000Genomes
ENSVATH14473518 61 P>S No 1000Genomes
ENSVATH06364707 111 V>A No 1000Genomes
tmp_3_23379571_T_C 143 I>T No 1000Genomes
tmp_3_23380247_A_C 241 K>T No 1000Genomes
ENSVATH06364720 276 T>S No 1000Genomes
tmp_3_23380455_C_T 282 S>F No 1000Genomes
tmp_3_23380458_A_G 283 E>G No 1000Genomes
ENSVATH06364721 285 D>E No 1000Genomes
ENSVATH14473523 286 A>S No 1000Genomes
ENSVATH12897199 293 R>G No 1000Genomes
tmp_3_23380501_C_A 297 S>R No 1000Genomes
tmp_3_23380514_T_A 302 L>M No 1000Genomes
ENSVATH06364722 311 A>T No 1000Genomes
tmp_3_23380569_C_T 320 A>V No 1000Genomes
ENSVATH06364723 323 T>S No 1000Genomes
ENSVATH06364724 324 P>S No 1000Genomes
ENSVATH06364728 350 E>G No 1000Genomes
ENSVATH02539536 373 Q>P No 1000Genomes
ENSVATH06364730 376 V>I No 1000Genomes
ENSVATH06364731 377 F>S No 1000Genomes
ENSVATH06364736 385 S>P No 1000Genomes
ENSVATH06364737 387 P>T No 1000Genomes
ENSVATH12897202 432 A>V No 1000Genomes
tmp_3_23380998_C_G 435 P>R No 1000Genomes
ENSVATH06364738 437 D>Y No 1000Genomes
ENSVATH14473536 465 H>Q No 1000Genomes
tmp_3_23381091_G_A 466 G>D No 1000Genomes
ENSVATH12897203 468 D>E No 1000Genomes
tmp_3_23381100_A_C 469 N>T No 1000Genomes
tmp_3_23381107_C_G 471 N>K No 1000Genomes
ENSVATH06364741 472 G>D No 1000Genomes
ENSVATH14473537 475 T>K No 1000Genomes
ENSVATH06364742 483 K>E No 1000Genomes
ENSVATH06364743 520 E>K No 1000Genomes
ENSVATH12897204 534 A>P No 1000Genomes
tmp_3_23381354_T_A 554 S>T No 1000Genomes

No associated diseases with Q8RXT4

3 regional properties for Q8RXT4

Type Name Position InterPro Accession
domain Protein kinase domain 4 - 258 IPR000719
active_site Serine/threonine-protein kinase, active site 125 - 137 IPR008271
binding_site Protein kinase, ATP binding site 10 - 33 IPR017441

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

1 GO annotations of biological process

Name Definition
protein phosphorylation The process of introducing a phosphate group on to a protein.

12 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P22209 KIN3 Serine/threonine-protein kinase KIN3 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q6P3R8 NEK5 Serine/threonine-protein kinase Nek5 Homo sapiens (Human) PR
Q8NE28 STKLD1 Serine/threonine kinase-like domain-containing protein STKLD1 Homo sapiens (Human) PR
P51957 NEK4 Serine/threonine-protein kinase Nek4 Homo sapiens (Human) PR
P51955 NEK2 Serine/threonine-protein kinase Nek2 Homo sapiens (Human) EV
Q8K1R7 Nek9 Serine/threonine-protein kinase Nek9 Mus musculus (Mouse) SS
Q7TSC3 Nek5 Serine/threonine-protein kinase Nek5 Mus musculus (Mouse) PR
O35942 Nek2 Serine/threonine-protein kinase Nek2 Mus musculus (Mouse) PR
Q10GB1 NEK1 Serine/threonine-protein kinase Nek1 Oryza sativa subsp japonica (Rice) PR
Q6ZEZ5 NEK3 Serine/threonine-protein kinase Nek3 Oryza sativa subsp japonica (Rice) PR
Q9LT35 NEK6 Serine/threonine-protein kinase Nek6 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SLI2 NEK1 Serine/threonine-protein kinase Nek1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MERYEVLEQI GKGSFGSALL VRHKQERKKY VLKKIRLARQ SDRARRSAHQ EMELISTVRN
70 80 90 100 110 120
PFVVEYKDSW VEKGCYVCIV IGYCQGGDMT DTIKRACGVH FPEEKLCQWL VQLLMALDYL
130 140 150 160 170 180
HSNHILHRDV KCSNIFLTKE QDIRLGDFGL AKILTSDDLT SSVVGTPSYM CPELLADIPY
190 200 210 220 230 240
GSKSDIWSLG CCMYEMAAHK PPFKASDVQT LITKIHKLIM DPIPAMYSGS FRGLIKSMLR
250 260 270 280 290 300
KNPELRPSAN ELLNHPHLQP YISMVYMKLE SPRRSTFPLQ FSERDATLKE RRRSSFSNDR
310 320 330 340 350 360
RLNPSVSDTE AGSVSSSGKA SPTPMFNGRK VSEVTVGVVR EEIVPQRQEE AKKQSGAART
370 380 390 400 410 420
PRVAGTSAKA STQRTVFKHE LMKVSNPTER RRRVSLPLVV ENPYTYESDI TALCSLNSPD
430 440 450 460 470 480
VSVNTPRFDK IAEFPEDIFQ NQNRETASRR EVARHSFSSP PCPPHGEDNS NGSITKDKCT
490 500 510 520 530 540
VQKRSVSEVK QRRFDTSSYQ QRAEALEGLL EFSAKLLQQE RYDELGVLLK PFGAERVSSR
550
ETAIWLTKSF KEASV